GREMLIN Database
FOLC - Bifunctional protein FolC
UniProt: P08192 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10327
Length: 422 (395)
Sequences: 5326 (4175)
Seq/√Len: 210.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_P183_S4.1151.00
90_T102_E3.8541.00
54_V64_C3.3941.00
212_V216_K3.3711.00
152_R187_E3.3561.00
165_V267_A3.3011.00
291_Q411_M3.1471.00
192_F198_A3.1401.00
170_A308_H3.1101.00
171_L174_T2.8871.00
104_A138_A2.8861.00
182_E204_E2.7781.00
212_V215_E2.6631.00
332_M341_T2.5531.00
163_V267_A2.5481.00
380_S383_Q2.5191.00
100_L134_L2.5021.00
180_D183_S2.4791.00
111_E137_Q2.4511.00
337_D340_G2.4211.00
257_N260_T2.3841.00
55_A147_V2.3211.00
57_T172_D2.3021.00
73_A283_S2.2911.00
101_P104_A2.2821.00
288_G407_V2.2631.00
68_E72_M2.2421.00
303_V404_F2.2401.00
39_A158_I2.2151.00
64_C80_V2.1571.00
71_L142_V2.1361.00
88_R99_E2.1341.00
140_L143_V2.1051.00
327_L353_Y2.0321.00
111_E133_W1.9801.00
207_S211_D1.9781.00
88_R102_E1.9671.00
89_Y127_G1.9371.00
353_Y378_F1.8841.00
292_I298_R1.8731.00
133_W137_Q1.8711.00
107_A137_Q1.8361.00
69_S280_G1.8321.00
149_L176_W1.8041.00
51_V159_V1.7541.00
48_A136_K1.7511.00
81_Y128_T1.7241.00
73_A279_D1.7121.00
64_C144_I1.7071.00
328_A349_V1.7041.00
37_L41_R1.6911.00
378_F387_A1.6851.00
292_I300_I1.6771.00
166_V192_F1.6691.00
77_K96_Q1.6621.00
273_S276_A1.6601.00
310_A341_T1.6451.00
171_L181_R1.6371.00
104_A107_A1.6271.00
163_V199_I1.6271.00
38_V121_L1.6261.00
49_P143_V1.6221.00
254_P257_N1.6161.00
274_E278_R1.6141.00
35_V129_L1.5991.00
313_L399_L1.5981.00
338_I363_A1.5901.00
327_L351_D1.5901.00
287_P291_Q1.5891.00
40_A44_V1.5881.00
66_T284_A1.5821.00
63_T167_T1.5781.00
325_R396_D1.5701.00
63_T165_V1.5611.00
279_D283_S1.5571.00
329_V388_A1.5501.00
90_T99_E1.5421.00
335_D361_R1.5381.00
311_E344_W1.5021.00
356_P365_A1.5011.00
194_S216_K1.4941.00
132_L145_L1.4891.00
41_R118_D1.4761.00
145_L159_V1.4741.00
67_L144_I1.4701.00
351_D376_K1.4641.00
192_F218_A1.4541.00
70_I280_G1.4471.00
198_A218_A1.4411.00
87_V408_A1.4381.00
183_S186_R1.4321.00
364_T367_Q1.4281.00
206_P222_R1.4281.00
290_F300_I1.4061.00
106_T110_A1.4021.00
108_S134_L1.3961.00
166_V209_I1.3941.00
58_N309_A1.3941.00
168_S308_H1.3931.00
329_V398_V1.3841.00
290_F316_R1.3831.00
342_L372_L1.3821.00
400_V410_V1.3651.00
108_S133_W1.3591.00
55_A191_I1.3511.00
317_M399_L1.3451.00
257_N262_L1.3451.00
68_E80_V1.3421.00
369_L373_G1.3411.00
299_V385_W1.3401.00
38_V129_L1.3351.00
307_P340_G1.3341.00
65_R284_A1.3331.00
210_A214_Q1.3281.00
