GREMLIN Database
ARAD - L-ribulose-5-phosphate 4-epimerase
UniProt: P08203 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10055
Length: 231 (199)
Sequences: 6309 (3867)
Seq/√Len: 274.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_S65_E4.8721.00
178_K182_D3.2481.00
195_Y199_F3.0871.00
100_H199_F3.0801.00
38_V58_V2.8721.00
5_L31_A2.6311.00
109_Q201_R2.6021.00
212_Q216_D2.5991.00
39_F81_R2.5081.00
8_Q181_E2.5031.00
40_V56_M2.4711.00
90_I176_W2.1991.00
82_L147_N2.0831.00
38_V67_V2.0781.00
103_I199_F2.0481.00
99_R195_Y2.0341.00
100_H195_Y2.0221.00
62_E65_E1.9921.00
52_T55_D1.9501.00
10_L53_A1.9471.00
127_P163_M1.9401.00
211_Q214_L1.9381.00
100_H198_I1.9071.00
7_R11_E1.9011.00
82_L85_Q1.8821.00
31_A180_A1.8311.00
165_G190_L1.8291.00
141_Y147_N1.8161.00
40_V58_V1.7971.00
94_V183_A1.7311.00
91_G179_N1.6971.00
199_F202_Q1.6881.00
15_A19_H1.6521.00
59_V77_T1.6301.00
179_N182_D1.6161.00
130_R169_H1.6111.00
33_D40_V1.6101.00
92_G180_A1.6091.00
12_A184_V1.5481.00
4_D8_Q1.5381.00
108_G169_H1.5031.00
62_E85_Q1.4951.00
9_V29_V1.4751.00
110_S125_T1.4441.00
7_R53_A1.4361.00
86_A154_E1.4271.00
19_H188_I1.4151.00
10_L14_L1.4141.00
177_G182_D1.4071.00
14_L18_K1.3921.00
86_A150_V1.3791.00
9_V56_M1.3661.00
173_P190_L1.3611.00
31_A92_G1.3581.00
96_T187_A1.3581.00
140_E144_E1.3451.00
99_R103_I1.3431.00
39_F61_I1.2951.00
87_F90_I1.2941.00
111_I194_A1.2911.00
112_P197_G1.2901.00
136_E148_V1.2791.00
82_L86_A1.2711.00
175_A187_A1.2701.00
30_S93_I1.2301.00
58_V68_E1.2251.00
104_W201_R1.2051.00
66_V69_G1.2041.00
15_A18_K1.1931.00
124_G216_D1.1771.00
81_R85_Q1.1721.00
30_S84_Y1.1671.00
97_H171_H1.1651.00
99_R192_E1.1571.00
34_R38_V1.1561.00
198_I203_L1.1531.00
214_L217_K1.1461.00
10_L56_M1.1451.00
164_P186_N1.1431.00
130_R151_E1.1371.00
46_V55_D1.1351.00
84_Y93_I1.1341.00
201_R205_P1.1271.00
95_H171_H1.1191.00
147_N151_E1.1191.00
101_A173_P1.1131.00
197_G201_R1.1051.00
12_A180_A1.1021.00
32_V91_G1.0921.00
33_D58_V1.0821.00
100_H191_E1.0771.00
102_T105_A1.0711.00
198_I202_Q1.0661.00
41_I74_S1.0591.00
16_L29_V1.0571.00
168_V174_F1.0531.00
107_A203_L1.0491.00
46_V71_K1.0431.00
110_S128_C1.0431.00
114_T197_G1.0401.00
17_P49_S1.0401.00
33_D36_R1.0401.00
16_L94_V1.0351.00
144_E147_N1.0311.00
96_T173_P1.0221.00
101_A190_L1.0171.00
149_I168_V1.0141.00
165_G175_A1.0081.00
153_F176_W0.9941.00
12_A29_V0.9851.00
13_N29_V0.9771.00
148_V151_E0.9751.00
191_E195_Y0.9731.00
153_F166_V0.9711.00
39_F77_T0.9681.00
61_I85_Q0.9581.00
192_E195_Y0.9531.00
55_D70_T0.9371.00
5_L33_D0.9261.00
177_G186_N0.9241.00
87_F176_W0.9181.00
98_S101_A0.9171.00
33_D38_V0.9131.00
130_R148_V0.9081.00
210_M214_L0.9031.00
213_T217_K0.8991.00
129_T148_V0.8941.00
200_C207_L0.8921.00
43_P56_M0.8861.00
16_L184_V0.8831.00
51_M55_D0.8821.00
8_Q11_E0.8811.00
43_P46_V0.8771.00
39_F59_V0.8771.00
19_H184_V0.8731.00
123_Y212_Q0.8721.00
103_I198_I0.8701.00
94_V187_A0.8651.00
99_R199_F0.8591.00
83_L153_F0.8581.00
8_Q31_A0.8551.00
55_D71_K0.8521.00
60_S67_V0.8501.00
124_G212_Q0.8491.00
10_L51_M0.8431.00
108_G206_Q0.8391.00
83_L90_I0.8280.99
213_T216_D0.8260.99
79_T174_F0.8260.99
41_I76_D0.8200.99
216_D219_Y0.8160.99
214_L218_H0.8130.99
82_L150_V0.8080.99
106_Q114_T0.8060.99
130_R136_E0.8010.99
173_P187_A0.7980.99
