GREMLIN Database
TDH - L-threonine 3-dehydrogenase
UniProt: P07913 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10993
Length: 341 (300)
Sequences: 52819 (36431)
Seq/√Len: 2103.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_D323_K3.0441.00
33_R141_D2.9721.00
31_K70_V2.8711.00
33_R68_E2.8071.00
29_L70_V2.7171.00
28_L132_A2.6721.00
140_S143_L2.5951.00
184_K210_T2.5741.00
84_R135_I2.4341.00
83_D134_K2.4191.00
80_K83_D2.4091.00
223_V226_E2.3861.00
202_E206_K2.3701.00
316_F327_A2.3541.00
65_Y120_C2.3491.00
31_K68_E2.3031.00
20_V124_Y2.2421.00
166_D189_R2.2111.00
142_D315_R2.2101.00
31_K124_Y2.2061.00
300_A304_S2.1561.00
201_L205_R2.1341.00
167_V183_A2.1251.00
78_G129_A2.1051.00
172_A193_I2.1001.00
314_H327_A2.0981.00
180_A209_I2.0331.00
26_N75_E2.0311.00
25_H74_Q2.0261.00
24_G27_D1.9951.00
84_R141_D1.9691.00
25_H75_E1.9631.00
317_S320_D1.9581.00
138_N303_Q1.9571.00
65_Y87_G1.9531.00
66_V141_D1.9521.00
22_E71_G1.9161.00
326_D330_S1.9081.00
165_E258_R1.8651.00
150_F178_M1.8271.00
202_E205_R1.8011.00
198_E202_E1.7991.00
70_V124_Y1.7971.00
323_K326_D1.7901.00
29_L126_V1.7851.00
168_L194_T1.7781.00
168_L233_F1.7741.00
46_N329_R1.7611.00
234_D254_N1.7331.00
316_F324_G1.7191.00
201_L212_A1.7191.00
192_V233_F1.7121.00
135_I141_D1.6811.00
258_R282_F1.6761.00
195_D201_L1.6691.00
323_K327_A1.6681.00
327_A332_Q1.6631.00
143_L309_S1.6311.00
253_M259_I1.6191.00
304_S307_D1.6181.00
73_G76_V1.6141.00
189_R211_R1.5911.00
198_E214_N1.5881.00
160_F235_V1.5871.00
170_S249_M1.5871.00
135_I144_A1.5781.00
218_E223_V1.5761.00
79_F134_K1.5741.00
211_R227_L1.5621.00
214_N217_K1.5581.00
258_R284_K1.5481.00
253_M281_L1.5451.00
203_L206_K1.5411.00
72_I81_I1.5401.00
219_N222_D1.5291.00
27_D128_P1.5171.00
23_L126_V1.5171.00
71_G81_I1.4991.00
29_L124_Y1.4871.00
198_E217_K1.4811.00
253_M257_G1.4551.00
32_I65_Y1.4531.00
79_F83_D1.4381.00
121_F325_F1.4341.00
23_L29_L1.4191.00
84_R137_D1.4151.00
68_E84_R1.4121.00
26_N128_P1.3951.00
27_D126_V1.3901.00
236_G249_M1.3821.00
34_K142_D1.3811.00
69_V79_F1.3741.00
313_T327_A1.3611.00
236_G253_M1.3541.00
180_A193_I1.3481.00
322_Q326_D1.3391.00
185_H307_D1.3311.00
28_L79_F1.3181.00
29_L71_G1.3061.00
166_D192_V1.3031.00
68_E141_D1.2961.00
158_L297_K1.2901.00
300_A303_Q1.2891.00
45_Y325_F1.2821.00
222_D226_E1.2791.00
189_R210_T1.2721.00
185_H301_L1.2451.00
179_A237_L1.2421.00
170_S194_T1.2391.00
158_L294_T1.2381.00
