GREMLIN Database
SYL - Leucine--tRNA ligase
UniProt: P07813 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10532
Length: 860 (831)
Sequences: 2153 (1075)
Seq/√Len: 37.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
821_T824_Q6.1871.00
200_D204_N4.8131.00
175_C182_K4.4711.00
822_E826_R4.4611.00
19_D113_K4.0601.00
231_E244_T4.0411.00
233_T244_T3.7731.00
439_D481_M3.5641.00
316_E357_K3.5611.00
237_N317_E3.5051.00
66_Q71_K3.4831.00
144_Y434_M3.4471.00
390_L398_A3.4401.00
391_D394_A3.4391.00
17_H21_K3.3871.00
200_D226_R3.2771.00
755_L778_G3.2681.00
278_L322_A3.1971.00
16_L20_E3.1771.00
142_E145_K3.0451.00
243_L261_V3.0131.00
350_S356_I2.9781.00
515_S519_N2.9671.00
204_N226_R2.9551.00
505_C508_Y2.9331.00
153_T187_E2.9161.00
799_S815_T2.8901.00
6_R9_E2.8761.00
207_D221_R2.8541.00
812_A832_E2.8171.00
611_E614_Y2.7891.00
437_L440_G2.7541.00
22_R25_E2.7531.00
304_D308_K2.7421.00
198_Y550_D2.6671.00
702_R752_E2.6231.00
69_L713_T2.6211.00
610_H614_Y2.5791.00
72_N520_Y2.5701.00
278_L303_V2.5681.00
233_T242_T2.5651.00
161_N181_T2.5121.00
343_Q347_E2.4981.00
434_M442_V2.4841.00
839_L844_V2.4671.00
440_G479_N2.4541.00
271_A307_F2.4521.00
610_H613_V2.4241.00
99_P103_D2.4111.00
758_V782_I2.4091.00
107_Y110_N2.4001.00
33_E71_K2.3851.00
437_L479_N2.3721.00
142_E447_D2.3611.00
402_K406_M2.3551.00
176_C179_C2.3461.00
275_N303_V2.3341.00
232_I403_L2.3091.00
308_K317_E2.3061.00
404_T410_E2.2650.99
404_T411_R2.2580.99
440_G478_V2.2540.99
256_C318_I2.2350.99
284_E301_K2.2270.99
822_E851_P2.2010.99
445_T449_Q2.1850.99
823_E826_R2.1740.99
266_P328_M2.1680.99
309_A320_V2.1570.99
231_E410_E2.1480.99
79_W124_E2.1440.99
226_R413_V2.1380.99
159_C179_C2.1320.99
379_G384_S2.1300.99
585_W588_P2.1290.99
81_A128_C2.1290.99
208_K557_D2.1290.99
810_V813_K2.1260.99
346_Y356_I2.1230.99
849_Y855_L2.1220.99
711_K728_A2.1220.99
68_M759_R2.1130.99
341_H359_V2.1120.99
827_E831_Q2.1040.99
154_S192_F2.0870.99
398_A401_D2.0840.99
79_W109_K2.0840.99
826_R847_V2.0760.99
704_D708_T2.0740.99
504_T522_L2.0740.99
514_D517_A2.0590.99
824_Q827_E2.0340.99
136_E495_E2.0320.99
261_V268_A2.0300.99
609_G612_L2.0280.99
500_Y545_H2.0270.99
232_I245_V2.0180.99
819_D824_Q2.0100.99
709_I760_M2.0090.99
437_L441_T1.9910.99
705_V753_A1.9830.98
386_E402_K1.9820.98
508_Y511_G1.9800.98
28_E517_A1.9740.98
441_T479_N1.9640.98
755_L759_R1.9640.98
707_K797_E1.9620.98
573_A618_S1.9590.98
612_L615_T1.9580.98
584_N587_S1.9570.98
710_A714_D1.9510.98
709_I756_A1.9470.98
159_C181_T1.9470.98
545_H556_S1.9340.98
676_L733_M1.9300.98
446_P449_Q1.9270.98
477_T482_P1.9200.98
228_E413_V1.8870.98
22_R122_S1.8800.98
713_T787_W1.8680.98
205_D546_K1.8670.98
159_C176_C1.8520.98
243_L259_L1.8470.98
604_A607_A1.8450.98
801_L815_T1.8360.97
310_V317_E1.8350.97
397_N411_R1.8320.97
109_K124_E1.8300.97
437_L478_V1.8190.97
609_G613_V1.8120.97
