FDHF - ECOLI - GREMLIN Contacts

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FDHF - Formate dehydrogenase H

UniProt:	P07658	Sequences: MKKVVTVCPYCASGCKINLVVDNGKIVRAEAAQGKTNQGTLCLKGYYGWDFINDTQILTPRLKTPMIRRQRGGKLEPVSWDEALNYVAERLSAIKEKYGPDAIQTTGSSRGTGNETNYVMQKFARAVIGTNNVDCCARVUHGPSVAGLHQSVGNGAMSNAINEIDNTDLVFVFGYNPADSHPIVANHVINAKRNGAKIIVCDPRKIETARIADMHIALKNGSNIALLNAMGHVIIEENLYDKAFVASRTEGFEEYRKIVEGYTPESVEDITGVSASEIRQAARMYAQAKSAAILWGMGVTQFYQGVETVRSLTSLAMLTGNLGKPHAGVNPVRGQNNVQGACDMGALPDTYPGYQYVKDPANREKFAKAWGVESLPAHTGYRISELPHRAAHGEVRAAYIMGEDPLQTDAELSAVRKAFEDLELVIVQDIFMTKTASAADVILPSTSWGEHEGVFTAADRGFQRFFKAVEPKWDLKTDWQIISEIATRMGYPMHYNNTQEIWDELRHLCPDFYGATYEKMGELGFIQWPCRDTSDADQGTSYLFKEKFDTPNGLAQFFTCDWVAPIDKLTDEYPMVLSTVREVGHYSCRSMTGNCAALAALADEPGYAQINTEDAKRLGIEDEALVWVHSRKGKIITRAQVSDRPNKGAIYMTYQWWIGACNELVTENLSPITKTPEYKYCAVRVEPIADQRAAEQYVIDEYNKLKTRLREAALA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10285
Length:	715 (668)
Sequences:	9537 (5779)
Seq/√Len:	223.6

ECOLI - FDHF NAPA YNFF TORZ DMSA TORA YNFE YDEP BISC FDNG FDOG NUOG
BACSU - NASC YJGC YOAE FDHL YYAE
HALSA - DMSA
SULSO - Q97ZA1 Q97V13 Q97XX8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_T	77_P	5.517	1.00
620_I	639_A	4.392	1.00
85_N	488_R	4.241	1.00
627_W	686_E	4.080	1.00
624_A	687_P	3.653	1.00
476_K	484_E	3.621	1.00
237_E	283_R	3.308	1.00
627_W	634_K	3.265	1.00
265_E	275_A	3.172	1.00
90_R	93_A	3.140	1.00
229_A	267_V	3.128	1.00
575_M	618_L	3.090	1.00
614_D	648_G	3.088	1.00
480_Q	484_E	3.070	1.00
613_E	647_K	2.991	1.00
69_R	76_E	2.943	1.00
233_V	237_E	2.927	1.00
242_K	246_A	2.869	1.00
467_K	470_E	2.865	1.00
629_H	686_E	2.858	1.00
86_Y	441_V	2.851	1.00
250_E	552_N	2.794	1.00
427_V	439_A	2.749	1.00
173_F	227_L	2.708	1.00
79_S	82_E	2.706	1.00
232_H	236_E	2.699	1.00
231_G	255_Y	2.692	1.00
629_H	684_R	2.675	1.00
84_L	488_R	2.637	1.00
268_E	275_A	2.635	1.00
87_V	441_V	2.631	1.00
93_A	97_K	2.610	1.00
94_I	102_A	2.558	1.00
552_N	556_Q	2.497	1.00
231_G	318_L	2.492	1.00
226_L	271_T	2.492	1.00
630_S	683_V	2.478	1.00
197_K	284_M	2.476	1.00
214_M	280_Q	2.452	1.00
275_A	279_R	2.446	1.00
274_S	277_E	2.428	1.00
610_I	685_V	2.410	1.00
64_T	474_D	2.398	1.00
200_V	212_A	2.396	1.00
626_V	639_A	2.396	1.00
78_V	441_V	2.387	1.00
610_I	639_A	2.385	1.00
277_E	280_Q	2.383	1.00
168_D	290_S	2.379	1.00
67_I	86_Y	2.378	1.00
615_A	641_V	2.362	1.00
84_L	484_E	2.361	1.00
617_R	647_K	2.344	1.00
629_H	634_K	2.313	1.00
67_I	441_V	2.296	1.00
240_Y	245_V	2.295	1.00
604_E	638_R	2.256	1.00
263_T	266_S	2.249	1.00
67_I	78_V	2.225	1.00
166_N	325_P	2.216	1.00
