ILVB - ECOLI - GREMLIN Contacts

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ILVB - Acetolactate synthase isozyme 1 large subunit

UniProt:	P08142	Sequences: MASSGTTSTRKRFTGAEFIVHFLEQQGIKIVTGIPGGSILPVYDALSQSTQIRHILARHEQGAGFIAQGMARTDGKPAVCMACSGPGATNLVTAIADARLDSIPLICITGQVPASMIGTDAFQEVDTYGISIPITKHNYLVRHIEELPQVMSDAFRIAQSGRPGPVWIDIPKDVQTAVFEIETQPAMAEKAAAPAFSEESIRDAAAMINAAKRPVLYLGGGVINAPARVRELAEKAQLPTTMTLMALGMLPKAHPLSLGMLGMHGVRSTNYILQEADLLIVLGARFDDRAIGKTEQFCPNAKIIHVDIDRAELGKIKQPHVAIQADVDDVLAQLIPLVEAQPRAEWHQLVADLQREFPCPIPKACDPLSHYGLINAVAACVDDNAIITTDVGQHQMWTAQAYPLNRPRQWLTSGGLGTMGFGLPAAIGAALANPDRKVLCFSGDGSLMMNIQEMATASENQLDVKIILMNNEALGLVHQQQSLFYEQGVFAATYPGKINFMQIAAGFGLETCDLNNEADPQASLQEIINRPGPALIHVRIDAEEKVYPMVPPGAANTEMVGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10494
Length:	562 (532)
Sequences:	14214 (8985)
Seq/√Len:	389.5

ECOLI - ILVB ILVG ILVI OXC GCL POXB MEND
BACSU - ILVX ILVB MEND IOLD YDAP
HALSA - MEND
SULSO - Q7LXT8 Q97ZB3 Q97UP3 Q980V7 Q97U16 Q97V62 Q97XR3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
502_Q	505_A	4.894	1.00
470_N	537_H	3.740	1.00
376_A	521_Q	3.699	1.00
64_G	94_A	3.574	1.00
234_E	254_H	3.403	1.00
512_C	526_E	3.398	1.00
228_R	332_A	3.231	1.00
29_K	76_K	3.072	1.00
516_N	519_D	3.054	1.00
513_D	539_R	2.956	1.00
202_R	337_L	2.936	1.00
380_C	525_Q	2.767	1.00
228_R	328_D	2.741	1.00
73_T	433_N	2.655	1.00
325_A	330_V	2.615	1.00
218_L	229_V	2.604	1.00
253_A	405_N	2.572	1.00
512_C	534_A	2.558	1.00
510_E	532_G	2.547	1.00
24_E	51_Q	2.515	1.00
376_A	379_A	2.483	1.00
24_E	49_S	2.435	1.00
30_I	53_R	2.435	1.00
306_V	330_V	2.406	1.00
515_N	519_D	2.397	1.00
204_A	304_I	2.385	1.00
282_L	327_V	2.324	1.00
426_A	440_C	2.320	1.00
512_C	523_S	2.290	1.00
276_A	279_L	2.223	1.00
82_A	91_L	2.216	1.00
510_E	526_E	2.168	1.00
513_D	537_H	2.161	1.00
499_N	502_Q	2.151	1.00
77_P	159_Q	2.143	1.00
433_N	436_R	2.108	1.00
379_A	521_Q	2.095	1.00
448_M	507_F	2.085	1.00
17_E	45_A	2.075	1.00
281_V	284_A	2.063	1.00
57_A	63_A	2.038	1.00
95_I	107_C	2.035	1.00
207_M	321_V	2.017	1.00
89_T	93_T	1.992	1.00
106_I	155_F	1.990	1.00
503_I	506_G	1.986	1.00
207_M	278_L	1.966	1.00
207_M	302_K	1.963	1.00
129_G	132_I	1.950	1.00
109_T	167_W	1.929	1.00
216_L	233_A	1.905	1.00
501_M	511_T	1.903	1.00
514_L	523_S	1.875	1.00
150_V	168_I	1.873	1.00
21_H	25_Q	1.860	1.00
235_K	335_I	1.850	1.00
378_A	403_P	1.848	1.00
208_I	280_I	1.840	1.00
447_L	451_I	1.818	1.00
77_P	106_I	1.816	1.00
197_S	200_S	1.806	1.00
17_E	48_Q	1.802	1.00