803_V854_L1.8080.97
374_A377_E1.8010.97
549_R557_D1.8010.97
13_K771_T1.7940.97
125_L503_Y1.7890.97
812_A834_L1.7880.97
583_R586_V1.7740.97
437_L443_M1.7730.97
176_C181_T1.7720.97
193_I494_M1.7690.97
387_F402_K1.7630.97
141_T444_P1.7630.97
65_Y69_L1.7560.97
358_P382_F1.7530.97
716_I764_F1.7420.97
232_I253_F1.7400.97
25_E122_S1.7390.97
422_V490_F1.7390.97
438_E481_M1.7230.96
400_A411_R1.7140.96
699_K798_D1.7070.96
816_V825_V1.7040.96
710_A790_A1.7020.96
256_C335_V1.6980.96
820_A825_V1.6950.96
259_L318_I1.6950.96
790_A795_M1.6650.96
541_F560_A1.6630.95
106_A109_K1.6570.95
511_G514_D1.6550.95
475_K484_L1.6540.95
161_N179_C1.6470.95
830_G857_L1.6380.95
109_K113_K1.6380.95
710_A792_E1.6330.95
673_V761_L1.6330.95
153_T189_P1.6320.95
826_R857_L1.6310.95
403_L408_V1.6270.95
445_T452_V1.6240.95
582_E585_W1.6190.95
151_K189_P1.6080.95
346_Y350_S1.6030.94
801_L813_K1.5840.94
830_G844_V1.5810.94
402_K405_A1.5730.94
313_L402_K1.5660.94
736_L753_A1.5640.94
570_L655_T1.5640.94
261_V271_A1.5550.94
382_F388_N1.5420.93
605_K610_H1.5420.93
392_H396_F1.5390.93
609_G614_Y1.5390.93
440_G443_M1.5370.93
254_M386_E1.5330.93
648_F730_M1.5320.93
632_V635_E1.5290.93
582_E586_V1.5240.93
727_A731_E1.5190.93
670_L765_T1.5170.93
59_G528_I1.5120.93
519_N555_N1.5090.92
438_E484_L1.5070.92
802_V825_V1.5020.92
291_A294_E1.4920.92
670_L768_I1.4920.92
401_D405_A1.4900.92
65_Y713_T1.4890.92
253_F403_L1.4730.91
311_H314_T1.4700.91
235_N408_V1.4700.91
604_A610_H1.4690.91
831_Q836_A1.4680.91
235_N242_T1.4660.91
584_N588_P1.4550.91
379_G383_N1.4510.91
343_Q346_Y1.4420.91
587_S590_D1.4400.91
278_L282_I1.4360.90
606_D611_E1.4290.90
608_A611_E1.4270.90
161_N176_C1.4240.90
756_A760_M1.4230.90
437_L483_A1.4060.89
479_N483_A1.3990.89
270_K273_E1.3960.89
230_V400_A1.3910.89
842_V859_V1.3900.89
675_K679_E1.3900.89
443_M483_A1.3860.89
644_L765_T1.3850.89
825_V849_Y1.3840.89
819_D852_G1.3830.89
826_R830_G1.3790.89
606_D610_H1.3790.89
142_E553_M1.3730.88
441_T478_V1.3650.88
701_L736_L1.3630.88
606_D609_G1.3590.88
138_K447_D1.3580.88
453_I456_E1.3520.88
712_V726_I1.3500.87
604_A608_A1.3450.87
114_M635_E1.3380.87
257_T357_K1.3380.87
194_K197_A1.3370.87
830_G847_V1.3360.87
705_V709_I1.3320.87
673_V765_T1.3310.87
701_L739_A1.3230.86
476_T483_A1.3220.86
435_V476_T1.3200.86
847_V857_L1.3090.86
283_D286_R1.3080.86
708_T712_V1.3050.86
513_L518_A1.3050.86
374_A379_G1.3040.86
839_L857_L1.3020.85
607_A611_E1.3020.85
149_V193_I1.3010.85
215_T531_I1.2990.85
50_M53_V1.2980.85
200_D415_Y1.2930.85
398_A402_K1.2910.85
678_Y775_E1.2880.85
380_V391_D1.2870.85
305_T322_A1.2870.85
751_Q755_L1.2850.85
605_K608_A1.2850.85
361_L382_F1.2790.84
694_L749_L1.2740.84
135_W138_K1.2700.84
197_A200_D1.2670.84
705_V732_L1.2660.84
584_N590_D1.2630.84
793_K796_V1.2610.84
385_G388_N1.2600.84
162_D179_C1.2600.84
205_D208_K1.2580.83
63_A118_G1.2580.83
