GREMLIN Database
TYPH - Thymidine phosphorylase
UniProt: P07650 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10219
Length: 440 (422)
Sequences: 2204 (1409)
Seq/√Len: 68.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_L46_I4.8421.00
16_A52_T4.2951.00
218_E436_R3.8151.00
14_G49_H3.7031.00
386_M401_V3.5141.00
10_K21_E3.3801.00
25_F39_I3.3521.00
19_D58_S3.3171.00
134_D141_R3.2701.00
312_V315_R3.2571.00
144_E148_D3.1021.00
104_A303_V2.8971.00
348_E394_D2.8551.00
54_P58_S2.8251.00
213_T216_L2.8101.00
352_S424_A2.7551.00
16_A54_P2.6891.00
387_A397_R2.6101.00
205_V239_L2.6001.00
105_C303_V2.5881.00
346_D418_K2.5551.00
250_A359_L2.4511.00
303_V306_N2.4381.00
302_A306_N2.4211.00
249_S384_T2.3871.00
68_T159_S2.2971.00
95_S153_I2.2941.00
138_D141_R2.2691.00
101_M300_L2.2311.00
348_E395_G2.2301.00
347_T425_D2.1971.00
359_L417_V2.1571.00
212_P357_R2.1311.00
53_M226_G2.1241.00
280_C300_L2.1181.00
222_E226_G2.1031.00
124_L135_I2.1011.00
261_Q266_E2.0971.00
145_I149_V2.0951.00
7_I25_F2.0931.00
25_F42_L2.0841.00
290_A296_A2.0511.00
281_V296_A2.0411.00
57_V230_G2.0301.00
344_Y398_P2.0211.00
355_D358_A2.0211.00
216_L219_A2.0081.00
19_D54_P1.9811.00
277_M300_L1.9561.00
342_A401_V1.9491.00
64_R192_L1.9391.00
372_Q375_D1.9381.00
102_V283_M1.9301.00
149_V319_A1.9201.00
363_V368_G1.8971.00
19_D23_R1.8971.00
107_G289_L1.8951.00
262_F273_F1.8841.00
27_N31_D1.8841.00
10_K15_H1.8781.00
141_R144_E1.8591.00
343_V417_V1.8491.00
7_I42_L1.8461.00
301_Q305_D1.8271.00
96_L256_V1.7991.00
371_R375_D1.7611.00
78_N147_K1.7491.00
378_D405_K1.7461.00
29_I39_I1.7351.00
351_V354_M1.7191.00
205_V217_S1.6931.00
65_D69_V1.6630.99
28_G33_T1.6580.99
254_V384_T1.6540.99
340_T401_V1.6380.99
97_M272_L1.6270.99
228_A235_T1.6230.99
13_D47_F1.6130.99
303_V308_K1.6130.99
354_M421_I1.5940.99
302_A308_K1.5890.99
297_R301_Q1.5870.99
57_V231_A1.5840.99
64_R69_V1.5810.99
130_I317_V1.5430.99
406_D409_N1.5130.99
350_F427_A1.5130.99
101_M280_C1.5120.99
9_R13_D1.4910.99
82_V198_A1.4910.99
101_M303_V1.4830.99
273_F305_D1.4700.99
94_T272_L1.4690.99
184_T223_A1.4590.99
105_C284_L1.4590.99
145_I319_A1.4540.99
311_E315_R1.4520.99
201_M224_I1.4480.98
256_V259_A1.4280.98
137_P145_I1.4270.98
192_L231_A1.4230.98
381_V404_A1.4170.98
273_F301_Q1.4130.98
394_D397_R1.4110.98
341_K414_A1.3960.98
414_A418_K1.3960.98
254_V403_H1.3930.98
264_T310_A1.3900.98
43_A167_F1.3890.98
384_T403_H1.3880.98
338_M405_K1.3530.98
93_V247_A1.3510.98
98_L280_C1.3470.98
56_R223_A1.3430.97
343_V400_A1.3400.97
142_F152_A1.3310.97
353_E422_K1.3260.97
271_R388_R1.3250.97
383_F400_A1.3180.97
213_T217_S1.3160.97
342_A398_P1.3150.97
318_A324_T1.3130.97
9_R175_A1.3120.97