243_A	247_S	2.174	1.00
238_N	242_K	2.158	1.00
91_L	397_A	2.130	1.00
87_V	426_I	2.100	1.00
618_L	684_R	2.099	1.00
622_D	641_V	2.071	1.00
167_T	170_V	2.064	1.00
497_N	500_E	2.031	1.00
216_I	281_A	2.021	1.00
396_R	423_E	2.019	1.00
484_E	488_R	2.019	1.00
608_A	650_I	2.016	1.00
169_L	284_M	1.994	1.00
86_Y	90_R	1.978	1.00
620_I	626_V	1.976	1.00
608_A	626_V	1.976	1.00
216_I	273_V	1.969	1.00
280_Q	284_M	1.949	1.00
516_T	519_K	1.941	1.00
94_I	397_A	1.925	1.00
214_M	277_E	1.924	1.00
472_K	475_L	1.920	1.00
77_P	474_D	1.910	1.00
78_V	86_Y	1.876	1.00
226_L	278_I	1.875	1.00
232_H	264_P	1.857	1.00
627_W	636_I	1.842	1.00
625_L	636_I	1.836	1.00
235_I	252_F	1.834	1.00
399_Y	428_Q	1.811	1.00
637_T	652_M	1.811	1.00
608_A	628_V	1.789	1.00
519_K	523_L	1.788	1.00
169_L	199_I	1.781	1.00
235_I	256_R	1.776	1.00
608_A	652_M	1.771	1.00
575_M	650_I	1.763	1.00
650_I	683_V	1.760	1.00
191_A	196_A	1.756	1.00
622_D	640_Q	1.744	1.00
257_K	260_E	1.743	1.00
432_M	436_A	1.737	1.00
613_E	616_K	1.735	1.00
67_I	76_E	1.730	1.00
621_E	624_A	1.726	1.00
610_I	650_I	1.723	1.00
245_V	252_F	1.722	1.00
192_K	213_D	1.711	1.00
239_L	286_A	1.703	1.00
500_E	503_D	1.692	1.00
222_S	270_I	1.681	1.00
324_K	327_A	1.678	1.00
214_M	284_M	1.675	1.00
233_V	279_R	1.669	1.00
237_E	279_R	1.666	1.00
267_V	278_I	1.660	1.00
85_N	89_E	1.658	1.00
233_V	283_R	1.631	1.00
63_K	473_W	1.628	1.00
240_Y	252_F	1.623	1.00
285_Y	291_A	1.620	1.00
235_I	259_V	1.597	1.00
201_C	226_L	1.595	1.00
285_Y	319_T	1.595	1.00
484_E	487_T	1.593	1.00
452_E	467_K	1.592	1.00
66_M	442_I	1.591	1.00
233_V	264_P	1.580	1.00
625_L	638_R	1.577	1.00
283_R	287_Q	1.566	1.00
422_L	425_V	1.562	1.00
249_T	557_F	1.562	1.00
268_E	274_S	1.556	1.00
226_L	281_A	1.547	1.00
580_V	651_Y	1.544	1.00
239_L	283_R	1.538	1.00
234_I	240_Y	1.535	1.00
16_K	34_G	1.530	1.00
236_E	260_E	1.529	1.00
102_A	396_R	1.526	1.00
92_S	96_E	1.524	1.00
318_L	557_F	1.521	1.00
250_E	556_Q	1.521	1.00
446_T	477_T	1.519	1.00
78_V	82_E	1.519	1.00
268_E	278_I	1.510	1.00
417_K	420_E	1.506	1.00
234_I	286_A	1.506	1.00
171_F	281_A	1.495	1.00
265_E	279_R	1.490	1.00
496_N	500_E	1.488	1.00
503_D	506_R	1.485	1.00
98_Y	396_R	1.474	1.00
609_Q	642_S	1.471	1.00
364_E	368_K	1.468	1.00
424_L	441_V	1.459	1.00
69_R	74_K	1.457	1.00
171_F	201_C	1.455	1.00
225_A	270_I	1.453	1.00
518_E	522_E	1.452	1.00
575_M	614_D	1.452	1.00
87_V	443_L	1.450	1.00
20_V	30_E	1.448	1.00
214_M	281_A	1.447	1.00
411_E	667_E	1.438	1.00
124_A	130_T	1.433	1.00
89_E	93_A	1.433	1.00
635_I	652_M	1.432	1.00
82_E	86_Y	1.427	1.00
391_A	414_A	1.425	1.00
251_G	254_E	1.416	1.00
