GREMLIN Database
PUR3 - Phosphoribosylglycinamide formyltransferase
UniProt: P08179 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10799
Length: 212 (188)
Sequences: 10949 (6957)
Seq/√Len: 507.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_E153_K3.6471.00
94_P141_D2.8841.00
142_E145_G2.8361.00
140_T145_G2.7301.00
160_D168_R2.7201.00
94_P98_S2.7161.00
114_K129_D2.5001.00
115_Y129_D2.4201.00
32_A78_Y2.3571.00
7_I42_G2.3131.00
115_Y127_N2.2811.00
135_S148_V2.2361.00
152_A179_L2.2241.00
136_V180_V2.2151.00
122_R162_E2.0931.00
160_D164_D2.0871.00
76_D99_H1.9921.00
183_W188_R1.9521.00
74_E77_M1.8381.00
63_S66_A1.8321.00
119_H122_R1.8041.00
73_H77_M1.7951.00
138_F149_I1.7741.00
150_L176_I1.7531.00
152_A172_Q1.7181.00
122_R126_E1.7011.00
22_K60_A1.6991.00
152_A175_A1.6881.00
150_L180_V1.6691.00
91_I143_L1.6641.00
157_F168_R1.6631.00
15_Q19_D1.6471.00
70_E73_H1.6171.00
161_S164_D1.6001.00
57_I60_A1.5441.00
138_F184_F1.5241.00
154_V172_Q1.5181.00
41_F44_E1.5021.00
44_E47_R1.4981.00
56_L60_A1.4971.00
157_F160_D1.4631.00
123_Q126_E1.4611.00
82_V181_I1.4351.00
20_A178_P1.4041.00
19_D56_L1.4001.00
28_G185_A1.3971.00
179_L183_W1.3781.00
182_S186_D1.3691.00
131_E155_P1.3561.00
69_R95_A1.3451.00
111_L133_G1.3271.00
135_S151_Q1.2901.00
125_L165_I1.2891.00
52_A78_Y1.2841.00
138_F191_M1.2821.00
19_D23_T1.2731.00
17_I107_I1.2711.00
105_L149_I1.2711.00
24_N27_K1.2631.00
62_D66_A1.2511.00
152_A176_I1.2511.00
5_V14_L1.2461.00
14_L33_V1.2431.00
150_L183_W1.2361.00
80_P83_V1.2131.00
154_V168_R1.2121.00
83_V104_L1.1971.00
97_V104_L1.1961.00
41_F45_R1.1931.00
44_E48_Q1.1821.00
22_K49_A1.1761.00
98_S141_D1.1691.00
72_I99_H1.1681.00
69_R73_H1.1671.00
147_P193_E1.1511.00
150_L179_L1.1491.00
18_I49_A1.1471.00
15_Q45_R1.1341.00
119_H123_Q1.1251.00
54_H74_E1.1141.00
74_E78_Y1.1121.00
72_I76_D1.1111.00
151_Q192_H1.1021.00
162_E166_T1.0981.00
27_K182_S1.0921.00
147_P191_M1.0821.00
184_F189_L1.0651.00
17_I181_I1.0591.00
123_Q127_N1.0551.00
62_D65_E1.0511.00
43_L53_T1.0511.00
148_V151_Q1.0471.00
31_R78_Y1.0451.00
149_I191_M1.0381.00
55_T58_A1.0361.00
20_A175_A1.0261.00
120_T123_Q1.0251.00
175_A179_L1.0181.00
84_V181_I1.0151.00
136_V176_I1.0091.00
72_I100_Y1.0001.00
32_A80_P0.9991.00
172_Q175_A0.9981.00
111_L151_Q0.9961.00
140_T147_P0.9941.00
132_H165_I0.9911.00
34_F71_L0.9761.00
75_I80_P0.9681.00
28_G182_S0.9671.00
132_H156_V0.9671.00
6_L80_P0.9661.00
166_T170_Q0.9631.00
56_L59_S0.9621.00
21_C28_G0.9611.00
16_A19_D0.9571.00
17_I177_Y0.9441.00
24_N178_P0.9381.00
183_W189_L0.9221.00
121_H169_V0.9191.00
100_Y104_L0.9161.00
18_I51_I0.9141.00
61_F70_E0.8901.00
156_V160_D0.8861.00
100_Y103_R0.8811.00
65_E95_A0.8801.00
107_I177_Y0.8791.00
54_H58_A0.8781.00
73_H76_D0.8761.00
17_I86_A0.8701.00
72_I95_A0.8601.00
124_A129_D0.8561.00
24_N182_S0.8531.00
38_A41_F0.8521.00
33_V46_A0.8501.00
32_A54_H0.8451.00
121_H166_T0.8441.00
64_R67_Y0.8441.00
10_N41_F0.8441.00
64_R68_D0.8431.00
136_V150_L0.8421.00
31_R80_P0.8421.00
41_F47_R0.8341.00
55_T59_S0.8341.00
134_T172_Q0.8311.00
104_L139_V0.8311.00
105_L184_F0.8191.00
105_L177_Y0.8171.00
