GREMLIN Database
DDLB - D-alanine--D-alanine ligase B
UniProt: P07862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10214
Length: 306 (256)
Sequences: 27107 (15490)
Seq/√Len: 968.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_P181_K3.6441.00
159_A162_A3.0951.00
239_A243_K2.9151.00
135_S160_E2.7681.00
131_L164_Q2.6191.00
139_L160_E2.4341.00
48_T52_S2.3611.00
115_V136_A2.3531.00
230_E233_Q2.3351.00
242_L246_T2.3061.00
119_R122_F2.2651.00
261_D265_Q2.2281.00
104_W244_A2.2131.00
74_G92_A2.1981.00
104_W268_L2.1871.00
240_L243_K2.1831.00
233_Q236_N2.1581.00
184_S262_S2.0081.00
110_P265_Q1.9591.00
156_K182_W1.9571.00
98_L116_A1.9381.00
101_K180_E1.9221.00
160_E164_Q1.9191.00
231_A235_A1.9081.00
106_G247_T1.8711.00
74_G78_L1.8541.00
98_L102_L1.8281.00
158_V162_A1.7711.00
105_Q113_P1.7681.00
235_A239_A1.7361.00
99_R102_L1.7331.00
233_Q260_L1.7331.00
240_L266_F1.7331.00
102_L106_G1.7111.00
75_M79_M1.7091.00
51_K79_M1.6971.00
236_N265_Q1.6771.00
131_L160_E1.6571.00
210_Y214_A1.6541.00
133_E136_A1.6461.00
196_E251_K1.6361.00
236_N240_L1.6351.00
188_F260_L1.6341.00
49_Q53_M1.6141.00
133_E137_L1.6131.00
234_E238_Q1.6001.00
30_L37_A1.5931.00
107_A247_T1.5831.00
164_Q168_R1.5811.00
102_L105_Q1.5791.00
235_A238_Q1.5611.00
100_S104_W1.5591.00
236_N239_A1.5581.00
93_L99_R1.5551.00
92_A99_R1.5521.00
118_T176_E1.5301.00
245_W254_G1.5121.00
58_V81_L1.5061.00
103_L247_T1.5001.00
190_V237_L1.5001.00
142_I156_K1.4861.00
110_P240_L1.4811.00
165_D169_L1.4651.00
67_G95_M1.4561.00
93_L103_L1.4561.00
134_I139_L1.4471.00
115_V133_E1.4431.00
109_L268_L1.4311.00
87_G90_A1.4301.00
96_D146_S1.4061.00
155_S169_L1.3921.00
158_V184_S1.3821.00
230_E264_G1.3751.00
243_K246_T1.3681.00
77_E83_Y1.3461.00
131_L135_S1.3401.00
260_L266_F1.3221.00
98_L146_S1.3221.00
132_A136_A1.3171.00
146_S176_E1.3111.00
89_M93_L1.3021.00
167_L171_F1.2811.00
75_M78_L1.2811.00
47_V51_K1.2691.00
105_Q111_V1.2541.00
103_L106_G1.2411.00
77_E87_G1.2381.00
231_A234_E1.2361.00
193_L253_W1.2341.00
238_Q242_L1.2281.00
256_I271_A1.2171.00
171_F175_E1.2171.00
113_P136_A1.2151.00
141_V179_I1.2081.00
48_T51_K1.2021.00
181_K267_Y1.1941.00
87_G251_K1.1871.00
94_S248_L1.1821.00
183_L269_L1.1741.00
101_K111_V1.1741.00
229_L233_Q1.1731.00
26_V59_F1.1711.00
198_L203_I1.1701.00
142_I154_M1.1521.00
102_L114_W1.1491.00
192_I241_V1.1471.00
142_I182_W1.1461.00
225_C286_A1.1411.00
120_A131_L1.1381.00
192_I245_W1.1351.00
76_L81_L1.1301.00
198_L202_R1.1301.00
77_E88_V1.1241.00
241_V258_V1.1181.00
232_S236_N1.0911.00
259_M269_L1.0781.00
64_G68_E1.0781.00
168_R172_Q1.0711.00
139_L159_A1.0661.00
157_V166_A1.0631.00
213_E217_L1.0611.00
244_A247_T1.0581.00
76_L83_Y1.0581.00
91_S273_T1.0521.00
74_G88_V1.0501.00
155_S166_A1.0481.00
233_Q264_G1.0441.00