196_V215_V1.2361.00
8_K12_G1.2251.00
79_F132_A1.2081.00
147_F302_I1.2011.00
33_R84_R1.1691.00
205_R212_A1.1621.00
8_K14_W1.1601.00
20_V29_L1.1531.00
201_L214_N1.1501.00
198_E201_L1.1481.00
162_L188_A1.1471.00
23_L27_D1.1461.00
166_D234_D1.1391.00
30_I67_G1.1291.00
70_V81_I1.1251.00
26_N129_A1.1151.00
9_A12_G1.1131.00
32_I125_L1.1001.00
297_K300_A1.0971.00
193_I209_I1.0911.00
127_I132_A1.0841.00
321_F338_L1.0821.00
15_M319_D1.0691.00
165_E234_D1.0621.00
159_S282_F1.0581.00
251_D275_K1.0551.00
37_I324_G1.0541.00
223_V227_L1.0511.00
217_K223_V1.0431.00
8_K11_E1.0401.00
219_N223_V1.0391.00
203_L333_S1.0381.00
160_F260_A1.0371.00
205_R211_R1.0361.00
30_I85_V1.0281.00
34_K141_D1.0271.00
45_Y329_R1.0251.00
155_H294_T1.0241.00
153_A182_V1.0171.00
296_Y300_A1.0081.00
33_R66_V1.0041.00
38_C64_E0.9961.00
327_A336_V0.9811.00
206_K310_P0.9771.00
121_F321_F0.9751.00
153_A179_A0.9741.00
162_L165_E0.9711.00
238_E241_G0.9611.00
150_F298_M0.9611.00
169_V179_A0.9591.00
240_S245_A0.9571.00
35_T120_C0.9561.00
221_N251_D0.9501.00
38_C63_H0.9501.00
196_V216_A0.9471.00
72_I76_V0.9451.00
196_V201_L0.9431.00
20_V71_G0.9391.00
35_T121_F0.9371.00
172_A195_D0.9371.00
156_T262_L0.9351.00
139_I144_A0.9341.00
228_G232_G0.9301.00
169_V183_A0.9231.00
192_V211_R0.9211.00
34_K337_I0.9151.00
180_A191_V0.9141.00
76_V129_A0.9131.00
221_N248_T0.9121.00
183_A188_A0.9111.00
80_K134_K0.9081.00
247_R251_D0.9031.00
31_K123_E0.9021.00
197_N200_R0.9011.00
326_D329_R0.9001.00
42_V328_M0.9001.00
22_E29_L0.8981.00
195_D212_A0.8971.00
121_F338_L0.8961.00
18_V118_P0.8951.00
292_F296_Y0.8921.00
275_K279_K0.8861.00
77_K129_A0.8861.00
248_T251_D0.8851.00
26_N73_G0.8851.00
154_V297_K0.8851.00
182_V298_M0.8821.00
172_A204_A0.8811.00
194_T215_V0.8801.00
307_D310_P0.8801.00
36_A64_E0.8791.00
328_M336_V0.8741.00
170_S236_G0.8731.00
168_L252_T0.8721.00
177_I203_L0.8711.00
20_V70_V0.8681.00
156_T237_L0.8661.00
59_M118_P0.8661.00
192_V213_V0.8651.00
199_Y202_E0.8621.00
172_A180_A0.8601.00
165_E235_V0.8591.00
166_D233_F0.8511.00
297_K301_L0.8491.00
65_Y125_L0.8481.00
197_N214_N0.8481.00
221_N225_A0.8361.00
200_R333_S0.8331.00
15_M318_I0.8241.00
224_M233_F0.8241.00
193_I204_A0.8211.00
86_S299_A0.8151.00
159_S284_K0.8151.00
137_D303_Q0.8151.00
276_V283_I0.8121.00
37_I328_M0.8081.00
182_V301_L0.8011.00
157_A183_A0.7991.00
204_A209_I0.7991.00
8_K16_T0.7971.00
316_F320_D0.7971.00
256_G280_G0.7931.00
