GREMLIN Database
FDHF - Formate dehydrogenase H
UniProt: P07658 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10285
Length: 715 (668)
Sequences: 9537 (5779)
Seq/√Len: 223.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_T77_P5.5171.00
620_I639_A4.3921.00
85_N488_R4.2411.00
627_W686_E4.0801.00
624_A687_P3.6531.00
476_K484_E3.6211.00
237_E283_R3.3081.00
627_W634_K3.2651.00
265_E275_A3.1721.00
90_R93_A3.1401.00
229_A267_V3.1281.00
575_M618_L3.0901.00
614_D648_G3.0881.00
480_Q484_E3.0701.00
613_E647_K2.9911.00
69_R76_E2.9431.00
233_V237_E2.9271.00
242_K246_A2.8691.00
467_K470_E2.8651.00
629_H686_E2.8581.00
86_Y441_V2.8511.00
250_E552_N2.7941.00
427_V439_A2.7491.00
173_F227_L2.7081.00
79_S82_E2.7061.00
232_H236_E2.6991.00
231_G255_Y2.6921.00
629_H684_R2.6751.00
84_L488_R2.6371.00
268_E275_A2.6351.00
87_V441_V2.6311.00
93_A97_K2.6101.00
94_I102_A2.5581.00
552_N556_Q2.4971.00
231_G318_L2.4921.00
226_L271_T2.4921.00
630_S683_V2.4781.00
197_K284_M2.4761.00
214_M280_Q2.4521.00
275_A279_R2.4461.00
274_S277_E2.4281.00
610_I685_V2.4101.00
64_T474_D2.3981.00
200_V212_A2.3961.00
626_V639_A2.3961.00
78_V441_V2.3871.00
610_I639_A2.3851.00
277_E280_Q2.3831.00
168_D290_S2.3791.00
67_I86_Y2.3781.00
615_A641_V2.3621.00
84_L484_E2.3611.00
617_R647_K2.3441.00
629_H634_K2.3131.00
67_I441_V2.2961.00
240_Y245_V2.2951.00
604_E638_R2.2561.00
263_T266_S2.2491.00
67_I78_V2.2251.00
166_N325_P2.2161.00
243_A247_S2.1741.00
238_N242_K2.1581.00
91_L397_A2.1301.00
87_V426_I2.1001.00
618_L684_R2.0991.00
622_D641_V2.0711.00
167_T170_V2.0641.00
497_N500_E2.0311.00
216_I281_A2.0211.00
396_R423_E2.0191.00
484_E488_R2.0191.00
608_A650_I2.0161.00
169_L284_M1.9941.00
86_Y90_R1.9781.00
620_I626_V1.9761.00
608_A626_V1.9761.00
216_I273_V1.9691.00
280_Q284_M1.9491.00
516_T519_K1.9411.00
94_I397_A1.9251.00
214_M277_E1.9241.00
472_K475_L1.9201.00
77_P474_D1.9101.00
78_V86_Y1.8761.00
226_L278_I1.8751.00
232_H264_P1.8571.00
627_W636_I1.8421.00
625_L636_I1.8361.00
235_I252_F1.8341.00
399_Y428_Q1.8111.00
637_T652_M1.8111.00
608_A628_V1.7891.00
519_K523_L1.7881.00
169_L199_I1.7811.00
235_I256_R1.7761.00
608_A652_M1.7711.00
575_M650_I1.7631.00
650_I683_V1.7601.00
191_A196_A1.7561.00
622_D640_Q1.7441.00
257_K260_E1.7431.00
432_M436_A1.7371.00
613_E616_K1.7351.00
67_I76_E1.7301.00
621_E624_A1.7261.00
610_I650_I1.7231.00
245_V252_F1.7221.00
192_K213_D1.7111.00
239_L286_A1.7031.00
500_E503_D1.6921.00
222_S270_I1.6811.00
324_K327_A1.6781.00
214_M284_M1.6751.00
233_V279_R1.6691.00
237_E279_R1.6661.00
267_V278_I1.6601.00
85_N89_E1.6581.00
233_V283_R1.6311.00
63_K473_W1.6281.00
240_Y252_F1.6231.00
285_Y291_A1.6201.00
235_I259_V1.5971.00
201_C226_L1.5951.00