382_D	385_A	1.795	1.00
198_E	333_Q	1.793	1.00
430_A	463_D	1.793	1.00
458_S	509_L	1.783	1.00
206_A	210_A	1.779	1.00
233_A	240_T	1.764	1.00
525_Q	529_N	1.758	1.00
68_Q	72_R	1.748	1.00
510_E	534_A	1.746	1.00
203_D	206_A	1.741	1.00
521_Q	525_Q	1.739	1.00
235_K	339_E	1.736	1.00
126_D	129_G	1.722	1.00
13_F	21_H	1.712	1.00
527_I	536_I	1.710	1.00
231_E	235_K	1.704	1.00
216_L	280_I	1.693	1.00
519_D	522_A	1.687	1.00
468_L	535_L	1.686	1.00
386_I	429_A	1.667	1.00
216_L	238_L	1.664	1.00
375_N	379_A	1.651	1.00
515_N	539_R	1.629	1.00
230_R	234_E	1.626	1.00
377_V	441_F	1.600	1.00
390_D	442_S	1.600	1.00
143_H	146_E	1.598	1.00
282_L	306_V	1.591	1.00
421_F	425_A	1.581	1.00
313_L	324_Q	1.572	1.00
33_G	54_H	1.554	1.00
505_A	510_E	1.538	1.00
43_Y	54_H	1.537	1.00
21_H	24_E	1.528	1.00
135_T	167_W	1.528	1.00
390_D	446_S	1.527	1.00
139_Y	168_I	1.526	1.00
372_G	517_E	1.523	1.00
380_C	521_Q	1.513	1.00
237_Q	256_L	1.502	1.00
275_E	349_L	1.498	1.00
411_L	429_A	1.494	1.00
430_A	462_L	1.489	1.00
74_D	432_A	1.488	1.00
501_M	513_D	1.472	1.00
22_F	152_S	1.472	1.00
240_T	250_L	1.470	1.00
211_A	214_P	1.464	1.00
372_G	376_A	1.463	1.00
522_A	526_E	1.462	1.00
344_A	348_Q	1.461	1.00
348_Q	352_D	1.460	1.00
200_S	203_D	1.457	1.00
136_K	164_G	1.453	1.00
208_I	278_L	1.441	1.00
522_A	525_Q	1.430	1.00
409_Q	436_R	1.427	1.00
457_A	509_L	1.427	1.00
19_I	170_I	1.419	1.00
349_L	353_L	1.418	1.00
457_A	464_V	1.415	1.00
62_G	453_E	1.411	1.00
144_I	177_A	1.409	1.00
454_M	509_L	1.406	1.00
467_I	536_I	1.402	1.00
205_A	337_L	1.400	1.00
376_A	380_C	1.394	1.00
385_A	437_K	1.393	1.00
467_I	524_L	1.392	1.00
108_I	170_I	1.388	1.00
382_D	437_K	1.386	1.00
205_A	334_L	1.385	1.00
91_L	107_C	1.377	1.00
19_I	151_M	1.372	1.00
77_P	155_F	1.363	1.00
57_A	66_I	1.362	1.00
20_V	49_S	1.357	1.00
231_E	335_I	1.350	1.00
373_L	538_V	1.349	1.00
278_L	304_I	1.343	1.00
232_L	236_A	1.338	1.00
114_A	173_D	1.335	1.00
106_I	158_A	1.329	1.00
439_L	528_I	1.329	1.00
26_Q	155_F	1.322	1.00
451_I	503_I	1.320	1.00
30_I	431_L	1.316	1.00
95_I	105_L	1.311	1.00
467_I	538_V	1.304	1.00
211_A	278_L	1.301	1.00
26_Q	152_S	1.300	1.00
53_R	460_N	1.298	1.00
465_K	527_I	1.298	1.00
383_D	405_N	1.297	1.00
501_M	505_A	1.293	1.00
232_L	335_I	1.293	1.00
431_L	462_L	1.287	1.00
302_K	320_H	1.281	1.00
381_V	439_L	1.278	1.00
64_G	91_L	1.274	1.00
88_A	109_T	1.273	1.00
427_I	457_A	1.272	1.00
21_H	49_S	1.271	1.00
351_A	354_Q	1.266	1.00
430_A	437_K	1.265	1.00
282_L	331_L	1.265	1.00
201_I	337_L	1.263	1.00
232_L	331_L	1.261	1.00
146_E	149_Q	1.255	1.00
