GREMLIN Database
PSTA - Phosphate transport system permease protein PstA
UniProt: P07654 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10782
Length: 296 (252)
Sequences: 71026 (46303)
Seq/√Len: 2916.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_K200_A4.0431.00
44_W48_I3.6211.00
84_A88_L3.2001.00
173_E177_K3.0041.00
188_Y197_M2.9811.00
184_R202_T2.5891.00
110_E184_R2.5881.00
81_N84_A2.5791.00
82_A252_T2.5641.00
187_A197_M2.4931.00
193_P196_K2.4521.00
175_M209_G2.4441.00
92_W157_V2.4111.00
96_F161_A2.3901.00
68_M71_P2.3891.00
80_A84_A2.3171.00
247_A255_K2.3041.00
94_T214_I2.3011.00
71_P75_E2.2521.00
194_K197_M2.2431.00
68_M72_P2.2371.00
195_W199_S2.2351.00
172_T210_I2.2321.00
54_T58_D2.1551.00
192_T196_K2.0411.00
196_K199_S2.0181.00
102_I198_I2.0111.00
168_V213_G1.9611.00
176_L206_S1.9421.00
109_A177_K1.9191.00
183_L205_A1.8791.00
113_R117_L1.8331.00
187_A192_T1.8301.00
102_I206_S1.7851.00
81_N85_G1.7321.00
284_I288_V1.7241.00
122_R173_E1.7191.00
188_Y194_K1.7181.00
90_I218_I1.7011.00
184_R197_M1.7001.00
98_T214_I1.6981.00
101_G168_V1.6561.00
88_L92_W1.6141.00
93_A221_I1.6111.00
264_W267_L1.6001.00
104_A169_I1.5841.00
108_L169_I1.5601.00
72_P267_L1.5591.00
102_I172_T1.5551.00
113_R118_A1.5381.00
184_R188_Y1.5381.00
48_I52_T1.4711.00
50_M54_T1.4231.00
181_Y184_R1.4221.00
51_S55_R1.4031.00
105_G172_T1.4001.00
234_S245_P1.4001.00
168_V217_A1.3931.00
72_P75_E1.3901.00
56_G70_P1.3871.00
112_G118_A1.3821.00
117_L120_V1.3811.00
252_T256_F1.3781.00
47_W51_S1.3761.00
109_A173_E1.3571.00
51_S54_T1.3551.00
203_L210_I1.3471.00
172_T213_G1.3321.00
212_T216_L1.3251.00
89_L248_N1.3241.00
176_L202_T1.3041.00
67_E71_P1.3021.00
225_T229_L1.2991.00
44_W52_T1.2951.00
97_G217_A1.2901.00
232_A246_I1.2851.00
78_G81_N1.2811.00
110_E181_Y1.2761.00
187_A201_I1.2681.00
31_L35_M1.2671.00
66_T69_T1.2671.00
181_Y185_E1.2621.00
28_R32_T1.2601.00
99_P103_M1.2571.00
227_P231_T1.2521.00
58_D64_L1.2511.00
225_T254_F1.2441.00
86_S249_L1.2401.00
159_A231_T1.2311.00
30_A34_S1.2291.00
46_I50_M1.2051.00
153_G246_I1.1991.00
106_I176_L1.1881.00
52_T70_P1.1851.00
70_P273_L1.1821.00
248_N251_V1.1771.00
92_W95_V1.1721.00
182_S185_E1.1721.00
102_I210_I1.1601.00
193_P197_M1.1381.00
156_G228_L1.1161.00
256_F264_W1.1161.00
85_G88_L1.1161.00
179_V205_A1.1111.00
144_V155_A1.1051.00
120_V123_F1.1031.00
95_V99_P1.0921.00
72_P76_G1.0811.00
98_T210_I1.0721.00
256_F260_P1.0681.00
35_M39_A1.0591.00
171_T213_G1.0571.00
247_A252_T1.0521.00
207_V211_M1.0481.00
172_T209_G1.0471.00
44_W57_I1.0451.00
235_N245_P1.0311.00
184_R194_K1.0281.00
55_R58_D1.0271.00
120_V124_I1.0261.00
93_A160_L1.0261.00
83_L249_L1.0211.00
228_L248_N1.0191.00
255_K259_S1.0191.00
285_L289_V1.0181.00