285_Y319_T1.5951.00
484_E487_T1.5931.00
452_E467_K1.5921.00
66_M442_I1.5911.00
233_V264_P1.5801.00
625_L638_R1.5771.00
283_R287_Q1.5661.00
422_L425_V1.5621.00
249_T557_F1.5621.00
268_E274_S1.5561.00
226_L281_A1.5471.00
580_V651_Y1.5441.00
239_L283_R1.5381.00
234_I240_Y1.5351.00
16_K34_G1.5301.00
236_E260_E1.5291.00
102_A396_R1.5261.00
92_S96_E1.5241.00
318_L557_F1.5211.00
250_E556_Q1.5211.00
446_T477_T1.5191.00
78_V82_E1.5191.00
268_E278_I1.5101.00
417_K420_E1.5061.00
234_I286_A1.5061.00
171_F281_A1.4951.00
265_E279_R1.4901.00
496_N500_E1.4881.00
503_D506_R1.4851.00
98_Y396_R1.4741.00
609_Q642_S1.4711.00
364_E368_K1.4681.00
424_L441_V1.4591.00
69_R74_K1.4571.00
171_F201_C1.4551.00
225_A270_I1.4531.00
518_E522_E1.4521.00
575_M614_D1.4521.00
87_V443_L1.4501.00
20_V30_E1.4481.00
214_M281_A1.4471.00
411_E667_E1.4381.00
124_A130_T1.4331.00
89_E93_A1.4331.00
635_I652_M1.4321.00
82_E86_Y1.4271.00
391_A414_A1.4251.00
251_G254_E1.4161.00
50_D597_A1.3981.00
502_W506_R1.3981.00
65_P80_W1.3921.00
169_L281_A1.3851.00
105_T124_A1.3791.00
66_M77_P1.3761.00
427_V436_A1.3681.00
104_Q395_V1.3651.00
430_I447_S1.3651.00
236_E279_R1.3641.00
254_E257_K1.3591.00
5_V18_N1.3441.00
216_I277_E1.3381.00
91_L426_I1.3371.00
123_F489_M1.3361.00
400_I425_V1.3341.00
570_T631_R1.3321.00
230_M281_A1.3321.00
416_R420_E1.3301.00
233_V236_E1.3241.00
476_K480_Q1.3231.00
6_T19_L1.3211.00
499_Q503_D1.3201.00
618_L685_V1.3191.00
243_A246_A1.3121.00
256_R260_E1.3111.00
288_A291_A1.3111.00
487_T492_P1.3101.00
222_S271_T1.3081.00
26_I52_I1.3021.00
432_M442_I1.2911.00
299_V312_L1.2911.00
232_H260_E1.2871.00
233_V239_L1.2861.00
200_V209_A1.2861.00
218_L273_V1.2821.00
95_K103_I1.2791.00
477_T480_Q1.2721.00
84_L476_K1.2611.00
266_S269_D1.2581.00
203_P215_H1.2551.00
612_T643_D1.2531.00
18_N32_A1.2451.00
19_L26_I1.2431.00
235_I240_Y1.2411.00
5_V32_A1.2411.00
611_N647_K1.2381.00
575_M684_R1.2371.00
272_G646_N1.2361.00
86_Y424_L1.2341.00
230_M285_Y1.2281.00
190_N193_R1.2271.00
608_A637_T1.2261.00
466_F521_G1.2251.00
168_D289_K1.2141.00
428_Q445_S1.2141.00
104_Q386_L1.2111.00
252_F256_R1.2091.00
92_S95_K1.2091.00
147_G309_V1.2021.00
262_Y266_S1.2011.00
367_A373_E1.1991.00
82_E441_V1.1921.00
88_A488_R1.1871.00
262_Y270_I1.1861.00
245_V557_F1.1851.00
414_A417_K1.1831.00
321_N327_A1.1811.00
19_L29_A1.1771.00
262_Y267_V1.1761.00
18_N30_E1.1731.00
401_M482_I1.1721.00
218_L222_S1.1711.00
428_Q481_I1.1701.00
261_G266_S1.1701.00
168_D288_A1.1691.00
607_Y640_Q1.1631.00
652_M661_C1.1631.00
242_K256_R1.1621.00
230_M282_A1.1581.00
411_E414_A1.1581.00
163_E166_N1.1571.00
199_I281_A1.1531.00
68_R75_L1.1531.00
258_I261_G1.1521.00
417_K421_D1.1481.00
233_V278_I1.1471.00
