TDH - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

TDH - L-threonine 3-dehydrogenase

UniProt:	P07913	Sequences: MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLAAIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAAAVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMSGAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10993
Length:	341 (300)
Sequences:	52819 (36431)
Seq/√Len:	2103.3

ECOLI - TDH YDJL YBDR RSPB YPHC YDJJ GATD YGGP AHR YJJN ADHP FRMA YAHK IDND YCJQ QOR1 ACUI CURA
BACSU - YJMD TDH DHSO ADHB YYCR BDHA ADHA YOGA YHFP YFMJ
HALSA - Q9HMB6 Q9HP38 GLCDH Q9HQS8 Q9HR85
SULSO - Q97YT7 Q97VV5 ADH Q7LXK1 Q97XR4 Q97VW0 Q97ZV3 Q97YM2 GLCD2 Q97WA1 GLCD1 Q97TZ4 Q97V32 GLCD3 Q97W06 Q97VB8 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
320_D	323_K	3.044	1.00
33_R	141_D	2.972	1.00
31_K	70_V	2.871	1.00
33_R	68_E	2.807	1.00
29_L	70_V	2.717	1.00
28_L	132_A	2.672	1.00
140_S	143_L	2.595	1.00
184_K	210_T	2.574	1.00
84_R	135_I	2.434	1.00
83_D	134_K	2.419	1.00
80_K	83_D	2.409	1.00
223_V	226_E	2.386	1.00
202_E	206_K	2.370	1.00
316_F	327_A	2.354	1.00
65_Y	120_C	2.349	1.00
31_K	68_E	2.303	1.00
20_V	124_Y	2.242	1.00
166_D	189_R	2.211	1.00
142_D	315_R	2.210	1.00
31_K	124_Y	2.206	1.00
300_A	304_S	2.156	1.00
201_L	205_R	2.134	1.00
167_V	183_A	2.125	1.00
78_G	129_A	2.105	1.00
172_A	193_I	2.100	1.00
314_H	327_A	2.098	1.00
180_A	209_I	2.033	1.00
26_N	75_E	2.031	1.00
25_H	74_Q	2.026	1.00
24_G	27_D	1.995	1.00
84_R	141_D	1.969	1.00
25_H	75_E	1.963	1.00
317_S	320_D	1.958	1.00
138_N	303_Q	1.957	1.00
65_Y	87_G	1.953	1.00
66_V	141_D	1.952	1.00
22_E	71_G	1.916	1.00
326_D	330_S	1.908	1.00
165_E	258_R	1.865	1.00
150_F	178_M	1.827	1.00
202_E	205_R	1.801	1.00
198_E	202_E	1.799	1.00
70_V	124_Y	1.797	1.00
323_K	326_D	1.790	1.00
29_L	126_V	1.785	1.00
168_L	194_T	1.778	1.00
168_L	233_F	1.774	1.00
46_N	329_R	1.761	1.00
234_D	254_N	1.733	1.00
316_F	324_G	1.719	1.00
201_L	212_A	1.719	1.00
192_V	233_F	1.712	1.00
135_I	141_D	1.681	1.00
258_R	282_F	1.676	1.00
195_D	201_L	1.669	1.00
323_K	327_A	1.668	1.00
327_A	332_Q	1.663	1.00
143_L	309_S	1.631	1.00
253_M	259_I	1.619	1.00
304_S	307_D	1.618	1.00
73_G	76_V	1.614	1.00
189_R	211_R	1.591	1.00
198_E	214_N	1.588	1.00
160_F	235_V	1.587	1.00
170_S	249_M	1.587	1.00
135_I	144_A	1.578	1.00