186_R212_V1.3241.00
327_L391_D1.3221.00
200_V206_P1.3221.00
211_D215_E1.3181.00
358_E409_H1.3121.00
80_V94_R1.2981.00
74_A276_A1.2961.00
87_V411_M1.2951.00
89_Y105_H1.2951.00
21_E123_Y1.2911.00
65_R286_L1.2901.00
195_E217_G1.2901.00
384_A388_A1.2871.00
201_G263_A1.2851.00
312_Y315_G1.2811.00
189_A212_V1.2801.00
33_E36_S1.2741.00
164_A196_K1.2701.00
76_Y141_D1.2611.00
381_V410_V1.2571.00
85_H92_R1.2571.00
260_T263_A1.2541.00
79_G135_F1.2481.00
326_V397_T1.2381.00
194_S217_G1.2301.00
206_P210_A1.2291.00
37_L40_A1.2281.00
200_V220_L1.2271.00
332_M338_I1.2221.00
153_L187_E1.2171.00
339_A371_H1.2061.00
213_A220_L1.1961.00
47_P160_D1.1891.00
197_P219_L1.1701.00
77_K138_A1.1681.00
210_A222_R1.1651.00
86_L408_A1.1601.00
249_P282_A1.1591.00
280_G284_A1.1591.00
85_H123_Y1.1511.00
132_L159_V1.1491.00
339_A374_N1.1441.00
68_E94_R1.1391.00
103_S107_A1.1381.00
310_A314_T1.1321.00
326_V349_V1.1311.00
72_M96_Q1.1271.00
131_A145_L1.1251.00
331_G357_L1.1251.00
53_T157_N1.1221.00
174_T179_P1.1221.00
52_F142_V1.1211.00
95_V140_L1.1211.00
392_A398_V1.1211.00
276_A280_G1.1201.00
356_P362_G1.1191.00
353_Y391_D1.1131.00
76_Y142_V1.1041.00
113_E117_G1.1041.00
255_Q315_G1.0891.00
205_M208_T1.0881.00
66_T264_A1.0841.00
329_V384_A1.0801.00
370_E373_G1.0801.00
314_T344_W1.0781.00
255_Q319_A1.0771.00
222_R225_V1.0761.00
327_L396_D1.0761.00
67_L165_V1.0751.00
104_A134_L1.0741.00
205_M209_I1.0721.00
142_V270_L1.0701.00
100_L104_A1.0691.00
161_A196_K1.0661.00
376_K387_A1.0561.00
123_Y127_G1.0441.00
324_G395_E1.0351.00
74_A272_V1.0331.00
68_E144_I1.0281.00
301_F407_V1.0241.00
160_D196_K1.0231.00
93_V134_L1.0161.00
387_A391_D1.0141.00
74_A273_S1.0131.00
308_H311_E1.0111.00
42_L133_W1.0101.00
109_F130_S1.0081.00
112_I115_A1.0051.00
299_V389_M1.0031.00
165_V263_A1.0021.00
104_A137_Q1.0021.00
355_A384_A1.0021.00
105_H130_S0.9991.00
353_Y387_A0.9991.00
334_H367_Q0.9971.00
387_A390_A0.9961.00
221_Q266_R0.9921.00
192_F209_I0.9871.00
199_I263_A0.9811.00
70_I281_I0.9801.00
81_Y155_A0.9801.00
134_L138_A0.9771.00
357_L406_T0.9741.00
248_L251_P0.9721.00
345_L401_C0.9721.00
192_F213_A0.9691.00
192_F216_K0.9681.00
152_R186_R0.9601.00
328_A399_L0.9571.00
79_G140_L0.9450.99
222_R226_E0.9400.99
286_L404_F0.9400.99
314_T318_K0.9380.99
69_S284_A0.9340.99
388_A398_V0.9340.99
252_L284_A0.9330.99
261_A281_I0.9290.99
371_H374_N0.9260.99
250_L261_A0.9250.99
330_I342_L0.9230.99
44_V47_P0.9200.99
365_A377_S0.9190.99
170_A311_E0.9180.99
207_S210_A0.9170.99
168_S202_E0.9160.99
94_R99_E0.9140.99
