GREMLIN Database
IDH - Isocitrate dehydrogenase [NADP]
UniProt: P08200 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10489
Length: 416 (339)
Sequences: 6984 (3060)
Seq/√Len: 166.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_I274_E4.3801.00
210_V245_G3.1341.00
44_A409_G3.0521.00
211_R215_E2.8801.00
28_I64_S2.7861.00
47_K410_D2.7491.00
284_A288_Q2.6781.00
211_R251_E2.6401.00
365_R377_V2.5961.00
386_A415_N2.5621.00
50_D65_W2.4551.00
86_A90_D2.4041.00
42_T356_I2.3541.00
203_E207_K2.3021.00
382_G415_N2.2751.00
411_A414_E2.2651.00
31_Y46_L2.2301.00
44_A47_K2.1851.00
365_R374_D2.1701.00
226_T278_K2.1671.00
80_Q86_A2.1231.00
59_G375_L2.1091.00
68_I91_L2.0721.00
69_Y77_V2.0261.00
224_S278_K2.0261.00
46_L67_E1.9931.00
245_G277_I1.9921.00
150_V216_Y1.9901.00
354_G412_I1.9861.00
207_K247_Q1.9691.00
30_P91_L1.9671.00
93_R122_L1.9471.00
358_L380_M1.9401.00
207_K244_W1.9141.00
369_W372_A1.9101.00
224_S276_V1.8981.00
215_E253_F1.8941.00
210_V300_A1.8931.00
388_T403_L1.8441.00
349_D406_S1.8371.00
374_D378_K1.8351.00
349_D404_K1.8161.00
74_S85_P1.8151.00
357_I412_I1.8151.00
292_R295_E1.8121.00
383_A415_N1.8051.00
37_I351_V1.7951.00
211_R253_F1.7941.00
388_T411_A1.7551.00
90_D94_E1.7551.00
39_V43_P1.7441.00
361_E377_V1.7391.00
246_Y279_D1.7351.00
207_K211_R1.7341.00
203_E247_Q1.7171.00
409_G413_I1.7051.00
228_V285_F1.6821.00
244_W247_Q1.6631.00
370_T374_D1.6551.00
93_R121_E1.6301.00
132_R381_E1.6241.00
192_E204_E1.6131.00
26_N64_S1.5781.00
135_Q385_N1.5701.00
52_A376_I1.5631.00
199_K302_M1.5521.00
166_K243_D1.5461.00
128_L150_V1.5451.00
410_D414_E1.5411.00
90_D93_R1.5161.00
30_P95_Y1.5031.00
27_P369_W1.4991.00
26_N62_K1.4981.00
73_K77_V1.4931.00
45_M360_A1.4861.00
211_R248_L1.4851.00
404_K407_E1.4771.00
89_L121_E1.4731.00
66_M94_E1.4721.00
365_R373_A1.4721.00
125_Y330_D1.4681.00
117_A121_E1.4511.00
290_L312_A1.4481.00
214_I249_A1.4431.00
65_W360_A1.4431.00
61_R369_W1.4331.00
32_I70_T1.4321.00
47_K413_I1.4301.00
53_V63_I1.4271.00
49_V63_I1.4111.00
30_P68_I1.4051.00
349_D405_C1.4031.00
227_L245_G1.3991.00
152_F212_A1.3981.00
46_L50_D1.3881.00
51_A413_I1.3801.00
66_M95_Y1.3661.00
215_E219_A1.3651.00
61_R372_A1.3491.00
248_L251_E1.3491.00
45_M99_I1.3481.00
222_R297_D1.3411.00
151_I310_S1.3381.00
69_Y78_Y1.3341.00
84_L89_L1.3301.00
136_G385_N1.3301.00
33_E67_E1.3231.00
193_H203_E1.3061.00
365_R370_T1.2821.00
286_L309_I1.2781.00
350_K391_Y1.2661.00
152_F216_Y1.2631.00
354_G408_F1.2491.00
240_A244_W1.2361.00
383_A411_A1.2351.00
363_M367_M1.2331.00
223_D297_D1.2311.00
227_L279_D1.2311.00
280_V288_Q1.2311.00
215_E218_I1.2281.00
105_T108_G1.2271.00
403_L411_A1.2251.00
46_L65_W1.2241.00
27_P367_M1.2201.00
210_V248_L1.2151.00