289_L299_K1.3050.97
229_N235_T1.3040.97
23_R65_D1.2960.97
214_Y218_E1.2940.97
248_S391_D1.2850.97
388_R391_D1.2800.97
350_F428_P1.2770.97
128_E135_I1.2750.97
268_R271_R1.2630.96
400_A417_V1.2610.96
97_M262_F1.2580.96
296_A300_L1.2580.96
93_V258_E1.2580.96
291_K295_E1.2570.96
51_M181_P1.2560.96
61_M64_R1.2530.96
7_I39_I1.2520.96
56_R181_P1.2500.96
257_R261_Q1.2500.96
184_T227_V1.2450.96
358_A416_A1.2440.96
23_R58_S1.2320.96
99_G151_V1.2270.96
23_R27_N1.2270.96
380_S405_K1.2200.96
79_G108_Y1.2140.95
9_R178_D1.2070.95
39_I167_F1.2020.95
109_I283_M1.1990.95
218_E222_E1.1960.95
74_S143_R1.1940.95
188_L228_A1.1870.95
284_L296_A1.1740.95
336_T380_S1.1710.94
381_V402_I1.1680.94
81_I197_D1.1550.94
308_K311_E1.1510.94
310_A314_G1.1500.94
298_A301_Q1.1490.94
77_L81_I1.1490.94
336_T403_H1.1470.94
253_A257_R1.1460.94
17_L42_L1.1450.94
335_P380_S1.1390.94
53_M230_G1.1340.93
274_D297_R1.1330.93
207_S355_D1.1260.93
63_M189_A1.1240.93
262_F268_R1.1210.93
250_A385_D1.1160.93
340_T403_H1.1120.93
359_L383_F1.1080.93
205_V435_Y1.1010.92
146_I152_A1.0970.92
198_A234_R1.0940.92
350_F392_Q1.0930.92
23_R62_A1.0850.92
428_P431_T1.0740.91
61_M65_D1.0690.91
229_N234_R1.0680.91
260_V326_F1.0640.91
378_D406_D1.0590.91
254_V337_A1.0580.91
362_A417_V1.0560.91
95_S111_M1.0550.91
4_A25_F1.0500.91
13_D178_D1.0460.90
277_M297_R1.0440.90
175_A178_D1.0380.90
50_D181_P1.0370.90
61_M231_A1.0340.90
241_D431_T1.0260.89
19_D61_M1.0220.89
415_K419_A1.0210.89
384_T401_V1.0170.89
362_A413_A1.0130.89
339_L404_A1.0110.89
101_M309_A1.0100.89
225_V237_A1.0090.89
101_M104_A1.0050.88
133_F320_Q1.0040.88
28_G31_D1.0030.88
68_T139_D0.9980.88
94_T276_T0.9980.88
236_T286_S0.9920.88
236_T282_E0.9900.88
141_R145_I0.9860.88
82_V287_G0.9850.87
358_A420_A0.9850.87
317_V326_F0.9840.87
411_Q414_A0.9820.87
207_S243_N0.9800.87
94_T275_V0.9800.87
238_L278_A0.9740.87
18_S21_E0.9710.87
339_L407_E0.9690.87
131_P323_P0.9630.86
345_A348_E0.9610.86
249_S254_V0.9590.86
290_A299_K0.9570.86
365_A416_A0.9550.86
196_L199_L0.9540.86
341_K411_Q0.9530.86
347_T423_L0.9520.86
234_R288_K0.9510.86
102_V287_G0.9500.85
131_P326_F0.9480.85
110_P199_L0.9450.85
431_T435_Y0.9430.85
273_F277_M0.9410.85
285_I290_A0.9390.85
153_I316_M0.9360.85
111_M199_L0.9330.84
326_F334_L0.9330.84
11_K55_E0.9320.84
36_E373_A0.9320.84
151_V316_M0.9300.84
386_M398_P0.9280.84
72_W81_I0.9280.84
50_D56_R0.9230.84
205_V214_Y0.9230.84
124_L199_L0.9170.83
281_V300_L0.9140.83
238_L282_E0.9130.83
253_A335_P0.9130.83
25_F46_I0.9080.83
346_D395_G0.9080.83
98_L276_T0.9080.83
317_V322_G0.9060.83
264_T307_G0.9060.83
410_W413_A0.9010.82
82_V107_G0.9000.82
346_D397_R0.9000.82
199_L233_V0.9000.82
