GREMLIN Database
ARAA - L-arabinose isomerase
UniProt: P08202 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10052
Length: 500 (452)
Sequences: 1680 (889)
Seq/√Len: 41.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_K299_Q5.3481.00
217_V269_Q4.3861.00
231_D235_S3.9191.00
218_V285_L3.9091.00
227_N254_L3.9031.00
32_E36_N3.8531.00
411_D430_K3.6281.00
8_E47_K3.5591.00
434_D437_T3.4661.00
28_T32_E3.2711.00
459_L475_V3.2291.00
162_S461_D3.2251.00
179_C272_F3.0391.00
21_P25_R2.9811.00
155_Q436_P2.9441.00
170_K469_H2.9151.00
222_S225_D2.8541.00
231_D234_E2.8201.00
225_D265_R2.8081.00
217_V265_R2.8001.00
230_V254_L2.6921.00
170_K174_R2.5871.00
407_V473_I2.5841.00
394_A462_M2.5721.00
465_F469_H2.5361.00
286_K377_D2.5011.00
227_N231_D2.4701.00
392_I462_M2.4501.00
221_I261_L2.4371.00
330_S358_I2.4221.00
411_D432_Q2.3811.00
170_K468_M2.3741.00
178_V274_A2.3171.00
402_R472_E2.3121.00
176_L273_H2.2531.00
345_L430_K2.2531.00
290_G351_M2.2281.00
409_C459_L2.2191.00
318_M462_M2.2181.00
314_L394_A2.2141.00
35_V39_N2.2061.00
145_A464_Q2.2021.00
396_L405_L2.1370.99
181_F214_L2.1290.99
8_E49_V2.1180.99
340_E343_N2.0800.99
409_C457_L2.0040.99
159_R440_E1.9860.99
277_T303_F1.9850.99
261_L265_R1.9490.99
120_F124_N1.9410.99
263_M292_A1.9350.99
229_L232_E1.9340.99
390_P411_D1.9240.99
315_L452_V1.8960.99
177_K271_G1.8960.99
29_Q33_H1.8960.99
179_C209_W1.8950.99
176_L317_I1.8930.99
101_L160_I1.8880.99
51_K66_D1.8750.99
435_L439_S1.8680.98
65_R69_Y1.8600.98
8_E72_R1.8420.98
176_L274_A1.8250.98
463_R475_V1.8080.98
207_N272_F1.8050.98
147_V160_I1.7950.98
239_M253_V1.7840.98
223_D258_R1.7690.98
332_M354_V1.7600.98
305_G351_M1.7170.97
39_N47_K1.7160.97
171_Q175_H1.6930.97
290_G305_G1.6820.97
12_V54_G1.6810.97
13_I31_A1.6710.97
223_D254_L1.6650.97
62_A66_D1.6620.97
179_C208_T1.6530.97
36_N40_T1.6460.97
260_E295_R1.6320.96
232_E299_Q1.6260.96
198_A313_A1.6140.96
75_G167_A1.6030.96
395_S448_A1.5990.96
173_T317_I1.5810.96
391_A412_T1.5770.96
102_Q133_F1.5600.95
179_C266_F1.5290.95
360_A414_K1.5290.95
227_N230_V1.4950.94
216_Q220_S1.4950.94
154_K158_E1.4880.94
86_A133_F1.4850.94
225_D228_A1.4810.94
109_A340_E1.4790.94
367_D383_I1.4660.94
387_Q455_H1.4650.93
215_V285_L1.4630.93
255_E286_K1.4420.93
55_T59_E1.4380.93
318_M452_V1.4260.93
383_I426_N1.4250.93
405_L466_A1.4180.92
230_V234_E1.4160.92
328_G333_E1.4120.92
