PSTA - ECOLI - GREMLIN Contacts

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PSTA - Phosphate transport system permease protein PstA

UniProt:	P07654	Sequences: MAMVEMQTTAALAESRRKMQARRRLKNRIALTLSMATMAFGLFWLIWILMSTITRGIDGMSLALFTEMTPPPNTEGGGLANALAGSGLLILWATVFGTPLGIMAGIYLAEYGRKSWLAEVIRFINDILLSAPSIVVGLFVYTIVVAQMEHFSGWAGVIALALLQVPIVIRTTENMLKLVPYSLREAAYALGTPKWKMISAITLKASVSGIMTGILLAIARIAGETAPLLFTALSNQFWSTDMMQPIANLPVTIFKFAMSPFAEWQQLAWAGVLIITLCVLLLNILARVVFAKNKHG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10782
Length:	296 (252)
Sequences:	71026 (46303)
Seq/√Len:	2916.8

ECOLI - PSTA POTH YDCU PSTC YCJO UGPA YDCV YCJP CYSW POTI MALG POTC CYST THIP UGPE POTB MALF YNJC TAUC MODB SSUC PHNE YEHY YEHW PROW METI YECS
BACSU - GANP YQGH YTEP LPLB MDXF AMYD ARAP YESQ YQGI YURM YURN GANQ YESP MDXG AMYC ARAQ LPLC YTLD SSUC YTCP OPUAB YVGM METP TCYB TCYL YXEN OPUCB OPUBD OPUCD OPUBB ARTQ
HALSA - Q9HML6 Q9HP01 Q9HS11 Q9HP02 Q9HHQ7 Q9HHQ6 Q9HMT4 Q9HR05 Q9HPK3 Q9HNI9 Q9HS12 Q9HML7
SULSO - Q97UF3 Q97YY2 Q97YY3 Q97ZT7 Q97UZ0 Q97ZC1 Q97UY9 Q97ZT6 Q97UF4 Q97Z98 Q97ZC2 Q97VC0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
196_K	200_A	4.043	1.00
44_W	48_I	3.621	1.00
84_A	88_L	3.200	1.00
173_E	177_K	3.004	1.00
188_Y	197_M	2.981	1.00
184_R	202_T	2.589	1.00
110_E	184_R	2.588	1.00
81_N	84_A	2.579	1.00
82_A	252_T	2.564	1.00
187_A	197_M	2.493	1.00
193_P	196_K	2.452	1.00
175_M	209_G	2.444	1.00
92_W	157_V	2.411	1.00
96_F	161_A	2.390	1.00
68_M	71_P	2.389	1.00
80_A	84_A	2.317	1.00
247_A	255_K	2.304	1.00
94_T	214_I	2.301	1.00
71_P	75_E	2.252	1.00
194_K	197_M	2.243	1.00
68_M	72_P	2.237	1.00
195_W	199_S	2.235	1.00
172_T	210_I	2.232	1.00
54_T	58_D	2.155	1.00
192_T	196_K	2.041	1.00
196_K	199_S	2.018	1.00
102_I	198_I	2.011	1.00
168_V	213_G	1.961	1.00
176_L	206_S	1.942	1.00
109_A	177_K	1.919	1.00
183_L	205_A	1.879	1.00
113_R	117_L	1.833	1.00
187_A	192_T	1.830	1.00
102_I	206_S	1.785	1.00
81_N	85_G	1.732	1.00
284_I	288_V	1.724	1.00
122_R	173_E	1.719	1.00
188_Y	194_K	1.718	1.00
90_I	218_I	1.701	1.00
184_R	197_M	1.700	1.00
98_T	214_I	1.698	1.00
101_G	168_V	1.656	1.00
88_L	92_W	1.614	1.00
93_A	221_I	1.611	1.00
264_W	267_L	1.600	1.00
104_A	169_I	1.584	1.00
108_L	169_I	1.560	1.00
72_P	267_L	1.559	1.00
102_I	172_T	1.555	1.00
113_R	118_A	1.538	1.00
184_R	188_Y	1.538	1.00
48_I	52_T	1.471	1.00
50_M	54_T	1.423	1.00
181_Y	184_R	1.422	1.00
51_S	55_R	1.403	1.00
105_G	172_T	1.400	1.00
234_S	245_P	1.400	1.00
168_V	217_A	1.393	1.00
72_P	75_E	1.390	1.00
56_G	70_P	1.387	1.00
112_G	118_A	1.382	1.00
117_L	120_V	1.381	1.00