218_E	223_V	1.576	1.00
79_F	134_K	1.574	1.00
211_R	227_L	1.562	1.00
214_N	217_K	1.558	1.00
258_R	284_K	1.548	1.00
253_M	281_L	1.545	1.00
203_L	206_K	1.541	1.00
72_I	81_I	1.540	1.00
219_N	222_D	1.529	1.00
27_D	128_P	1.517	1.00
23_L	126_V	1.517	1.00
71_G	81_I	1.499	1.00
29_L	124_Y	1.487	1.00
198_E	217_K	1.481	1.00
253_M	257_G	1.455	1.00
32_I	65_Y	1.453	1.00
79_F	83_D	1.438	1.00
121_F	325_F	1.434	1.00
23_L	29_L	1.419	1.00
84_R	137_D	1.415	1.00
68_E	84_R	1.412	1.00
26_N	128_P	1.395	1.00
27_D	126_V	1.390	1.00
236_G	249_M	1.382	1.00
34_K	142_D	1.381	1.00
69_V	79_F	1.374	1.00
313_T	327_A	1.361	1.00
236_G	253_M	1.354	1.00
180_A	193_I	1.348	1.00
322_Q	326_D	1.339	1.00
185_H	307_D	1.331	1.00
28_L	79_F	1.318	1.00
29_L	71_G	1.306	1.00
166_D	192_V	1.303	1.00
68_E	141_D	1.296	1.00
158_L	297_K	1.290	1.00
300_A	303_Q	1.289	1.00
45_Y	325_F	1.282	1.00
222_D	226_E	1.279	1.00
189_R	210_T	1.272	1.00
185_H	301_L	1.245	1.00
179_A	237_L	1.242	1.00
170_S	194_T	1.239	1.00
158_L	294_T	1.238	1.00
196_V	215_V	1.236	1.00
8_K	12_G	1.225	1.00
79_F	132_A	1.208	1.00
147_F	302_I	1.201	1.00
33_R	84_R	1.169	1.00
205_R	212_A	1.162	1.00
8_K	14_W	1.160	1.00
20_V	29_L	1.153	1.00
201_L	214_N	1.150	1.00
198_E	201_L	1.148	1.00
162_L	188_A	1.147	1.00
23_L	27_D	1.146	1.00
166_D	234_D	1.139	1.00
30_I	67_G	1.129	1.00
70_V	81_I	1.125	1.00
26_N	129_A	1.115	1.00
9_A	12_G	1.113	1.00
32_I	125_L	1.100	1.00
297_K	300_A	1.097	1.00
193_I	209_I	1.091	1.00
127_I	132_A	1.084	1.00
321_F	338_L	1.082	1.00
15_M	319_D	1.069	1.00
165_E	234_D	1.062	1.00
159_S	282_F	1.058	1.00
251_D	275_K	1.055	1.00
37_I	324_G	1.054	1.00
223_V	227_L	1.051	1.00
217_K	223_V	1.043	1.00
8_K	11_E	1.040	1.00
219_N	223_V	1.039	1.00
203_L	333_S	1.038	1.00
160_F	260_A	1.037	1.00
205_R	211_R	1.036	1.00
30_I	85_V	1.028	1.00
34_K	141_D	1.027	1.00
45_Y	329_R	1.025	1.00
155_H	294_T	1.024	1.00
153_A	182_V	1.017	1.00
296_Y	300_A	1.008	1.00
33_R	66_V	1.004	1.00
38_C	64_E	0.996	1.00
327_A	336_V	0.981	1.00
206_K	310_P	0.977	1.00
121_F	321_F	0.975	1.00
153_A	179_A	0.974	1.00
162_L	165_E	0.971	1.00
238_E	241_G	0.961	1.00
150_F	298_M	0.961	1.00
169_V	179_A	0.959	1.00
240_S	245_A	0.957	1.00
35_T	120_C	0.956	1.00
221_N	251_D	0.950	1.00
38_C	63_H	0.950	1.00
196_V	216_A	0.947	1.00
72_I	76_V	0.945	1.00
196_V	201_L	0.943	1.00
20_V	71_G	0.939	1.00
