GREMLIN Database
PUR5 - Phosphoribosylformylglycinamidine cyclo-ligase
UniProt: P08178 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10798
Length: 345 (332)
Sequences: 3449 (1850)
Seq/√Len: 101.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_H154_Y3.6771.00
32_K131_L3.6151.00
189_P197_V3.5891.00
175_V244_A3.0371.00
216_K224_A2.9201.00
177_D335_A2.7371.00
128_E132_Q2.7281.00
77_L219_A2.6881.00
182_I327_A2.6261.00
128_E131_L2.6101.00
133_S228_I2.6101.00
57_E167_S2.5741.00
181_L305_I2.5261.00
302_V330_I2.4941.00
268_V332_I2.4891.00
50_A166_K2.3951.00
35_R101_E2.3841.00
200_I289_V2.3491.00
181_L307_A2.3321.00
245_I304_M2.3171.00
317_L327_A2.2751.00
57_E166_K2.2681.00
268_V334_K2.2151.00
10_K15_D2.2061.00
79_R220_D2.1301.00
182_I317_L2.1151.00
271_E291_H2.1091.00
25_R120_S2.0881.00
266_Q334_K2.0861.00
21_A25_R2.0591.00
75_M153_D2.0441.00
260_V307_A2.0221.00
181_L267_A2.0111.00
183_A302_V1.9991.00
267_A333_I1.9701.00
243_H309_P1.9641.00
216_K221_H1.9321.00
308_L316_A1.9221.00
179_D243_H1.9211.00
177_D265_T1.9181.00
95_L160_C1.9101.00
227_R325_E1.8641.00
47_A138_V1.8411.00
264_N336_S1.8181.00
56_R167_S1.8001.00
174_K243_H1.7911.00
145_M149_Y1.7881.00
200_I283_L1.7191.00
207_D210_T1.7161.00
111_T119_A1.6831.00
20_N255_E1.6651.00
253_F257_I1.6621.00
81_D124_S1.6601.00
189_P194_Y1.6601.00
240_V316_A1.6461.00
164_V169_I1.6361.00
244_A260_V1.6331.00
129_G228_I1.6311.00
284_Q291_H1.6221.00
295_Y300_C1.6051.00
309_P312_E1.5961.00
313_V329_K1.5951.00
314_D318_A1.5801.00
29_V124_S1.5571.00
124_S128_E1.5491.00
59_V169_I1.5441.00
71_L148_M1.5401.00
85_I129_G1.5381.00
221_H224_A1.5371.00
37_E49_C1.5371.00
17_D296_R1.5321.00
245_I306_I1.5211.00
232_S325_E1.4971.00
253_F305_I1.4941.00
63_G95_L1.4851.00
72_R153_D1.4801.00
22_L26_I1.4771.00
8_S11_D1.4711.00
317_L329_K1.4681.00
271_E295_Y1.4621.00
97_V245_I1.4581.00
18_A116_V1.4561.00
56_R165_E1.4551.00
22_L119_A1.4471.00
312_E315_K1.4461.00
85_I132_Q1.4431.00
25_R117_D1.4341.00
257_I269_I1.4341.00
24_G27_K1.4221.00
109_Y119_A1.4191.00
265_T333_I1.4111.00
241_D312_E1.4101.00
284_Q294_M1.4091.00
275_Q328_W1.3981.00
236_L320_L1.3911.00
185_G328_W1.3861.00
266_Q336_S1.3831.00
132_Q228_I1.3760.99
182_I329_K1.3730.99
315_K318_A1.3640.99
39_M59_V1.3630.99
181_L269_I1.3560.99
118_T152_E1.3560.99
275_Q281_N1.3410.99
313_V317_L1.3370.99
310_A332_I1.3270.99
29_V120_S1.3130.99
175_V260_V1.3110.99
83_I156_V1.3080.99
236_L316_A1.3040.99
216_K220_D1.2980.99
78_K118_T1.2980.99
239_K319_L1.2790.99
19_G23_V1.2750.99
187_S224_A1.2680.99
55_Y165_E1.2520.99
73_L77_L1.2480.99
62_S104_F1.2440.99
233_V306_I1.2400.99
233_V304_M1.2340.99
276_W281_N1.2280.99