239_L287_Q1.1461.00
230_M234_I1.1461.00
103_I397_A1.1431.00
388_H414_A1.1421.00
567_D632_K1.1401.00
227_L312_L1.1351.00
480_Q487_T1.1351.00
397_A424_L1.1311.00
205_K210_R1.1311.00
231_G259_V1.1271.00
69_R72_G1.1271.00
400_I435_T1.1251.00
252_F318_L1.1181.00
391_A417_K1.1101.00
499_Q521_G1.1051.00
642_S645_P1.1041.00
234_I319_T1.1021.00
171_F230_M1.0961.00
572_E684_R1.0941.00
550_T556_Q1.0931.00
608_A685_V1.0921.00
172_V175_Y1.0901.00
577_L683_V1.0901.00
146_A672_I1.0891.00
609_Q640_Q1.0881.00
170_V188_V1.0871.00
397_A426_I1.0871.00
572_E631_R1.0821.00
173_F201_C1.0801.00
230_M315_L1.0781.00
206_I209_A1.0741.00
169_L288_A1.0731.00
443_L481_I1.0731.00
628_V652_M1.0721.00
95_K128_I1.0711.00
90_R423_E1.0701.00
249_T317_M1.0691.00
192_K211_I1.0681.00
60_P594_N1.0681.00
170_V196_A1.0671.00
627_W688_I1.0671.00
650_I685_V1.0641.00
169_L291_A1.0631.00
446_T475_L1.0621.00
574_P684_R1.0601.00
164_I292_A1.0601.00
54_D60_P1.0581.00
205_K644_R1.0551.00
229_A278_I1.0541.00
267_V271_T1.0541.00
385_E388_H1.0541.00
276_S279_R1.0461.00
170_V191_A1.0451.00
52_I469_V1.0451.00
95_K100_P1.0401.00
210_R644_R1.0391.00
317_M555_A1.0381.00
25_K53_N1.0371.00
464_R521_G1.0321.00
168_D194_N1.0311.00
91_L489_M1.0301.00
386_L395_V1.0201.00
406_L412_L1.0191.00
372_V375_L1.0191.00
507_H510_P1.0181.00
268_E271_T1.0171.00
94_I423_E1.0131.00
99_G102_A1.0121.00
94_I424_L1.0111.00
293_I316_A1.0071.00
87_V485_I1.0051.00
285_Y293_I1.0001.00
29_A49_W0.9951.00
31_A39_G0.9951.00
578_S649_A0.9921.00
573_Y684_R0.9921.00
452_E464_R0.9911.00
255_Y259_V0.9911.00
250_E554_L0.9901.00
611_N645_P0.9891.00
263_T267_V0.9891.00
291_A321_N0.9851.00
20_V28_R0.9801.00
382_R385_E0.9731.00
227_L311_S0.9701.00
201_C216_I0.9701.00
16_K32_A0.9691.00
197_K213_D0.9681.00
399_Y485_I0.9681.00
359_D362_N0.9681.00
63_K472_K0.9671.00
219_K646_N0.9671.00
273_V278_I0.9651.00
199_I284_M0.9641.00
575_M685_V0.9611.00
101_D378_H0.9601.00
253_E256_R0.9601.00
612_T616_K0.9571.00
203_P217_A0.9561.00
610_I620_I0.9531.00
90_R94_I0.9531.00
233_V282_A0.9521.00
165_D187_H0.9521.00
151_S310_R0.9521.00
87_V424_L0.9511.00
268_E276_S0.9501.00
388_H391_A0.9501.00
22_D27_V0.9501.00
63_K77_P0.9461.00
280_Q283_R0.9451.00
610_I615_A0.9431.00
628_V683_V0.9401.00
80_W443_L0.9391.00
70_Q73_G0.9381.00
84_L480_Q0.9381.00
229_A233_V0.9381.00
449_G468_A0.9351.00
232_H263_T0.9351.00
255_Y318_L0.9341.00
103_I128_I0.9331.00
220_N649_A0.9321.00
445_S481_I0.9311.00
406_L416_R0.9271.00
570_T682_A0.9251.00
84_L485_I0.9241.00
75_L442_I0.9231.00
573_Y630_S0.9211.00
91_L399_Y0.9200.99
224_I308_T0.9190.99
613_E643_D0.9180.99
279_R283_R0.9160.99
88_A489_M0.9160.99
177_P188_V0.9110.99
88_A92_S0.9100.99
499_Q517_Y0.9100.99