325_R350_D0.9140.99
275_N279_D0.9130.99
325_R351_D0.9120.99
175_D335_D0.9110.99
200_V222_R0.9100.99
210_A220_L0.9070.99
166_V198_A0.9050.99
328_A401_C0.9020.99
152_R212_V0.9000.99
186_R211_D0.8990.99
292_I295_E0.8990.99
71_L144_I0.8990.99
252_L257_N0.8980.99
67_L267_A0.8980.99
181_R205_M0.8970.99
155_A187_E0.8960.99
95_V138_A0.8930.99
298_R397_T0.8930.99
310_A345_L0.8830.99
338_I371_H0.8810.99
51_V143_V0.8790.99
254_P260_T0.8790.99
108_S130_S0.8780.99
185_G208_T0.8770.99
168_S201_G0.8770.99
307_P337_D0.8720.99
256_P260_T0.8720.99
181_R204_E0.8710.99
66_T281_I0.8700.99
240_D243_G0.8690.99
18_S21_E0.8670.99
58_N306_N0.8660.99
62_T257_N0.8640.99
147_V191_I0.8630.99
28_I31_G0.8630.99
50_F162_D0.8630.99
165_V199_I0.8610.99
250_L281_I0.8590.99
108_S137_Q0.8590.99
182_E205_M0.8580.99
174_T337_D0.8550.99
323_N397_T0.8540.99
385_W410_V0.8520.99
307_P311_E0.8510.99
93_V100_L0.8480.99
100_L105_H0.8430.99
333_L405_H0.8420.99
260_T264_A0.8380.99
367_Q370_E0.8360.99
189_A192_F0.8350.99
256_P312_Y0.8320.99
281_I284_A0.8320.99
310_A344_W0.8300.99
85_H91_E0.8290.99
300_I397_T0.8270.99
236_W261_A0.8260.99
409_H412_E0.8260.99
257_N263_A0.8260.99
277_I280_G0.8210.99
182_E208_T0.8200.99
343_A375_G0.8170.98
357_L362_G0.8150.98
354_C365_A0.8110.98
39_A129_L0.8100.98
157_N193_R0.8090.98
363_A367_Q0.8070.98
108_S111_E0.8060.98
299_V398_V0.8050.98
239_S244_T0.8030.98
248_L278_R0.8020.98
170_A307_P0.8020.98
116_R126_Y0.8000.98
172_D306_N0.7990.98
39_A46_K0.7990.98
224_G227_W0.7980.98
318_K348_V0.7970.98
354_C377_S0.7960.98
378_F383_Q0.7950.98
359_G405_H0.7940.98
66_T251_P0.7930.98
65_R69_S0.7920.98
51_V145_L0.7910.98
68_E97_G0.7900.98
265_L277_I0.7890.98
69_S73_A0.7890.98
19_Y23_L0.7880.98
331_G355_A0.7880.98
73_A280_G0.7800.98
49_P140_L0.7800.98
70_I277_I0.7750.98
31_G35_V0.7720.98
260_T267_A0.7700.98
323_N326_V0.7690.98
370_E374_N0.7680.98
199_I267_A0.7640.98
329_V400_V0.7620.98
28_I149_L0.7610.98
333_L357_L0.7600.98
80_V144_I0.7590.98
363_A371_H0.7580.98
379_D383_Q0.7560.97
105_H127_G0.7550.97
42_L112_I0.7550.97
162_D196_K0.7550.97
189_A209_I0.7540.97
53_T193_R0.7510.97
70_I74_A0.7490.97
30_L34_R0.7490.97
72_M78_V0.7490.97
210_A225_V0.7460.97
311_E315_G0.7440.97
304_A309_A0.7430.97
339_A375_G0.7420.97
313_L401_C0.7410.97
164_A198_A0.7400.97
116_R121_L0.7390.97
309_A312_Y0.7360.97
53_T156_T0.7340.97
294_S298_R0.7270.97
72_M97_G0.7270.97
355_A381_V0.7270.97
122_T125_E0.7270.97
369_L377_S0.7240.97
310_A313_L0.7200.97
200_V209_I0.7190.97