50_D	597_A	1.398	1.00
502_W	506_R	1.398	1.00
65_P	80_W	1.392	1.00
169_L	281_A	1.385	1.00
105_T	124_A	1.379	1.00
66_M	77_P	1.376	1.00
427_V	436_A	1.368	1.00
104_Q	395_V	1.365	1.00
430_I	447_S	1.365	1.00
236_E	279_R	1.364	1.00
254_E	257_K	1.359	1.00
5_V	18_N	1.344	1.00
216_I	277_E	1.338	1.00
91_L	426_I	1.337	1.00
123_F	489_M	1.336	1.00
400_I	425_V	1.334	1.00
570_T	631_R	1.332	1.00
230_M	281_A	1.332	1.00
416_R	420_E	1.330	1.00
233_V	236_E	1.324	1.00
476_K	480_Q	1.323	1.00
6_T	19_L	1.321	1.00
499_Q	503_D	1.320	1.00
618_L	685_V	1.319	1.00
243_A	246_A	1.312	1.00
256_R	260_E	1.311	1.00
288_A	291_A	1.311	1.00
487_T	492_P	1.310	1.00
222_S	271_T	1.308	1.00
26_I	52_I	1.302	1.00
432_M	442_I	1.291	1.00
299_V	312_L	1.291	1.00
232_H	260_E	1.287	1.00
233_V	239_L	1.286	1.00
200_V	209_A	1.286	1.00
218_L	273_V	1.282	1.00
95_K	103_I	1.279	1.00
477_T	480_Q	1.272	1.00
84_L	476_K	1.261	1.00
266_S	269_D	1.258	1.00
203_P	215_H	1.255	1.00
612_T	643_D	1.253	1.00
18_N	32_A	1.245	1.00
19_L	26_I	1.243	1.00
235_I	240_Y	1.241	1.00
5_V	32_A	1.241	1.00
611_N	647_K	1.238	1.00
575_M	684_R	1.237	1.00
272_G	646_N	1.236	1.00
86_Y	424_L	1.234	1.00
230_M	285_Y	1.228	1.00
190_N	193_R	1.227	1.00
608_A	637_T	1.226	1.00
466_F	521_G	1.225	1.00
168_D	289_K	1.214	1.00
428_Q	445_S	1.214	1.00
104_Q	386_L	1.211	1.00
252_F	256_R	1.209	1.00
92_S	95_K	1.209	1.00
147_G	309_V	1.202	1.00
262_Y	266_S	1.201	1.00
367_A	373_E	1.199	1.00
82_E	441_V	1.192	1.00
88_A	488_R	1.187	1.00
262_Y	270_I	1.186	1.00
245_V	557_F	1.185	1.00
414_A	417_K	1.183	1.00
321_N	327_A	1.181	1.00
19_L	29_A	1.177	1.00
262_Y	267_V	1.176	1.00
18_N	30_E	1.173	1.00
401_M	482_I	1.172	1.00
218_L	222_S	1.171	1.00
428_Q	481_I	1.170	1.00
261_G	266_S	1.170	1.00
168_D	288_A	1.169	1.00
607_Y	640_Q	1.163	1.00
652_M	661_C	1.163	1.00
242_K	256_R	1.162	1.00
230_M	282_A	1.158	1.00
411_E	414_A	1.158	1.00
163_E	166_N	1.157	1.00
199_I	281_A	1.153	1.00
68_R	75_L	1.153	1.00
258_I	261_G	1.152	1.00
417_K	421_D	1.148	1.00
233_V	278_I	1.147	1.00
239_L	287_Q	1.146	1.00
230_M	234_I	1.146	1.00
103_I	397_A	1.143	1.00
388_H	414_A	1.142	1.00
567_D	632_K	1.140	1.00
227_L	312_L	1.135	1.00
480_Q	487_T	1.135	1.00
397_A	424_L	1.131	1.00
205_K	210_R	1.131	1.00
231_G	259_V	1.127	1.00
69_R	72_G	1.127	1.00
400_I	435_T	1.125	1.00
252_F	318_L	1.118	1.00
391_A	417_K	1.110	1.00
499_Q	521_G	1.105	1.00
642_S	645_P	1.104	1.00
234_I	319_T	1.102	1.00
171_F	230_M	1.096	1.00
572_E	684_R	1.094	1.00
550_T	556_Q	1.093	1.00
608_A	685_V	1.092	1.00
172_V	175_Y	1.090	1.00
577_L	683_V	1.090	1.00
146_A	672_I	1.089	1.00