611_E615_T1.2580.83
714_D718_R1.2570.83
761_L769_C1.2570.83
400_A404_T1.2510.83
241_N270_K1.2460.83
817_P820_A1.2430.83
387_F399_I1.2370.82
705_V756_A1.2310.82
513_L548_M1.2270.82
701_L735_K1.2230.82
696_E752_E1.2210.82
443_M479_N1.2100.81
607_A610_H1.2090.81
845_R859_V1.2080.81
35_Y66_Q1.2060.81
33_E66_Q1.2060.81
818_V852_G1.2010.80
280_A283_D1.2000.80
736_L757_V1.1990.80
361_L380_V1.1980.80
102_Y129_T1.1970.80
756_A759_R1.1950.80
575_Y618_S1.1950.80
440_G481_M1.1950.80
585_W590_D1.1940.80
823_E827_E1.1920.80
316_E355_N1.1920.80
313_L337_A1.1890.80
834_L837_K1.1830.79
397_N401_D1.1820.79
582_E587_S1.1800.79
603_K607_A1.1800.79
676_L754_L1.1690.79
383_N388_N1.1690.79
704_D735_K1.1660.78
803_V810_V1.1660.78
217_K221_R1.1650.78
162_D176_C1.1640.78
260_A326_V1.1580.78
606_D613_V1.1560.78
66_Q69_L1.1520.78
575_Y585_W1.1480.77
136_E490_F1.1480.77
159_C180_D1.1470.77
706_H709_I1.1450.77
440_G483_A1.1400.77
253_F313_L1.1400.77
702_R794_A1.1390.77
490_F495_E1.1380.77
13_K774_Q1.1370.77
780_G785_A1.1350.76
138_K553_M1.1330.76
465_S468_K1.1280.76
803_V853_K1.1250.76
474_A484_L1.1240.76
162_D181_T1.1170.75
604_A611_E1.1130.75
826_R849_Y1.1080.75
142_E551_A1.1070.75
501_A518_A1.1070.75
99_P456_E1.1050.75
604_A609_G1.1040.74
501_A522_L1.1030.74
125_L132_Y1.1010.74
39_S75_Q1.0970.74
138_K142_E1.0960.74
155_A185_R1.0930.74
37_C62_I1.0900.73
758_V776_L1.0860.73
24_F783_D1.0850.73
673_V757_V1.0840.73
833_H836_A1.0840.73
474_A487_T1.0830.73
762_N782_I1.0810.73
260_A337_A1.0800.73
603_K610_H1.0790.73
590_D594_E1.0760.73
677_V758_V1.0740.72
443_M478_V1.0690.72
375_L379_G1.0680.72
522_L556_S1.0670.72
231_E412_K1.0660.72
478_V483_A1.0660.72
569_V629_D1.0650.72
825_V854_L1.0650.72
844_V847_V1.0640.72
358_P361_L1.0610.71
23_T783_D1.0600.71
299_E351_K1.0570.71
803_V813_K1.0510.71
125_L129_T1.0510.71
677_V754_L1.0480.70
291_A296_A1.0450.70
708_T760_M1.0450.70
141_T447_D1.0440.70
586_V590_D1.0430.70
143_L551_A1.0400.70
375_L378_K1.0390.70
605_K611_E1.0370.70
816_V828_R1.0370.70
500_Y554_V1.0360.70
268_A271_A1.0290.69
518_A555_N1.0280.69
14_V770_F1.0270.69
155_A187_E1.0270.69
445_T448_D1.0260.69
214_D218_T1.0250.69
759_R785_A1.0250.69
5_Y11_E1.0240.69
154_S190_Q1.0220.69
59_G75_Q1.0210.68
245_V335_V1.0200.68
228_E411_R1.0190.68
14_V771_T1.0180.68
34_K520_Y1.0160.68
213_P216_V1.0140.68
822_E849_Y1.0130.68
824_Q828_R1.0110.68
277_E280_A1.0100.68
103_D106_A1.0100.68
340_G346_Y1.0060.67
379_G382_F1.0030.67
704_D707_K1.0020.67
603_K606_D1.0020.67
15_Q767_H1.0000.67
258_Y392_H1.0000.67
701_L753_A0.9990.67
711_K731_E0.9990.67
822_E827_E0.9990.67
844_V859_V0.9980.67
438_E482_P0.9970.67
476_T481_M0.9970.67
594_E604_A0.9950.66
705_V749_L0.9950.66
802_V852_G0.9940.66
758_V772_L0.9930.66
806_V829_A0.9900.66
253_F337_A0.9890.66
729_I757_V0.9880.66
343_Q374_A0.9880.66
501_A548_M0.9870.66