408_F412_I1.2151.00
45_M356_I1.2121.00
69_Y74_S1.2111.00
378_K382_G1.1951.00
197_G236_F1.1931.00
28_I66_M1.1871.00
66_M91_L1.1821.00
280_V284_A1.1691.00
92_I98_A1.1631.00
247_Q250_R1.1601.00
199_K236_F1.1581.00
246_Y250_R1.1471.00
280_V296_Y1.1441.00
364_L372_A1.1381.00
403_L407_E1.1381.00
151_I313_L1.1271.00
289_I299_I1.1181.00
243_D247_Q1.1171.00
31_Y67_E1.1121.00
48_V376_I1.1051.00
207_K248_L1.1051.00
203_E244_W1.1031.00
149_M289_I1.1021.00
280_V285_F1.1011.00
74_S78_Y1.0891.00
407_E410_D1.0851.00
218_I223_D1.0801.00
55_K375_L1.0791.00
49_V360_A1.0781.00
30_P92_I1.0761.00
78_Y87_E1.0761.00
214_I253_F1.0751.00
349_D407_E1.0710.99
123_D208_R1.0710.99
214_I275_I1.0690.99
286_L312_A1.0690.99
146_L294_A1.0640.99
128_L152_F1.0600.99
99_I360_A1.0580.99
345_Y351_V1.0580.99
206_T210_V1.0460.99
47_K406_S1.0440.99
225_V277_I1.0400.99
132_R148_D1.0380.99
195_G240_A1.0380.99
220_N297_D1.0260.99
282_A308_Y1.0250.99
52_A372_A1.0140.99
231_G242_K1.0100.99
382_G386_A0.9970.99
201_C302_M0.9900.99
45_M357_I0.9900.99
53_V61_R0.9900.99
207_K251_E0.9890.99
159_I199_K0.9860.99
204_E207_K0.9790.99
218_I275_I0.9780.99
159_I302_M0.9780.99
164_E198_I0.9750.99
288_Q295_E0.9750.99
44_A406_S0.9740.99
228_V282_A0.9730.99
391_Y402_L0.9700.99
100_K115_N0.9700.99
216_Y220_N0.9650.99
47_K409_G0.9600.99
350_K402_L0.9600.99
87_E90_D0.9590.99
126_I209_L0.9560.99
354_G384_I0.9480.99
245_G300_A0.9470.99
107_V110_G0.9460.99
218_I253_F0.9430.99
132_R377_V0.9410.99
155_N327_N0.9390.99
135_Q145_E0.9320.99
85_P88_T0.9320.99
225_V248_L0.9260.99
158_D199_K0.9250.99
278_K295_E0.9250.99
48_V357_I0.9240.99
28_I94_E0.9230.99
329_G332_C0.9220.98
194_C200_P0.9210.98
31_Y42_T0.9200.98
74_S88_T0.9200.98
52_A360_A0.9200.98
247_Q251_E0.9180.98
358_L377_V0.9170.98
225_V298_V0.9160.98
51_A54_E0.9140.98
48_V413_I0.9130.98
354_G380_M0.9090.98
291_L315_A0.9070.98
40_D347_G0.9040.98
149_M313_L0.9030.98
80_Q117_A0.9020.98
44_A349_D0.9010.98
229_H242_K0.8990.98
33_E43_P0.8930.98
214_I225_V0.8910.98
41_V101_G0.8900.98
53_V62_K0.8870.98
384_I389_V0.8860.98
134_Y381_E0.8860.98
238_E305_N0.8840.98
374_D377_V0.8770.98
201_C206_T0.8770.98
213_A225_V0.8740.98
70_T118_L0.8720.98
345_Y391_Y0.8700.98
361_E365_R0.8680.98
41_V356_I0.8660.98
337_A356_I0.8640.98
68_I88_T0.8580.98
68_I95_Y0.8530.97
91_L95_Y0.8500.97
345_Y350_K0.8480.97
158_D302_M0.8470.97
249_A277_I0.8460.97
288_Q292_R0.8440.97
357_I380_M0.8440.97
44_A410_D0.8380.97
55_K59_G0.8370.97
136_G381_E0.8330.97
372_A375_L0.8330.97
128_L212_A0.8330.97
87_E91_L0.8320.97
144_P294_A0.8250.97
131_V313_L0.8230.97
76_Q105_T0.8220.97
225_V300_A0.8210.97
227_L277_I0.8170.97
382_G385_N0.8170.97
42_T101_G0.8150.97
360_A363_M0.8150.97
379_G383_A0.8130.97