120_A168_R1.0391.00
137_L141_V1.0371.00
169_L172_Q1.0341.00
103_L107_A1.0341.00
38_Y55_F1.0291.00
190_V241_V1.0291.00
89_M92_A1.0281.00
183_L267_Y1.0271.00
98_L176_E1.0261.00
198_L201_I1.0211.00
50_L55_F1.0181.00
170_A177_V1.0131.00
199_P202_R1.0091.00
58_V76_L1.0081.00
94_S271_A1.0071.00
243_K247_T1.0061.00
132_A135_S1.0061.00
147_R174_D1.0041.00
31_R34_G0.9961.00
120_A167_L0.9941.00
169_L173_H0.9901.00
141_V157_V0.9831.00
130_Q163_L0.9791.00
181_K261_D0.9781.00
212_Y215_K0.9761.00
118_T122_F0.9761.00
25_A294_F0.9751.00
64_G67_G0.9751.00
198_L205_P0.9651.00
49_Q52_S0.9611.00
28_A32_E0.9611.00
188_F237_L0.9611.00
41_D46_D0.9601.00
47_V79_M0.9561.00
155_S170_A0.9551.00
261_D267_Y0.9501.00
253_W274_S0.9491.00
96_D147_R0.9481.00
139_L163_L0.9431.00
239_A242_L0.9411.00
27_L37_A0.9281.00
120_A164_Q0.9221.00
184_S261_D0.9201.00
237_L266_F0.9191.00
35_I41_D0.9161.00
74_G89_M0.9121.00
110_P267_Y0.9091.00
194_G246_T0.9001.00
96_D176_E0.9001.00
112_A183_L0.8991.00
146_S178_L0.8941.00
24_A28_A0.8931.00
225_C289_Q0.8921.00
224_F228_G0.8811.00
57_K84_T0.8801.00
134_I160_E0.8801.00
212_Y216_Y0.8781.00
162_A165_D0.8731.00
43_K46_D0.8701.00
113_P137_L0.8701.00
212_Y217_L0.8621.00
116_A176_E0.8621.00
190_V238_Q0.8611.00
165_D168_R0.8591.00
192_I254_G0.8571.00
202_R205_P0.8551.00
134_I141_V0.8531.00
185_G262_S0.8531.00
73_Q83_Y0.8511.00
245_W248_L0.8481.00
237_L258_V0.8461.00
192_I256_I0.8451.00
204_Q207_G0.8451.00
186_P202_R0.8441.00
244_A249_G0.8341.00
29_G32_E0.8301.00
40_V44_E0.8241.00
261_D264_G0.8231.00
105_Q114_W0.8211.00
202_R238_Q0.8211.00
41_D44_E0.8151.00
134_I163_L0.8141.00
197_I202_R0.8131.00
30_L35_I0.8131.00
98_L178_L0.8091.00
143_V157_V0.8071.00
117_L133_E0.8051.00
229_L234_E0.8041.00
27_L31_R0.8021.00
186_P260_L0.8011.00
197_I203_I0.8001.00
171_F177_V0.8001.00
37_A41_D0.8001.00
194_G200_S0.7971.00
217_L220_E0.7961.00
203_I206_S0.7841.00
25_A40_V0.7831.00
27_L39_P0.7791.00
183_L261_D0.7781.00
130_Q167_L0.7761.00
29_G33_G0.7761.00
245_W249_G0.7721.00
186_P228_G0.7661.00
117_L122_F0.7651.00
236_N266_F0.7541.00
50_L81_L0.7511.00
161_N164_Q0.7511.00
244_A248_L0.7511.00
143_V177_V0.7431.00
42_P46_D0.7381.00
287_A290_A0.7301.00
191_A283_V0.7251.00
138_G181_K0.7241.00
50_L53_M0.7211.00
94_S273_T0.7201.00
89_M99_R0.7191.00
31_R37_A0.7151.00
143_V166_A0.7141.00
157_V163_L0.7111.00
286_A289_Q0.7101.00
204_Q224_F0.7091.00
114_W180_E0.7081.00
258_V266_F0.7061.00
74_G77_E0.7041.00
47_V75_M0.7041.00
182_W259_M0.7001.00
221_T224_F0.6991.00
260_L264_G0.6941.00
201_I204_Q0.6901.00
256_I268_L0.6871.00
96_D99_R0.6841.00
79_M82_P0.6841.00
82_P196_E0.6821.00
194_G245_W0.6821.00
71_T74_G0.6801.00
102_L116_A0.6781.00
241_V256_I0.6781.00
166_A170_A0.6771.00
28_A35_I0.6761.00
30_L33_G0.6731.00
191_A286_A0.6711.00