609_Q	640_Q	1.088	1.00
170_V	188_V	1.087	1.00
397_A	426_I	1.087	1.00
572_E	631_R	1.082	1.00
173_F	201_C	1.080	1.00
230_M	315_L	1.078	1.00
206_I	209_A	1.074	1.00
169_L	288_A	1.073	1.00
443_L	481_I	1.073	1.00
628_V	652_M	1.072	1.00
95_K	128_I	1.071	1.00
90_R	423_E	1.070	1.00
249_T	317_M	1.069	1.00
192_K	211_I	1.068	1.00
60_P	594_N	1.068	1.00
170_V	196_A	1.067	1.00
627_W	688_I	1.067	1.00
650_I	685_V	1.064	1.00
169_L	291_A	1.063	1.00
446_T	475_L	1.062	1.00
574_P	684_R	1.060	1.00
164_I	292_A	1.060	1.00
54_D	60_P	1.058	1.00
205_K	644_R	1.055	1.00
229_A	278_I	1.054	1.00
267_V	271_T	1.054	1.00
385_E	388_H	1.054	1.00
276_S	279_R	1.046	1.00
170_V	191_A	1.045	1.00
52_I	469_V	1.045	1.00
95_K	100_P	1.040	1.00
210_R	644_R	1.039	1.00
317_M	555_A	1.038	1.00
25_K	53_N	1.037	1.00
464_R	521_G	1.032	1.00
168_D	194_N	1.031	1.00
91_L	489_M	1.030	1.00
386_L	395_V	1.020	1.00
406_L	412_L	1.019	1.00
372_V	375_L	1.019	1.00
507_H	510_P	1.018	1.00
268_E	271_T	1.017	1.00
94_I	423_E	1.013	1.00
99_G	102_A	1.012	1.00
94_I	424_L	1.011	1.00
293_I	316_A	1.007	1.00
87_V	485_I	1.005	1.00
285_Y	293_I	1.000	1.00
29_A	49_W	0.995	1.00
31_A	39_G	0.995	1.00
578_S	649_A	0.992	1.00
573_Y	684_R	0.992	1.00
452_E	464_R	0.991	1.00
255_Y	259_V	0.991	1.00
250_E	554_L	0.990	1.00
611_N	645_P	0.989	1.00
263_T	267_V	0.989	1.00
291_A	321_N	0.985	1.00
20_V	28_R	0.980	1.00
382_R	385_E	0.973	1.00
227_L	311_S	0.970	1.00
201_C	216_I	0.970	1.00
16_K	32_A	0.969	1.00
197_K	213_D	0.968	1.00
399_Y	485_I	0.968	1.00
359_D	362_N	0.968	1.00
63_K	472_K	0.967	1.00
219_K	646_N	0.967	1.00
273_V	278_I	0.965	1.00
199_I	284_M	0.964	1.00
575_M	685_V	0.961	1.00
101_D	378_H	0.960	1.00
253_E	256_R	0.960	1.00
612_T	616_K	0.957	1.00
203_P	217_A	0.956	1.00
610_I	620_I	0.953	1.00
90_R	94_I	0.953	1.00
233_V	282_A	0.952	1.00
165_D	187_H	0.952	1.00
151_S	310_R	0.952	1.00
87_V	424_L	0.951	1.00
268_E	276_S	0.950	1.00
388_H	391_A	0.950	1.00
22_D	27_V	0.950	1.00
63_K	77_P	0.946	1.00
280_Q	283_R	0.945	1.00
610_I	615_A	0.943	1.00
628_V	683_V	0.940	1.00
80_W	443_L	0.939	1.00
70_Q	73_G	0.938	1.00
84_L	480_Q	0.938	1.00
229_A	233_V	0.938	1.00
449_G	468_A	0.935	1.00
232_H	263_T	0.935	1.00
255_Y	318_L	0.934	1.00
103_I	128_I	0.933	1.00
220_N	649_A	0.932	1.00
445_S	481_I	0.931	1.00
406_L	416_R	0.927	1.00
570_T	682_A	0.925	1.00
84_L	485_I	0.924	1.00
75_L	442_I	0.923	1.00
573_Y	630_S	0.921	1.00
91_L	399_Y	0.920	0.99
224_I	308_T	0.919	0.99
613_E	643_D	0.918	0.99
279_R	283_R	0.916	0.99
88_A	489_M	0.916	0.99
177_P	188_V	0.911	0.99
88_A	92_S	0.910	0.99
499_Q	517_Y	0.910	0.99
201_C	281_A	0.910	0.99