202_R	206_A	1.255	1.00
437_K	528_I	1.254	1.00
368_L	538_V	1.250	1.00
503_I	507_F	1.249	1.00
141_V	147_L	1.248	1.00
386_I	433_N	1.248	1.00
352_D	356_E	1.240	1.00
328_D	332_A	1.236	1.00
351_A	355_R	1.235	1.00
215_V	276_A	1.233	1.00
229_V	331_L	1.229	1.00
419_M	449_M	1.228	1.00
440_C	466_I	1.227	1.00
463_D	532_G	1.223	1.00
151_M	168_I	1.220	1.00
368_L	373_L	1.219	1.00
55_I	431_L	1.216	1.00
463_D	531_P	1.207	1.00
326_D	329_D	1.204	1.00
149_Q	153_D	1.203	1.00
520_P	538_V	1.201	1.00
32_T	70_M	1.201	1.00
383_D	406_R	1.199	1.00
502_Q	506_G	1.198	1.00
472_E	497_K	1.191	1.00
16_A	45_A	1.190	1.00
31_V	46_L	1.190	1.00
333_Q	336_P	1.190	1.00
71_A	104_P	1.184	1.00
70_M	432_A	1.182	1.00
314_G	319_P	1.180	1.00
196_F	330_V	1.178	1.00
22_F	151_M	1.177	1.00
14_T	17_E	1.174	1.00
504_A	509_L	1.174	1.00
509_L	535_L	1.173	1.00
230_R	251_P	1.169	1.00
242_M	257_S	1.166	1.00
386_I	438_V	1.162	1.00
68_Q	97_D	1.159	1.00
203_D	207_M	1.157	1.00
15_G	147_L	1.155	1.00
523_S	536_I	1.145	1.00
329_D	332_A	1.145	1.00
29_K	53_R	1.145	1.00
504_A	535_L	1.144	1.00
216_L	232_L	1.142	1.00
28_I	79_V	1.141	1.00
171_P	174_V	1.140	1.00
222_V	229_V	1.138	1.00
18_F	179_F	1.130	1.00
139_Y	153_D	1.129	1.00
271_Y	275_E	1.126	1.00
455_A	459_E	1.123	1.00
205_A	209_N	1.120	1.00
231_E	234_E	1.119	1.00
228_R	335_I	1.116	1.00
198_E	337_L	1.115	1.00
139_Y	150_V	1.115	1.00
258_L	272_I	1.115	1.00
80_C	91_L	1.113	1.00
96_A	416_L	1.110	1.00
115_S	173_D	1.109	1.00
92_V	130_I	1.108	1.00
214_P	277_D	1.105	1.00
130_I	134_I	1.097	1.00
228_R	231_E	1.096	1.00
230_R	250_L	1.094	1.00
218_L	222_V	1.089	1.00
68_Q	103_I	1.086	1.00
73_T	429_A	1.086	1.00
384_N	436_R	1.083	1.00
234_E	256_L	1.082	1.00
14_T	178_V	1.080	1.00
89_T	130_I	1.077	1.00
141_V	150_V	1.075	1.00
99_R	165_P	1.074	1.00
209_N	339_E	1.073	1.00
210_A	302_K	1.068	1.00
504_A	511_T	1.066	1.00
430_A	434_P	1.066	1.00
213_R	275_E	1.065	1.00
231_E	332_A	1.065	1.00
92_V	134_I	1.065	1.00
30_I	55_I	1.063	1.00
114_A	177_A	1.063	1.00
117_I	140_L	1.061	1.00
512_C	536_I	1.059	1.00
520_P	524_L	1.057	1.00
157_I	166_V	1.055	1.00
62_G	450_N	1.054	1.00
205_A	338_V	1.053	1.00
511_T	535_L	1.051	1.00
247_L	252_K	1.048	1.00
64_G	80_C	1.047	1.00
233_A	250_L	1.047	1.00
45_A	48_Q	1.045	1.00
69_G	73_T	1.043	1.00
510_E	530_R	1.043	1.00
267_R	271_Y	1.039	1.00
209_N	341_Q	1.039	1.00
430_A	438_V	1.038	1.00
204_A	323_I	1.038	1.00
472_E	539_R	1.037	1.00
135_T	138_N	1.036	1.00
39_I	42_V	1.030	1.00
437_K	465_K	1.030	1.00
215_V	241_T	1.027	1.00