235_E238_E1.2260.99
73_L208_P1.2220.99
48_L61_V1.2070.99
261_L265_T1.2030.99
50_A57_E1.2000.99
235_E323_N1.1900.99
175_V333_I1.1810.98
189_P279_V1.1770.98
180_V313_V1.1670.98
316_A319_L1.1660.98
211_T214_D1.1630.98
232_S235_E1.1620.98
121_A124_S1.1550.98
180_V329_K1.1520.98
176_S309_P1.1450.98
72_R76_D1.1430.98
119_A122_V1.1380.98
321_N326_N1.1260.98
290_E293_E1.1240.98
134_G231_K1.1140.98
90_M191_S1.1130.98
235_E319_L1.1110.98
294_M298_F1.1090.98
90_M226_T1.1060.98
281_N285_T1.1030.98
129_G133_S1.1010.98
105_F158_G1.1010.98
217_P220_D1.0940.97
58_P165_E1.0890.97
91_C160_C1.0860.97
114_L119_A1.0750.97
184_L304_M1.0710.97
59_V164_V1.0660.97
29_V127_A1.0640.97
240_V319_L1.0640.97
183_A275_Q1.0560.97
172_G175_V1.0550.97
134_G234_L1.0420.97
129_G132_Q1.0390.96
21_A24_G1.0380.96
306_I316_A1.0340.96
165_E168_E1.0340.96
181_L333_I1.0290.96
185_G326_N1.0240.96
35_R49_C1.0240.96
8_S293_E1.0210.96
289_V294_M1.0190.96
202_E208_P1.0080.96
31_K34_R1.0060.96
191_S226_T1.0020.96
76_D202_E1.0000.96
17_D20_N1.0000.96
212_E215_G0.9960.96
48_L169_I0.9960.96
239_K315_K0.9960.96
104_F138_V0.9920.95
109_Y122_V0.9910.95
230_V234_L0.9900.95
174_K241_D0.9870.95
55_Y163_V0.9850.95
62_S161_V0.9800.95
56_R168_E0.9760.95
201_L208_P0.9760.95
92_V160_C0.9730.95
180_V310_A0.9710.95
185_G327_A0.9710.95
214_D221_H0.9700.95
319_L323_N0.9700.95
276_W300_C0.9690.95
101_E134_G0.9660.95
132_Q231_K0.9660.95
59_V166_K0.9650.95
293_E297_T0.9600.95
104_F161_V0.9590.95
96_V304_M0.9530.94
201_L206_C0.9490.94
201_L282_W0.9400.94
75_M148_M0.9340.94
61_V100_A0.9330.94
318_A322_A0.9270.93
85_I128_E0.9270.93
308_L313_V0.9270.93
237_I245_I0.9260.93
302_V328_W0.9260.93
314_D329_K0.9240.93
287_G294_M0.9220.93
38_V41_G0.9210.93
101_E238_E0.9200.93
233_V237_I0.9180.93
34_R38_V0.9180.93
266_Q337_D0.9170.93
232_S320_L0.9160.93
281_N284_Q0.9130.93
266_Q338_S0.9080.93
184_L325_E0.9030.93
254_W257_I0.9020.93
7_L11_D0.9020.93
22_L116_V0.9010.92
280_F294_M0.8930.92
122_V156_V0.8920.92
275_Q278_E0.8850.92
233_V245_I0.8840.92
89_A228_I0.8830.92
46_G61_V0.8820.92
257_I267_A0.8740.91
96_V233_V0.8700.91
184_L320_L0.8630.91
179_D309_P0.8600.91
115_D152_E0.8580.91
90_M228_I0.8540.90
240_V315_K0.8500.90
255_E258_P0.8480.90
282_W286_A0.8440.90
182_I308_L0.8430.90
318_A321_N0.8430.90
72_R148_M0.8360.89
20_N296_R0.8360.89
235_E239_K0.8350.89
300_C336_S0.8330.89
101_E234_L0.8320.89
22_L123_I0.8320.89
268_V271_E0.8250.89
72_R75_M0.8190.88
176_S243_H0.8160.88
270_D332_I0.8150.88
275_Q326_N0.8140.88
206_C218_L0.8090.88
26_I30_V0.8060.88
51_L163_V0.8050.88
240_V312_E0.8020.87
64_T159_F0.7990.87
52_P57_E0.7980.87
34_R40_G0.7950.87
317_L321_N0.7930.87
