GREMLIN Database
NIRB - Nitrite reductase (NADH) large subunit
UniProt: P08201 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10653
Length: 847 (794)
Sequences: 1359 (660)
Seq/√Len: 23.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
590_E619_Q6.0231.00
266_N270_Q5.9941.00
87_R273_D5.9691.00
657_L726_R5.2771.00
725_D728_T5.1371.00
766_A770_D4.8351.00
579_E589_R4.7331.00
505_I511_L4.5541.00
90_K275_D4.3221.00
571_S576_I4.3041.00
80_E96_A4.2761.00
172_H205_H4.1461.00
715_R718_D4.0051.00
660_E726_R3.8801.00
91_V99_T3.8781.00
9_I107_M3.8701.00
791_L796_E3.8531.00
784_A788_E3.7801.00
571_S597_I3.7221.00
445_T448_A3.6721.00
104_K275_D3.5201.00
449_L470_L3.4671.00
600_S637_M3.4561.00
149_A234_V3.3961.00
795_T799_N3.3611.00
162_G166_N3.3341.00
151_V224_M3.2371.00
582_M585_G3.2061.00
762_D765_K3.1761.00
428_F458_G3.1751.00
618_R622_E3.1651.00
87_R276_I3.1591.00
618_R804_Q3.1151.00
5_R32_D3.1091.00
640_T658_G3.0941.00
439_I470_L3.0811.00
586_R589_R3.0471.00
424_I469_V2.9671.00
435_L449_L2.9651.00
693_V736_F2.9261.00
798_V804_Q2.9131.00
267_D285_W2.9050.99
149_A174_I2.9040.99
273_D276_I2.8570.99
258_A284_S2.8480.99
5_R34_T2.8050.99
80_E98_R2.7750.99
40_P133_E2.7270.99
93_H99_T2.7250.99
256_D272_S2.7230.99
591_F619_Q2.6360.99
267_D286_N2.5860.99
732_Y769_I2.5240.99
85_I107_M2.4710.98
208_K226_F2.4500.98
670_T674_M2.4220.98
212_E225_R2.4150.98
214_V223_T2.4100.98
456_G463_I2.3750.98
170_E203_R2.3720.98
575_E659_V2.3670.98
277_Y306_H2.3540.98
718_D754_L2.3350.98
8_I19_I2.3170.97
225_R231_E2.2950.97
704_L732_Y2.2660.97
255_L276_I2.2640.97
9_I82_A2.2440.97
761_I765_K2.2390.97
580_G583_A2.2370.97
86_N89_E2.2030.96
23_L33_I2.2010.96
503_E514_K2.1620.96
80_E94_S2.1550.96
303_A307_I2.1300.96
52_Y136_N2.1210.96
36_F94_S2.1170.96
467_T471_N2.1130.95
36_F100_V2.0960.95
748_T756_N2.0920.95
255_L273_D2.0850.95
420_D433_G2.0780.95
84_T93_H2.0700.95
89_E99_T2.0690.95
333_I371_A2.0660.95
36_F82_A2.0490.95
528_V532_L2.0370.94
676_F693_V2.0290.94
314_F317_A2.0200.94
305_D310_S2.0000.94
81_R95_S1.9910.94
582_M586_R1.9870.94
609_Q612_D1.9860.94
707_C754_L1.9490.93
4_V104_K1.9450.93
114_W241_T1.9400.93
754_L764_L1.9380.93
16_H35_V1.9360.93
656_G660_E1.9360.93
125_D141_C1.9310.93
42_I76_V1.9270.93
11_N69_Y1.9250.93
284_S289_V1.9220.93
7_A100_V1.9160.92
55_H60_E1.9140.92
107_M263_I1.9130.92
768_I776_N1.9110.92
706_V720_L1.9090.92
123_T215_Q1.9050.92
17_R21_D1.9010.92
764_L768_I1.8850.92
25_K305_D1.8760.92
37_C82_A1.8640.91
582_M589_R1.8640.91
80_E95_S1.8550.91
248_K252_Q1.8370.91
705_Y717_A1.8340.91
782_E786_L1.8320.91
739_F763_Y1.8240.90