216_L	229_V	1.024	1.00
526_E	529_N	1.023	1.00
18_F	148_P	1.022	1.00
465_K	534_A	1.019	1.00
250_L	254_H	1.018	1.00
233_A	256_L	1.017	1.00
204_A	321_V	1.017	1.00
241_T	258_L	1.014	1.00
19_I	108_I	1.013	1.00
381_V	387_I	1.012	1.00
355_R	359_C	1.011	1.00
230_R	254_H	1.010	1.00
430_A	435_D	1.008	1.00
13_F	178_V	1.008	1.00
55_I	460_N	1.006	1.00
387_I	402_Y	1.005	1.00
128_Y	138_N	1.000	1.00
514_L	519_D	0.998	1.00
281_V	286_F	0.998	1.00
196_F	333_Q	0.996	1.00
514_L	520_P	0.993	1.00
82_A	107_C	0.990	1.00
31_V	79_V	0.988	1.00
298_C	301_A	0.987	1.00
329_D	333_Q	0.985	1.00
348_Q	351_A	0.981	1.00
80_C	107_C	0.979	1.00
530_R	534_A	0.976	1.00
138_N	167_W	0.973	1.00
378_A	402_Y	0.973	1.00
195_A	333_Q	0.972	1.00
423_L	447_L	0.970	1.00
422_G	440_C	0.969	1.00
231_E	339_E	0.965	1.00
352_D	355_R	0.965	1.00
468_L	500_F	0.963	1.00
447_L	468_L	0.962	1.00
102_S	162_R	0.962	1.00
42_V	170_I	0.960	1.00
388_T	438_V	0.957	1.00
527_I	534_A	0.953	1.00
319_P	322_A	0.952	1.00
369_S	544_E	0.950	1.00
454_M	535_L	0.947	1.00
346_W	350_V	0.947	1.00
235_K	340_A	0.946	1.00
501_M	537_H	0.945	1.00
454_M	466_I	0.944	1.00
137_H	157_I	0.944	1.00
19_I	42_V	0.944	1.00
465_K	536_I	0.942	1.00
95_I	131_S	0.942	1.00
354_Q	358_P	0.941	1.00
111_Q	169_D	0.940	1.00
388_T	440_C	0.938	1.00
17_E	21_H	0.935	1.00
76_K	159_Q	0.935	1.00
64_G	105_L	0.935	1.00
159_Q	163_P	0.934	1.00
523_S	527_I	0.931	1.00
465_K	528_I	0.929	1.00
451_I	507_F	0.929	1.00
210_A	278_L	0.928	1.00
209_N	338_V	0.926	1.00
211_A	277_D	0.924	1.00
88_A	131_S	0.921	1.00
195_A	329_D	0.918	1.00
509_L	533_P	0.918	1.00
137_H	150_V	0.916	1.00
291_I	294_T	0.909	1.00
406_R	409_Q	0.904	1.00
323_I	330_V	0.903	1.00
461_Q	531_P	0.903	1.00
232_L	338_V	0.901	1.00
469_M	540_I	0.899	1.00
199_E	202_R	0.898	1.00
153_D	157_I	0.896	1.00
457_A	466_I	0.895	1.00
206_A	209_N	0.895	1.00
306_V	323_I	0.894	1.00
455_A	507_F	0.893	1.00
374_I	441_F	0.893	1.00
198_E	202_R	0.892	1.00
46_L	52_I	0.891	1.00
129_G	133_P	0.889	1.00
447_L	535_L	0.888	1.00
373_L	469_M	0.885	1.00
349_L	352_D	0.885	1.00
15_G	144_I	0.884	1.00
215_V	279_L	0.884	1.00
228_R	331_L	0.881	1.00
137_H	154_A	0.877	1.00
72_R	103_I	0.876	1.00
215_V	273_L	0.876	1.00
380_C	524_L	0.875	1.00
22_F	26_Q	0.872	1.00
44_D	47_S	0.870	1.00
73_T	411_L	0.869	1.00
204_A	207_M	0.869	1.00
189_E	192_A	0.869	1.00
519_D	523_S	0.869	1.00
428_G	432_A	0.868	1.00
372_G	520_P	0.866	1.00
13_F	18_F	0.865	1.00
448_M	451_I	0.862	1.00
206_A	341_Q	0.861	1.00
430_A	532_G	0.860	1.00
204_A	278_L	0.860	1.00