36_N223_D1.3940.92
17_H55_T1.3930.92
305_G331_F1.3930.92
265_R269_Q1.3890.92
217_V220_S1.3870.91
28_T31_A1.3860.91
158_E162_S1.3860.91
9_V46_C1.3830.91
274_A452_V1.3830.91
256_A380_A1.3740.91
322_S457_L1.3740.91
386_T427_A1.3680.91
459_L473_I1.3620.91
202_F403_Y1.3570.91
238_T365_I1.3530.90
238_T363_K1.3480.90
33_H152_Q1.3320.90
46_C74_A1.3310.90
211_V281_D1.3300.90
330_S355_C1.3230.89
29_Q32_E1.3220.89
173_T204_F1.3160.89
345_L413_V1.3030.89
294_Q382_L1.3010.89
33_H37_A1.2870.88
463_R473_I1.2840.88
251_Q255_E1.2760.88
25_R29_Q1.2740.88
224_G228_A1.2740.88
208_T278_T1.2720.87
76_L100_L1.2690.87
30_H34_V1.2640.87
233_Y257_A1.2600.87
230_V257_A1.2580.87
146_V444_L1.2460.86
368_V373_I1.2460.86
234_E244_Q1.2410.86
104_H439_S1.2370.86
256_A291_L1.2360.86
35_V48_L1.2270.85
110_A340_E1.2260.85
264_K268_E1.2250.85
161_G165_R1.2200.85
91_N199_Q1.2160.85
12_V76_L1.2150.85
41_E157_H1.2130.85
365_I369_Q1.2080.85
9_V164_M1.2050.84
444_L467_E1.2040.84
159_R436_P1.2000.84
409_C432_Q1.1950.84
172_D175_H1.1770.83
343_N430_K1.1750.83
397_I448_A1.1720.83
162_S460_N1.1700.83
33_H36_N1.1690.83
25_R28_T1.1650.82
243_T253_V1.1630.82
37_A157_H1.1590.82
185_M353_E1.1570.82
319_K355_C1.1560.82
412_T427_A1.1510.82
228_A232_E1.1430.81
390_P432_Q1.1430.81
90_I133_F1.1400.81
368_V371_L1.1350.81
253_V368_V1.1340.81
137_G142_Q1.1320.80
466_A473_I1.1310.80
274_A312_A1.1300.80
172_D316_R1.1280.80
197_A201_K1.1140.79
454_S458_N1.1130.79
390_P409_C1.1130.79
61_T65_R1.1040.79
218_V262_G1.0890.78
407_V463_R1.0860.78
102_Q134_G1.0790.77
255_E259_I1.0700.77
232_E236_C1.0700.77
229_L261_L1.0640.76
340_E344_D1.0610.76
220_S231_D1.0590.76
172_D317_I1.0550.76
366_L371_L1.0550.76
166_Q461_D1.0520.75
321_M465_F1.0510.75
392_I456_A1.0490.75
78_V89_W1.0470.75
314_L452_V1.0450.75
397_I406_L1.0430.75
240_T244_Q1.0430.75
321_M461_D1.0420.75
73_C76_L1.0400.74
194_D197_A1.0400.74
410_I451_T1.0360.74
9_V256_A1.0350.74
39_N42_A1.0310.74
331_F334_D1.0310.74
199_Q206_V1.0280.74
31_A39_N1.0270.74
154_K157_H1.0240.73
12_V63_I1.0220.73
306_E450_H1.0180.73
74_A171_Q1.0150.73
134_G443_I1.0120.72
393_V451_T1.0110.72
175_H178_V1.0100.72
188_V279_F1.0090.72
409_C475_V1.0080.72
253_V256_A1.0070.72
370_H373_I1.0050.72
369_Q373_I1.0020.72
360_A387_Q1.0010.72
222_S228_A0.9950.71
200_I400_G0.9940.71
322_S458_N0.9930.71
169_S465_F0.9880.71
17_H56_T0.9870.71