207_S353_E0.8960.82
94_T279_L0.8950.82
198_A286_S0.8930.82
310_A324_T0.8900.82
281_V293_D0.8900.82
64_R231_A0.8890.81
244_Q389_L0.8880.81
257_R384_T0.8880.81
105_C299_K0.8860.81
112_I196_L0.8850.81
365_A371_R0.8850.81
240_T275_V0.8790.81
214_Y435_Y0.8770.81
26_I163_A0.8750.80
243_N353_E0.8710.80
337_A380_S0.8700.80
347_T395_G0.8690.80
96_L100_P0.8630.80
108_Y150_G0.8590.79
17_L22_I0.8590.79
247_A258_E0.8550.79
80_P198_A0.8540.79
241_D244_Q0.8520.79
253_A380_S0.8520.79
50_D179_S0.8500.78
12_R178_D0.8490.78
124_L133_F0.8470.78
99_G316_M0.8440.78
287_G290_A0.8370.77
341_K407_E0.8370.77
361_M365_A0.8330.77
79_G197_D0.8300.77
39_I42_L0.8250.76
5_Q175_A0.8240.76
112_I156_Q0.8240.76
107_G284_L0.8220.76
188_L227_V0.8220.76
424_A428_P0.8210.76
22_I26_I0.8190.76
278_A282_E0.8120.75
375_D379_Y0.8100.75
299_K303_V0.8100.75
214_Y217_S0.8100.75
392_Q427_A0.8080.75
269_N274_D0.8060.75
204_K275_V0.8030.74
188_L201_M0.8020.74
364_V371_R0.8000.74
273_F304_L0.7970.74
262_F267_Y0.7940.74
149_V315_R0.7930.73
262_F272_L0.7930.73
58_S61_M0.7920.73
136_F157_T0.7920.73
68_T158_S0.7880.73
285_I296_A0.7870.73
22_I62_A0.7860.73
11_K51_M0.7840.73
78_N81_I0.7820.72
278_A297_R0.7800.72
250_A363_V0.7800.72
102_V280_C0.7790.72
124_L316_M0.7770.72
214_Y436_R0.7760.72
140_N144_E0.7740.72
345_A396_Q0.7740.72
107_G287_G0.7700.71
26_I30_R0.7700.71
351_V421_I0.7690.71
337_A403_H0.7680.71
253_A334_L0.7640.71
4_A7_I0.7640.71
276_T280_C0.7600.70
9_R12_R0.7590.70
290_A295_E0.7590.70
93_V388_R0.7580.70
183_I211_M0.7570.70
4_A35_S0.7570.70
177_V181_P0.7560.70
98_L279_L0.7540.70
352_S428_P0.7530.70
56_R59_L0.7520.69
351_V389_L0.7500.69
308_K312_V0.7480.69
32_N166_R0.7470.69
348_E422_K0.7470.69
341_K410_W0.7470.69
198_A287_G0.7460.69
151_V154_I0.7450.69
350_F424_A0.7440.69
110_P276_T0.7430.69
249_S257_R0.7430.69
215_E218_E0.7430.69
111_M196_L0.7410.68
221_A237_A0.7410.68
368_G381_V0.7400.68
4_A34_I0.7390.68
24_F28_G0.7380.68
129_S379_Y0.7380.68
93_V249_S0.7330.68
412_E415_K0.7310.67
409_N413_A0.7260.67
387_A391_D0.7240.67
46_I59_L0.7230.66
97_M276_T0.7220.66
41_A175_A0.7200.66
229_N232_G0.7200.66
29_I170_T0.7180.66
101_M304_L0.7180.66
257_R334_L0.7180.66
274_D278_A0.7140.65
336_T340_T0.7130.65
343_V418_K0.7120.65
97_M259_A0.7120.65
53_M219_A0.7120.65
12_R47_F0.7110.65
184_T188_L0.7090.65
212_P216_L0.7080.65
281_V285_I0.7080.65
74_S147_K0.7080.65
311_E314_G0.7070.65
101_M296_A0.7040.64
344_Y418_K0.7010.64
103_A312_V0.6980.64
22_I51_M0.6970.64
417_V421_I0.6940.63
389_L431_T0.6940.63
380_S403_H0.6940.63
281_V297_R0.6900.63
99_G153_I0.6880.63
323_P326_F0.6880.63
30_R62_A0.6880.63
387_A393_V0.6870.62
47_F178_D0.6860.62