85_L139_V0.8171.00
50_G58_A0.8161.00
167_A171_T0.8071.00
84_V177_Y0.8061.00
112_L116_P0.8061.00
14_L18_I0.8051.00
10_N170_Q0.8051.00
16_A170_Q0.8021.00
157_F164_D0.7991.00
164_D168_R0.7981.00
72_I96_F0.7981.00
32_A74_E0.7941.00
183_W186_D0.7911.00
22_K56_L0.7881.00
92_L104_L0.7871.00
63_S67_Y0.7841.00
150_L155_P0.7831.00
19_D49_A0.7831.00
82_V184_F0.7821.00
8_S83_V0.7791.00
80_P99_H0.7781.00
182_S185_A0.7751.00
24_N28_G0.7741.00
7_I35_S0.7681.00
34_F54_H0.7671.00
16_A174_H0.7661.00
70_E74_E0.7661.00
176_I180_V0.7601.00
95_A98_S0.7601.00
121_H124_A0.7591.00
65_E68_D0.7541.00
170_Q174_H0.7511.00
20_A23_T0.7461.00
6_L83_V0.7351.00
125_L162_E0.7331.00
124_A132_H0.7311.00
36_N58_A0.7291.00
124_A156_V0.7251.00
134_T176_I0.7221.00
36_N90_R0.7131.00
114_K131_E0.7091.00
130_E155_P0.7041.00
38_A55_T0.7021.00
15_Q56_L0.6981.00
171_T175_A0.6961.00
18_I30_V0.6961.00
5_V82_V0.6951.00
65_E69_R0.6941.00
35_S51_I0.6821.00
66_A69_R0.6821.00
160_D165_I0.6781.00
66_A71_L0.6721.00
154_V160_D0.6721.00
8_S34_F0.6691.00
75_I83_V0.6661.00
97_V139_V0.6611.00
38_A54_H0.6581.00
68_D93_S0.6581.00
15_Q48_Q0.6561.00
107_I134_T0.6521.00
105_L136_V0.6491.00
156_V165_I0.6471.00
13_N109_P0.6451.00
163_D167_A0.6451.00
20_A24_N0.6441.00
56_L67_Y0.6441.00
7_I17_I0.6331.00
10_N51_I0.6201.00
35_S53_T0.6191.00
118_L123_Q0.6171.00
83_V100_Y0.6121.00
172_Q176_I0.6111.00
27_K186_D0.6101.00
35_S43_L0.6101.00
16_A20_A0.6091.00
116_P145_G0.6071.00
54_H78_Y0.6060.99
21_C30_V0.6030.99
15_Q49_A0.5990.99
43_L55_T0.5990.99
17_I21_C0.5990.99
109_P121_H0.5980.99
125_L156_V0.5950.99
36_N39_D0.5940.99
19_D22_K0.5910.99
67_Y71_L0.5850.99
159_G164_D0.5840.99
7_I14_L0.5830.99
6_L32_A0.5820.99
58_A90_R0.5820.99
68_D71_L0.5820.99
130_E158_A0.5810.99
107_I173_E0.5790.99
167_A170_Q0.5770.99
41_F48_Q0.5760.99
67_Y93_S0.5740.99
180_V183_W0.5740.99
11_G87_G0.5730.99
93_S96_F0.5710.99
6_L75_I0.5710.99
154_V169_V0.5660.99
45_R49_A0.5660.99
76_D100_Y0.5650.99
132_H154_V0.5650.99
118_L143_L0.5620.99
40_A43_L0.5540.99
92_L96_F0.5490.99
5_V30_V0.5470.99
75_I96_F0.5460.99
110_S120_T0.5450.99
19_D59_S0.5450.99
111_L153_K0.5440.99
107_I136_V0.5410.99
120_T132_H0.5400.99
69_R72_I0.5400.99
76_D79_A0.5400.99
6_L34_F0.5350.99
18_I45_R0.5340.99
6_L71_L0.5340.99
119_H162_E0.5330.99
149_I184_F0.5220.99
110_S143_L0.5210.98
47_R50_G0.5170.98
10_N45_R0.5170.98
109_P169_V0.5150.98
90_R93_S0.5120.98
116_P142_E0.5120.98
67_Y88_F0.5100.98
121_H132_H0.5090.98
132_H169_V0.5080.98
114_K127_N0.5080.98
93_S97_V0.5070.98
71_L74_E0.5050.98
121_H162_E0.5010.98
35_S40_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3av3A 1 0.8774 100 0.127 Contact Map
3tqqA 1 0.9387 100 0.138 Contact Map
4wkgA 5 0.9434 100 0.144 Contact Map
1jkxA 2 0.9858 100 0.144 Contact Map
4ew1A 2 0.967 100 0.145 Contact Map
4ds3A 2 0.8962 100 0.146 Contact Map
2blnA 1 0.9292 100 0.147 Contact Map
3q0iA 1 0.9292 100 0.149 Contact Map
4iqfA 1 0.9575 100 0.151 Contact Map
1fmtA 1 0.9481 100 0.153 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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