GREMLIN Database
FIMH - Protein FimH
UniProt: P08191 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10315
Length: 300 (291)
Sequences: 526 (482)
Seq/√Len: 28.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_S96_V4.3581.00
194_P289_V4.1031.00
44_N48_V3.4101.00
191_V202_I3.1451.00
44_N47_P3.0361.00
229_I278_A3.0021.00
244_V291_S2.9301.00
91_N95_T2.8461.00
93_S100_G2.8091.00
93_S101_S2.7561.00
44_N51_V2.7331.00
96_V101_S2.7151.00
96_V102_S2.7131.00
46_A49_V2.6370.99
194_P290_Q2.5260.99
93_S102_S2.4890.99
48_V51_V2.4610.99
232_N289_V2.4520.99
94_G100_G2.4190.99
46_A51_V2.4070.99
39_A46_A2.4010.99
96_V99_S2.4000.99
93_S97_K2.3930.99
131_T134_S2.3150.99
47_P51_V2.2760.98
94_G102_S2.2300.98
96_V100_G2.2270.98
130_L134_S2.2060.98
96_V104_P2.1990.98
43_V46_A2.1480.98
42_Y46_A2.0970.97
41_V44_N2.0740.97
93_S99_S2.0730.97
52_G55_L1.9510.96
131_T135_S1.9440.96
44_N52_G1.9420.96
97_K102_S1.9370.96
97_K101_S1.9310.96
48_V52_G1.8930.95
89_L93_S1.8930.95
94_G101_S1.8530.95
99_S102_S1.8500.94
132_P135_S1.8460.94
94_G98_Y1.8430.94
44_N49_V1.8250.94
87_G91_N1.8220.94
47_P52_G1.8200.94
51_V55_L1.7580.93
247_T276_N1.7560.93
96_V103_Y1.7270.92
229_I243_G1.7240.92
97_K100_G1.6780.91
92_F95_T1.6550.90
88_V91_N1.6470.90
46_A55_L1.6330.90
240_Q285_T1.6280.90
43_V48_V1.6070.89
43_V47_P1.5810.88
94_G99_S1.5810.88
87_G92_F1.5460.87
85_Y91_N1.5370.87
136_A139_V1.5230.86
48_V54_N1.5170.86
224_D227_N1.5090.86
204_L295_V1.4890.85
279_R289_V1.4430.83
245_Q276_N1.4410.83
43_V51_V1.4390.83
90_S101_S1.4340.83
143_A146_L1.4330.83
42_Y48_V1.4320.82
85_Y89_L1.4310.82
186_A189_V1.4260.82
87_G90_S1.3830.80
92_F96_V1.3790.80
84_A88_V1.3740.80
94_G104_P1.3570.79
88_V92_F1.3540.79
199_S276_N1.3520.79
50_N54_N1.3410.78
42_Y47_P1.3310.78
41_V47_P1.3290.77
194_P200_V1.3280.77
94_G97_K1.2840.75
93_S104_P1.2760.74
254_P257_N1.2740.74
98_Y101_S1.2720.74
43_V52_G1.2660.74
84_A93_S1.2530.73
194_P232_N1.2510.73
47_P54_N1.2490.73
41_V46_A1.2480.73
43_V49_V1.2470.73
8_F12_L1.2330.72
219_S256_N1.2280.71
139_V142_K1.2210.71
140_A143_A1.2160.71
204_L246_L1.1960.69
218_L295_V1.1840.69
83_S87_G1.1740.68
97_K104_P1.1700.68
84_A87_G1.1610.67
44_N55_L1.1560.67
189_V295_V1.1510.66
256_N296_T1.1460.66
232_N290_Q1.1440.66
216_Y273_L1.1430.66
16_S19_A1.1410.66
85_Y95_T1.1400.66
220_G255_A1.1370.65
88_V93_S1.1370.65
193_L244_V1.1320.65
95_T98_Y1.1320.65
277_Y299_Y1.1300.65
290_Q294_G1.1250.65
279_R284_V1.1190.64
180_G206_V1.1120.64
13_M16_S1.1100.64
46_A52_G1.1090.63
89_L95_T1.1080.63
43_V55_L1.1060.63
232_N238_P1.1020.63
102_S105_F1.1020.63
85_Y92_F1.0780.61
218_L273_L1.0770.61
46_A54_N1.0690.61
39_A52_G1.0680.61
39_A51_V1.0620.60
130_L133_V1.0570.60
129_Y132_P1.0560.60
202_I295_V1.0520.59
49_V52_G1.0470.59
51_V54_N1.0420.59
100_G103_Y1.0350.58
91_N96_V1.0260.57
48_V55_L1.0250.57
37_G41_V1.0230.57
97_K103_Y1.0150.57
96_V105_F1.0150.57
93_S103_Y1.0110.56
99_S104_P0.9980.55
84_A92_F0.9980.55
233_T290_Q0.9940.55
93_S98_Y0.9930.55
280_T289_V0.9880.54
202_I273_L0.9870.54
92_F98_Y0.9800.54
20_W253_I0.9750.53
129_Y134_S0.9690.53