697_A702_W1.8220.90
576_I580_G1.8060.90
510_E514_K1.7970.90
584_V603_L1.7870.89
568_I630_A1.7800.89
446_V466_V1.7770.89
634_A670_T1.7770.89
593_L616_I1.7750.89
82_A94_S1.7740.89
568_I604_A1.7510.88
4_V30_N1.7470.88
215_Q222_K1.7400.88
580_G584_V1.7330.88
263_I282_C1.7220.88
147_R170_E1.7200.88
792_C795_T1.7050.87
575_E594_Y1.7020.87
194_R198_E1.7010.87
38_E246_R1.6920.87
208_K228_D1.6910.87
797_T803_A1.6890.87
57_T60_E1.6890.87
594_Y646_W1.6880.87
211_L227_A1.6880.87
600_S604_A1.6840.86
123_T222_K1.6790.86
693_V733_L1.6780.86
463_I466_V1.6730.86
668_I737_M1.6680.86
575_E646_W1.6550.85
214_V225_R1.6540.85
94_S98_R1.6280.84
19_I23_L1.6270.84
350_D353_K1.6220.84
593_L608_A1.6220.84
87_R255_L1.6210.84
87_R253_C1.6120.84
583_A621_I1.6090.84
736_F754_L1.6030.83
604_A637_M1.5920.83
77_L98_R1.5790.83
539_Y803_A1.5750.82
757_L764_L1.5670.82
578_P588_A1.5650.82
18_F279_I1.5640.82
707_C736_F1.5530.81
668_I786_L1.5520.81
36_F77_L1.5390.81
85_I276_I1.5340.81
470_L474_L1.5320.81
251_T257_V1.5170.80
303_A306_H1.5150.80
715_R755_E1.5100.80
149_A224_M1.5050.79
802_S805_T1.5040.79
485_L527_T1.4960.79
706_V754_L1.4930.79
6_L31_F1.4930.79
612_D615_E1.4870.78
385_Q389_N1.4810.78
578_P595_T1.4700.78
763_Y767_V1.4700.78
728_T732_Y1.4440.76
5_R101_F1.4430.76
270_Q277_Y1.4420.76
224_M237_I1.4320.76
89_E93_H1.4300.76
119_K212_E1.4230.75
80_E83_I1.4200.75
38_E81_R1.4190.75
571_S584_V1.4120.75
506_K536_W1.4080.74
571_S659_V1.4080.74
721_A724_I1.4000.74
14_V296_G1.3990.74
64_V68_F1.3900.74
17_R428_F1.3900.74
587_I605_M1.3890.73
473_E476_K1.3870.73
551_S555_F1.3810.73
739_F743_T1.3780.73
660_E727_E1.3740.73
18_F106_I1.3710.72
568_I600_S1.3710.72
720_L769_I1.3570.72
285_W290_F1.3560.72
264_V284_S1.3540.72
583_A622_E1.3530.71
210_T224_M1.3480.71
174_I207_S1.3450.71
127_F141_C1.3440.71
588_A593_L1.3430.71
331_G377_T1.3430.71
140_S143_R1.3390.71
702_W726_R1.3370.71
706_V764_L1.3330.70
551_S559_I1.3310.70
48_H51_S1.3170.69
31_F307_I1.3170.69
583_A623_A1.3160.69
661_L677_G1.3160.69
67_G70_E1.3150.69
778_H781_E1.3090.69
423_Q429_D1.3060.69
162_G326_L1.3040.69
584_V677_G1.2980.68
11_N15_G1.2870.68
495_E498_H1.2850.67
695_I729_L1.2850.67
709_N751_A1.2800.67
219_E222_K1.2800.67
781_E785_R1.2780.67
498_H502_V1.2770.67
771_D775_L1.2740.67
511_L528_V1.2730.67
443_C448_A1.2690.66
56_H60_E1.2690.66
87_R275_D1.2640.66
660_E702_W1.2560.66
771_D774_G1.2530.65
67_G71_K1.2440.65
210_T237_I1.2380.64
424_I439_I1.2330.64
357_K379_D1.2250.64
151_V237_I1.2250.64
507_T510_E1.2210.63
618_R798_V1.2200.63
444_H448_A1.2180.63
418_L422_A1.2090.63
37_C41_R1.2030.62
781_E786_L1.2020.62