201_C281_A0.9100.99
201_C218_L0.9090.99
290_S324_K0.9090.99
76_E82_E0.9080.99
67_I82_E0.9070.99
192_K198_I0.9060.99
240_Y318_L0.9040.99
389_R394_E0.9040.99
609_Q644_R0.9040.99
264_P279_R0.9040.99
228_N262_Y0.9030.99
517_Y521_G0.9030.99
81_D488_R0.9030.99
314_S557_F0.9020.99
101_D131_N0.9000.99
589_R593_G0.9000.99
19_L449_G0.8990.99
266_S270_I0.8990.99
275_A278_I0.8970.99
62_L442_I0.8930.99
80_W481_I0.8930.99
91_L128_I0.8920.99
436_A442_I0.8890.99
234_I315_L0.8860.99
398_A422_L0.8850.99
569_L682_A0.8840.99
197_K214_M0.8820.99
218_L226_L0.8810.99
228_N258_I0.8790.99
171_F293_I0.8770.99
614_D647_K0.8770.99
165_D190_N0.8760.99
383_I387_P0.8760.99
172_V198_I0.8740.99
369_A507_H0.8730.99
199_I214_M0.8730.99
241_D324_K0.8640.99
611_N641_V0.8640.99
225_A229_A0.8630.99
570_T574_P0.8630.99
273_V277_E0.8630.99
615_A620_I0.8620.99
255_Y557_F0.8620.99
64_T79_S0.8610.99
276_S280_Q0.8600.99
299_V308_T0.8590.99
446_T471_P0.8580.99
413_S417_K0.8570.99
264_P267_V0.8570.99
635_I664_L0.8550.99
169_L197_K0.8500.99
172_V208_T0.8460.99
189_I192_K0.8430.99
150_Q672_I0.8390.99
502_W505_L0.8380.99
231_G315_L0.8380.99
92_S489_M0.8380.99
205_K217_A0.8380.99
433_T436_A0.8320.99
87_V90_R0.8310.99
290_S327_A0.8310.99
628_V637_T0.8310.99
476_K481_I0.8290.99
547_K553_G0.8280.99
65_P79_S0.8270.99
232_H259_V0.8260.99
570_T573_Y0.8260.99
461_G527_Q0.8230.99
226_L230_M0.8230.99
7_V463_Q0.8210.99
217_A646_N0.8190.99
382_R674_K0.8170.99
264_P268_E0.8170.99
17_I41_L0.8170.99
646_N649_A0.8150.99
283_R286_A0.8150.99
205_K643_D0.8140.99
90_R424_L0.8120.99
632_K681_C0.8070.99
63_K66_M0.8060.99
631_R682_A0.8040.99
169_L285_Y0.8040.99
227_L315_L0.8040.99
178_A208_T0.8030.99
5_V33_Q0.8030.99
381_Y389_R0.8030.99
233_V275_A0.8020.99
55_T60_P0.8010.99
385_E389_R0.8000.99
277_E284_M0.7990.99
229_A266_S0.7970.99
365_K368_K0.7960.99
390_A421_D0.7950.99
202_D206_I0.7940.99
420_E438_A0.7940.99
218_L271_T0.7930.99
503_D507_H0.7930.99
150_Q310_R0.7920.98
91_L95_K0.7920.98
122_K125_R0.7910.98
236_E264_P0.7910.98
8_C11_C0.7890.98
52_I447_S0.7880.98
610_I626_V0.7870.98
237_E286_A0.7870.98
637_T661_C0.7840.98
11_C15_C0.7830.98
469_V472_K0.7810.98
84_L88_A0.7810.98
219_K272_G0.7800.98
355_Q365_K0.7800.98
66_M432_M0.7790.98
31_A41_L0.7760.98
284_M288_A0.7750.98
80_W476_K0.7750.98
54_D431_F0.7750.98
78_V83_A0.7740.98
556_Q559_T0.7740.98
396_R422_L0.7740.98
462_F515_A0.7710.98
420_E423_E0.7700.98
268_E273_V0.7700.98
86_Y89_E0.7690.98
22_D25_K0.7680.98
367_A372_V0.7680.98
613_E617_R0.7670.98
297_M301_Q0.7670.98
123_F482_I0.7670.98
483_S487_T0.7640.98
362_N365_K0.7640.98
497_N506_R0.7630.98
447_S472_K0.7630.98
365_K369_A0.7620.98
255_Y258_I0.7620.98
317_M557_F0.7610.98