268_E301_Y0.9830.70
457_L461_D0.9830.70
259_I263_M0.9810.70
63_I76_L0.9810.70
220_S258_R0.9780.70
187_E280_E0.9780.70
179_C270_G0.9760.70
345_L416_P0.9760.70
385_N426_N0.9730.69
256_A366_L0.9700.69
7_Y171_Q0.9680.69
14_G84_S0.9600.68
241_P244_Q0.9560.68
44_L161_G0.9500.68
78_V133_F0.9490.67
39_N48_L0.9460.67
221_I226_V0.9460.67
158_E161_G0.9450.67
128_H449_H0.9440.67
215_V286_K0.9430.67
330_S333_E0.9410.67
228_A231_D0.9400.67
261_L394_A0.9380.67
332_M348_G0.9370.66
66_D71_D0.9350.66
440_E444_L0.9280.66
68_N97_N0.9220.65
202_F396_L0.9220.65
36_N39_N0.9200.65
346_V431_A0.9190.65
26_Q123_L0.9190.65
26_Q34_V0.9140.65
138_A474_T0.9130.64
37_A40_T0.9110.64
233_Y295_R0.9110.64
26_Q29_Q0.9070.64
174_R432_Q0.9050.64
30_H126_T0.9040.64
61_T91_N0.8990.63
368_V380_A0.8990.63
36_N231_D0.8980.63
174_R258_R0.8970.63
224_G227_N0.8960.63
344_D436_P0.8950.63
57_P187_E0.8930.63
94_T200_I0.8920.63
28_T52_P0.8890.62
167_A468_M0.8860.62
204_F313_A0.8850.62
267_L301_Y0.8830.62
201_K471_I0.8790.61
83_F188_V0.8750.61
359_A387_Q0.8740.61
363_K366_L0.8740.61
211_V285_L0.8730.61
269_Q390_P0.8720.61
172_D274_A0.8700.61
119_D124_N0.8700.61
33_H107_F0.8680.60
388_T414_K0.8650.60
260_E264_K0.8650.60
355_C358_I0.8620.60
223_D227_N0.8590.60
56_T59_E0.8580.60
154_K235_S0.8540.59
395_S405_L0.8520.59
120_F123_L0.8510.59
169_S317_I0.8490.59
375_G379_P0.8470.59
387_Q456_A0.8420.58
277_T291_L0.8420.58
328_G334_D0.8380.58
188_V349_S0.8380.58
159_R460_N0.8350.57
10_W67_A0.8330.57
358_I387_Q0.8310.57
365_I368_V0.8310.57
78_V100_L0.8280.57
172_D320_V0.8270.57
226_V230_V0.8270.57
298_Q357_S0.8260.57
322_S329_T0.8250.57
192_D195_K0.8240.56
188_V424_V0.8230.56
155_Q158_E0.8230.56
458_N461_D0.8230.56
209_W213_D0.8220.56
74_A168_V0.8210.56
165_R461_D0.8200.56
126_T293_V0.8180.56
394_A407_V0.8170.56
83_F190_V0.8160.56
396_L471_I0.8150.56
367_D373_I0.8120.55
243_T380_A0.8090.55
277_T293_V0.8090.55
28_T39_N0.8090.55
175_H273_H0.8070.55
54_G59_E0.8040.55
142_Q162_S0.8030.55
334_D442_W0.8020.54
238_T362_E0.8000.54
214_L263_M0.8000.54
30_H33_H0.7990.54
39_N44_L0.7990.54
302_G319_K0.7980.54
230_V239_M0.7980.54
125_Q335_Y0.7960.54
175_H271_G0.7950.54
391_A453_F0.7950.54
405_L471_I0.7910.53
7_Y168_V0.7910.53
173_T313_A0.7880.53
97_N174_R0.7870.53
311_T395_S0.7870.53
362_E385_N0.7850.53
133_F137_G0.7830.53
54_G76_L0.7820.53
153_D436_P0.7810.52