803_V825_V0.9860.66
481_M484_L0.9860.66
303_V329_E0.9840.66
359_V363_A0.9820.65
280_A284_E0.9820.65
98_A102_Y0.9780.65
259_L335_V0.9760.65
145_K447_D0.9760.65
715_D724_T0.9740.65
236_V241_N0.9740.65
284_E287_N0.9680.64
341_H358_P0.9660.64
697_N752_E0.9620.64
797_E815_T0.9620.64
791_D794_A0.9610.64
387_F392_H0.9590.64
545_H554_V0.9580.63
106_A110_N0.9580.63
761_L765_T0.9570.63
66_Q717_G0.9540.63
576_Y586_V0.9540.63
705_V708_T0.9530.63
69_L789_V0.9520.63
204_N207_D0.9520.63
729_I760_M0.9490.63
126_A129_T0.9480.63
703_R797_E0.9470.63
65_Y717_G0.9450.62
814_I832_E0.9440.62
711_K715_D0.9380.62
435_V483_A0.9370.62
68_M786_P0.9360.62
511_G515_S0.9360.62
475_K482_P0.9350.62
237_N310_V0.9340.61
281_F301_K0.9340.61
609_G615_T0.9330.61
618_S624_K0.9320.61
581_G611_E0.9290.61
76_P121_W0.9280.61
490_F494_M0.9210.60
259_L337_A0.9200.60
363_A380_V0.9190.60
650_S656_L0.9190.60
89_A100_W0.9180.60
401_D411_R0.9150.60
728_A731_E0.9140.60
57_T117_F0.9110.60
835_V838_Y0.9100.59
505_C517_A0.9090.59
102_Y106_A0.9080.59
62_I720_Q0.9080.59
373_Q376_T0.9060.59
376_T379_G0.9060.59
172_I535_I0.9050.59
645_F649_A0.9030.59
602_V605_K0.9010.59
41_L560_A0.9010.59
95_T100_W0.9010.59
633_M642_V0.9000.59
470_D475_K0.9000.59
582_E588_P0.8980.58
769_C782_I0.8980.58
362_A365_G0.8970.58
288_T291_A0.8970.58
575_Y625_N0.8960.58
834_L838_Y0.8920.58
590_D607_A0.8910.58
323_A335_V0.8910.58
435_V446_P0.8900.58
782_I785_A0.8900.58
269_Q282_I0.8900.58
293_A297_T0.8880.58
844_V857_L0.8880.58
254_M313_L0.8870.57
346_Y374_A0.8830.57
507_Q517_A0.8830.57
172_I176_C0.8820.57
806_V837_K0.8820.57
159_C162_D0.8760.57
232_I259_L0.8750.56
7_P667_N0.8730.56
841_G844_V0.8700.56
490_F501_A0.8690.56
669_F733_M0.8660.56
829_A847_V0.8620.55
576_Y582_E0.8620.55
151_K442_V0.8620.55
236_V240_D0.8610.55
156_V165_V0.8610.55
629_D656_L0.8610.55
583_R618_S0.8610.55
214_D226_R0.8600.55
518_A556_S0.8590.55
362_A366_S0.8560.55
79_W113_K0.8550.55
605_K612_L0.8540.55
341_H381_L0.8530.54
314_T317_E0.8500.54
272_A307_F0.8500.54
151_K436_T0.8470.54
386_E399_I0.8470.54
221_R541_F0.8440.54
69_L717_G0.8440.54
152_K192_F0.8420.54
346_Y373_Q0.8410.53
587_S625_N0.8410.53
673_V716_I0.8400.53
829_A849_Y0.8390.53
176_C180_D0.8360.53
254_M384_S0.8360.53
27_T30_E0.8360.53
781_D784_N0.8360.53
603_K608_A0.8330.53
515_S555_N0.8320.53
645_F662_G0.8320.53
800_T818_V0.8310.53
250_P396_F0.8310.53
839_L859_V0.8300.52
832_E835_V0.8290.52
802_V816_V0.8290.52
216_V531_I0.8280.52
435_V440_G0.8230.52
435_V479_N0.8230.52
358_P362_A0.8230.52
627_G631_Q0.8220.52
839_L843_T0.8220.52
59_G325_F0.8210.52
360_I381_L0.8210.52
669_F730_M0.8210.52
75_Q119_Y0.8210.52
605_K609_G0.8190.51
698_Q749_L0.8190.51
179_C544_F0.8190.51
602_V608_A0.8180.51
610_H615_T0.8180.51
34_K525_D0.8170.51
393_E397_N0.8150.51
701_L743_G0.8150.51
195_I539_L0.8140.51
29_D520_Y0.8130.51