47_P55_L0.9670.53
184_V296_T0.9600.52
217_Y298_V0.9600.52
239_A277_Y0.9590.52
128_L134_S0.9580.52
41_V48_V0.9570.52
95_T102_S0.9550.52
85_Y93_S0.9530.52
10_V19_A0.9500.52
39_A42_Y0.9410.51
239_A299_Y0.9410.51
44_N50_N0.9410.51
44_N54_N0.9340.50
189_V204_L0.9300.50
253_I296_T0.9280.50
128_L132_P0.9260.50
277_Y280_T0.9250.50
88_V95_T0.9250.50
16_S20_W0.9100.48
95_T101_S0.9090.48
62_Q177_V0.9080.48
277_Y290_Q0.9040.48
47_P50_N0.9040.48
29_G32_I0.9030.48
220_G230_F0.9000.48
88_V96_V0.8970.47
234_A271_L0.8940.47
233_T289_V0.8910.47
92_F101_S0.8880.47
255_A295_V0.8870.47
228_S273_L0.8850.47
126_V131_T0.8840.46
212_Q271_L0.8830.46
217_Y258_T0.8820.46
85_Y90_S0.8810.46
262_G296_T0.8810.46
151_I154_Q0.8790.46
219_S278_A0.8780.46
220_G271_L0.8770.46
95_T100_G0.8760.46
201_P274_T0.8720.46
99_S103_Y0.8700.45
49_V55_L0.8660.45
140_A145_S0.8660.45
38_S190_T0.8640.45
91_N94_G0.8640.45
220_G298_V0.8620.45
65_C81_R0.8600.45
230_F293_I0.8590.45
193_L222_T0.8560.44
215_G298_V0.8540.44
87_G95_T0.8510.44
126_V134_S0.8480.44
94_G103_Y0.8470.44
204_L228_S0.8460.44
39_A50_N0.8440.43
193_L289_V0.8430.43
220_G225_A0.8330.43
8_F13_M0.8280.42
178_P210_K0.8280.42
211_S264_V0.8250.42
181_G210_K0.8210.42
237_S288_N0.8080.41
95_T104_P0.8070.41
203_P272_G0.8050.41
187_R205_T0.8010.40
87_G93_S0.8010.40
38_S41_V0.7940.40
15_W19_A0.7910.39
290_Q293_I0.7910.39
273_L295_V0.7850.39
48_V53_Q0.7840.39
230_F234_A0.7830.39
184_V297_F0.7830.39
232_N235_S0.7830.39
75_D80_Q0.7770.38
142_K145_S0.7770.38
213_N263_A0.7730.38
125_P130_L0.7690.38
126_V130_L0.7670.38
191_V295_V0.7640.38
137_G294_G0.7620.37
98_Y102_S0.7610.37
253_I262_G0.7610.37
193_L291_S0.7600.37
220_G231_T0.7590.37
40_N44_N0.7570.37
45_L48_V0.7550.37
193_L232_N0.7550.37
277_Y289_V0.7550.37
262_G295_V0.7530.37
113_R147_I0.7520.37
92_F99_S0.7520.37
11_L16_S0.7520.37
191_V273_L0.7460.36
194_P279_R0.7450.36
21_S24_C0.7440.36
49_V53_Q0.7440.36
241_G245_Q0.7410.36
262_G269_V0.7330.35
218_L259_V0.7330.35
173_N180_G0.7310.35
39_A43_V0.7250.35
235_S238_P0.7250.35
34_I155_T0.7190.34
111_T116_Y0.7180.34
128_L131_T0.7180.34
206_V267_S0.7170.34
90_S96_V0.7160.34
252_I255_A0.7160.34
39_A48_V0.7130.34
261_L271_L0.7110.34
14_G18_N0.7100.34
182_C208_C0.7030.33
39_A44_N0.6920.32
11_L20_W0.6870.32
127_A131_T0.6860.32
184_V189_V0.6840.32
128_L133_V0.6760.31
130_L137_G0.6730.31
90_S93_S0.6730.31
214_L273_L0.6720.31
222_T225_A0.6720.31
276_N298_V0.6720.31
95_T99_S0.6710.31
204_L261_L0.6710.31
101_S104_P0.6690.31
139_V143_A0.6690.31
216_Y264_V0.6670.31
100_G104_P0.6660.31
46_A50_N0.6640.31
92_F103_Y0.6630.31
198_G228_S0.6610.30
225_A283_Q0.6610.30
209_A212_Q0.6590.30
245_Q275_A0.6570.30
40_N48_V0.6540.30
76_Y81_R0.6540.30
193_L256_N0.6540.30
237_S259_V0.6510.30
134_S138_G0.6510.30
45_L51_V0.6500.30
241_G299_Y0.6470.30
225_A296_T0.6460.29
222_T228_S0.6450.29
14_G17_V0.6450.29
287_G299_Y0.6440.29
220_G278_A0.6420.29
50_N55_L0.6390.29
149_V154_Q0.6380.29
134_S137_G0.6370.29
39_A47_P0.6350.29
238_P295_V0.6350.29
130_L138_G0.6320.29
181_G202_I0.6320.29
37_G40_N0.6300.28
205_T270_S0.6260.28