111_I193_V0.7950.99
109_Q205_P0.7950.99
110_S127_P0.7920.99
13_N48_Y0.7880.99
211_Q217_K0.7870.99
98_S187_A0.7790.99
86_A151_E0.7770.99
57_V72_K0.7740.99
151_E154_E0.7720.99
126_I190_L0.7710.99
182_D186_N0.7640.99
141_Y144_E0.7630.99
11_E50_V0.7620.99
111_I167_L0.7490.99
44_S72_K0.7480.99
79_T149_I0.7450.99
104_W197_G0.7410.99
50_V181_E0.7390.99
125_T163_M0.7330.99
42_K84_Y0.7320.99
190_L194_A0.7300.99
15_A184_V0.7300.99
127_P166_V0.7300.99
30_S41_I0.7280.99
129_T168_V0.7180.99
6_K40_V0.7140.98
46_V51_M0.7120.98
98_S191_E0.7090.98
108_G208_P0.7070.98
4_D7_R0.7050.98
6_K68_E0.7050.98
22_V29_V0.7000.98
42_K51_M0.6940.98
37_G61_I0.6930.98
155_K163_M0.6920.98
77_T81_R0.6880.98
5_L8_Q0.6850.98
210_M215_L0.6850.98
129_T152_T0.6780.98
175_A186_N0.6750.98
20_N195_Y0.6750.98
107_A205_P0.6740.98
34_R37_G0.6730.98
91_G178_K0.6620.98
16_L21_L0.6590.97
24_L185_H0.6580.97
87_F153_F0.6550.97
32_V61_I0.6540.97
113_A118_H0.6490.97
85_Q150_V0.6470.97
102_T196_M0.6450.97
116_T119_A0.6410.97
114_T201_R0.6390.97
76_D145_T0.6390.97
32_V37_G0.6390.97
152_T166_V0.6370.97
50_V55_D0.6350.97
28_N74_S0.6310.97
28_N76_D0.6310.97
27_G48_Y0.6290.97
5_L40_V0.6260.97
47_D50_V0.6240.96
150_V153_F0.6220.96
98_S173_P0.6210.96
23_T192_E0.6200.96
92_G183_A0.6190.96
25_T44_S0.6190.96
148_V152_T0.6180.96
83_L174_F0.6170.96
9_V40_V0.6160.96
17_P22_V0.6110.96
89_S178_K0.6070.96
60_S64_G0.6070.96
6_K58_V0.6070.96
136_E145_T0.6070.96
141_Y146_G0.6030.96
23_T26_W0.6030.96
212_Q215_L0.6030.96
64_G81_R0.6010.96
144_E148_V0.6000.96
101_A167_L0.5940.95
78_P141_Y0.5940.95
106_Q115_G0.5940.95
104_W194_A0.5930.95
215_L218_H0.5910.95
182_D185_H0.5910.95
32_V39_F0.5880.95
203_L207_L0.5880.95
102_T172_G0.5880.95
121_Y186_N0.5830.95
107_A198_I0.5800.95
61_I81_R0.5800.95
37_G62_E0.5730.94
103_I196_M0.5710.94
107_A200_C0.5710.94
164_P178_K0.5700.94
58_V67_V0.5690.94
152_T155_K0.5680.94
44_S74_S0.5670.94
105_A167_L0.5640.94
164_P182_D0.5600.94
104_W198_I0.5590.94
200_C206_Q0.5570.94
131_K168_V0.5550.93
94_V175_A0.5530.93
44_S75_S0.5490.93
126_I165_G0.5470.93
200_C204_A0.5450.93
137_I213_T0.5410.93
115_G118_H0.5410.93
9_V13_N0.5390.92
78_P82_L0.5390.92
59_V81_R0.5370.92
38_V61_I0.5370.92
150_V154_E0.5360.92
101_A194_A0.5310.92
166_V174_F0.5310.92
6_K53_A0.5300.92
17_P23_T0.5300.92
101_A187_A0.5270.92
104_W109_Q0.5270.92
29_V180_A0.5230.91
17_P48_Y0.5200.91
57_V66_V0.5190.91
38_V60_S0.5190.91
19_H24_L0.5170.91
121_Y189_V0.5170.91
106_Q196_M0.5150.91
13_N51_M0.5150.91
6_K56_M0.5140.91
87_F164_P0.5130.90
26_W192_E0.5110.90
117_T189_V0.5110.90
84_Y92_G0.5090.90
100_H103_I0.5080.90
28_N42_K0.5060.90
15_A24_L0.5050.90
108_G207_L0.5040.90
139_G144_E0.5020.90
8_Q179_N0.5010.89
205_P208_P0.5010.89
13_N42_K0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k0wA 3 0.9524 100 0.149 Contact Map
4c24A 3 0.8961 100 0.153 Contact Map
1e4cP 3 0.8831 100 0.178 Contact Map
3ocrA 4 0.9264 100 0.196 Contact Map
2opiA 3 0.8701 100 0.208 Contact Map
4xxfA 3 0.9004 100 0.215 Contact Map
2z7bA 3 0.9351 100 0.219 Contact Map
2fk5A 4 0.8182 100 0.221 Contact Map
2v9lA 3 0.9394 100 0.225 Contact Map
1pvtA 3 0.8398 100 0.237 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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