562_W565_P0.7600.98
615_A642_S0.7590.98
101_D130_T0.7570.98
390_A422_L0.7550.98
197_K287_Q0.7550.98
228_N259_V0.7540.98
361_A364_E0.7540.98
635_I663_E0.7530.98
245_V249_T0.7530.98
72_G76_E0.7530.98
349_D352_P0.7530.98
147_G313_T0.7500.98
290_S325_P0.7500.98
94_I396_R0.7500.98
264_P275_A0.7500.98
216_I226_L0.7500.98
367_A370_W0.7500.98
229_A264_P0.7490.98
677_E680_Y0.7480.98
123_F485_I0.7480.98
258_I262_Y0.7480.98
160_A527_Q0.7460.98
413_S663_E0.7450.98
429_D442_I0.7450.98
38_Q190_N0.7440.98
499_Q507_H0.7430.98
452_E466_F0.7420.98
250_E254_E0.7420.98
632_K665_V0.7420.98
191_A194_N0.7420.98
209_A215_H0.7410.98
387_P391_A0.7410.98
406_L419_F0.7410.98
518_E521_G0.7390.98
526_I530_C0.7380.98
24_G470_E0.7330.98
163_E326_H0.7330.98
293_I312_L0.7320.97
224_I311_S0.7320.97
229_A263_T0.7310.97
151_S558_F0.7310.97
68_R73_G0.7310.97
505_L509_C0.7290.97
89_E92_S0.7260.97
387_P390_A0.7220.97
8_C15_C0.7210.97
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134_D138_R0.5250.87
500_E506_R0.5250.87
15_C45_G0.5240.86
187_H190_N0.5240.86
483_S496_N0.5230.86
42_C45_G0.5230.86
418_A421_D0.5230.86
62_L432_M0.5220.86
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128_I491_Y0.5220.86
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29_A48_G0.5190.86
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515_A526_I0.5190.86
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410_A678_Y0.5180.86
604_E625_L0.5180.86
630_S633_G0.5170.86
398_A419_F0.5160.86
230_M233_V0.5150.85
112_T116_T0.5150.85
542_Y545_K0.5110.85
569_L572_E0.5110.85
124_A133_V0.5110.85
549_D553_G0.5110.85
596_A599_A0.5100.85
47_Y50_D0.5100.85
661_C664_L0.5090.85
257_K262_Y0.5090.85
278_I282_A0.5080.85
620_I687_P0.5080.85
618_L650_I0.5080.85
202_D208_T0.5080.85
563_V567_D0.5080.85
105_T130_T0.5070.85
179_D583_V0.5070.85
321_N324_K0.5060.85
263_T269_D0.5050.84
630_S682_A0.5050.84
612_T641_V0.5050.84
17_I31_A0.5040.84
32_A524_G0.5030.84
344_M505_L0.5030.84
78_V424_L0.5030.84
17_I48_G0.5020.84
609_Q641_V0.5020.84
394_E421_D0.5020.84
519_K530_C0.5020.84
549_D552_N0.5010.84
381_Y395_V0.5010.84
635_I638_R0.5010.84
367_A371_G0.5000.84
506_R510_P0.5000.84
82_E85_N0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iv2X 1 0.9664 100 0.163 Contact Map
2napA 1 0.951 100 0.197 Contact Map
1h0hA 1 0.951 100 0.203 Contact Map
1kqfA 3 0.9483 100 0.206 Contact Map
3ml1A 1 0.9538 100 0.212 Contact Map
2e7zA 1 0.9203 100 0.213 Contact Map
2vpzA 1 0.9497 100 0.222 Contact Map
2ivfA 1 0.9427 100 0.235 Contact Map
4aayA 6 0.9287 100 0.257 Contact Map
1g8kA 3 0.9259 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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