GREMLIN Database
FIMF - Protein FimF
UniProt: P08189 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10313
Length: 176 (161)
Sequences: 3585 (2805)
Seq/√Len: 221.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_L114_G3.0341.00
111_S161_T2.9091.00
115_I151_A2.8361.00
61_N64_A2.8191.00
116_Q152_R2.7041.00
118_L152_R2.6911.00
116_Q154_M2.6481.00
39_S77_P2.6121.00
85_V173_L2.6071.00
72_R146_T2.5271.00
101_L127_L2.4211.00
41_A76_S2.3201.00
153_L165_I2.2471.00
103_L165_I2.2261.00
60_N64_A2.1961.00
112_G160_V2.1201.00
74_L146_T2.0971.00
115_I167_A2.0361.00
122_Q150_Y1.9431.00
72_R148_N1.9241.00
101_L169_A1.9061.00
126_P129_A1.9051.00
119_N123_N1.8431.00
109_A164_H1.8341.00
68_V152_R1.8011.00
65_T116_Q1.7581.00
17_V21_L1.7461.00
41_A74_L1.7381.00
116_Q124_Q1.6581.00
91_G101_L1.6571.00
100_L154_M1.6411.00
94_D156_T1.6021.00
41_A44_S1.5691.00
70_P150_Y1.5371.00
54_N66_T1.5111.00
52_M69_V1.4991.00
90_T172_T1.4841.00
90_T128_N1.4651.00
42_A47_F1.4631.00
59_F155_A1.3761.00
99_N126_P1.3701.00
44_S47_F1.3631.00
52_M165_I1.3621.00
86_K174_E1.3601.00
44_S74_L1.2901.00
61_N155_A1.2781.00
32_Y53_E1.2681.00
70_P148_N1.2641.00
105_N109_A1.2591.00
71_F117_L1.2471.00
139_L145_N1.2451.00
65_T152_R1.2441.00
14_W18_S1.2341.00
52_M67_P1.2281.00
51_L153_L1.2191.00
49_V71_F1.2081.00
11_A14_W1.1941.00
85_V145_N1.1821.00
21_L24_D1.1751.00
105_N164_H1.1691.00
12_F15_L1.1611.00
47_F73_I1.1521.00
89_F149_F1.1461.00
155_A160_V1.1251.00
18_S22_A1.1131.00
18_S21_L1.1121.00
25_S29_I1.1121.00
51_L165_I1.0891.00
59_F160_V1.0881.00
139_L142_G1.0861.00
10_C13_L1.0841.00
65_T118_L1.0751.00
20_A23_A1.0721.00
100_L116_Q1.0701.00
59_F113_L1.0651.00
15_L18_S1.0601.00
55_A58_Q1.0591.00
88_G130_P1.0591.00
9_L12_F1.0561.00
51_L115_I1.0481.00
89_F117_L1.0451.00
95_S114_G1.0241.00
28_T168_T1.0181.00
68_V150_Y1.0171.00
85_V139_L1.0161.00
95_S98_A1.0031.00
120_E148_N1.0011.00
65_T154_M0.9961.00
19_H23_A0.9951.00
60_N155_A0.9951.00
117_L169_A0.9911.00
87_V147_L0.9901.00
155_A159_P0.9811.00
73_I171_F0.9761.00
39_S76_S0.9671.00
93_A99_N0.9591.00
113_L153_L0.9571.00
138_T141_P0.9531.00
88_G174_E0.9531.00
118_L150_Y0.9291.00
35_D56_A0.9291.00
114_G156_T0.9240.99
10_C14_W0.8980.99
110_A113_L0.8950.99
54_N165_I0.8940.99
17_V20_A0.8910.99
84_A138_T0.8890.99
94_D102_A0.8810.99
25_S171_F0.8810.99
125_I131_S0.8620.99
59_F64_A0.8360.99
64_A155_A0.8330.99
12_F16_A0.8200.99
104_E168_T0.8160.99
58_Q66_T0.8130.99
13_L17_V0.8060.99
101_L167_A0.8060.99
142_G145_N0.8020.99
14_W17_V0.8020.99
115_I165_I0.7940.98
35_D79_G0.7910.98
33_V160_V0.7900.98
16_A19_H0.7800.98
18_S24_D0.7790.98
50_D69_V0.7750.98
75_L145_N0.7740.98
33_V54_N0.7670.98
94_D97_N0.7660.98