206_C286_A0.7920.87
201_L204_S0.7910.87
16_I296_R0.7900.87
91_C105_F0.7890.86
257_I305_I0.7880.86
116_V120_S0.7850.86
329_K332_I0.7840.86
46_G98_Q0.7820.86
175_V262_P0.7790.86
175_V243_H0.7780.86
274_W302_V0.7750.85
232_S323_N0.7750.85
261_L267_A0.7740.85
127_A131_L0.7690.85
15_D18_A0.7680.85
117_D121_A0.7670.85
252_G256_N0.7640.85
87_L156_V0.7640.85
37_E101_E0.7620.85
81_D121_A0.7550.84
89_A226_T0.7540.84
49_C163_V0.7530.84
170_I245_I0.7520.84
83_I122_V0.7510.84
16_I19_G0.7470.83
18_A113_K0.7440.83
52_P165_E0.7420.83
206_C210_T0.7390.83
213_L221_H0.7390.83
109_Y156_V0.7380.83
148_M153_D0.7340.82
246_A305_I0.7330.82
89_A191_S0.7320.82
199_K203_V0.7320.82
29_V32_K0.7310.82
145_M148_M0.7240.81
183_A328_W0.7230.81
191_S228_I0.7230.81
175_V265_T0.7170.81
180_V332_I0.7160.81
208_P218_L0.7160.81
234_L238_E0.7150.81
235_E241_D0.7140.80
182_I316_A0.7130.80
254_W296_R0.7120.80
96_V235_E0.7100.80
7_L200_I0.7100.80
171_D174_K0.7040.80
293_E296_R0.7040.80
115_D118_T0.6990.79
49_C104_F0.6970.79
310_A313_V0.6950.79
7_L297_T0.6930.78
130_C137_L0.6930.78
62_S138_V0.6920.78
34_R41_G0.6910.78
16_I20_N0.6910.78
21_A117_D0.6880.78
61_V164_V0.6840.78
89_A129_G0.6830.77
22_L30_V0.6810.77
25_R116_V0.6780.77
183_A330_I0.6780.77
38_V136_S0.6780.77
52_P166_K0.6760.77
320_L325_E0.6740.77
254_W292_H0.6730.76
112_G150_H0.6720.76
284_Q289_V0.6710.76
204_S286_A0.6700.76
208_P222_L0.6670.76
55_Y167_S0.6670.76
63_G96_V0.6670.76
53_Q163_V0.6660.76
315_K319_L0.6660.76
305_I330_I0.6650.76
18_A21_A0.6650.76
168_E241_D0.6630.75
202_E206_C0.6630.75
21_A116_V0.6600.75
201_L283_L0.6600.75
113_K151_G0.6590.75
310_A329_K0.6590.75
276_W284_Q0.6580.75
78_K121_A0.6570.75
253_F295_Y0.6560.75
37_E136_S0.6550.74
22_L122_V0.6540.74
7_L289_V0.6540.74
181_L306_I0.6520.74
221_H279_V0.6520.74
237_I242_V0.6520.74
218_L222_L0.6510.74
214_D282_W0.6480.74
147_G195_S0.6460.73
150_H153_D0.6400.73
214_D279_V0.6390.73
22_L109_Y0.6390.73
208_P219_A0.6380.73
37_E50_A0.6360.72
213_L217_P0.6350.72
170_I244_A0.6330.72
50_A163_V0.6330.72
276_W291_H0.6310.72
19_G144_E0.6290.71
129_G230_V0.6280.71
77_L223_L0.6280.71
22_L87_L0.6270.71
242_V316_A0.6270.71
236_L306_I0.6270.71
270_D329_K0.6260.71
16_I293_E0.6260.71
23_V144_E0.6250.71
16_I297_T0.6240.71
50_A59_V0.6220.71
95_L162_G0.6150.70
246_A254_W0.6130.70
170_I304_M0.6120.69
8_S296_R0.6120.69
122_V126_I0.6100.69
55_Y101_E0.6080.69
31_K41_G0.6070.69
91_C255_E0.6070.69
30_V42_L0.6060.69
197_V283_L0.6060.69
236_L242_V0.6060.69
265_T268_V0.6050.69
294_M300_C0.6050.69
118_T122_V0.6050.69
74_A83_I0.6050.69
40_G47_A0.6040.68
237_I240_V0.6030.68
214_D217_P0.6020.68
246_A253_F0.6010.68