35_T	121_F	0.937	1.00
172_A	195_D	0.937	1.00
156_T	262_L	0.935	1.00
139_I	144_A	0.934	1.00
228_G	232_G	0.930	1.00
169_V	183_A	0.923	1.00
192_V	211_R	0.921	1.00
34_K	337_I	0.915	1.00
180_A	191_V	0.914	1.00
76_V	129_A	0.913	1.00
221_N	248_T	0.912	1.00
183_A	188_A	0.911	1.00
80_K	134_K	0.908	1.00
247_R	251_D	0.903	1.00
31_K	123_E	0.902	1.00
197_N	200_R	0.901	1.00
326_D	329_R	0.900	1.00
42_V	328_M	0.900	1.00
22_E	29_L	0.898	1.00
195_D	212_A	0.897	1.00
121_F	338_L	0.896	1.00
18_V	118_P	0.895	1.00
292_F	296_Y	0.892	1.00
275_K	279_K	0.886	1.00
77_K	129_A	0.886	1.00
248_T	251_D	0.885	1.00
26_N	73_G	0.885	1.00
154_V	297_K	0.885	1.00
182_V	298_M	0.882	1.00
172_A	204_A	0.881	1.00
194_T	215_V	0.880	1.00
307_D	310_P	0.880	1.00
36_A	64_E	0.879	1.00
328_M	336_V	0.874	1.00
170_S	236_G	0.873	1.00
168_L	252_T	0.872	1.00
177_I	203_L	0.871	1.00
20_V	70_V	0.868	1.00
156_T	237_L	0.866	1.00
59_M	118_P	0.866	1.00
192_V	213_V	0.865	1.00
199_Y	202_E	0.862	1.00
172_A	180_A	0.860	1.00
165_E	235_V	0.859	1.00
166_D	233_F	0.851	1.00
297_K	301_L	0.849	1.00
65_Y	125_L	0.848	1.00
197_N	214_N	0.848	1.00
221_N	225_A	0.836	1.00
200_R	333_S	0.833	1.00
15_M	318_I	0.824	1.00
224_M	233_F	0.824	1.00
193_I	204_A	0.821	1.00
86_S	299_A	0.815	1.00
159_S	284_K	0.815	1.00
137_D	303_Q	0.815	1.00
276_V	283_I	0.812	1.00
37_I	328_M	0.808	1.00
182_V	301_L	0.801	1.00
157_A	183_A	0.799	1.00
204_A	209_I	0.799	1.00
8_K	16_T	0.797	1.00
316_F	320_D	0.797	1.00
256_G	280_G	0.793	1.00
7_L	16_T	0.792	1.00
26_N	74_Q	0.792	1.00
301_L	305_G	0.790	1.00
85_V	132_A	0.789	1.00
222_D	225_A	0.775	1.00
156_T	179_A	0.774	1.00
38_C	41_D	0.774	1.00
7_L	10_E	0.774	1.00
24_G	126_V	0.773	1.00
153_A	178_M	0.772	1.00
220_L	248_T	0.769	1.00
139_I	302_I	0.765	1.00
153_A	175_I	0.765	1.00
151_G	294_T	0.762	1.00
301_L	304_S	0.760	1.00
162_L	235_V	0.760	1.00
170_S	245_A	0.759	1.00
249_M	259_I	0.759	1.00
87_G	127_I	0.755	1.00
40_T	63_H	0.752	1.00
236_G	259_I	0.748	1.00
186_V	297_K	0.746	1.00
37_I	121_F	0.745	1.00
221_N	252_T	0.743	1.00
167_V	188_A	0.743	1.00
23_L	71_G	0.742	1.00
192_V	224_M	0.740	1.00
191_V	210_T	0.735	1.00
18_V	60_V	0.734	1.00
327_A	330_S	0.733	1.00
23_L	73_G	0.732	1.00
38_C	148_D	0.726	1.00
316_F	338_L	0.726	1.00
219_N	248_T	0.725	1.00
28_L	129_A	0.725	1.00
72_I	80_K	0.725	1.00
64_E	148_D	0.724	1.00