92_V102_A0.7630.98
30_R50_D0.7630.98
59_F156_T0.7590.98
62_I158_V0.7510.98
54_N59_F0.7500.98
93_A127_L0.7460.98
51_L151_A0.7430.98
117_L127_L0.7410.98
94_D98_A0.7400.98
62_I155_A0.7370.97
54_N153_L0.7370.97
11_A18_S0.7340.97
88_G129_A0.7320.97
97_N100_L0.7320.97
8_L14_W0.7270.97
8_L11_A0.7210.97
89_F171_F0.7150.97
129_A132_S0.7100.97
127_L149_F0.7090.97
9_L13_L0.7070.97
50_D153_L0.7020.97
56_A160_V0.7000.97
16_A21_L0.6990.97
14_W22_A0.6980.97
79_G118_L0.6980.97
17_V22_A0.6920.96
30_R48_T0.6900.96
79_G82_V0.6880.96
43_E47_F0.6850.96
131_S134_L0.6750.96
74_L144_P0.6740.96
26_T46_N0.6700.96
131_S149_F0.6650.95
56_A162_A0.6630.95
104_E166_N0.6630.95
12_F21_L0.6550.95
103_L109_A0.6540.95
87_V173_L0.6510.95
51_L69_V0.6500.95
15_L19_H0.6490.95
37_G153_L0.6480.95
118_L124_Q0.6480.95
16_A20_A0.6460.95
47_F171_F0.6420.94
15_L21_L0.6410.94
125_I149_F0.6390.94
15_L22_A0.6380.94
62_I157_Q0.6360.94
52_M166_N0.6290.94
20_A24_D0.6280.94
9_L16_A0.6220.94
155_A158_V0.6210.93
14_W21_L0.6210.93
13_L16_A0.6090.93
28_T46_N0.6060.93
98_A101_L0.6050.93
90_T170_T0.6010.92
51_L54_N0.6000.92
91_G168_T0.5990.92
89_F173_L0.5930.92
65_T68_V0.5930.92
112_G157_Q0.5880.92
103_L166_N0.5880.92
72_R93_A0.5870.91
113_L160_V0.5870.91
49_V146_T0.5830.91
121_Q134_L0.5810.91
18_S23_A0.5750.91
42_A45_T0.5740.91
66_T152_R0.5730.90
10_C19_H0.5700.90
79_G139_L0.5680.90
126_P131_S0.5670.90
86_K130_P0.5660.90
42_A76_S0.5660.90
51_L116_Q0.5650.90
62_I160_V0.5600.89
11_A15_L0.5580.89
68_V118_L0.5560.89
10_C17_V0.5560.89
27_I169_A0.5540.89
89_F147_L0.5500.89
62_I112_G0.5490.89
96_H99_N0.5480.88
28_T48_T0.5470.88
99_N124_Q0.5460.88
46_N171_F0.5430.88
86_K134_L0.5380.88
91_G94_D0.5350.87
12_F17_V0.5350.87
51_L71_F0.5330.87
66_T69_V0.5320.87
123_N132_S0.5290.87
58_Q67_P0.5250.86
103_L110_A0.5250.86
35_D83_S0.5240.86
36_N57_K0.5240.86
37_G58_Q0.5230.86
50_D53_E0.5210.86
153_L166_N0.5200.86
76_S144_P0.5200.86
66_T153_L0.5190.86
112_G156_T0.5160.85
12_F20_A0.5160.85
103_L153_L0.5150.85
84_A133_A0.5150.85
37_G79_G0.5140.85
8_L21_L0.5120.85
80_N141_P0.5120.85
10_C18_S0.5110.85
110_A162_A0.5070.84
94_D114_G0.5060.84
27_I48_T0.5000.83
127_L167_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jmrA 1 0.8807 100 0.212 Contact Map
2xg5B 1 0.7898 100 0.243 Contact Map
2jtyA 1 0.8864 100 0.247 Contact Map
2uy6B 2 0.8125 100 0.265 Contact Map
1pdkB 1 0.8011 100 0.281 Contact Map
3bwuF 1 0.7273 100 0.312 Contact Map
2w07B 1 0.6648 99.9 0.353 Contact Map
4dwhB 1 0.767 99.9 0.359 Contact Map
3bfqG 1 0.7386 99.9 0.368 Contact Map
5afoA 1 0.9545 99.9 0.37 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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