GREMLIN Database
FHUD - Iron(3+)-hydroxamate-binding protein FhuD
UniProt: P07822 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10305
Length: 296 (268)
Sequences: 14585 (11330)
Seq/√Len: 692.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_T152_E4.0291.00
135_R159_E3.9921.00
142_A151_A3.9321.00
231_K259_P3.8751.00
147_L150_A3.4581.00
143_D148_Q3.1251.00
161_F286_R3.1041.00
259_P263_A3.0051.00
40_A46_V2.9151.00
139_T155_L2.8511.00
150_A153_T2.7051.00
163_R167_P2.5611.00
201_L206_I2.4991.00
156_A160_D2.4621.00
91_L94_E2.4301.00
152_E156_A2.4081.00
23_W28_A2.3961.00
226_R229_A2.3851.00
198_Q202_D2.1701.00
38_I145_L2.1471.00
39_V92_L2.1081.00
54_I145_L2.0611.00
49_L145_L2.0471.00
54_I147_L2.0181.00
37_R57_Y2.0171.00
247_D251_A1.9971.00
250_M264_G1.9791.00
159_E163_R1.9491.00
164_S168_R1.9341.00
48_L138_L1.9281.00
160_D164_S1.8911.00
161_F282_M1.8831.00
233_V259_P1.8801.00
112_M115_R1.8791.00
176_P207_P1.8551.00
27_T114_A1.8341.00
234_D267_Q1.8181.00
101_V141_M1.7641.00
24_Q29_H1.7581.00
153_T157_Q1.7541.00
21_L28_A1.7401.00
110_P114_A1.7191.00
246_M250_M1.7181.00
133_M136_K1.6971.00
234_D265_R1.6671.00
258_M261_V1.6651.00
58_G95_M1.6571.00
163_R166_K1.6471.00
149_S153_T1.6321.00
111_E115_R1.6271.00
259_P262_R1.5891.00
157_Q161_F1.5691.00
150_A154_H1.5691.00
247_D250_M1.5561.00
87_P92_L1.5221.00
257_A262_R1.5151.00
136_K139_T1.5101.00
135_R155_L1.4581.00
136_K140_E1.4361.00
88_N91_L1.4181.00
224_I252_T1.4011.00
57_Y95_M1.3951.00
165_M289_D1.3931.00
20_P28_A1.3901.00
79_I91_L1.3811.00
39_V95_M1.3751.00
120_R140_E1.3691.00
148_Q152_E1.3671.00
267_Q291_A1.3651.00
286_R290_N1.3641.00
226_R230_Y1.3591.00
102_W121_G1.3561.00
287_V290_N1.3481.00
60_A63_I1.3471.00
40_A49_L1.3461.00
187_H221_A1.3401.00
93_T116_I1.3311.00
156_A159_E1.3291.00
111_E114_A1.3191.00
154_H157_Q1.3091.00
22_L28_A1.3041.00
167_P170_V1.3001.00
235_V260_F1.3001.00
139_T159_E1.2971.00
99_F120_R1.2871.00
255_W261_V1.2851.00
140_E143_D1.2841.00
52_L147_L1.2681.00
209_A230_Y1.2661.00
89_L112_M1.2651.00
120_R144_L1.2531.00
161_F164_S1.2521.00
39_V58_G1.2491.00
178_L181_T1.2471.00
149_S152_E1.2441.00
160_D163_R1.2431.00
100_M117_A1.2431.00
90_E225_D1.2351.00
138_L151_A1.2321.00
168_R289_D1.2311.00
31_A34_D1.2221.00
193_P202_D1.2141.00
166_K203_E1.2041.00
164_S167_P1.1991.00
210_W230_Y1.1831.00
155_L159_E1.1771.00
107_G111_E1.1711.00
165_M285_V1.1651.00
49_L54_I1.1551.00
73_P76_D1.1551.00
177_L206_I1.1491.00
106_Y109_S1.1351.00
36_N98_S1.1341.00
35_P98_S1.1291.00
282_M286_R1.1281.00
177_L180_T1.1131.00
157_Q160_D1.1051.00
36_N55_V1.1031.00
51_A154_H1.0851.00
37_R96_K1.0711.00
212_G230_Y1.0591.00
174_A207_P1.0511.00
248_A251_A1.0461.00
18_L33_I1.0421.00
175_R234_D1.0421.00
283_H287_V1.0411.00
207_P211_Q1.0171.00
255_W258_M1.0121.00
278_T282_M1.0041.00
61_D80_D0.9981.00
161_F165_M0.9881.00
237_C268_R0.9871.00
166_K170_V0.9731.00