282_E293_D0.6840.62
277_M301_Q0.6840.62
218_E239_L0.6820.62
48_F56_R0.6820.62
111_M124_L0.6820.62
295_E298_A0.6810.62
95_S187_I0.6790.62
345_A423_L0.6790.62
72_W142_F0.6790.62
203_V237_A0.6780.61
398_P401_V0.6780.61
238_L279_L0.6770.61
392_Q423_L0.6770.61
178_D181_P0.6770.61
278_A281_V0.6750.61
249_S258_E0.6750.61
102_V107_G0.6740.61
250_A383_F0.6740.61
30_R163_A0.6730.61
240_T278_A0.6710.61
342_A386_M0.6700.61
269_N273_F0.6690.60
293_D296_A0.6670.60
344_Y397_R0.6670.60
104_A306_N0.6660.60
201_M235_T0.6650.60
37_G40_A0.6640.60
7_I24_F0.6630.60
344_Y395_G0.6610.60
97_M101_M0.6600.59
69_V233_V0.6600.59
112_I224_I0.6590.59
64_R233_V0.6560.59
402_I417_V0.6540.59
180_I219_A0.6530.59
178_D182_L0.6530.59
243_N435_Y0.6530.59
214_Y239_L0.6520.58
277_M281_V0.6520.58
358_A419_A0.6510.58
143_R147_K0.6510.58
314_G324_T0.6490.58
295_E299_K0.6490.58
137_P320_Q0.6490.58
349_G423_L0.6480.58
158_S165_K0.6480.58
110_P146_I0.6480.58
344_Y396_Q0.6470.58
29_I166_R0.6440.58
35_S40_A0.6430.57
146_I195_G0.6420.57
245_V249_S0.6410.57
129_S336_T0.6410.57
257_R403_H0.6400.57
110_P316_M0.6400.57
39_I170_T0.6400.57
146_I160_L0.6400.57
400_A421_I0.6380.57
40_A43_A0.6370.57
104_A312_V0.6360.57
302_A305_D0.6350.56
46_I51_M0.6340.56
26_I235_T0.6330.56
146_I194_E0.6330.56
385_D388_R0.6310.56
354_M389_L0.6310.56
339_L410_W0.6300.56
53_M223_A0.6300.56
248_S384_T0.6280.56
404_A410_W0.6280.56
137_P141_R0.6270.56
240_T433_T0.6260.55
355_D420_A0.6240.55
112_I199_L0.6230.55
38_Q44_M0.6230.55
28_G34_I0.6210.55
57_V61_M0.6190.55
212_P217_S0.6180.54
432_P435_Y0.6130.54
70_L368_G0.6090.53
275_V433_T0.6080.53
10_K18_S0.6080.53
161_A409_N0.6060.53
156_Q160_L0.6050.53
54_P230_G0.6050.53
74_S78_N0.6040.53
7_I17_L0.6020.53
20_E24_F0.6010.52
134_D137_P0.6010.52
110_P233_V0.6000.52
99_G217_S0.6000.52
69_V161_A0.5990.52
30_R166_R0.5980.52
338_M407_E0.5970.52
105_C316_M0.5970.52
59_L185_A0.5960.52
372_Q376_T0.5960.52
112_I154_I0.5960.52
26_I29_I0.5920.51
241_D435_Y0.5920.51
402_I410_W0.5920.51
30_R161_A0.5920.51
262_F271_R0.5900.51
298_A302_A0.5900.51
90_V119_H0.5890.51
53_M57_V0.5880.51
5_Q9_R0.5870.51
151_V156_Q0.5870.51
243_N389_L0.5870.51
124_L155_G0.5860.51
4_A24_F0.5860.51
244_Q431_T0.5860.51
357_R361_M0.5850.51
113_S124_L0.5850.51
248_S386_M0.5840.50
267_Y271_R0.5830.50
359_L413_A0.5830.50
77_L147_K0.5830.50
280_C283_M0.5830.50
393_V399_L0.5820.50
257_R336_T0.5820.50
285_I300_L0.5820.50
243_N431_T0.5810.50
281_V290_A0.5790.50
261_Q264_T0.5790.50
79_G107_G0.5770.50
277_M304_L0.5750.49
137_P154_I0.5720.49
20_E23_R0.5710.49
5_Q371_R0.5710.49
73_K81_I0.5710.49
126_K182_L0.5710.49
72_W196_L0.5710.49
105_C300_L0.5690.49