464_Q467_E0.7810.52
31_A34_V0.7790.52
407_V459_L0.7770.52
143_Q440_E0.7760.52
28_T38_L0.7760.52
214_L462_M0.7740.52
446_G449_H0.7740.52
405_L462_M0.7730.52
350_H446_G0.7710.52
94_T217_V0.7690.51
90_I140_M0.7660.51
223_D226_V0.7660.51
253_V380_A0.7620.51
388_T412_T0.7610.51
103_F156_A0.7610.51
65_R95_M0.7610.51
143_Q470_D0.7600.50
329_T456_A0.7590.50
304_A349_S0.7580.50
226_V258_R0.7570.50
86_A185_M0.7570.50
235_S463_R0.7490.49
330_S354_V0.7470.49
353_E383_I0.7440.49
239_M244_Q0.7440.49
9_V74_A0.7440.49
229_L264_K0.7420.49
58_D62_A0.7420.49
169_S172_D0.7420.49
180_R309_W0.7410.49
99_P389_G0.7390.49
158_E224_G0.7360.48
172_D176_L0.7360.48
206_V304_A0.7360.48
412_T455_H0.7350.48
268_E299_Q0.7340.48
23_T26_Q0.7340.48
359_A384_F0.7330.48
278_T448_A0.7320.48
154_K223_D0.7320.48
65_R68_N0.7310.48
338_H345_L0.7290.48
364_P371_L0.7260.47
358_I391_A0.7240.47
412_T453_F0.7210.47
304_A312_A0.7200.47
153_D156_A0.7180.47
59_E62_A0.7160.46
300_G350_H0.7140.46
173_T461_D0.7090.46
351_M424_V0.7090.46
226_V254_L0.7080.46
16_Q19_Y0.7050.45
68_N95_M0.7040.45
54_G63_I0.7030.45
204_F256_A0.7020.45
44_L47_K0.7000.45
180_R208_T0.6990.45
77_V101_L0.6950.44
362_E387_Q0.6940.44
94_T140_M0.6940.44
34_V77_V0.6910.44
37_A152_Q0.6870.44
138_A168_V0.6860.44
161_G224_G0.6860.44
327_G456_A0.6860.44
217_V221_I0.6830.43
162_S166_Q0.6830.43
279_F424_V0.6790.43
148_T440_E0.6780.43
45_P161_G0.6780.43
265_R268_E0.6780.43
111_L427_A0.6760.43
452_V462_M0.6760.43
31_A35_V0.6750.43
95_M271_G0.6750.43
7_Y74_A0.6740.42
108_N124_N0.6720.42
176_L452_V0.6720.42
193_G309_W0.6720.42
29_Q224_G0.6700.42
108_N120_F0.6690.42
75_G163_W0.6660.42
212_G283_H0.6650.42
390_P457_L0.6640.42
187_E456_A0.6640.42
33_H158_E0.6620.41
82_T86_A0.6620.41
143_Q174_R0.6620.41
219_N231_D0.6620.41
318_M394_A0.6620.41
291_L366_L0.6600.41
36_N41_E0.6600.41
76_L302_G0.6590.41
352_L425_A0.6560.41
392_I409_C0.6540.41
43_K161_G0.6520.40
36_N42_A0.6510.40
263_M299_Q0.6490.40
362_E414_K0.6490.40
350_H449_H0.6490.40
216_Q284_G0.6490.40
153_D158_E0.6480.40
157_H161_G0.6480.40
71_D239_M0.6470.40
26_Q30_H0.6470.40
187_E315_L0.6440.40
134_G146_V0.6440.40
275_F293_V0.6430.40
205_S426_N0.6420.40
209_W266_F0.6420.40
83_F279_F0.6410.39
279_F333_E0.6410.39
198_A309_W0.6400.39
52_P59_E0.6400.39
73_C118_M0.6390.39
65_R235_S0.6380.39
63_I214_L0.6360.39
222_S231_D0.6350.39