201_C	218_L	0.909	0.99
290_S	324_K	0.909	0.99
76_E	82_E	0.908	0.99
67_I	82_E	0.907	0.99
192_K	198_I	0.906	0.99
240_Y	318_L	0.904	0.99
389_R	394_E	0.904	0.99
609_Q	644_R	0.904	0.99
264_P	279_R	0.904	0.99
228_N	262_Y	0.903	0.99
517_Y	521_G	0.903	0.99
81_D	488_R	0.903	0.99
314_S	557_F	0.902	0.99
101_D	131_N	0.900	0.99
589_R	593_G	0.900	0.99
19_L	449_G	0.899	0.99
266_S	270_I	0.899	0.99
275_A	278_I	0.897	0.99
62_L	442_I	0.893	0.99
80_W	481_I	0.893	0.99
91_L	128_I	0.892	0.99
436_A	442_I	0.889	0.99
234_I	315_L	0.886	0.99
398_A	422_L	0.885	0.99
569_L	682_A	0.884	0.99
197_K	214_M	0.882	0.99
218_L	226_L	0.881	0.99
228_N	258_I	0.879	0.99
171_F	293_I	0.877	0.99
614_D	647_K	0.877	0.99
165_D	190_N	0.876	0.99
383_I	387_P	0.876	0.99
172_V	198_I	0.874	0.99
369_A	507_H	0.873	0.99
199_I	214_M	0.873	0.99
241_D	324_K	0.864	0.99
611_N	641_V	0.864	0.99
225_A	229_A	0.863	0.99
570_T	574_P	0.863	0.99
273_V	277_E	0.863	0.99
615_A	620_I	0.862	0.99
255_Y	557_F	0.862	0.99
64_T	79_S	0.861	0.99
276_S	280_Q	0.860	0.99
299_V	308_T	0.859	0.99
446_T	471_P	0.858	0.99
413_S	417_K	0.857	0.99
264_P	267_V	0.857	0.99
635_I	664_L	0.855	0.99
169_L	197_K	0.850	0.99
172_V	208_T	0.846	0.99
189_I	192_K	0.843	0.99
150_Q	672_I	0.839	0.99
502_W	505_L	0.838	0.99
231_G	315_L	0.838	0.99
92_S	489_M	0.838	0.99
205_K	217_A	0.838	0.99
433_T	436_A	0.832	0.99
87_V	90_R	0.831	0.99
290_S	327_A	0.831	0.99
628_V	637_T	0.831	0.99
476_K	481_I	0.829	0.99
547_K	553_G	0.828	0.99
65_P	79_S	0.827	0.99
232_H	259_V	0.826	0.99
570_T	573_Y	0.826	0.99
461_G	527_Q	0.823	0.99
226_L	230_M	0.823	0.99
7_V	463_Q	0.821	0.99
217_A	646_N	0.819	0.99
382_R	674_K	0.817	0.99
264_P	268_E	0.817	0.99
17_I	41_L	0.817	0.99
646_N	649_A	0.815	0.99
283_R	286_A	0.815	0.99
205_K	643_D	0.814	0.99
90_R	424_L	0.812	0.99
632_K	681_C	0.807	0.99
63_K	66_M	0.806	0.99
631_R	682_A	0.804	0.99
169_L	285_Y	0.804	0.99
227_L	315_L	0.804	0.99
178_A	208_T	0.803	0.99
5_V	33_Q	0.803	0.99
381_Y	389_R	0.803	0.99
233_V	275_A	0.802	0.99
55_T	60_P	0.801	0.99
385_E	389_R	0.800	0.99
277_E	284_M	0.799	0.99
229_A	266_S	0.797	0.99
365_K	368_K	0.796	0.99
390_A	421_D	0.795	0.99
202_D	206_I	0.794	0.99
420_E	438_A	0.794	0.99
218_L	271_T	0.793	0.99
503_D	507_H	0.793	0.99
150_Q	310_R	0.792	0.98
91_L	95_K	0.792	0.98
122_K	125_R	0.791	0.98
236_E	264_P	0.791	0.98
8_C	11_C	0.789	0.98
52_I	447_S	0.788	0.98
610_I	626_V	0.787	0.98
237_E	286_A	0.787	0.98
637_T	661_C	0.784	0.98
11_C	15_C	0.783	0.98
469_V	472_K	0.781	0.98
84_L	88_A	0.781	0.98
219_K	272_G	0.780	0.98
355_Q	365_K	0.780	0.98
66_M	432_M	0.779	0.98