35_V76_V1.2020.62
657_L695_I1.2010.62
416_D472_A1.2000.62
604_A677_G1.1960.62
597_I603_L1.1940.62
176_F209_N1.1910.61
428_F454_K1.1910.61
571_S580_G1.1860.61
81_R96_A1.1850.61
22_L307_I1.1830.61
743_T757_L1.1800.61
192_Q227_A1.1790.61
769_I780_E1.1780.60
26_S30_N1.1780.60
676_F695_I1.1740.60
593_L646_W1.1710.60
329_D377_T1.1700.60
578_P589_R1.1690.60
221_R237_I1.1650.60
270_Q306_H1.1640.60
164_L238_V1.1640.60
13_M297_Y1.1610.59
115_I118_I1.1590.59
330_V374_V1.1580.59
212_E307_I1.1550.59
576_I597_I1.1540.59
41_R132_I1.1410.58
41_R133_E1.1390.58
118_I210_T1.1370.58
508_F512_L1.1340.58
364_D392_E1.1330.57
10_G13_M1.1310.57
622_E804_Q1.1300.57
695_I733_L1.1240.57
587_I616_I1.1210.57
657_L702_W1.1180.56
539_Y797_T1.1180.56
115_I128_V1.1160.56
727_E731_K1.1150.56
126_C239_F1.1140.56
187_Q191_E1.1130.56
710_G751_A1.1120.56
436_I473_E1.1110.56
779_L782_E1.1110.56
178_P187_Q1.0990.55
77_L80_E1.0980.55
588_A616_I1.0970.55
674_M737_M1.0930.55
205_H208_K1.0930.55
499_L515_H1.0920.55
19_I69_Y1.0870.54
223_T231_E1.0860.54
508_F528_V1.0860.54
542_K803_A1.0860.54
656_G764_L1.0850.54
709_N750_T1.0830.54
31_F308_L1.0820.54
191_E194_R1.0820.54
84_T252_Q1.0810.54
337_H372_V1.0800.54
277_Y303_A1.0790.54
333_I384_L1.0770.54
23_L26_S1.0750.53
443_C449_L1.0730.53
113_P240_S1.0720.53
26_S29_A1.0700.53
19_I68_F1.0700.53
775_L779_L1.0700.53
539_Y542_K1.0670.53
653_D656_G1.0640.53
585_G640_T1.0630.53
580_G625_F1.0620.53
743_T753_W1.0590.52
415_V424_I1.0590.52
527_T531_L1.0570.52
11_N76_V1.0560.52
22_L308_L1.0550.52
176_F182_A1.0540.52
104_K277_Y1.0530.52
82_A92_I1.0520.52
450_K463_I1.0480.52
255_L272_S1.0470.51
660_E730_I1.0420.51
585_G589_R1.0400.51
174_I189_G1.0390.51
629_H637_M1.0380.51
32_D75_K1.0360.51
335_D360_I1.0360.51
482_N495_E1.0340.51
336_A340_T1.0330.50
583_A586_R1.0330.50
11_N43_A1.0290.50
287_N350_D1.0290.50
19_I33_I1.0280.50
68_F72_H1.0230.50
132_I357_K1.0210.50
657_L660_E1.0200.50
68_F126_C1.0200.50
179_M187_Q1.0200.50
600_S629_H1.0180.49
21_D301_Q1.0160.49
263_I284_S1.0150.49
693_V729_L1.0140.49
177_A182_A1.0080.49
766_A772_K1.0060.49
34_T75_K1.0060.49
499_L503_E1.0050.49
132_I136_N1.0040.48
720_L736_F0.9980.48
777_A781_E0.9950.48
216_E222_K0.9920.48
782_E785_R0.9920.48
554_N559_I0.9900.47
153_G180_L0.9890.47
348_Y355_I0.9880.47
9_I33_I0.9860.47
367_T390_A0.9800.47
779_L786_L0.9800.47
64_V67_G0.9790.47
657_L697_A0.9780.47
38_E248_K0.9780.47
142_A290_F0.9770.47
267_D313_A0.9730.46
83_I95_S0.9730.46
362_S366_K0.9720.46
706_V768_I0.9700.46
359_L368_L0.9680.46
146_K235_D0.9660.46
8_I16_H0.9660.46
583_A587_I0.9650.46