267_L275_F0.6340.39
17_H59_E0.6310.39
119_D123_L0.6300.39
268_E271_G0.6300.39
165_R176_L0.6270.38
459_L463_R0.6260.38
274_A317_I0.6250.38
239_M243_T0.6250.38
83_F449_H0.6240.38
227_N235_S0.6230.38
44_L48_L0.6220.38
37_A158_E0.6210.38
251_Q254_L0.6210.38
224_G342_G0.6210.38
31_A42_A0.6200.38
404_R445_A0.6190.38
344_D434_D0.6180.37
314_L395_S0.6180.37
169_S462_M0.6180.37
293_V303_F0.6170.37
61_T97_N0.6150.37
48_L161_G0.6140.37
47_K158_E0.6120.37
279_F349_S0.6120.37
238_T268_E0.6120.37
222_S226_V0.6120.37
318_M322_S0.6120.37
344_D430_K0.6100.37
39_N225_D0.6090.37
160_I232_E0.6080.37
363_K372_G0.6080.37
364_P368_V0.6070.36
36_N365_I0.6070.36
335_Y351_M0.6050.36
392_I459_L0.6040.36
57_P231_D0.6040.36
83_F290_G0.6030.36
7_Y164_M0.6030.36
267_L303_F0.6030.36
461_D465_F0.6030.36
262_G272_F0.6030.36
132_E190_V0.6010.36
33_H468_M0.6000.36
25_R37_A0.6000.36
120_F126_T0.5990.36
399_L404_R0.5970.36
9_V465_F0.5950.35
296_L303_F0.5930.35
416_P421_K0.5930.35
333_E352_L0.5910.35
32_E39_N0.5910.35
29_Q36_N0.5910.35
15_S20_G0.5910.35
358_I427_A0.5910.35
323_T327_G0.5900.35
158_E227_N0.5890.35
197_A401_D0.5880.35
58_D177_K0.5880.35
251_Q411_D0.5850.35
407_V462_M0.5850.35
7_Y46_C0.5850.35
29_Q43_K0.5830.34
158_E228_A0.5820.34
235_S342_G0.5820.34
229_L260_E0.5770.34
126_T428_L0.5770.34
69_Y224_G0.5770.34
194_D400_G0.5770.34
296_L301_Y0.5760.34
35_V44_L0.5760.34
9_V253_V0.5760.34
395_S451_T0.5760.34
278_T281_D0.5750.34
125_Q131_R0.5730.34
9_V77_V0.5730.34
279_F351_M0.5730.34
369_Q372_G0.5730.34
469_H473_I0.5720.34
129_G308_D0.5710.33
118_M122_N0.5710.33
173_T178_V0.5700.33
431_A438_A0.5660.33
408_N438_A0.5650.33
209_W214_L0.5640.33
318_M454_S0.5640.33
65_R72_R0.5640.33
12_V264_K0.5630.33
38_L46_C0.5630.33
50_L66_D0.5620.33
86_A191_T0.5600.33
58_D65_R0.5590.32
42_A160_I0.5580.32
427_A430_K0.5580.32
204_F274_A0.5580.32
172_D273_H0.5580.32
215_V219_N0.5580.32
62_A223_D0.5580.32
81_H139_R0.5580.32
61_T152_Q0.5570.32
349_S424_V0.5560.32
30_H38_L0.5560.32
48_L77_V0.5550.32
257_A328_G0.5550.32
387_Q475_V0.5540.32
128_H279_F0.5540.32
36_N62_A0.5540.32
128_H351_M0.5530.32
54_G60_I0.5530.32
205_S272_F0.5530.32
125_Q185_M0.5520.32
342_G440_E0.5510.32
177_K270_G0.5490.32
178_V219_N0.5490.32
233_Y260_E0.5470.31
213_D270_G0.5460.31
143_Q467_E0.5460.31
158_E460_N0.5450.31
230_V253_V0.5450.31
41_E46_C0.5440.31
143_Q175_H0.5430.31