252_T	256_F	1.378	1.00
47_W	51_S	1.376	1.00
109_A	173_E	1.357	1.00
51_S	54_T	1.355	1.00
203_L	210_I	1.347	1.00
172_T	213_G	1.332	1.00
212_T	216_L	1.325	1.00
89_L	248_N	1.324	1.00
176_L	202_T	1.304	1.00
67_E	71_P	1.302	1.00
225_T	229_L	1.299	1.00
44_W	52_T	1.295	1.00
97_G	217_A	1.290	1.00
232_A	246_I	1.285	1.00
78_G	81_N	1.281	1.00
110_E	181_Y	1.276	1.00
187_A	201_I	1.268	1.00
31_L	35_M	1.267	1.00
66_T	69_T	1.267	1.00
181_Y	185_E	1.262	1.00
28_R	32_T	1.260	1.00
99_P	103_M	1.257	1.00
227_P	231_T	1.252	1.00
58_D	64_L	1.251	1.00
225_T	254_F	1.244	1.00
86_S	249_L	1.240	1.00
159_A	231_T	1.231	1.00
30_A	34_S	1.229	1.00
46_I	50_M	1.205	1.00
153_G	246_I	1.199	1.00
106_I	176_L	1.188	1.00
52_T	70_P	1.185	1.00
70_P	273_L	1.182	1.00
248_N	251_V	1.177	1.00
92_W	95_V	1.172	1.00
182_S	185_E	1.172	1.00
102_I	210_I	1.160	1.00
193_P	197_M	1.138	1.00
156_G	228_L	1.116	1.00
256_F	264_W	1.116	1.00
85_G	88_L	1.116	1.00
179_V	205_A	1.111	1.00
144_V	155_A	1.105	1.00
120_V	123_F	1.103	1.00
95_V	99_P	1.092	1.00
72_P	76_G	1.081	1.00
98_T	210_I	1.072	1.00
256_F	260_P	1.068	1.00
35_M	39_A	1.059	1.00
171_T	213_G	1.057	1.00
247_A	252_T	1.052	1.00
207_V	211_M	1.048	1.00
172_T	209_G	1.047	1.00
44_W	57_I	1.045	1.00
235_N	245_P	1.031	1.00
184_R	194_K	1.028	1.00
55_R	58_D	1.027	1.00
120_V	124_I	1.026	1.00
93_A	160_L	1.026	1.00
83_L	249_L	1.021	1.00
228_L	248_N	1.019	1.00
255_K	259_S	1.019	1.00
285_L	289_V	1.018	1.00
154_W	158_I	1.015	1.00
106_I	198_I	1.012	1.00
53_I	273_L	1.008	1.00
38_M	42_L	1.000	1.00
106_I	194_K	0.999	1.00
118_A	177_K	0.998	1.00
26_K	30_A	0.997	1.00
165_V	169_I	0.995	1.00
109_A	176_L	0.993	1.00
87_G	91_L	0.989	1.00
96_F	157_V	0.988	1.00
88_L	153_G	0.988	1.00
205_A	208_S	0.985	1.00
93_A	97_G	0.984	1.00
160_L	221_I	0.977	1.00
74_T	80_A	0.974	1.00
92_W	96_F	0.971	1.00
192_T	197_M	0.966	1.00
48_I	57_I	0.965	1.00
103_M	107_Y	0.961	1.00
42_L	46_I	0.961	1.00
69_T	266_Q	0.956	1.00
224_E	228_L	0.956	1.00
247_A	251_V	0.942	1.00
252_T	271_G	0.937	1.00
58_D	62_L	0.930	1.00
48_I	56_G	0.923	1.00
234_S	246_I	0.921	1.00
39_A	43_F	0.920	1.00
150_H	153_G	0.917	1.00
126_D	170_R	0.914	1.00
197_M	200_A	0.912	1.00
257_A	268_A	0.912	1.00
140_V	231_T	0.909	1.00
79_L	271_G	0.907	1.00
254_F	258_M	0.905	1.00
52_T	273_L	0.903	1.00
27_N	30_A	0.903	1.00
88_L	91_L	0.902	1.00
224_E	227_P	0.893	1.00
149_E	154_W	0.890	1.00
157_V	161_A	0.888	1.00
72_P	264_W	0.888	1.00
142_T	146_A	0.883	1.00
93_A	157_V	0.880	1.00
252_T	255_K	0.878	1.00
91_L	95_V	0.875	1.00
25_L	28_R	0.874	1.00
101_G	169_I	0.872	1.00
175_M	206_S	0.871	1.00