684_E696_I0.9610.45
226_F230_S0.9570.45
338_G345_S0.9550.45
456_G464_P0.9540.45
572_P666_K0.9530.45
116_P239_F0.9490.45
591_F804_Q0.9490.45
418_L424_I0.9470.44
509_E512_L0.9470.44
732_Y780_E0.9460.44
414_G417_K0.9430.44
189_G374_V0.9410.44
209_N227_A0.9410.44
800_T803_A0.9380.44
591_F615_E0.9370.44
672_H714_P0.9360.44
37_C76_V0.9350.44
661_L695_I0.9310.43
197_I204_V0.9300.43
440_N477_Q0.9300.43
34_T77_L0.9290.43
573_G659_V0.9280.43
667_G790_V0.9280.43
779_L787_R0.9280.43
765_K769_I0.9270.43
690_G710_G0.9250.43
149_A206_T0.9230.43
197_I202_V0.9200.43
483_N495_E0.9190.43
608_A616_I0.9170.42
138_I236_F0.9120.42
194_R206_T0.9100.42
185_L377_T0.9100.42
439_I443_C0.9090.42
92_I102_Y0.9090.42
706_V776_N0.9070.42
125_D221_R0.9060.42
710_G750_T0.9050.42
361_V393_L0.9020.41
6_L18_F0.9000.41
16_H19_I0.8970.41
118_I121_S0.8960.41
6_L24_D0.8960.41
446_V456_G0.8950.41
175_E182_A0.8940.41
672_H710_G0.8940.41
693_V776_N0.8940.41
474_L479_I0.8930.41
497_F782_E0.8930.41
584_V741_I0.8930.41
433_G437_A0.8930.41
268_S306_H0.8920.41
635_L661_L0.8920.41
439_I699_E0.8920.41
83_I248_K0.8900.41
505_I528_V0.8900.41
162_G165_K0.8900.41
768_I774_G0.8890.40
234_V237_I0.8890.40
37_C78_V0.8880.40
729_L733_L0.8860.40
768_I783_M0.8860.40
230_S584_V0.8840.40
94_S100_V0.8840.40
6_L307_I0.8830.40
491_Y515_H0.8810.40
726_R729_L0.8810.40
577_T593_L0.8790.40
483_N492_S0.8750.40
441_K452_E0.8750.40
192_Q349_L0.8740.39
434_D441_K0.8670.39
248_K730_I0.8640.39
106_I303_A0.8630.39
786_L790_V0.8630.39
796_E800_T0.8580.38
580_G605_M0.8560.38
8_I35_V0.8540.38
663_N666_K0.8540.38
105_L249_L0.8530.38
763_Y766_A0.8530.38
181_M210_T0.8530.38
715_R754_L0.8520.38
561_K676_F0.8490.38
775_L778_H0.8470.38
112_Y246_R0.8460.38
106_I279_I0.8440.37
450_K456_G0.8380.37
497_F535_C0.8380.37
580_G587_I0.8380.37
185_L202_V0.8330.37
491_Y499_L0.8330.37
215_Q223_T0.8320.37
162_G200_M0.8290.37
674_M693_V0.8260.36
626_E667_G0.8250.36
7_A36_F0.8240.36
21_D25_K0.8240.36
165_K202_V0.8240.36
523_V746_K0.8240.36
50_S166_N0.8240.36
51_S56_H0.8240.36
497_F501_R0.8230.36
615_E618_R0.8200.36
290_F314_F0.8180.36
68_F74_I0.8180.36
202_V326_L0.8170.36
769_I774_G0.8160.36
41_R58_A0.8120.35
82_A100_V0.8120.35
73_G344_R0.8120.35
91_V101_F0.8110.35
500_I531_L0.8100.35
454_K457_T0.8100.35
501_R535_C0.8100.35
93_H253_C0.8090.35
347_V720_L0.8090.35
345_S358_R0.8080.35
664_R779_L0.8060.35
90_K104_K0.8050.35
14_V53_F0.8050.35
250_A263_I0.8040.35
42_I78_V0.8040.35
19_I35_V0.8030.35
13_M296_G0.8030.35
282_C741_I0.8020.35
779_L783_M0.8020.35
696_I716_H0.7980.35
104_K270_Q0.7970.34
415_V469_V0.7970.34
782_E788_E0.7970.34