38_I99_F0.9721.00
56_P78_V0.9661.00
158_Y203_E0.9561.00
253_P256_Q0.9491.00
285_V289_D0.9451.00
52_L154_H0.9451.00
49_L101_V0.9431.00
178_L232_D0.9361.00
49_L56_P0.9341.00
55_V147_L0.9331.00
162_I166_K0.9321.00
140_E144_L0.9281.00
199_E202_D0.9171.00
40_A56_P0.9171.00
139_T143_D0.9161.00
109_S112_M0.9141.00
169_F172_R0.9141.00
59_V78_V0.9121.00
199_E203_E0.9041.00
261_V266_F0.9031.00
23_W27_T0.9021.00
34_D147_L0.9011.00
236_L288_L0.9001.00
122_F140_E0.8991.00
59_V80_D0.8961.00
19_S34_D0.8951.00
137_S140_E0.8911.00
177_L181_T0.8911.00
178_L182_L0.8831.00
151_A155_L0.8821.00
280_S283_H0.8761.00
141_M145_L0.8751.00
210_W226_R0.8751.00
48_L141_M0.8721.00
50_L56_P0.8701.00
23_W26_N0.8671.00
20_P30_A0.8641.00
162_I285_V0.8631.00
31_A118_P0.8621.00
227_L258_M0.8571.00
93_T117_A0.8521.00
50_L69_V0.8501.00
250_M266_F0.8461.00
19_S30_A0.8461.00
256_Q261_V0.8431.00
114_A119_G0.8411.00
31_A35_P0.8331.00
38_I49_L0.8331.00
179_L201_L0.8321.00
161_F283_H0.8311.00
169_F289_D0.8281.00
259_P265_R0.8251.00
19_S33_I0.8241.00
22_L27_T0.8241.00
101_V144_L0.8211.00
142_A155_L0.8201.00
51_A138_L0.8181.00
135_R139_T0.8121.00
158_Y162_I0.8121.00
19_S22_L0.8001.00
24_Q27_T0.7991.00
75_P78_V0.7941.00
21_L30_A0.7931.00
237_C266_F0.7901.00
24_Q110_P0.7851.00
176_P233_V0.7851.00
19_S143_D0.7811.00
161_F289_D0.7791.00
141_M144_L0.7781.00
153_T156_A0.7781.00
152_E155_L0.7771.00
18_L30_A0.7741.00
79_I82_G0.7721.00
35_P99_F0.7671.00
276_G279_L0.7631.00
104_A123_N0.7611.00
81_V95_M0.7601.00
139_T142_A0.7551.00
236_L267_Q0.7541.00
66_R69_V0.7511.00
132_A136_K0.7511.00
234_D292_I0.7461.00
97_P100_M0.7461.00
41_L100_M0.7451.00
74_L78_V0.7431.00
25_M114_A0.7411.00
45_P101_V0.7411.00
232_D235_V0.7401.00
52_L145_L0.7391.00
34_D146_N0.7371.00
92_L113_L0.7351.00
19_S23_W0.7351.00
33_I36_N0.7311.00
228_A257_A0.7261.00
19_S32_A0.7261.00
53_G147_L0.7251.00
162_I203_E0.7251.00
52_L142_A0.7241.00
132_A135_R0.7231.00
287_V291_A0.7221.00
252_T256_Q0.7211.00
145_L148_Q0.7161.00
228_A232_D0.7131.00
206_I292_I0.7121.00
65_Y68_W0.7121.00
52_L150_A0.7101.00
190_V210_W0.7101.00
277_A280_S0.7081.00
285_V290_N0.7051.00
65_Y69_V0.7051.00
138_L154_H0.7041.00
165_M169_F0.6981.00
246_M268_R0.6951.00
222_V230_Y0.6951.00
191_F219_S0.6951.00
83_L86_E0.6951.00
99_F144_L0.6891.00
18_L21_L0.6881.00
234_D238_F0.6831.00
18_L34_D0.6831.00
122_F141_M0.6821.00
135_R162_I0.6791.00
223_S226_R0.6771.00
90_E93_T0.6741.00
279_L283_H0.6731.00
39_V97_P0.6701.00
110_P121_G0.6671.00
193_P211_Q0.6671.00
228_A258_M0.6661.00
284_F288_L0.6651.00
273_W287_V0.6641.00
45_P122_F0.6631.00
154_H158_Y0.6561.00
25_M121_G0.6561.00
191_F195_S0.6551.00
51_A279_L0.6551.00
200_I285_V0.6541.00
53_G150_A0.6531.00
134_A158_Y0.6531.00
175_R178_L0.6501.00
37_R98_S0.6491.00
22_L26_N0.6481.00
21_L27_T0.6481.00
112_M116_I0.6471.00
175_R265_R0.6461.00
24_Q28_A0.6461.00
177_L201_L0.6461.00
277_A281_A0.6461.00