28_I176_W0.7160.97
211_D214_Q0.7140.96
90_T105_H0.7140.96
166_V190_G0.7120.96
354_C369_L0.7070.96
185_G209_I0.7070.96
112_I130_S0.7060.96
366_E377_S0.7050.96
186_R208_T0.7020.96
262_L266_R0.7010.96
202_E209_I0.7000.96
386_D390_A0.7000.96
367_Q371_H0.6960.96
356_P379_D0.6940.96
339_A343_A0.6930.96
124_F148_G0.6920.96
338_I368_L0.6920.96
89_Y93_V0.6910.96
89_Y123_Y0.6890.96
50_F142_V0.6880.96
328_A352_W0.6870.96
28_I122_T0.6860.96
279_D282_A0.6850.96
332_M363_A0.6840.95
293_V301_F0.6830.95
100_L108_S0.6810.95
179_P182_E0.6800.95
388_A392_A0.6790.95
95_V134_L0.6790.95
308_H312_Y0.6790.95
330_I401_C0.6780.95
304_A399_L0.6780.95
327_L392_A0.6750.95
247_N250_L0.6750.95
133_W136_K0.6750.95
230_S233_D0.6740.95
349_V399_L0.6730.95
272_V276_A0.6730.95
111_E115_A0.6730.95
340_G344_W0.6710.95
66_T261_A0.6710.95
237_A247_N0.6690.95
293_V297_P0.6690.95
31_G34_R0.6690.95
35_V155_A0.6690.95
287_P411_M0.6690.95
329_V355_A0.6680.95
224_G228_N0.6680.95
57_T170_A0.6670.95
23_L126_Y0.6660.95
200_V263_A0.6660.95
24_H29_D0.6650.95
372_L375_G0.6650.95
153_L186_R0.6650.95
174_T183_S0.6620.95
67_L71_L0.6620.95
258_A262_L0.6620.95
324_G396_D0.6610.95
63_T264_A0.6600.95
324_G397_T0.6570.94
41_R115_A0.6540.94
201_G259_A0.6540.94
294_S297_P0.6540.94
300_I316_R0.6540.94
93_V135_F0.6520.94
89_Y92_R0.6520.94
237_A244_T0.6500.94
77_K141_D0.6440.94
39_A45_L0.6440.94
257_N267_A0.6430.94
131_A135_F0.6410.94
353_Y388_A0.6410.94
274_E277_I0.6380.93
34_R119_I0.6380.93
356_P364_T0.6370.93
199_I221_Q0.6370.93
164_A197_P0.6360.93
175_D334_H0.6350.93
301_F400_V0.6350.93
29_D34_R0.6330.93
313_L317_M0.6310.93
63_T263_A0.6290.93
333_L363_A0.6280.93
340_G343_A0.6270.93
204_E207_S0.6240.93
67_L264_A0.6240.93
198_A220_L0.6230.93
354_C368_L0.6210.93
185_G189_A0.6200.93
181_R202_E0.6190.92
227_W262_L0.6190.92
223_R227_W0.6160.92
42_L115_A0.6160.92
169_I209_I0.6140.92
351_D391_D0.6130.92
71_L76_Y0.6130.92
366_E370_E0.6130.92
349_V352_W0.6120.92
55_A169_I0.6120.92
71_L78_V0.6110.92
87_V412_E0.6090.92
157_N191_I0.6080.92
67_L70_I0.6070.92
386_D389_M0.6060.92
294_S389_M0.6050.92
245_L248_L0.6010.91
236_W240_D0.5990.91
406_T410_V0.5990.91
19_Y22_N0.5990.91
185_G205_M0.5970.91
93_V127_G0.5970.91
299_V400_V0.5940.91
93_V131_A0.5940.91
256_P290_F0.5930.91
27_T31_G0.5930.91
32_L35_V0.5920.91
301_F411_M0.5920.91
189_A208_T0.5900.91
196_K218_A0.5900.91
38_V126_Y0.5890.90
371_H375_G0.5880.90
257_N264_A0.5860.90
164_A191_I0.5850.90
166_V191_I0.5850.90
234_H238_F0.5850.90
365_A369_L0.5840.90