31_A	41_L	0.776	0.98
284_M	288_A	0.775	0.98
80_W	476_K	0.775	0.98
54_D	431_F	0.775	0.98
78_V	83_A	0.774	0.98
556_Q	559_T	0.774	0.98
396_R	422_L	0.774	0.98
462_F	515_A	0.771	0.98
420_E	423_E	0.770	0.98
268_E	273_V	0.770	0.98
86_Y	89_E	0.769	0.98
22_D	25_K	0.768	0.98
367_A	372_V	0.768	0.98
613_E	617_R	0.767	0.98
297_M	301_Q	0.767	0.98
123_F	482_I	0.767	0.98
483_S	487_T	0.764	0.98
362_N	365_K	0.764	0.98
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447_S	472_K	0.763	0.98
365_K	369_A	0.762	0.98
255_Y	258_I	0.762	0.98
317_M	557_F	0.761	0.98
562_W	565_P	0.760	0.98
615_A	642_S	0.759	0.98
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390_A	422_L	0.755	0.98
197_K	287_Q	0.755	0.98
228_N	259_V	0.754	0.98
361_A	364_E	0.754	0.98
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72_G	76_E	0.753	0.98
349_D	352_P	0.753	0.98
147_G	313_T	0.750	0.98
290_S	325_P	0.750	0.98
94_I	396_R	0.750	0.98
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216_I	226_L	0.750	0.98
367_A	370_W	0.750	0.98
229_A	264_P	0.749	0.98
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258_I	262_Y	0.748	0.98
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429_D	442_I	0.745	0.98
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499_Q	507_H	0.743	0.98
452_E	466_F	0.742	0.98
250_E	254_E	0.742	0.98
632_K	665_V	0.742	0.98
191_A	194_N	0.742	0.98
209_A	215_H	0.741	0.98
387_P	391_A	0.741	0.98
406_L	419_F	0.741	0.98
518_E	521_G	0.739	0.98
526_I	530_C	0.738	0.98
24_G	470_E	0.733	0.98
163_E	326_H	0.733	0.98
293_I	312_L	0.732	0.97
224_I	311_S	0.732	0.97
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505_L	509_C	0.729	0.97
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577_L	652_M	0.718	0.97
229_A	269_D	0.718	0.97
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480_Q	483_S	0.716	0.97
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282_A	286_A	0.704	0.97
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517_Y	520_M	0.701	0.97
303_Y	677_E	0.700	0.97
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567_D	631_R	0.699	0.97
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253_E	257_K	0.695	0.97
467_K	471_P	0.695	0.97
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179_D	207_E	0.693	0.97
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430_I	445_S	0.580	0.91
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356_Y	362_N	0.535	0.88
666_T	677_E	0.535	0.88
574_P	618_L	0.535	0.88
288_A	324_K	0.534	0.87
202_D	215_H	0.534	0.87
254_E	558_F	0.533	0.87
408_T	588_C	0.533	0.87