180_T183_I0.6451.00
20_P27_T0.6431.00
18_L146_N0.6381.00
271_A274_F0.6381.00
235_V255_W0.6371.00
108_P111_E0.6371.00
157_Q282_M0.6361.00
122_F137_S0.6361.00
243_S247_D0.6351.00
195_S198_Q0.6331.00
75_P79_I0.6331.00
29_H120_R0.6301.00
26_N29_H0.6281.00
210_W222_V0.6261.00
178_L190_V0.6261.00
47_E280_S0.6251.00
58_G82_G0.6241.00
39_V100_M0.6211.00
139_T148_Q0.6211.00
281_A285_V0.6201.00
155_L158_Y0.6181.00
135_R158_Y0.6171.00
168_R171_K0.6151.00
19_S31_A0.6111.00
52_L151_A0.6111.00
280_S284_F0.6071.00
135_R203_E0.6071.00
20_P143_D0.6071.00
189_L221_A0.6061.00
178_L227_L0.6061.00
49_L141_M0.6051.00
179_L182_L0.6021.00
286_R289_D0.6011.00
100_M119_G0.6001.00
166_K169_F0.6001.00
73_P79_I0.5991.00
89_L116_I0.5991.00
175_R206_I0.5981.00
271_A275_Y0.5951.00
283_H286_R0.5951.00
252_T255_W0.5951.00
18_L32_A0.5951.00
24_Q140_E0.5941.00
288_L292_I0.5921.00
270_P287_V0.5921.00
210_W213_E0.5911.00
46_V59_V0.5891.00
138_L155_L0.5891.00
241_D244_K0.5891.00
58_G81_V0.5871.00
31_A99_F0.5871.00
82_G87_P0.5851.00
52_L138_L0.5841.00
100_M116_I0.5831.00
91_L95_M0.5801.00
204_Y289_D0.5801.00
238_F269_V0.5791.00
194_N198_Q0.5761.00
32_A118_P0.5751.00
158_Y161_F0.5741.00
184_D187_H0.5721.00
279_L282_M0.5711.00
40_A45_P0.5681.00
174_A177_L0.5671.00
100_M113_L0.5671.00
130_P133_M0.5661.00
52_L141_M0.5661.00
21_L120_R0.5641.00
89_L92_L0.5621.00
278_T281_A0.5611.00
154_H278_T0.5601.00
50_L78_V0.5601.00
45_P48_L0.5581.00
79_I95_M0.5521.00
170_V173_G0.5481.00
282_M285_V0.5481.00
179_L238_F0.5481.00
198_Q211_Q0.5471.00
93_T225_D0.5471.00
74_L77_S0.5461.00
34_D98_S0.5441.00
166_K204_Y0.5441.00
165_M168_R0.5431.00
39_V81_V0.5421.00
73_P78_V0.5411.00
89_L109_S0.5401.00
208_N211_Q0.5391.00
134_A138_L0.5391.00
180_T235_V0.5391.00
47_E277_A0.5361.00
104_A107_G0.5341.00
176_P180_T0.5331.00
224_I255_W0.5301.00
26_N107_G0.5301.00
182_L185_P0.5301.00
48_L51_A0.5271.00
195_S219_S0.5261.00
114_A118_P0.5231.00
35_P145_L0.5231.00
27_T110_P0.5231.00
159_E162_I0.5221.00
206_I234_D0.5201.00
125_S133_M0.5201.00
244_K248_A0.5191.00
278_T284_F0.5160.99
108_P112_M0.5140.99
23_W29_H0.5120.99
72_P75_P0.5110.99
31_A144_L0.5100.99
213_E220_T0.5090.99
240_H243_S0.5080.99
62_T80_D0.5080.99
31_A120_R0.5070.99
72_P76_D0.5060.99
29_H118_P0.5060.99
180_T190_V0.5060.99
179_L197_F0.5050.99
45_P141_M0.5040.99
191_F197_F0.5040.99
231_K235_V0.5020.99
188_M191_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tnyA 1 0.9122 100 0.22 Contact Map
4hn9A 1 0.9493 100 0.228 Contact Map
3lhsA 1 0.9358 100 0.231 Contact Map
3tefA 1 0.9155 100 0.232 Contact Map
4mx8A 1 0.9392 100 0.236 Contact Map
4ovkA 1 0.9155 100 0.239 Contact Map
3gfvA 1 0.9324 100 0.24 Contact Map
3pshA 1 0.9257 100 0.245 Contact Map
3r5tA 1 0.9291 100 0.245 Contact Map
4m7oA 1 0.8378 100 0.245 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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