42_Y51_V0.6260.28
213_N254_P0.6240.28
17_V20_W0.6240.28
83_S88_V0.6210.28
204_L255_A0.6210.28
142_K148_A0.6210.28
197_P271_L0.6210.28
252_I267_S0.6200.28
253_I259_V0.6180.28
9_A204_L0.6170.28
13_M19_A0.6170.28
201_P244_V0.6150.27
92_F104_P0.6130.27
240_Q289_V0.6110.27
175_V297_F0.6110.27
131_T137_G0.6090.27
259_V291_S0.6080.27
86_G91_N0.6080.27
9_A12_L0.6050.27
212_Q220_G0.6040.27
123_P133_V0.5960.26
219_S296_T0.5960.26
106_P110_E0.5950.26
143_A211_S0.5940.26
223_A227_N0.5920.26
11_L14_G0.5910.26
8_F19_A0.5900.26
107_T110_E0.5900.26
233_T284_V0.5890.26
191_V200_V0.5890.26
42_Y49_V0.5890.26
196_Y272_G0.5880.26
227_N231_T0.5870.26
129_Y141_I0.5870.26
181_G294_G0.5830.26
186_A298_V0.5830.26
180_G187_R0.5820.26
98_Y104_P0.5820.26
10_V14_G0.5770.25
180_G209_A0.5770.25
280_T285_T0.5750.25
142_K159_N0.5730.25
211_S279_R0.5730.25
113_R184_V0.5720.25
84_A94_G0.5700.25
38_S44_N0.5690.25
191_V201_P0.5690.25
228_S255_A0.5680.25
183_D203_P0.5660.25
30_T36_G0.5660.25
215_G229_I0.5640.24
258_T298_V0.5640.24
183_D210_K0.5630.24
289_V299_Y0.5610.24
182_C287_G0.5610.24
246_L273_L0.5600.24
129_Y133_V0.5590.24
138_G148_A0.5580.24
84_A90_S0.5560.24
123_P134_S0.5550.24
46_A53_Q0.5510.24
178_P262_G0.5490.24
143_A235_S0.5490.24
75_D78_T0.5480.24
218_L262_G0.5460.23
19_A82_G0.5440.23
220_G248_R0.5440.23
71_E109_S0.5430.23
125_P132_P0.5430.23
220_G228_S0.5420.23
83_S92_F0.5420.23
148_A154_Q0.5410.23
85_Y96_V0.5400.23
169_I172_N0.5400.23
98_Y103_Y0.5390.23
111_T284_V0.5380.23
183_D224_D0.5380.23
84_A91_N0.5380.23
45_L52_G0.5340.23
255_A292_I0.5340.23
181_G248_R0.5340.23
108_T115_V0.5320.23
162_D165_F0.5320.23
239_A275_A0.5320.23
25_K76_Y0.5310.23
202_I278_A0.5300.23
26_T34_I0.5270.22
225_A254_P0.5270.22
126_V132_P0.5260.22
40_N46_A0.5260.22
178_P181_G0.5250.22
206_V276_N0.5250.22
84_A89_L0.5220.22
206_V292_I0.5220.22
230_F278_A0.5220.22
83_S95_T0.5210.22
217_Y295_V0.5180.22
206_V299_Y0.5180.22
148_A188_D0.5170.22
181_G198_G0.5170.22
291_S295_V0.5170.22
269_V272_G0.5160.22
237_S286_A0.5160.22
43_V181_G0.5150.22
41_V49_V0.5150.22
38_S46_A0.5150.22
228_S295_V0.5150.22
53_Q56_V0.5120.22
223_A257_N0.5120.22
12_L63_I0.5120.22
208_C287_G0.5120.22
198_G214_L0.5120.22
195_D236_F0.5100.22
106_P125_P0.5090.21
30_T34_I0.5090.21
271_L281_G0.5090.21
175_V181_G0.5080.21
205_T295_V0.5080.21
23_A284_V0.5070.21
10_V13_M0.5070.21
74_T77_V0.5060.21
107_T111_T0.5040.21
39_A78_T0.5040.21
37_G44_N0.5030.21
241_G277_Y0.5020.21
277_Y284_V0.5020.21
225_A253_I0.5010.21
9_A16_S0.5010.21
237_S295_V0.5010.21
191_V199_S0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jwnH 1 0.93 100 0.405 Contact Map
1ze3H 1 0.4067 100 0.591 Contact Map
5afoA 1 0.9033 100 0.596 Contact Map
2jmrA 1 0.45 99.9 0.633 Contact Map
3bwuF 1 0.3767 99.9 0.64 Contact Map
2xg5B 1 0.4133 99.9 0.646 Contact Map
2jtyA 1 0.46 99.9 0.651 Contact Map
1pdkB 1 0.4067 99.9 0.659 Contact Map
3bfqG 1 0.39 99.9 0.659 Contact Map
4dwhB 1 0.39 99.9 0.661 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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