194_C202_S0.8130.97
344_K391_Y0.8110.97
97_V367_M0.8100.97
231_G281_I0.8090.97
70_T114_L0.8060.96
226_T280_V0.7980.96
225_V249_A0.7950.96
225_V275_I0.7930.96
123_D156_S0.7920.96
151_I309_I0.7910.96
126_I212_A0.7890.96
50_D53_V0.7890.96
45_M49_V0.7870.96
32_I92_I0.7860.96
348_Q391_Y0.7840.96
383_A412_I0.7840.96
411_A415_N0.7830.96
229_H279_D0.7810.96
102_P339_H0.7800.96
135_Q381_E0.7790.96
282_A302_M0.7790.96
165_W196_I0.7780.96
108_G111_I0.7770.96
127_C338_T0.7760.96
31_Y65_W0.7740.96
43_P47_K0.7740.96
52_A61_R0.7730.96
159_I304_L0.7720.96
75_T83_W0.7700.95
213_A300_A0.7690.95
131_V317_V0.7680.95
69_Y73_K0.7680.95
246_Y277_I0.7630.95
63_I360_A0.7630.95
171_D191_P0.7600.95
244_W248_L0.7600.95
378_K381_E0.7590.95
210_V277_I0.7590.95
403_L408_F0.7560.95
168_D194_C0.7540.95
249_A273_K0.7510.95
391_Y404_K0.7500.95
49_V364_L0.7500.95
212_A216_Y0.7500.95
326_A335_F0.7450.95
43_P406_S0.7450.95
282_A286_L0.7440.95
99_I356_I0.7430.94
91_L94_E0.7410.94
70_T100_K0.7390.94
390_T408_F0.7380.94
80_Q87_E0.7360.94
228_V309_I0.7360.94
289_I313_L0.7350.94
324_P362_M0.7350.94
112_R117_A0.7340.94
219_A368_G0.7340.94
72_E105_T0.7310.94
72_E76_Q0.7300.94
102_P356_I0.7300.94
43_P67_E0.7290.94
199_K304_L0.7260.94
360_A364_L0.7260.94
228_V299_I0.7260.94
89_L93_R0.7240.94
166_K195_G0.7220.94
27_P61_R0.7200.94
138_P389_V0.7150.93
44_A413_I0.7150.93
406_S410_D0.7140.93
383_A388_T0.7090.93
248_L253_F0.7090.93
285_F296_Y0.7070.93
148_D297_D0.7000.93
243_D250_R0.7000.93
344_K351_V0.7000.93
214_I277_I0.6990.92
50_D54_E0.6970.92
138_P393_F0.6910.92
133_Y147_T0.6910.92
285_F299_I0.6890.92
406_S409_G0.6880.92
59_G372_A0.6880.92
152_F209_L0.6870.92
246_Y249_A0.6870.92
124_L334_L0.6860.92
76_Q107_V0.6850.92
203_E240_A0.6830.92
104_T341_T0.6820.92
199_K305_N0.6790.91
72_E104_T0.6770.91
51_A55_K0.6770.91
68_I87_E0.6740.91
284_A320_I0.6730.91
164_E196_I0.6730.91
131_V149_M0.6720.91
93_R332_C0.6700.91
401_K407_E0.6700.91
47_K50_D0.6690.91
49_V65_W0.6680.91
324_P358_L0.6670.91
371_E374_D0.6650.91
70_T84_L0.6650.91
342_A345_Y0.6620.90
157_E205_G0.6560.90
44_A357_I0.6550.90
143_H146_L0.6540.90
410_D413_I0.6530.90
150_V220_N0.6510.90
84_L118_L0.6510.90
242_K246_Y0.6500.90
215_E251_E0.6480.89
381_E385_N0.6480.89
191_P204_E0.6480.89
42_T45_M0.6470.89
319_G355_S0.6440.89
209_L300_A0.6400.89
373_A377_V0.6370.89
326_A362_M0.6370.89
98_A334_L0.6340.88
166_K169_S0.6330.88
86_A117_A0.6300.88
288_Q291_L0.6300.88
383_A408_F0.6290.88
149_M316_Q0.6280.88
73_K76_Q0.6270.88
170_A194_C0.6240.88
375_L379_G0.6230.87
357_I376_I0.6200.87
229_H281_I0.6190.87
80_Q83_W0.6180.87
324_P355_S0.6150.87
84_L117_A0.6150.87
101_G356_I0.6140.87
199_K238_E0.6140.87
228_V301_C0.6110.86