95_V	214_I	0.865	1.00
96_F	99_P	0.862	1.00
83_L	87_G	0.862	1.00
55_R	59_G	0.858	1.00
88_L	154_W	0.853	1.00
207_V	210_I	0.849	1.00
172_T	206_S	0.848	1.00
105_G	109_A	0.841	1.00
229_L	251_V	0.838	1.00
199_S	203_L	0.835	1.00
148_M	151_F	0.834	1.00
168_V	172_T	0.827	1.00
206_S	209_G	0.820	1.00
198_I	203_L	0.820	1.00
119_E	122_R	0.815	1.00
28_R	31_L	0.815	1.00
107_Y	113_R	0.815	1.00
217_A	221_I	0.812	1.00
105_G	176_L	0.808	1.00
34_S	38_M	0.808	1.00
97_G	101_G	0.805	1.00
29_I	33_L	0.804	1.00
285_L	288_V	0.804	1.00
159_A	227_P	0.798	1.00
256_F	271_G	0.798	1.00
32_T	36_A	0.797	1.00
137_G	226_A	0.797	1.00
197_M	202_T	0.789	1.00
140_V	159_A	0.787	1.00
133_S	163_L	0.787	1.00
37_T	41_G	0.780	1.00
108_L	122_R	0.780	1.00
151_F	234_S	0.777	1.00
48_I	59_G	0.774	1.00
73_N	274_I	0.774	1.00
141_Y	145_V	0.772	1.00
29_I	32_T	0.770	1.00
44_W	55_R	0.770	1.00
198_I	202_T	0.768	1.00
192_T	200_A	0.768	1.00
58_D	63_A	0.766	1.00
64_L	67_E	0.765	1.00
97_G	164_Q	0.760	1.00
279_V	283_N	0.759	1.00
155_A	159_A	0.758	1.00
82_A	249_L	0.757	1.00
84_A	87_G	0.756	1.00
90_I	94_T	0.748	1.00
183_L	201_I	0.747	1.00
108_L	121_I	0.745	1.00
89_L	160_L	0.745	1.00
92_W	161_A	0.744	1.00
59_G	63_A	0.742	1.00
27_N	31_L	0.741	1.00
265_Q	268_A	0.738	1.00
105_G	169_I	0.733	1.00
256_F	267_L	0.730	1.00
154_W	157_V	0.730	1.00
194_K	198_I	0.728	1.00
281_L	285_L	0.720	1.00
137_G	230_F	0.716	1.00
101_G	172_T	0.715	1.00
232_A	247_A	0.715	1.00
172_T	176_L	0.714	1.00
126_D	129_L	0.709	1.00
145_V	150_H	0.709	1.00
98_T	172_T	0.706	1.00
267_L	271_G	0.705	1.00
89_L	156_G	0.705	1.00
97_G	168_V	0.703	1.00
261_F	264_W	0.696	1.00
82_A	85_G	0.692	1.00
163_L	166_P	0.692	1.00
181_Y	188_Y	0.691	1.00
179_V	206_S	0.687	1.00
250_P	275_I	0.682	1.00
269_W	272_V	0.681	1.00
94_T	218_I	0.681	1.00
104_A	165_V	0.679	1.00
253_I	271_G	0.679	1.00
25_L	29_I	0.678	1.00
86_S	222_A	0.677	1.00
52_T	56_G	0.677	1.00
86_S	250_P	0.676	1.00
70_P	270_A	0.675	1.00
202_T	205_A	0.675	1.00
235_N	247_A	0.672	1.00
80_A	83_L	0.670	1.00
48_I	55_R	0.665	1.00
224_E	248_N	0.664	1.00
48_I	60_M	0.664	1.00
129_L	166_P	0.663	1.00
186_A	190_L	0.661	1.00
77_G	81_N	0.658	1.00
133_S	226_A	0.657	1.00
210_I	213_G	0.653	1.00
155_A	231_T	0.652	1.00
249_L	275_I	0.650	1.00
108_L	173_E	0.647	1.00
265_Q	269_W	0.644	1.00
171_T	209_G	0.636	1.00
228_L	251_V	0.632	1.00
136_V	162_L	0.631	1.00
209_G	213_G	0.631	1.00
89_L	157_V	0.629	1.00
122_R	170_R	0.627	1.00
71_P	74_T	0.626	1.00
269_W	273_L	0.626	1.00
73_N	267_L	0.625	1.00
94_T	98_T	0.622	1.00
100_L	161_A	0.619	1.00
47_W	50_M	0.618	1.00