7_L16_T0.7921.00
26_N74_Q0.7921.00
301_L305_G0.7901.00
85_V132_A0.7891.00
222_D225_A0.7751.00
156_T179_A0.7741.00
38_C41_D0.7741.00
7_L10_E0.7741.00
24_G126_V0.7731.00
153_A178_M0.7721.00
220_L248_T0.7691.00
139_I302_I0.7651.00
153_A175_I0.7651.00
151_G294_T0.7621.00
301_L304_S0.7601.00
162_L235_V0.7601.00
170_S245_A0.7591.00
249_M259_I0.7591.00
87_G127_I0.7551.00
40_T63_H0.7521.00
236_G259_I0.7481.00
186_V297_K0.7461.00
37_I121_F0.7451.00
221_N252_T0.7431.00
167_V188_A0.7431.00
23_L71_G0.7421.00
192_V224_M0.7401.00
191_V210_T0.7351.00
18_V60_V0.7341.00
327_A330_S0.7331.00
23_L73_G0.7321.00
38_C148_D0.7261.00
316_F338_L0.7261.00
219_N248_T0.7251.00
28_L129_A0.7251.00
72_I80_K0.7251.00
64_E148_D0.7241.00
86_S135_I0.7241.00
239_M262_L0.7231.00
166_D231_E0.7201.00
161_D258_R0.7181.00
66_V145_A0.7171.00
261_M283_I0.7171.00
293_E297_K0.7141.00
192_V227_L0.7121.00
312_I315_R0.7121.00
314_H323_K0.7111.00
231_E254_N0.7071.00
181_A307_D0.7031.00
84_R138_N0.7011.00
299_A303_Q0.7011.00
133_F296_Y0.7011.00
155_H280_G0.6991.00
34_K315_R0.6961.00
233_F236_G0.6921.00
195_D204_A0.6911.00
183_A191_V0.6901.00
316_F336_V0.6901.00
188_A235_V0.6881.00
169_V193_I0.6851.00
314_H336_V0.6851.00
276_V281_L0.6841.00
189_R192_V0.6821.00
235_V260_A0.6791.00
38_C149_P0.6771.00
11_E326_D0.6741.00
182_V186_V0.6741.00
188_A191_V0.6741.00
154_V298_M0.6741.00
152_N175_I0.6741.00
66_V135_I0.6721.00
149_P174_P0.6721.00
272_D275_K0.6691.00
295_W299_A0.6681.00
225_A228_G0.6671.00
148_D152_N0.6641.00
120_C125_L0.6621.00
255_H279_K0.6611.00
83_D137_D0.6591.00
133_F295_W0.6591.00
78_G134_K0.6581.00
63_H148_D0.6581.00
153_A157_A0.6571.00
269_M272_D0.6511.00
246_F259_I0.6511.00
164_G189_R0.6501.00
136_P303_Q0.6491.00
140_S144_A0.6471.00
242_A245_A0.6471.00
195_D215_V0.6471.00
203_L207_M0.6471.00
39_G43_H0.6451.00
228_G231_E0.6451.00
133_F299_A0.6441.00
201_L204_A0.6441.00
203_L311_I0.6421.00
224_M252_T0.6411.00
34_K66_V0.6391.00
154_V301_L0.6391.00
158_L186_V0.6351.00
181_A207_M0.6331.00
78_G81_I0.6331.00
28_L69_V0.6321.00
177_I311_I0.6321.00
276_V285_G0.6301.00
66_V84_R0.6301.00
15_M321_F0.6291.00
225_A232_G0.6281.00
325_F329_R0.6271.00
26_N130_F0.6271.00
161_D284_K0.6271.00
141_D144_A0.6271.00
21_P126_V0.6261.00
30_I87_G0.6241.00
180_A207_M0.6231.00
32_I35_T0.6221.00
247_R275_K0.6211.00
201_L215_V0.6211.00
194_T213_V0.6191.00
160_F258_R0.6171.00
233_F252_T0.6151.00
247_R270_S0.6131.00