290_L316_Q0.6100.86
351_V391_Y0.6090.86
338_T355_S0.6080.86
138_P142_K0.6080.86
197_G239_G0.6070.86
335_F366_H0.6060.86
163_I200_P0.6050.86
206_T244_W0.6040.86
29_I363_M0.6030.86
134_Y358_L0.6030.86
212_A330_D0.6020.86
114_L117_A0.6020.86
29_I63_I0.6000.85
328_I366_H0.5970.85
193_H243_D0.5960.85
147_T294_A0.5960.85
74_S84_L0.5950.85
123_D204_E0.5910.85
150_V298_V0.5890.84
227_L241_F0.5880.84
69_Y87_E0.5870.84
332_C335_F0.5860.84
193_H204_E0.5860.84
192_E202_S0.5850.84
49_V376_I0.5830.84
218_I273_K0.5820.84
42_T46_L0.5810.84
191_P207_K0.5800.83
123_D157_E0.5780.83
371_E375_L0.5780.83
171_D192_E0.5780.83
322_I393_F0.5770.83
364_L376_I0.5760.83
388_T401_K0.5740.83
29_I65_W0.5720.83
151_I299_I0.5710.83
194_C203_E0.5700.82
249_A275_I0.5700.82
206_T302_M0.5700.82
357_I409_G0.5660.82
164_E167_A0.5660.82
67_E73_K0.5640.82
107_V111_I0.5640.82
123_D329_G0.5640.82
284_A295_E0.5630.82
105_T113_S0.5620.82
113_S117_A0.5620.82
205_G208_R0.5610.81
367_M370_T0.5570.81
163_I198_I0.5540.81
42_T99_I0.5530.81
390_T393_F0.5510.80
32_I68_I0.5500.80
160_Y336_E0.5490.80
389_V393_F0.5470.80
92_I118_L0.5470.80
125_Y209_L0.5460.80
218_I249_A0.5450.80
103_L341_T0.5440.79
63_I369_W0.5430.79
319_G322_I0.5430.79
148_D222_R0.5430.79
167_A243_D0.5420.79
234_M237_T0.5410.79
212_A215_E0.5390.79
340_G343_P0.5380.79
88_T114_L0.5380.79
253_F273_K0.5380.79
100_K118_L0.5370.79
92_I122_L0.5370.79
150_V222_R0.5340.78
333_A366_H0.5320.78
30_P66_M0.5310.78
400_A403_L0.5310.78
197_G234_M0.5280.77
393_F400_A0.5270.77
157_E202_S0.5230.77
43_P46_L0.5220.77
45_M48_V0.5220.77
329_G333_A0.5200.76
63_I372_A0.5200.76
196_I200_P0.5190.76
125_Y212_A0.5180.76
210_V244_W0.5180.76
349_D410_D0.5170.76
68_I85_P0.5170.76
215_E248_L0.5170.76
328_I333_A0.5160.76
388_T408_F0.5150.76
92_I95_Y0.5150.76
223_D275_I0.5140.76
388_T415_N0.5140.76
166_K235_K0.5130.75
285_F309_I0.5130.75
212_A328_I0.5120.75
52_A375_L0.5100.75
74_S77_V0.5100.75
389_V403_L0.5090.75
249_A253_F0.5090.75
71_G74_S0.5080.75
230_K283_D0.5080.75
49_V52_A0.5080.75
39_V73_K0.5070.75
223_D274_E0.5070.75
217_A225_V0.5070.75
84_L88_T0.5060.74
245_G248_L0.5060.74
302_M305_N0.5050.74
83_W87_E0.5050.74
170_A192_E0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d4vA 2 0.9952 100 0.086 Contact Map
3dmsA 2 0.988 100 0.099 Contact Map
2iv0A 2 0.9784 100 0.103 Contact Map
1hqsA 2 0.9784 100 0.114 Contact Map
2e0cA 2 0.9543 100 0.114 Contact Map
1tyoA 2 0.9856 100 0.115 Contact Map
3flkA 3 0.8197 100 0.148 Contact Map
2d1cA 2 0.8389 100 0.15 Contact Map
3blxB 1 0.8197 100 0.152 Contact Map
3u1hA 2 0.8053 100 0.155 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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