140_V	143_I	0.618	1.00
156_G	232_A	0.617	1.00
97_G	221_I	0.615	1.00
251_V	255_K	0.612	1.00
97_G	161_A	0.610	1.00
48_I	54_T	0.610	1.00
286_A	289_V	0.607	1.00
164_Q	217_A	0.604	1.00
65_F	68_M	0.601	1.00
26_K	29_I	0.600	1.00
134_I	230_F	0.598	1.00
280_L	284_I	0.596	1.00
210_I	214_I	0.594	1.00
266_Q	269_W	0.594	1.00
275_I	279_V	0.590	1.00
197_M	201_I	0.589	1.00
156_G	160_L	0.589	1.00
36_A	39_A	0.588	1.00
226_A	230_F	0.587	1.00
186_A	189_A	0.587	1.00
211_M	214_I	0.585	1.00
59_G	62_L	0.583	1.00
111_Y	118_A	0.581	1.00
235_N	246_I	0.581	1.00
137_G	141_Y	0.578	1.00
164_Q	220_R	0.574	1.00
35_M	38_M	0.574	1.00
104_A	125_N	0.573	1.00
142_T	145_V	0.571	1.00
77_G	80_A	0.570	1.00
160_L	228_L	0.569	1.00
89_L	153_G	0.566	1.00
36_A	40_F	0.564	1.00
117_L	121_I	0.563	1.00
144_V	150_H	0.562	1.00
107_Y	111_Y	0.559	1.00
232_A	235_N	0.558	1.00
48_I	269_W	0.555	1.00
251_V	254_F	0.553	1.00
94_T	221_I	0.553	1.00
89_L	93_A	0.553	1.00
43_F	47_W	0.552	1.00
105_G	173_E	0.551	1.00
219_A	223_G	0.549	1.00
129_L	167_I	0.548	1.00
113_R	121_I	0.547	1.00
100_L	165_V	0.547	1.00
119_E	123_F	0.542	1.00
90_I	221_I	0.541	1.00
78_G	252_T	0.539	1.00
106_I	202_T	0.535	1.00
58_D	61_S	0.533	1.00
44_W	54_T	0.532	1.00
193_P	199_S	0.532	1.00
67_E	70_P	0.532	1.00
90_I	222_A	0.530	1.00
163_L	227_P	0.530	1.00
199_S	202_T	0.528	1.00
104_A	107_Y	0.528	1.00
52_T	57_I	0.528	1.00
53_I	57_I	0.526	1.00
73_N	271_G	0.525	1.00
220_R	223_G	0.521	1.00
93_A	161_A	0.520	1.00
64_L	68_M	0.520	1.00
185_E	188_Y	0.518	1.00
133_S	137_G	0.518	1.00
53_I	65_F	0.518	1.00
150_H	154_W	0.515	1.00
160_L	224_E	0.515	1.00
283_N	287_R	0.514	1.00
43_F	46_I	0.514	1.00
98_T	102_I	0.514	1.00
55_R	60_M	0.514	1.00
51_S	59_G	0.513	1.00
121_I	125_N	0.511	1.00
88_L	157_V	0.510	1.00
51_S	58_D	0.510	1.00
32_T	35_M	0.509	1.00
69_T	72_P	0.508	1.00
253_I	272_V	0.507	1.00
214_I	217_A	0.507	1.00
186_A	192_T	0.506	1.00
76_G	80_A	0.506	1.00
31_L	34_S	0.506	1.00
179_V	184_R	0.505	1.00
123_F	127_I	0.504	1.00
260_P	264_W	0.503	1.00
78_G	247_A	0.501	1.00
33_L	37_T	0.500	1.00
85_G	248_N	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.8209	100	0.3	Contact Map
3d31C	2	0.8007	100	0.322	Contact Map
4tquM	1	0.8885	100	0.336	Contact Map
4tquN	1	0.8784	100	0.368	Contact Map
3rlfG	1	0.875	100	0.371	Contact Map
3rlfF	1	0.9392	100	0.392	Contact Map
4ymuD	2	0.723	100	0.492	Contact Map
3tuiA	2	0.7095	99.9	0.511	Contact Map
2m8rA	1	0.1723	12.5	0.948	Contact Map
2kogA	1	0.1723	11.4	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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