117_L120_A0.6691.00
201_I286_A0.6681.00
181_K265_Q0.6621.00
143_V179_I0.6621.00
158_V182_W0.6551.00
167_L177_V0.6541.00
90_A249_G0.6511.00
240_L258_V0.6511.00
77_E251_K0.6431.00
99_R103_L0.6431.00
157_V162_A0.6431.00
117_L130_Q0.6431.00
155_S165_D0.6411.00
213_E216_Y0.6411.00
223_Y282_L0.6401.00
232_S235_A0.6381.00
134_I138_G0.6341.00
57_K60_I0.6331.00
110_P236_N0.6331.00
262_S265_Q0.6311.00
104_W271_A0.6301.00
23_G26_V0.6261.00
83_Y88_V0.6241.00
198_L204_Q0.6241.00
112_A267_Y0.6221.00
37_A40_V0.6211.00
232_S264_G0.6201.00
60_I84_T0.6201.00
190_V258_V0.6171.00
289_Q293_S0.6171.00
188_F229_L0.6141.00
25_A279_S0.6121.00
73_Q77_E0.6111.00
197_I201_I0.6091.00
188_F258_V0.6081.00
199_P204_Q0.6071.00
240_L244_A0.6071.00
143_V167_L0.6071.00
250_C254_G0.6061.00
166_A169_L0.6061.00
131_L134_I0.6021.00
109_L240_L0.6011.00
161_N165_D0.6001.00
31_R35_I0.5991.00
47_V50_L0.5971.00
199_P246_T0.5971.00
199_P203_I0.5941.00
245_W256_I0.5931.00
82_P85_G0.5921.00
120_A171_F0.5921.00
245_W250_C0.5871.00
197_I200_S0.5871.00
111_V114_W0.5831.00
90_A250_C0.5811.00
134_I140_P0.5811.00
62_L72_L0.5801.00
170_A173_H0.5781.00
121_E132_A0.5771.00
101_K114_W0.5751.00
135_S164_Q0.5711.00
288_R291_G0.5681.00
87_G249_G0.5681.00
191_A253_W0.5671.00
147_R176_E0.5641.00
24_A27_L0.5631.00
98_L114_W0.5621.00
90_A94_S0.5561.00
97_K144_K0.5551.00
275_P294_F0.5551.00
191_A255_R0.5531.00
188_F227_A0.5531.00
236_N243_K0.5531.00
288_R293_S0.5521.00
195_E199_P0.5511.00
197_I242_L0.5511.00
97_K154_M0.5481.00
105_Q116_A0.5461.00
253_W283_V0.5451.00
263_D267_Y0.5431.00
119_R171_F0.5421.00
31_R39_P0.5421.00
120_A130_Q0.5421.00
200_S203_I0.5411.00
244_A271_A0.5401.00
200_S234_E0.5391.00
198_L206_S0.5391.00
72_L76_L0.5391.00
25_A28_A0.5391.00
39_P42_P0.5381.00
88_V92_A0.5371.00
133_E141_V0.5361.00
140_P182_W0.5341.00
62_L67_G0.5291.00
109_L243_K0.5291.00
211_D214_A0.5281.00
155_S173_H0.5271.00
230_E260_L0.5251.00
103_L248_L0.5221.00
86_S250_C0.5221.00
153_G170_A0.5201.00
87_G91_S0.5171.00
233_Q266_F0.5161.00
214_A217_L0.5161.00
40_V46_D0.5161.00
201_I205_P0.5151.00
163_L167_L0.5131.00
202_R207_G0.5131.00
112_A269_L0.5111.00
28_A39_P0.5091.00
137_L181_K0.5091.00
138_G141_V0.5071.00
244_A268_L0.5051.00
197_I204_Q0.5041.00
253_W275_P0.5031.00
152_V173_H0.5001.00
204_Q222_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c5cA 2 0.9739 100 0.212 Contact Map
3i12A 2 0.9706 100 0.216 Contact Map
3e5nA 2 0.9216 100 0.219 Contact Map
4fu0A 2 0.9804 100 0.221 Contact Map
3lwbA 2 0.951 100 0.225 Contact Map
2i87A 2 0.9608 100 0.225 Contact Map
3k3pA 2 0.9085 100 0.226 Contact Map
3tqtA 2 0.9444 100 0.226 Contact Map
1ehiA 2 0.9902 100 0.227 Contact Map
2fb9A 2 0.9542 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0095 seconds.