184_K191_V0.6121.00
161_D282_F0.6121.00
238_E259_I0.6101.00
293_E296_Y0.6101.00
43_H48_D0.6091.00
10_E326_D0.6061.00
40_T44_I0.6031.00
236_G252_T0.6001.00
167_V235_V0.5991.00
179_A262_L0.5991.00
23_L75_E0.5971.00
235_V258_R0.5971.00
38_C335_K0.5961.00
275_K281_L0.5931.00
268_D272_D0.5921.00
243_P247_R0.5891.00
156_T286_I0.5871.00
88_E133_F0.5841.00
147_F298_M0.5821.00
7_L12_G0.5821.00
211_R223_V0.5801.00
21_P124_Y0.5791.00
154_V294_T0.5771.00
55_I59_M0.5741.00
149_P178_M0.5741.00
56_P59_M0.5721.00
42_V329_R0.5721.00
152_N262_L0.5721.00
20_V23_L0.5691.00
204_A212_A0.5681.00
40_T43_H0.5681.00
39_G173_G0.5671.00
21_P29_L0.5671.00
195_D214_N0.5641.00
77_K80_K0.5641.00
238_E263_G0.5621.00
213_V218_E0.5611.00
196_V214_N0.5591.00
168_L236_G0.5591.00
213_V220_L0.5571.00
87_G132_A0.5571.00
20_V126_V0.5511.00
72_I83_D0.5501.00
166_D228_G0.5491.00
245_A249_M0.5481.00
158_L161_D0.5461.00
7_L57_V0.5451.00
157_A182_V0.5451.00
163_V186_V0.5431.00
275_K278_F0.5421.00
195_D200_R0.5401.00
314_H333_S0.5391.00
220_L224_M0.5391.00
184_K209_I0.5391.00
178_M182_V0.5391.00
180_A204_A0.5371.00
62_G121_F0.5371.00
146_I337_I0.5371.00
79_F129_A0.5371.00
64_E335_K0.5371.00
30_I132_A0.5361.00
35_T338_L0.5361.00
154_V186_V0.5361.00
66_V144_A0.5341.00
78_G292_F0.5331.00
129_A132_A0.5331.00
32_I87_G0.5321.00
13_I325_F0.5311.00
213_V223_V0.5311.00
136_P144_A0.5301.00
260_A286_I0.5301.00
192_V228_G0.5301.00
294_T297_K0.5301.00
135_I139_I0.5291.00
302_I308_L0.5271.00
316_F323_K0.5231.00
301_L307_D0.5201.00
149_P335_K0.5201.00
163_V187_G0.5191.00
42_V46_N0.5191.00
213_V227_L0.5161.00
277_I285_G0.5151.00
280_G290_E0.5131.00
140_S315_R0.5121.00
87_G120_C0.5101.00
21_P27_D0.5101.00
72_I79_F0.5091.00
171_G239_M0.5081.00
170_S220_L0.5081.00
313_T334_G0.5081.00
30_I65_Y0.5071.00
23_L26_N0.5071.00
177_I207_M0.5041.00
278_F287_Y0.5041.00
180_A184_K0.5001.00
87_G125_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dq4A 4 0.9941 100 0.129 Contact Map
2d8aA 3 0.9619 100 0.138 Contact Map
4ej6A 1 0.9736 100 0.156 Contact Map
4ilkA 2 0.9648 100 0.16 Contact Map
3ukoA 4 0.9824 100 0.162 Contact Map
1h2bA 4 0.9824 100 0.162 Contact Map
1vj0A 4 0.9853 100 0.163 Contact Map
4oh1A 4 0.9765 100 0.165 Contact Map
3ip1A 4 0.9912 100 0.166 Contact Map
1f8fA 4 0.9765 100 0.168 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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