234_F341_H0.8130.51
827_E830_G0.8110.51
289_K295_M0.8100.51
393_E396_F0.8100.51
203_L226_R0.8100.51
185_R289_K0.8090.51
589_V594_E0.8090.51
263_A293_A0.8090.51
564_L720_Q0.8080.51
381_L392_H0.8080.51
381_L396_F0.8080.51
341_H382_F0.8070.50
56_Y79_W0.8060.50
17_H781_D0.8050.50
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22_R817_P0.5240.27
290_V298_M0.5240.27
733_M790_A0.5240.27
610_H628_I0.5240.27
95_T467_I0.5240.27
316_E789_V0.5240.27
668_R725_A0.5240.27
248_T326_V0.5230.27
709_I713_T0.5230.27
812_A835_V0.5230.27
378_K382_F0.5230.27
379_G388_N0.5230.27
564_L624_K0.5230.27
576_Y583_R0.5220.27
92_K619_K0.5220.27
849_Y857_L0.5220.27
726_I758_V0.5220.27
707_K794_A0.5220.27
77_I184_E0.5200.27
590_D608_A0.5200.27
131_E275_N0.5190.27
253_F323_A0.5190.27
494_M548_M0.5180.27
151_K488_D0.5180.27
255_G359_V0.5180.27
495_E656_L0.5180.27
170_Q493_F0.5180.27
256_C338_V0.5170.27
360_I383_N0.5170.27
19_D833_H0.5160.27
28_E520_Y0.5160.27
177_W464_T0.5160.27
663_V672_R0.5150.27
214_D448_D0.5150.27
493_F518_A0.5150.27
136_E544_F0.5150.27
572_D594_E0.5140.26
89_A170_Q0.5140.26
321_W358_P0.5140.26
228_E414_N0.5140.26
141_T144_Y0.5140.26
480_G485_R0.5140.26
547_L571_A0.5140.26
810_V853_K0.5130.26
272_A293_A0.5130.26
38_L524_V0.5130.26
39_S59_G0.5120.26
129_T813_K0.5120.26
535_I660_E0.5120.26
195_I498_W0.5120.26
244_T845_R0.5120.26
134_R447_D0.5120.26
227_S248_T0.5110.26
176_C582_E0.5110.26
100_W491_D0.5110.26
348_F352_Y0.5110.26
547_L669_F0.5110.26
673_V676_L0.5100.26
55_N430_A0.5100.26
111_Q629_D0.5100.26
172_I175_C0.5100.26
243_L322_A0.5090.26
197_A848_I0.5080.26
119_Y564_L0.5080.26
65_Y71_K0.5080.26
485_R488_D0.5080.26
330_Y336_M0.5070.26
67_R74_L0.5070.26
359_V365_G0.5060.26
441_T444_P0.5060.26
590_D593_V0.5060.26
708_T732_L0.5060.26
188_I487_T0.5060.26
311_H402_K0.5060.26
810_V854_L0.5050.26
359_V366_S0.5050.26
142_E430_A0.5050.26
113_K122_S0.5050.26
789_V792_E0.5050.26
57_T185_R0.5040.26
243_L411_R0.5040.26
281_F324_N0.5040.26
159_C184_E0.5040.26
194_K201_E0.5030.26
248_T252_T0.5030.26
449_Q478_V0.5030.26
55_N526_I0.5030.26
491_D495_E0.5030.26
56_Y121_W0.5030.26
76_P634_V0.5020.26
333_G345_D0.5020.26
107_Y654_M0.5020.26
136_E176_C0.5020.26
341_H361_L0.5010.26
252_T344_R0.5010.26
347_E359_V0.5010.26
765_T769_C0.5010.26
696_E700_A0.5000.26
115_L139_F0.5000.26
422_V847_V0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4arcA 1 0.9419 100 0.296 Contact Map
2v0cA 1 0.9128 100 0.303 Contact Map
3ziuA 1 0.6988 100 0.501 Contact Map
1ileA 1 0.807 100 0.585 Contact Map
1ffyA 1 0.8547 100 0.592 Contact Map
1gaxA 1 0.7953 100 0.6 Contact Map
1wz2A 1 0.836 100 0.604 Contact Map
1wkbA 1 0.7465 100 0.626 Contact Map
4qreA 1 0.5593 100 0.753 Contact Map
2x1lA 1 0.5605 100 0.756 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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