66_T252_L0.5830.90
85_H127_G0.5830.90
190_G193_R0.5820.90
327_L388_A0.5810.90
326_V350_D0.5810.90
263_A267_A0.5800.90
382_A386_D0.5800.90
36_S160_D0.5780.90
81_Y92_R0.5770.90
132_L158_I0.5750.89
278_R282_A0.5740.89
238_F265_L0.5740.89
128_T132_L0.5730.89
30_L122_T0.5730.89
79_G93_V0.5690.89
275_N278_R0.5680.89
240_D245_L0.5680.89
77_K140_L0.5680.89
57_T306_N0.5660.89
19_Y113_E0.5650.89
166_V189_A0.5630.88
147_V187_E0.5630.88
46_K158_I0.5620.88
327_L398_V0.5610.88
149_L187_E0.5610.88
18_S22_N0.5600.88
228_N239_S0.5590.88
110_A114_S0.5580.88
357_L405_H0.5580.88
39_A44_V0.5570.88
273_S277_I0.5570.88
110_A113_E0.5560.88
346_K375_G0.5550.88
223_R259_A0.5540.88
174_T180_D0.5540.88
381_V406_T0.5530.88
102_E105_H0.5510.87
30_L149_L0.5490.87
74_A280_G0.5470.87
77_K95_V0.5460.87
23_L26_K0.5460.87
383_Q386_D0.5450.87
70_I265_L0.5430.87
192_F208_T0.5420.87
22_N25_S0.5390.86
81_Y131_A0.5350.86
393_K396_D0.5340.86
35_V128_T0.5330.86
68_E78_V0.5330.86
174_T184_I0.5330.86
159_V162_D0.5320.86
162_D193_R0.5320.86
53_T164_A0.5310.85
52_F67_L0.5310.85
238_F266_R0.5310.85
150_G178_G0.5310.85
49_P136_K0.5300.85
147_V164_A0.5290.85
61_G286_L0.5290.85
91_E408_A0.5280.85
69_S72_M0.5270.85
26_K29_D0.5270.85
328_A345_L0.5260.85
58_N333_L0.5250.85
147_V190_G0.5250.85
86_L407_V0.5250.85
54_V147_V0.5240.85
290_F313_L0.5240.85
171_L176_W0.5230.85
252_L256_P0.5220.84
109_F126_Y0.5210.84
366_E379_D0.5210.84
192_F212_V0.5190.84
272_V277_I0.5190.84
74_A277_I0.5190.84
92_R123_Y0.5180.84
317_M326_V0.5180.84
112_I116_R0.5170.84
304_A401_C0.5150.84
35_V39_A0.5150.84
213_A218_A0.5150.84
70_I272_V0.5150.84
112_I133_W0.5130.83
341_T344_W0.5130.83
64_C147_V0.5130.83
329_V410_V0.5130.83
161_A164_A0.5130.83
108_S138_A0.5120.83
316_R320_L0.5110.83
128_T155_A0.5090.83
67_L163_V0.5090.83
237_A240_D0.5070.83
142_V162_D0.5060.83
196_K219_L0.5060.83
78_V141_D0.5060.83
294_S299_V0.5050.82
189_A213_A0.5030.82
64_C68_E0.5030.82
166_V187_E0.5020.82
252_L260_T0.5020.82
107_A111_E0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vosA 1 0.9716 100 0.259 Contact Map
1jbwA 1 0.9194 100 0.274 Contact Map
1o5zA 1 0.9336 100 0.294 Contact Map
3nrsA 1 0.9384 100 0.307 Contact Map
1w78A 1 0.981 100 0.308 Contact Map
4bubA 1 0.9076 100 0.519 Contact Map
1e8cA 1 0.9242 100 0.529 Contact Map
4c12A 2 0.9076 100 0.54 Contact Map
2wtzA 1 0.9147 100 0.543 Contact Map
3zl8A 1 0.8649 100 0.558 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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