504_E	507_H	0.533	0.87
302_F	680_Y	0.533	0.87
95_K	102_A	0.533	0.87
97_K	396_R	0.533	0.87
412_L	416_R	0.533	0.87
18_N	33_Q	0.532	0.87
88_A	484_E	0.532	0.87
684_R	687_P	0.531	0.87
144_S	295_W	0.531	0.87
173_F	299_V	0.531	0.87
464_R	517_Y	0.530	0.87
175_Y	294_L	0.530	0.87
582_E	602_A	0.530	0.87
305_G	309_V	0.530	0.87
369_A	373_E	0.530	0.87
500_E	510_P	0.530	0.87
486_A	489_M	0.529	0.87
116_T	451_H	0.529	0.87
520_M	525_F	0.528	0.87
498_T	505_L	0.528	0.87
100_P	129_G	0.528	0.87
173_F	226_L	0.528	0.87
425_V	439_A	0.527	0.87
386_L	391_A	0.527	0.87
200_V	208_T	0.527	0.87
234_I	285_Y	0.527	0.87
614_D	641_V	0.526	0.87
614_D	618_L	0.526	0.87
141_H	144_S	0.525	0.87
134_D	138_R	0.525	0.87
500_E	506_R	0.525	0.87
15_C	45_G	0.524	0.86
187_H	190_N	0.524	0.86
483_S	496_N	0.523	0.86
42_C	45_G	0.523	0.86
418_A	421_D	0.523	0.86
62_L	432_M	0.522	0.86
356_Y	359_D	0.522	0.86
128_I	491_Y	0.522	0.86
304_Q	308_T	0.522	0.86
76_E	86_Y	0.521	0.86
281_A	285_Y	0.521	0.86
147_G	306_V	0.521	0.86
365_K	370_W	0.520	0.86
483_S	492_P	0.520	0.86
406_L	435_T	0.519	0.86
29_A	48_G	0.519	0.86
88_A	485_I	0.519	0.86
515_A	526_I	0.519	0.86
416_R	663_E	0.518	0.86
410_A	678_Y	0.518	0.86
604_E	625_L	0.518	0.86
630_S	633_G	0.517	0.86
398_A	419_F	0.516	0.86
230_M	233_V	0.515	0.85
112_T	116_T	0.515	0.85
542_Y	545_K	0.511	0.85
569_L	572_E	0.511	0.85
124_A	133_V	0.511	0.85
549_D	553_G	0.511	0.85
596_A	599_A	0.510	0.85
47_Y	50_D	0.510	0.85
661_C	664_L	0.509	0.85
257_K	262_Y	0.509	0.85
278_I	282_A	0.508	0.85
620_I	687_P	0.508	0.85
618_L	650_I	0.508	0.85
202_D	208_T	0.508	0.85
563_V	567_D	0.508	0.85
105_T	130_T	0.507	0.85
179_D	583_V	0.507	0.85
321_N	324_K	0.506	0.85
263_T	269_D	0.505	0.84
630_S	682_A	0.505	0.84
612_T	641_V	0.505	0.84
17_I	31_A	0.504	0.84
32_A	524_G	0.503	0.84
344_M	505_L	0.503	0.84
78_V	424_L	0.503	0.84
17_I	48_G	0.502	0.84
609_Q	641_V	0.502	0.84
394_E	421_D	0.502	0.84
519_K	530_C	0.502	0.84
549_D	552_N	0.501	0.84
381_Y	395_V	0.501	0.84
635_I	638_R	0.501	0.84
367_A	371_G	0.500	0.84
506_R	510_P	0.500	0.84
82_E	85_N	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2iv2X	1	0.9664	100	0.163	Contact Map
2napA	1	0.951	100	0.197	Contact Map
1h0hA	1	0.951	100	0.203	Contact Map
1kqfA	3	0.9483	100	0.206	Contact Map
3ml1A	1	0.9538	100	0.212	Contact Map
2e7zA	1	0.9203	100	0.213	Contact Map
2vpzA	1	0.9497	100	0.222	Contact Map
2ivfA	1	0.9427	100	0.235	Contact Map
4aayA	6	0.9287	100	0.257	Contact Map
1g8kA	3	0.9259	100	0.257	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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