110_P194_E0.5670.48
253_A296_A0.5670.48
194_E199_L0.5650.48
394_D423_L0.5650.48
95_S368_G0.5640.48
313_F317_V0.5640.48
26_I167_F0.5620.48
385_D391_D0.5620.48
404_A409_N0.5610.48
149_V312_V0.5610.48
260_V310_A0.5600.48
35_S48_F0.5580.47
101_M277_M0.5580.47
244_Q381_V0.5580.47
352_S422_K0.5570.47
414_A417_V0.5560.47
14_G48_F0.5550.47
157_T243_N0.5540.47
263_L309_A0.5530.47
267_Y273_F0.5530.47
29_I33_T0.5510.46
77_L108_Y0.5510.46
98_L300_L0.5510.46
179_S185_A0.5500.46
347_T392_Q0.5490.46
422_K427_A0.5480.46
6_E361_M0.5470.46
4_A43_A0.5460.46
200_V284_L0.5460.46
175_A313_F0.5460.46
8_I51_M0.5460.46
127_L256_V0.5450.46
93_V271_R0.5450.46
348_E392_Q0.5450.46
119_H204_K0.5450.46
365_A412_E0.5450.46
111_M194_E0.5450.46
47_F175_A0.5440.46
257_R335_P0.5420.45
341_K404_A0.5410.45
78_N150_G0.5400.45
419_A432_P0.5390.45
16_A19_D0.5380.45
78_N108_Y0.5380.45
402_I414_A0.5370.45
161_A231_A0.5370.45
219_A223_A0.5360.45
248_S269_N0.5350.45
97_M313_F0.5340.44
111_M373_A0.5330.44
144_E392_Q0.5330.44
36_E40_A0.5320.44
133_F316_M0.5320.44
111_M259_A0.5310.44
385_D400_A0.5300.44
97_M267_Y0.5300.44
293_D297_R0.5300.44
159_S165_K0.5280.44
93_V259_A0.5280.44
72_W227_V0.5280.44
106_G289_L0.5260.43
217_S222_E0.5250.43
392_Q411_Q0.5240.43
63_M164_D0.5230.43
70_L157_T0.5230.43
207_S357_R0.5230.43
152_A156_Q0.5230.43
104_A308_K0.5220.43
22_I274_D0.5200.43
115_R128_E0.5200.43
111_M224_I0.5190.43
153_I368_G0.5190.43
407_E411_Q0.5180.43
148_D315_R0.5180.43
149_V316_M0.5170.42
63_M167_F0.5170.42
399_L421_I0.5170.42
179_S182_L0.5170.42
427_A430_S0.5150.42
124_L157_T0.5140.42
254_V336_T0.5130.42
211_M217_S0.5120.42
226_G230_G0.5120.42
196_L233_V0.5120.42
304_L422_K0.5110.42
53_M181_P0.5100.42
4_A372_Q0.5080.41
38_Q41_A0.5070.41
144_E147_K0.5070.41
279_L286_S0.5060.41
98_L101_M0.5060.41
116_G173_I0.5050.41
387_A421_I0.5040.41
154_I194_E0.5040.41
129_S253_A0.5040.41
315_R318_A0.5040.41
80_P288_K0.5040.41
170_T373_A0.5040.41
4_A194_E0.5030.41
205_V216_L0.5030.41
135_I396_Q0.5020.41
78_N131_P0.5020.41
68_T397_R0.5020.41
97_M268_R0.5010.41
351_V430_S0.5010.41
72_W77_L0.5010.41
392_Q425_D0.5010.41
406_D410_W0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1brwA 2 0.9841 100 0.277 Contact Map
3h5qA 2 0.9864 100 0.279 Contact Map
4eadA 2 0.9977 100 0.28 Contact Map
2dsjA 2 0.9614 100 0.293 Contact Map
1uouA 2 0.9727 100 0.299 Contact Map
4ga6A 2 0.9227 100 0.393 Contact Map
1vquA 2 0.6818 100 0.613 Contact Map
2elcA 4 0.675 100 0.622 Contact Map
4giuA 2 0.6795 100 0.624 Contact Map
1khdA 2 0.6636 100 0.626 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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