154_W158_I1.0151.00
106_I198_I1.0121.00
53_I273_L1.0081.00
38_M42_L1.0001.00
106_I194_K0.9991.00
118_A177_K0.9981.00
26_K30_A0.9971.00
165_V169_I0.9951.00
109_A176_L0.9931.00
87_G91_L0.9891.00
96_F157_V0.9881.00
88_L153_G0.9881.00
205_A208_S0.9851.00
93_A97_G0.9841.00
160_L221_I0.9771.00
74_T80_A0.9741.00
92_W96_F0.9711.00
192_T197_M0.9661.00
48_I57_I0.9651.00
103_M107_Y0.9611.00
42_L46_I0.9611.00
69_T266_Q0.9561.00
224_E228_L0.9561.00
247_A251_V0.9421.00
252_T271_G0.9371.00
58_D62_L0.9301.00
48_I56_G0.9231.00
234_S246_I0.9211.00
39_A43_F0.9201.00
150_H153_G0.9171.00
126_D170_R0.9141.00
197_M200_A0.9121.00
257_A268_A0.9121.00
140_V231_T0.9091.00
79_L271_G0.9071.00
254_F258_M0.9051.00
52_T273_L0.9031.00
27_N30_A0.9031.00
88_L91_L0.9021.00
224_E227_P0.8931.00
149_E154_W0.8901.00
157_V161_A0.8881.00
72_P264_W0.8881.00
142_T146_A0.8831.00
93_A157_V0.8801.00
252_T255_K0.8781.00
91_L95_V0.8751.00
25_L28_R0.8741.00
101_G169_I0.8721.00
175_M206_S0.8711.00
95_V214_I0.8651.00
96_F99_P0.8621.00
83_L87_G0.8621.00
55_R59_G0.8581.00
88_L154_W0.8531.00
207_V210_I0.8491.00
172_T206_S0.8481.00
105_G109_A0.8411.00
229_L251_V0.8381.00
199_S203_L0.8351.00
148_M151_F0.8341.00
168_V172_T0.8271.00
206_S209_G0.8201.00
198_I203_L0.8201.00
119_E122_R0.8151.00
28_R31_L0.8151.00
107_Y113_R0.8151.00
217_A221_I0.8121.00
105_G176_L0.8081.00
34_S38_M0.8081.00
97_G101_G0.8051.00
29_I33_L0.8041.00
285_L288_V0.8041.00
159_A227_P0.7981.00
256_F271_G0.7981.00
32_T36_A0.7971.00
137_G226_A0.7971.00
197_M202_T0.7891.00
140_V159_A0.7871.00
133_S163_L0.7871.00
37_T41_G0.7801.00
108_L122_R0.7801.00
151_F234_S0.7771.00
48_I59_G0.7741.00
73_N274_I0.7741.00
141_Y145_V0.7721.00
29_I32_T0.7701.00
44_W55_R0.7701.00
198_I202_T0.7681.00
192_T200_A0.7681.00
58_D63_A0.7661.00
64_L67_E0.7651.00
97_G164_Q0.7601.00
279_V283_N0.7591.00
155_A159_A0.7581.00
82_A249_L0.7571.00
84_A87_G0.7561.00
90_I94_T0.7481.00
183_L201_I0.7471.00
108_L121_I0.7451.00
89_L160_L0.7451.00
92_W161_A0.7441.00
59_G63_A0.7421.00
27_N31_L0.7411.00
265_Q268_A0.7381.00
105_G169_I0.7331.00
256_F267_L0.7301.00
154_W157_V0.7301.00
194_K198_I0.7281.00
281_L285_L0.7201.00
137_G230_F0.7161.00
101_G172_T0.7151.00
232_A247_A0.7151.00
172_T176_L0.7141.00
126_D129_L0.7091.00
145_V150_H0.7091.00
98_T172_T0.7061.00
267_L271_G0.7051.00
89_L156_G0.7051.00
97_G168_V0.7031.00
261_F264_W0.6961.00
82_A85_G0.6921.00
163_L166_P0.6921.00
181_Y188_Y0.6911.00
179_V206_S0.6871.00
250_P275_I0.6821.00
269_W272_V0.6811.00
94_T218_I0.6811.00
104_A165_V0.6791.00
253_I271_G0.6791.00
25_L29_I0.6781.00
86_S222_A0.6771.00
52_T56_G0.6771.00
86_S250_P0.6761.00
70_P270_A0.6751.00
202_T205_A0.6751.00
235_N247_A0.6721.00
80_A83_L0.6701.00
48_I55_R0.6651.00