373_L379_D0.7970.34
50_S142_A0.7970.34
81_R248_K0.7940.34
37_C69_Y0.7940.34
23_L37_C0.7930.34
84_T91_V0.7920.34
584_V605_M0.7910.34
606_F655_V0.7900.34
11_N77_L0.7890.34
332_G336_A0.7880.34
185_L189_G0.7840.34
576_I584_V0.7840.34
43_A135_L0.7830.34
632_A744_A0.7820.34
145_S235_D0.7820.34
62_S68_F0.7810.33
9_I12_G0.7810.33
66_E78_V0.7780.33
147_R233_E0.7780.33
293_V297_Y0.7770.33
7_A92_I0.7770.33
568_I606_F0.7760.33
384_L388_L0.7730.33
190_G657_L0.7730.33
774_G777_A0.7730.33
210_T213_I0.7720.33
270_Q273_D0.7710.33
149_A790_V0.7710.33
778_H782_E0.7710.33
499_L514_K0.7700.33
26_S308_L0.7700.33
782_E790_V0.7670.33
428_F466_V0.7670.33
486_C521_C0.7650.32
500_I649_Y0.7640.32
580_G595_T0.7640.32
90_K95_S0.7640.32
310_S313_A0.7630.32
632_A790_V0.7610.32
693_V704_L0.7600.32
344_R363_E0.7590.32
534_S741_I0.7590.32
660_E663_N0.7580.32
780_E783_M0.7580.32
419_P422_A0.7570.32
521_C524_C0.7560.32
785_R788_E0.7540.32
579_E590_E0.7540.32
33_I74_I0.7530.32
175_E240_S0.7500.32
174_I224_M0.7460.31
743_T767_V0.7460.31
505_I515_H0.7450.31
544_E554_N0.7440.31
396_N399_S0.7440.31
63_L94_S0.7440.31
677_G690_G0.7440.31
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631_Y642_V0.5090.19
599_G633_K0.5080.19
106_I139_E0.5080.19
215_Q221_R0.5080.19
594_Y773_L0.5080.19
631_Y639_K0.5070.19
599_G650_G0.5070.19
558_N687_E0.5070.19
349_L424_I0.5070.19
463_I467_T0.5060.19
43_A562_D0.5060.19
599_G628_G0.5060.19
424_I502_V0.5060.19
397_P403_P0.5060.19
151_V239_F0.5060.19
734_D780_E0.5050.19
317_A515_H0.5050.19
604_A629_H0.5050.19
385_Q422_A0.5050.19
358_R746_K0.5050.19
121_S147_R0.5050.19
586_R605_M0.5040.19
611_D808_K0.5040.19
383_L705_Y0.5040.19
96_A433_G0.5040.19
138_I435_L0.5040.19
617_W633_K0.5030.19
163_A585_G0.5030.19
418_L469_V0.5030.19
621_I797_T0.5020.19
71_K89_E0.5020.19
290_F441_K0.5020.19
230_S469_V0.5020.19
496_L531_L0.5020.19
355_I402_L0.5020.19
67_G587_I0.5010.19
16_H64_V0.5010.19
491_Y512_L0.5010.19
772_K784_A0.5010.19
170_E228_D0.5010.19
640_T783_M0.5010.19
636_R687_E0.5010.19
104_K307_I0.5010.19
23_L73_G0.5010.19
558_N636_R0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lxdA 1 0.4711 100 0.832 Contact Map
1q1rA 1 0.477 100 0.835 Contact Map
3fg2P 1 0.4675 100 0.836 Contact Map
2gqwA 2 0.4569 100 0.836 Contact Map
3kljA 1 0.4451 100 0.836 Contact Map
3ef6A 1 0.464 100 0.838 Contact Map
1xhcA 1 0.4073 100 0.841 Contact Map
3iwaA 2 0.4416 100 0.842 Contact Map
3cgbA 2 0.4852 100 0.845 Contact Map
2gagA 1 0.7426 100 0.845 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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