79_R219_A0.5990.68
283_L289_V0.5930.67
96_V234_L0.5930.67
272_S275_Q0.5910.67
177_D332_I0.5890.66
9_Y13_G0.5880.66
83_I148_M0.5880.66
32_K128_E0.5870.66
105_F159_F0.5860.66
73_L197_V0.5860.66
283_L294_M0.5850.66
261_L333_I0.5850.66
236_L323_N0.5850.66
87_L253_F0.5790.65
254_W258_P0.5780.65
106_L159_F0.5780.65
276_W295_Y0.5760.65
76_D208_P0.5760.65
241_D309_P0.5760.65
168_E238_E0.5740.65
184_L232_S0.5690.64
236_L319_L0.5680.64
44_G98_Q0.5670.64
313_V327_A0.5650.63
7_L203_V0.5640.63
82_T125_G0.5630.63
231_K234_L0.5630.63
321_N327_A0.5630.63
183_A305_I0.5620.63
189_P222_L0.5620.63
48_L59_V0.5620.63
267_A307_A0.5610.63
71_L149_Y0.5580.62
168_E237_I0.5570.62
79_R82_T0.5560.62
53_Q56_R0.5550.62
257_I261_L0.5540.62
90_M160_C0.5540.62
266_Q333_I0.5520.62
50_A53_Q0.5500.61
69_T145_M0.5490.61
118_T121_A0.5480.61
30_V34_R0.5470.61
235_E240_V0.5470.61
180_V183_A0.5460.61
126_I160_C0.5440.60
242_V319_L0.5430.60
237_I316_A0.5420.60
217_P221_H0.5420.60
30_V127_A0.5410.60
8_S289_V0.5400.60
22_L300_C0.5400.60
160_C226_T0.5390.60
197_V200_I0.5390.60
108_Y155_D0.5380.60
201_L222_L0.5370.59
142_T145_M0.5360.59
254_W295_Y0.5350.59
8_S297_T0.5350.59
26_I29_V0.5340.59
176_S239_K0.5340.59
96_V237_I0.5340.59
213_L216_K0.5340.59
75_M154_Y0.5340.59
54_K101_E0.5330.59
192_N250_G0.5330.59
280_F287_G0.5330.59
187_S221_H0.5320.59
314_D317_L0.5310.59
63_G91_C0.5300.58
19_G42_L0.5290.58
120_S124_S0.5290.58
35_R136_S0.5280.58
199_K202_E0.5270.58
77_L208_P0.5260.58
114_L156_V0.5260.58
87_L114_L0.5260.58
46_G95_L0.5250.58
272_S276_W0.5240.58
276_W294_M0.5240.58
269_I330_I0.5230.57
308_L319_L0.5230.57
319_L322_A0.5220.57
201_L205_G0.5210.57
189_P280_F0.5210.57
89_A225_P0.5170.57
83_I87_L0.5170.57
39_M169_I0.5160.56
26_I114_L0.5130.56
197_V202_E0.5120.56
109_Y153_D0.5120.56
89_A133_S0.5120.56
249_T259_R0.5120.56
39_M50_A0.5110.56
278_E281_N0.5110.56
111_T118_T0.5110.56
202_E282_W0.5100.56
62_S159_F0.5090.55
173_S318_A0.5080.55
253_F269_I0.5070.55
233_V236_L0.5060.55
49_C52_P0.5060.55
44_G48_L0.5050.55
55_Y58_P0.5040.55
177_D334_K0.5020.54
16_I119_A0.5010.54
28_G31_K0.5000.54
181_L260_V0.5000.54
201_L218_L0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kizA 2 0.8812 100 0.419 Contact Map
3mdoA 2 0.8812 100 0.435 Contact Map
2btuA 2 0.9362 100 0.44 Contact Map
2z01A 2 0.8957 100 0.455 Contact Map
3p4eA 2 0.9333 100 0.462 Contact Map
3m84A 2 0.9826 100 0.471 Contact Map
2v9yA 2 0.858 100 0.523 Contact Map
4lgyA 1 0.8957 100 0.654 Contact Map
3wjpA 2 0.8928 100 0.655 Contact Map
3u0oA 2 0.8928 100 0.66 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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