207_M	304_I	0.859	1.00
66_I	457_A	0.859	1.00
128_Y	140_L	0.855	1.00
398_T	441_F	0.853	1.00
213_R	277_D	0.852	1.00
89_T	96_A	0.850	1.00
505_A	511_T	0.847	1.00
223_I	249_M	0.846	1.00
30_I	70_M	0.846	1.00
252_K	257_S	0.842	1.00
253_A	383_D	0.842	1.00
158_A	166_V	0.841	1.00
457_A	533_P	0.839	1.00
441_F	469_M	0.839	1.00
22_F	25_Q	0.837	1.00
106_I	159_Q	0.835	1.00
445_G	474_L	0.834	1.00
459_E	496_G	0.834	1.00
23_L	79_V	0.832	1.00
374_I	469_M	0.831	1.00
464_V	533_P	0.830	1.00
93_T	418_T	0.829	1.00
376_A	520_P	0.827	1.00
216_L	282_L	0.824	1.00
472_E	542_A	0.822	1.00
92_V	131_S	0.821	1.00
69_G	425_A	0.821	1.00
79_V	106_I	0.821	1.00
313_L	322_A	0.819	1.00
278_L	302_K	0.817	1.00
385_A	439_L	0.817	1.00
523_S	526_E	0.815	1.00
41_P	176_T	0.813	1.00
203_D	321_V	0.812	1.00
170_I	175_Q	0.810	1.00
14_T	45_A	0.806	1.00
526_E	530_R	0.803	1.00
345_E	348_Q	0.803	1.00
201_I	333_Q	0.802	1.00
380_C	528_I	0.802	1.00
347_H	351_A	0.799	1.00
156_R	160_S	0.798	1.00
439_L	467_I	0.797	1.00
218_L	242_M	0.795	1.00
144_I	148_P	0.794	1.00
384_N	406_R	0.792	1.00
499_N	513_D	0.791	1.00
73_T	432_A	0.790	1.00
236_A	338_V	0.787	1.00
470_N	539_R	0.786	1.00
29_K	70_M	0.784	1.00
35_P	56_L	0.783	1.00
218_L	240_T	0.782	1.00
394_H	446_S	0.781	1.00
465_K	531_P	0.775	1.00
378_A	405_N	0.774	1.00
204_A	330_V	0.772	1.00
136_K	166_V	0.768	1.00
518_A	522_A	0.768	1.00
333_Q	337_L	0.766	1.00
427_I	462_L	0.762	1.00
65_F	418_T	0.760	1.00
137_H	153_D	0.760	1.00
81_M	108_I	0.759	1.00
389_T	412_T	0.758	1.00
423_L	466_I	0.757	1.00
374_I	402_Y	0.757	1.00
57_A	62_G	0.757	1.00
251_P	405_N	0.754	1.00
137_H	166_V	0.754	1.00
499_N	505_A	0.754	1.00
71_A	105_L	0.754	1.00
95_I	134_I	0.752	1.00
140_L	169_D	0.751	1.00
261_L	273_L	0.751	1.00
222_V	249_M	0.751	1.00
96_A	134_I	0.751	1.00
310_R	324_Q	0.748	1.00
31_V	81_M	0.748	1.00
44_D	488_G	0.747	1.00
426_A	464_V	0.746	1.00
39_I	43_Y	0.745	1.00
511_T	537_H	0.744	1.00
458_S	533_P	0.744	1.00
82_A	109_T	0.743	1.00
343_R	347_H	0.739	1.00
448_M	498_I	0.737	1.00
61_Q	90_N	0.736	1.00
28_I	155_F	0.736	1.00
34_I	91_L	0.734	1.00
17_E	49_S	0.733	1.00
242_M	252_K	0.733	1.00
187_M	190_K	0.732	1.00
381_V	385_A	0.731	1.00
32_T	66_I	0.730	1.00
214_P	238_L	0.729	1.00
441_F	467_I	0.728	1.00
26_Q	159_Q	0.728	1.00
368_L	517_E	0.727	1.00
24_E	29_K	0.726	1.00
209_N	336_P	0.726	1.00
209_N	337_L	0.725	1.00
389_T	398_T	0.722	1.00
71_A	103_I	0.722	1.00
220_G	245_M	0.721	1.00
330_V	333_Q	0.721	1.00
312_E	315_K	0.719	1.00
136_K	157_I	0.717	1.00
492_A	495_P	0.717	1.00