86_S	135_I	0.724	1.00
239_M	262_L	0.723	1.00
166_D	231_E	0.720	1.00
161_D	258_R	0.718	1.00
66_V	145_A	0.717	1.00
261_M	283_I	0.717	1.00
293_E	297_K	0.714	1.00
192_V	227_L	0.712	1.00
312_I	315_R	0.712	1.00
314_H	323_K	0.711	1.00
231_E	254_N	0.707	1.00
181_A	307_D	0.703	1.00
84_R	138_N	0.701	1.00
299_A	303_Q	0.701	1.00
133_F	296_Y	0.701	1.00
155_H	280_G	0.699	1.00
34_K	315_R	0.696	1.00
233_F	236_G	0.692	1.00
195_D	204_A	0.691	1.00
183_A	191_V	0.690	1.00
316_F	336_V	0.690	1.00
188_A	235_V	0.688	1.00
169_V	193_I	0.685	1.00
314_H	336_V	0.685	1.00
276_V	281_L	0.684	1.00
189_R	192_V	0.682	1.00
235_V	260_A	0.679	1.00
38_C	149_P	0.677	1.00
11_E	326_D	0.674	1.00
182_V	186_V	0.674	1.00
188_A	191_V	0.674	1.00
154_V	298_M	0.674	1.00
152_N	175_I	0.674	1.00
66_V	135_I	0.672	1.00
149_P	174_P	0.672	1.00
272_D	275_K	0.669	1.00
295_W	299_A	0.668	1.00
225_A	228_G	0.667	1.00
148_D	152_N	0.664	1.00
120_C	125_L	0.662	1.00
255_H	279_K	0.661	1.00
83_D	137_D	0.659	1.00
133_F	295_W	0.659	1.00
78_G	134_K	0.658	1.00
63_H	148_D	0.658	1.00
153_A	157_A	0.657	1.00
269_M	272_D	0.651	1.00
246_F	259_I	0.651	1.00
164_G	189_R	0.650	1.00
136_P	303_Q	0.649	1.00
140_S	144_A	0.647	1.00
242_A	245_A	0.647	1.00
195_D	215_V	0.647	1.00
203_L	207_M	0.647	1.00
39_G	43_H	0.645	1.00
228_G	231_E	0.645	1.00
133_F	299_A	0.644	1.00
201_L	204_A	0.644	1.00
203_L	311_I	0.642	1.00
224_M	252_T	0.641	1.00
34_K	66_V	0.639	1.00
154_V	301_L	0.639	1.00
158_L	186_V	0.635	1.00
181_A	207_M	0.633	1.00
78_G	81_I	0.633	1.00
28_L	69_V	0.632	1.00
177_I	311_I	0.632	1.00
276_V	285_G	0.630	1.00
66_V	84_R	0.630	1.00
15_M	321_F	0.629	1.00
225_A	232_G	0.628	1.00
325_F	329_R	0.627	1.00
26_N	130_F	0.627	1.00
161_D	284_K	0.627	1.00
141_D	144_A	0.627	1.00
21_P	126_V	0.626	1.00
30_I	87_G	0.624	1.00
180_A	207_M	0.623	1.00
32_I	35_T	0.622	1.00
247_R	275_K	0.621	1.00
201_L	215_V	0.621	1.00
194_T	213_V	0.619	1.00
160_F	258_R	0.617	1.00
233_F	252_T	0.615	1.00
247_R	270_S	0.613	1.00
184_K	191_V	0.612	1.00
161_D	282_F	0.612	1.00
238_E	259_I	0.610	1.00
293_E	296_Y	0.610	1.00
43_H	48_D	0.609	1.00
10_E	326_D	0.606	1.00
40_T	44_I	0.603	1.00
236_G	252_T	0.600	1.00
167_V	235_V	0.599	1.00
179_A	262_L	0.599	1.00
23_L	75_E	0.597	1.00
235_V	258_R	0.597	1.00
38_C	335_K	0.596	1.00
275_K	281_L	0.593	1.00
268_D	272_D	0.592	1.00