9_V204_F0.5430.31
345_L428_L0.5420.31
125_Q128_H0.5410.31
224_G299_Q0.5410.31
251_Q286_K0.5410.31
42_A72_R0.5410.31
71_D362_E0.5410.31
311_T314_L0.5400.31
28_T34_V0.5400.31
368_V372_G0.5400.31
404_R472_E0.5390.31
47_K231_D0.5380.31
54_G69_Y0.5380.31
169_S321_M0.5380.31
13_I53_L0.5380.31
230_V436_P0.5370.31
38_L161_G0.5370.31
297_M353_E0.5370.31
178_V273_H0.5370.31
86_A179_C0.5370.31
74_A133_F0.5360.31
54_G235_S0.5350.30
339_F344_D0.5340.30
107_F126_T0.5330.30
214_L221_I0.5330.30
128_H188_V0.5320.30
317_I321_M0.5320.30
393_V408_N0.5320.30
62_A174_R0.5320.30
455_H473_I0.5310.30
371_L379_P0.5310.30
172_D178_V0.5290.30
125_Q188_V0.5290.30
100_L142_Q0.5290.30
372_G375_G0.5280.30
226_V261_L0.5270.30
65_R97_N0.5260.30
36_N228_A0.5260.30
83_F351_M0.5260.30
43_K141_R0.5260.30
44_L160_I0.5240.30
27_V31_A0.5240.30
9_V427_A0.5230.30
169_S177_K0.5230.30
192_D349_S0.5230.30
83_F424_V0.5230.30
25_R228_A0.5230.30
330_S334_D0.5220.29
181_F275_F0.5220.29
391_A410_I0.5210.29
36_N224_G0.5210.29
47_K225_D0.5200.29
238_T390_P0.5200.29
97_N231_D0.5200.29
58_D271_G0.5190.29
331_F358_I0.5190.29
176_L258_R0.5190.29
177_K205_S0.5180.29
228_A412_T0.5180.29
185_M188_V0.5180.29
320_V410_I0.5180.29
224_G241_P0.5180.29
69_Y228_A0.5170.29
153_D164_M0.5160.29
95_M274_A0.5160.29
223_D251_Q0.5160.29
162_S169_S0.5150.29
33_H40_T0.5140.29
188_V290_G0.5140.29
62_A460_N0.5140.29
438_A441_A0.5130.29
170_K465_F0.5120.29
30_H39_N0.5120.29
236_C414_K0.5110.29
231_D238_T0.5110.29
266_F272_F0.5090.28
271_G411_D0.5090.28
251_Q467_E0.5090.28
12_V141_R0.5080.28
359_A386_T0.5080.28
57_P91_N0.5070.28
204_F465_F0.5070.28
362_E365_I0.5070.28
328_G357_S0.5060.28
25_R42_A0.5060.28
36_N230_V0.5050.28
201_K264_K0.5050.28
173_T176_L0.5050.28
36_N219_N0.5040.28
64_C98_K0.5040.28
228_A460_N0.5020.28
188_V351_M0.5020.28
263_M303_F0.5010.28
132_E193_G0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f2dA 5 0.992 100 0.258 Contact Map
4lqlA 5 0.942 100 0.318 Contact Map
1fuiA 5 0.952 100 0.389 Contact Map
3a9sA 5 0.952 100 0.4 Contact Map
3rotA 2 0.52 96.7 0.947 Contact Map
4rxmA 1 0.556 96.5 0.947 Contact Map
3hs3A 2 0.506 95.9 0.951 Contact Map
4rk1A 4 0.524 95.6 0.952 Contact Map
3gbvA 2 0.544 95.5 0.952 Contact Map
3l6uA 2 0.522 95.4 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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