70_M	76_K	0.716	1.00
244_L	399_A	0.716	1.00
201_I	334_L	0.715	1.00
109_T	169_D	0.715	1.00
368_L	516_N	0.714	1.00
458_S	508_G	0.714	1.00
332_A	335_I	0.714	1.00
53_R	434_P	0.713	1.00
389_T	410_W	0.711	1.00
44_D	48_Q	0.711	1.00
437_K	463_D	0.710	1.00
466_I	509_L	0.710	1.00
200_S	204_A	0.709	1.00
196_F	201_I	0.709	1.00
83_C	123_Q	0.709	1.00
350_V	353_L	0.708	1.00
42_V	175_Q	0.705	1.00
213_R	346_W	0.704	1.00
250_L	257_S	0.704	1.00
478_H	482_S	0.703	1.00
39_I	81_M	0.701	1.00
280_I	306_V	0.701	1.00
29_K	51_Q	0.698	1.00
128_Y	132_I	0.698	1.00
390_D	422_G	0.697	1.00
114_A	142_R	0.695	1.00
361_I	375_N	0.694	1.00
332_A	336_P	0.694	1.00
307_D	312_E	0.693	0.99
214_P	278_L	0.691	0.99
222_V	227_A	0.691	0.99
467_I	520_P	0.690	0.99
457_A	462_L	0.690	0.99
386_I	436_R	0.689	0.99
103_I	421_F	0.689	0.99
448_M	500_F	0.688	0.99
217_Y	281_V	0.686	0.99
336_P	339_E	0.686	0.99
196_F	329_D	0.684	0.99
423_L	453_E	0.681	0.99
388_T	411_L	0.681	0.99
423_L	442_S	0.681	0.99
89_T	92_V	0.681	0.99
251_P	254_H	0.679	0.99
439_L	465_K	0.679	0.99
354_Q	357_F	0.678	0.99
388_T	429_A	0.676	0.99
208_I	236_A	0.676	0.99
98_A	105_L	0.675	0.99
144_I	179_F	0.673	0.99
256_L	347_H	0.673	0.99
458_S	496_G	0.671	0.99
153_D	156_R	0.671	0.99
345_E	349_L	0.669	0.99
262_G	265_G	0.667	0.99
99_R	136_K	0.667	0.99
195_A	198_E	0.667	0.99
42_V	81_M	0.666	0.99
111_Q	117_I	0.666	0.99
221_G	307_D	0.665	0.99
64_G	107_C	0.665	0.99
447_L	500_F	0.661	0.99
141_V	171_P	0.660	0.99
200_S	323_I	0.659	0.99
509_L	532_G	0.659	0.99
227_A	328_D	0.658	0.99
473_A	478_H	0.658	0.99
237_Q	255_P	0.658	0.99
216_L	240_T	0.658	0.99
150_V	153_D	0.657	0.99
82_A	88_A	0.656	0.99
207_M	210_A	0.655	0.99
305_H	319_P	0.654	0.99
271_Y	274_Q	0.652	0.99
144_I	174_V	0.652	0.99
373_L	467_I	0.651	0.99
427_I	456_T	0.650	0.99
148_P	152_S	0.649	0.99
39_I	110_G	0.647	0.99
30_I	76_K	0.647	0.99
366_D	517_E	0.647	0.99
255_P	351_A	0.646	0.99
514_L	536_I	0.645	0.99
463_D	533_P	0.644	0.99
440_C	446_S	0.643	0.99
212_K	345_E	0.642	0.99
70_M	74_D	0.642	0.99
131_S	167_W	0.642	0.99
89_T	125_V	0.642	0.99
353_L	356_E	0.641	0.99
157_I	161_G	0.641	0.99
359_C	362_P	0.641	0.99
385_A	436_R	0.637	0.99
114_A	171_P	0.635	0.99
335_I	339_E	0.635	0.99
523_S	534_A	0.634	0.99
90_N	93_T	0.632	0.99
225_A	326_D	0.632	0.99
58_R	459_E	0.632	0.99
118_G	124_E	0.631	0.99
217_Y	243_T	0.631	0.99
235_K	338_V	0.630	0.99
228_R	232_L	0.629	0.99
366_D	516_N	0.627	0.99
426_A	438_V	0.627	0.99
41_P	175_Q	0.625	0.99
47_S	488_G	0.624	0.99
498_I	506_G	0.624	0.99