243_P	247_R	0.589	1.00
156_T	286_I	0.587	1.00
88_E	133_F	0.584	1.00
147_F	298_M	0.582	1.00
7_L	12_G	0.582	1.00
211_R	223_V	0.580	1.00
21_P	124_Y	0.579	1.00
154_V	294_T	0.577	1.00
55_I	59_M	0.574	1.00
149_P	178_M	0.574	1.00
56_P	59_M	0.572	1.00
42_V	329_R	0.572	1.00
152_N	262_L	0.572	1.00
20_V	23_L	0.569	1.00
204_A	212_A	0.568	1.00
40_T	43_H	0.568	1.00
39_G	173_G	0.567	1.00
21_P	29_L	0.567	1.00
195_D	214_N	0.564	1.00
77_K	80_K	0.564	1.00
238_E	263_G	0.562	1.00
213_V	218_E	0.561	1.00
196_V	214_N	0.559	1.00
168_L	236_G	0.559	1.00
213_V	220_L	0.557	1.00
87_G	132_A	0.557	1.00
20_V	126_V	0.551	1.00
72_I	83_D	0.550	1.00
166_D	228_G	0.549	1.00
245_A	249_M	0.548	1.00
158_L	161_D	0.546	1.00
7_L	57_V	0.545	1.00
157_A	182_V	0.545	1.00
163_V	186_V	0.543	1.00
275_K	278_F	0.542	1.00
195_D	200_R	0.540	1.00
314_H	333_S	0.539	1.00
220_L	224_M	0.539	1.00
184_K	209_I	0.539	1.00
178_M	182_V	0.539	1.00
180_A	204_A	0.537	1.00
62_G	121_F	0.537	1.00
146_I	337_I	0.537	1.00
79_F	129_A	0.537	1.00
64_E	335_K	0.537	1.00
30_I	132_A	0.536	1.00
35_T	338_L	0.536	1.00
154_V	186_V	0.536	1.00
66_V	144_A	0.534	1.00
78_G	292_F	0.533	1.00
129_A	132_A	0.533	1.00
32_I	87_G	0.532	1.00
13_I	325_F	0.531	1.00
213_V	223_V	0.531	1.00
136_P	144_A	0.530	1.00
260_A	286_I	0.530	1.00
192_V	228_G	0.530	1.00
294_T	297_K	0.530	1.00
135_I	139_I	0.529	1.00
302_I	308_L	0.527	1.00
316_F	323_K	0.523	1.00
301_L	307_D	0.520	1.00
149_P	335_K	0.520	1.00
163_V	187_G	0.519	1.00
42_V	46_N	0.519	1.00
213_V	227_L	0.516	1.00
277_I	285_G	0.515	1.00
280_G	290_E	0.513	1.00
140_S	315_R	0.512	1.00
87_G	120_C	0.510	1.00
21_P	27_D	0.510	1.00
72_I	79_F	0.509	1.00
171_G	239_M	0.508	1.00
170_S	220_L	0.508	1.00
313_T	334_G	0.508	1.00
30_I	65_Y	0.507	1.00
23_L	26_N	0.507	1.00
177_I	207_M	0.504	1.00
278_F	287_Y	0.504	1.00
180_A	184_K	0.500	1.00
87_G	125_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2dq4A	4	0.9941	100	0.129	Contact Map
2d8aA	3	0.9619	100	0.138	Contact Map
4ej6A	1	0.9736	100	0.156	Contact Map
4ilkA	2	0.9648	100	0.16	Contact Map
3ukoA	4	0.9824	100	0.162	Contact Map
1h2bA	4	0.9824	100	0.162	Contact Map
1vj0A	4	0.9853	100	0.163	Contact Map
4oh1A	4	0.9765	100	0.165	Contact Map
3ip1A	4	0.9912	100	0.166	Contact Map
1f8fA	4	0.9765	100	0.168	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.