224_E248_N0.6641.00
48_I60_M0.6641.00
129_L166_P0.6631.00
186_A190_L0.6611.00
77_G81_N0.6581.00
133_S226_A0.6571.00
210_I213_G0.6531.00
155_A231_T0.6521.00
249_L275_I0.6501.00
108_L173_E0.6471.00
265_Q269_W0.6441.00
171_T209_G0.6361.00
228_L251_V0.6321.00
136_V162_L0.6311.00
209_G213_G0.6311.00
89_L157_V0.6291.00
122_R170_R0.6271.00
71_P74_T0.6261.00
269_W273_L0.6261.00
73_N267_L0.6251.00
94_T98_T0.6221.00
100_L161_A0.6191.00
47_W50_M0.6181.00
140_V143_I0.6181.00
156_G232_A0.6171.00
97_G221_I0.6151.00
251_V255_K0.6121.00
97_G161_A0.6101.00
48_I54_T0.6101.00
286_A289_V0.6071.00
164_Q217_A0.6041.00
65_F68_M0.6011.00
26_K29_I0.6001.00
134_I230_F0.5981.00
280_L284_I0.5961.00
210_I214_I0.5941.00
266_Q269_W0.5941.00
275_I279_V0.5901.00
197_M201_I0.5891.00
156_G160_L0.5891.00
36_A39_A0.5881.00
226_A230_F0.5871.00
186_A189_A0.5871.00
211_M214_I0.5851.00
59_G62_L0.5831.00
111_Y118_A0.5811.00
235_N246_I0.5811.00
137_G141_Y0.5781.00
164_Q220_R0.5741.00
35_M38_M0.5741.00
104_A125_N0.5731.00
142_T145_V0.5711.00
77_G80_A0.5701.00
160_L228_L0.5691.00
89_L153_G0.5661.00
36_A40_F0.5641.00
117_L121_I0.5631.00
144_V150_H0.5621.00
107_Y111_Y0.5591.00
232_A235_N0.5581.00
48_I269_W0.5551.00
251_V254_F0.5531.00
94_T221_I0.5531.00
89_L93_A0.5531.00
43_F47_W0.5521.00
105_G173_E0.5511.00
219_A223_G0.5491.00
129_L167_I0.5481.00
113_R121_I0.5471.00
100_L165_V0.5471.00
119_E123_F0.5421.00
90_I221_I0.5411.00
78_G252_T0.5391.00
106_I202_T0.5351.00
58_D61_S0.5331.00
44_W54_T0.5321.00
193_P199_S0.5321.00
67_E70_P0.5321.00
90_I222_A0.5301.00
163_L227_P0.5301.00
199_S202_T0.5281.00
104_A107_Y0.5281.00
52_T57_I0.5281.00
53_I57_I0.5261.00
73_N271_G0.5251.00
220_R223_G0.5211.00
93_A161_A0.5201.00
64_L68_M0.5201.00
185_E188_Y0.5181.00
133_S137_G0.5181.00
53_I65_F0.5181.00
150_H154_W0.5151.00
160_L224_E0.5151.00
283_N287_R0.5141.00
43_F46_I0.5141.00
98_T102_I0.5141.00
55_R60_M0.5141.00
51_S59_G0.5131.00
121_I125_N0.5111.00
88_L157_V0.5101.00
51_S58_D0.5101.00
32_T35_M0.5091.00
69_T72_P0.5081.00
253_I272_V0.5071.00
214_I217_A0.5071.00
186_A192_T0.5061.00
76_G80_A0.5061.00
31_L34_S0.5061.00
179_V184_R0.5051.00
123_F127_I0.5041.00
260_P264_W0.5031.00
78_G247_A0.5011.00
33_L37_T0.5001.00
85_G248_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.8209 100 0.3 Contact Map
3d31C 2 0.8007 100 0.322 Contact Map
4tquM 1 0.8885 100 0.336 Contact Map
4tquN 1 0.8784 100 0.368 Contact Map
3rlfG 1 0.875 100 0.371 Contact Map
3rlfF 1 0.9392 100 0.392 Contact Map
4ymuD 2 0.723 100 0.492 Contact Map
3tuiA 2 0.7095 99.9 0.511 Contact Map
2m8rA 1 0.1723 12.5 0.948 Contact Map
2kogA 1 0.1723 11.4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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