531_P	534_A	0.622	0.99
482_S	489_V	0.621	0.99
330_V	334_L	0.621	0.99
65_F	97_D	0.620	0.99
236_A	256_L	0.619	0.99
424_P	453_E	0.618	0.99
431_L	460_N	0.618	0.99
231_E	336_P	0.616	0.99
362_P	375_N	0.615	0.99
281_V	303_I	0.614	0.99
136_K	161_G	0.613	0.99
146_E	150_V	0.612	0.99
100_L	416_L	0.611	0.99
31_V	52_I	0.610	0.99
201_I	323_I	0.609	0.99
512_C	530_R	0.608	0.99
304_I	321_V	0.605	0.99
136_K	160_S	0.605	0.99
359_C	363_K	0.605	0.99
266_V	359_C	0.604	0.99
411_L	421_F	0.603	0.99
516_N	522_A	0.603	0.99
429_A	438_V	0.602	0.99
59_H	90_N	0.602	0.99
69_G	428_G	0.602	0.99
24_E	52_I	0.601	0.99
478_H	494_Y	0.601	0.99
229_V	233_A	0.600	0.99
499_N	537_H	0.600	0.99
377_V	467_I	0.599	0.99
29_K	74_D	0.598	0.99
217_Y	284_A	0.597	0.99
388_T	422_G	0.596	0.98
247_L	404_L	0.596	0.98
384_N	437_K	0.596	0.98
442_S	466_I	0.595	0.98
13_F	17_E	0.594	0.98
442_S	450_N	0.592	0.98
215_V	272_I	0.591	0.98
212_K	277_D	0.590	0.98
157_I	160_S	0.590	0.98
193_A	326_D	0.589	0.98
233_A	236_A	0.589	0.98
15_G	18_F	0.589	0.98
355_R	358_P	0.588	0.98
223_I	408_R	0.588	0.98
337_L	341_Q	0.587	0.98
394_H	469_M	0.585	0.98
447_L	466_I	0.585	0.98
478_H	542_A	0.585	0.98
237_Q	343_R	0.585	0.98
139_Y	166_V	0.584	0.98
106_I	166_V	0.584	0.98
423_L	457_A	0.583	0.98
230_R	406_R	0.582	0.98
237_Q	347_H	0.582	0.98
122_F	417_G	0.581	0.98
154_A	168_I	0.581	0.98
373_L	520_P	0.581	0.98
22_F	148_P	0.580	0.98
108_I	168_I	0.577	0.98
198_E	336_P	0.577	0.98
108_I	151_M	0.577	0.98
313_L	319_P	0.576	0.98
371_Y	544_E	0.576	0.98
173_D	177_A	0.575	0.98
357_F	361_I	0.575	0.98
367_P	541_D	0.574	0.98
111_Q	140_L	0.574	0.98
465_K	532_G	0.573	0.98
77_P	158_A	0.573	0.98
512_C	522_A	0.572	0.98
217_Y	279_L	0.572	0.98
248_G	252_K	0.571	0.98
114_A	174_V	0.570	0.98
451_I	506_G	0.570	0.98
34_I	474_L	0.570	0.98
186_A	189_E	0.568	0.98
270_N	274_Q	0.567	0.98
461_Q	532_G	0.567	0.98
477_V	481_Q	0.566	0.98
70_M	78_A	0.566	0.98
114_A	143_H	0.565	0.98
109_T	127_T	0.564	0.98
524_L	528_I	0.564	0.98
372_G	521_Q	0.564	0.98
64_G	95_I	0.564	0.98
526_E	534_A	0.563	0.98
66_I	431_L	0.563	0.98
370_H	397_W	0.562	0.98
498_I	503_I	0.561	0.98
209_N	212_K	0.561	0.98
22_F	155_F	0.560	0.98
448_M	452_Q	0.559	0.98
196_F	325_A	0.559	0.98
386_I	411_L	0.559	0.98
389_T	422_G	0.558	0.98
106_I	168_I	0.557	0.98
68_Q	425_A	0.557	0.98
458_S	461_Q	0.554	0.98
381_V	402_Y	0.552	0.98
456_T	462_L	0.551	0.97
314_G	322_A	0.551	0.97
499_N	506_G	0.551	0.97
510_E	531_P	0.551	0.97
73_T	386_I	0.551	0.97
58_R	455_A	0.551	0.97
53_R	431_L	0.551	0.97
498_I	507_F	0.550	0.97
37_G	83_C	0.550	0.97
327_V	332_A	0.550	0.97
245_M	414_G	0.549	0.97
374_I	378_A	0.548	0.97
356_E	359_C	0.548	0.97
79_V	155_F	0.547	0.97
242_M	247_L	0.546	0.97
230_R	233_A	0.546	0.97
309_D	312_E	0.545	0.97
455_A	498_I	0.545	0.97
212_K	343_R	0.543	0.97
224_N	227_A	0.542	0.97
104_P	158_A	0.540	0.97
71_A	78_A	0.540	0.97
514_L	522_A	0.540	0.97
127_T	167_W	0.539	0.97
353_L	357_F	0.539	0.97
258_L	269_T	0.539	0.97
155_F	159_Q	0.539	0.97
272_I	350_V	0.539	0.97
389_T	392_G	0.539	0.97
97_D	101_D	0.538	0.97
32_T	431_L	0.538	0.97
25_Q	181_I	0.537	0.97
18_F	181_I	0.536	0.97
72_R	101_D	0.533	0.97
20_V	46_L	0.533	0.97
465_K	530_R	0.532	0.97
15_G	177_A	0.532	0.97
96_A	125_V	0.531	0.97
204_A	334_L	0.531	0.97
388_T	425_A	0.530	0.97
99_R	135_T	0.530	0.97
91_L	94_A	0.530	0.97
466_I	535_L	0.529	0.97
482_S	487_Q	0.528	0.97
91_L	109_T	0.528	0.97
34_I	57_A	0.527	0.97
63_A	80_C	0.527	0.97
36_G	83_C	0.526	0.97
505_A	512_C	0.525	0.97
48_Q	488_G	0.525	0.97
350_V	354_Q	0.524	0.97
442_S	446_S	0.522	0.97
338_V	341_Q	0.522	0.97
144_I	147_L	0.522	0.97
390_D	440_C	0.522	0.97
148_P	151_M	0.521	0.96
230_R	256_L	0.519	0.96
306_V	327_V	0.519	0.96
141_V	168_I	0.518	0.96
71_A	77_P	0.517	0.96
55_I	456_T	0.516	0.96
357_F	360_P	0.516	0.96
248_G	409_Q	0.515	0.96
141_V	170_I	0.515	0.96
200_S	321_V	0.514	0.96
61_Q	450_N	0.514	0.96
381_V	528_I	0.513	0.96
406_R	436_R	0.513	0.96
252_K	403_P	0.512	0.96
37_G	480_Q	0.512	0.96
358_P	403_P	0.511	0.96
242_M	249_M	0.511	0.96
237_Q	340_A	0.511	0.96
220_G	285_R	0.510	0.96
79_V	108_I	0.509	0.96
74_D	428_G	0.508	0.96
65_F	94_A	0.507	0.96
477_V	480_Q	0.507	0.96
38_S	84_S	0.507	0.96
145_E	180_E	0.507	0.96
423_L	451_I	0.507	0.96
149_Q	152_S	0.507	0.96
226_P	408_R	0.506	0.96
404_L	409_Q	0.504	0.96
453_E	456_T	0.504	0.96
161_G	164_G	0.503	0.96
360_P	363_K	0.503	0.96
303_I	317_K	0.503	0.96
517_E	521_Q	0.502	0.96
199_E	203_D	0.501	0.96
35_P	43_Y	0.500	0.96
113_P	116_M	0.500	0.96
424_P	450_N	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ybhA	4	0.9911	100	0.163	Contact Map
1t9bA	2	0.9875	100	0.172	Contact Map
1ozhA	4	0.9609	100	0.173	Contact Map
2panA	3	0.9822	100	0.173	Contact Map
3eyaA	5	0.9306	100	0.179	Contact Map
2ihtA	4	0.9555	100	0.179	Contact Map
4rjjA	5	0.9733	100	0.183	Contact Map
2pgnA	4	0.9609	100	0.187	Contact Map
2uz1A	4	0.9573	100	0.19	Contact Map
2x7jA	4	0.9858	100	0.191	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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