GREMLIN Database
AROB - 3-dehydroquinate synthase
UniProt: P07639 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10074
Length: 362 (346)
Sequences: 4470 (3140)
Seq/√Len: 168.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_E292_R4.4411.00
336_L340_K3.1991.00
123_R161_A3.1301.00
85_F117_S3.0371.00
232_A239_L2.9751.00
79_A82_D2.9321.00
176_R266_E2.8251.00
116_A156_A2.7941.00
99_L111_T2.7721.00
245_L272_M2.6491.00
256_E318_H2.4561.00
282_L351_L2.4291.00
286_S289_E2.4091.00
81_L114_A2.3561.00
281_R354_N2.3371.00
174_P177_E2.2591.00
336_L342_E2.2341.00
348_S351_L2.1981.00
188_Y222_C2.1981.00
88_L99_L2.1961.00
280_E290_T2.1731.00
193_D221_R2.1651.00
279_S335_P2.1651.00
46_A50_L2.1491.00
113_F117_S2.1301.00
313_Q353_L2.1241.00
42_N71_D2.1101.00
88_L93_H2.0951.00
108_G137_S2.0651.00
239_L242_L2.0541.00
221_R224_E2.0351.00
220_R224_E2.0321.00
224_E228_E2.0081.00
50_L66_S2.0061.00
65_D91_K1.9881.00
44_T71_D1.9811.00
186_I300_A1.9461.00
78_L145_V1.9221.00
175_P179_A1.8781.00
93_H97_T1.8781.00
67_V87_A1.8731.00
228_E232_A1.8581.00
38_M88_L1.8311.00
147_H154_I1.8291.00
192_L225_L1.8181.00
150_G153_M1.8141.00
87_A91_K1.7991.00
190_I293_I1.7941.00
276_A293_I1.7901.00
190_I335_P1.7901.00
86_T149_L1.7771.00
40_V111_T1.7761.00
46_A68_I1.7521.00
242_L341_S1.7331.00
81_L85_F1.7321.00
285_F289_E1.7271.00
23_N52_K1.7251.00
15_I223_C1.7031.00
81_L117_S1.6871.00
175_P210_L1.6801.00
277_R294_I1.6791.00
262_W270_A1.6591.00
96_D326_L1.6571.00
337_A340_K1.6501.00
38_M93_H1.6431.00
192_L228_E1.6231.00
194_G198_N1.6211.00
203_N206_A1.6191.00
229_V242_L1.6191.00
69_L107_V1.6111.00
311_S314_A1.5921.00
101_A111_T1.5831.00
36_Q63_N1.5661.00
159_Q234_E1.5461.00
280_E287_S1.5461.00
51_D55_G1.5291.00
272_M297_L1.5231.00
249_F274_M1.4901.00
195_A198_N1.4751.00
335_P341_S1.4671.00
287_S291_Q1.4581.00
78_L82_D1.4581.00
81_L144_A1.4531.00
139_V223_C1.4451.00
273_V294_I1.4351.00
197_F338_I1.4331.00
199_W218_C1.4291.00
80_V83_T1.4231.00
269_A297_L1.4221.00
41_T46_A1.4161.00
43_E70_P1.4141.00
87_A90_Q1.4111.00
205_D299_R1.4101.00
54_R66_S1.4091.00
24_E27_S1.4061.00
135_V185_V1.3771.00
86_T90_Q1.3701.00
320_L349_H1.3651.00
204_L300_A1.3471.00
180_S263_L1.3461.00
20_G168_D1.3431.00
278_T332_L1.3401.00
69_L75_Y1.3351.00
84_V110_L1.3331.00
38_M87_A1.3161.00
191_I245_L1.3101.00
19_S168_D1.2961.00
316_L353_L1.2941.00
314_A317_P1.2931.00
188_Y225_L1.2921.00
255_A318_H1.2901.00
334_L344_R1.2881.00
84_V114_A1.2871.00
108_G126_Q1.2871.00
190_I197_F1.2831.00
289_E337_A1.2821.00
38_M67_V1.2741.00
199_W203_N1.2581.00
217_Y221_R1.2561.00
81_L145_V1.2541.00
167_L219_I1.2461.00
40_V114_A1.2341.00
171_K212_G1.2321.00
37_V98_T1.2321.00
81_L110_L1.2251.00
316_L320_L1.2241.00
97_T122_V1.2221.00
67_V84_V1.2151.00
134_Q170_L1.2021.00
51_D54_R1.1931.00
86_T147_H1.1871.00
92_P321_R1.1861.00
256_E314_A1.1791.00
37_V100_V1.1771.00
349_H353_L1.1741.00
289_E338_I1.1741.00
116_A158_Y1.1721.00
312_A353_L1.1641.00
331_R345_S1.1641.00
130_T133_S1.1611.00
43_E71_D1.1601.00
40_V99_L1.1551.00
182_L185_V1.1521.00
329_E345_S1.1471.00
214_A217_Y1.1451.00
227_A231_A1.1361.00
18_A167_L1.1301.00
177_E263_L1.1241.00
291_Q295_T1.1161.00
196_F199_W1.1071.00
199_W217_Y1.1021.00
245_L293_I1.1011.00
207_L218_C1.0941.00
278_T355_A1.0911.00
75_Y80_V1.0881.00
197_F292_R1.0801.00
294_I298_K1.0731.00
25_P53_V1.0721.00
165_V223_C1.0711.00
117_S156_A1.0691.00
34_G123_R1.0681.00
263_L266_E1.0671.00
94_G97_T1.0661.00
196_F218_C1.0590.99
245_L276_A1.0580.99
41_T107_V1.0580.99
46_A66_S1.0550.99
43_E47_P1.0520.99
124_F158_Y1.0490.99
277_R280_E1.0480.99
250_G267_A1.0450.99
275_A333_I1.0430.99
177_E180_S1.0430.99
249_F275_A1.0400.99
167_L216_A1.0380.99
273_V297_L1.0310.99
26_A56_V1.0300.99
16_T162_S1.0300.99
26_A29_L1.0240.99
14_P162_S1.0140.99
99_L122_V1.0100.99
54_R58_E1.0080.99
53_V102_L1.0010.99
206_A214_A0.9970.99
69_L110_L0.9920.99
185_V200_L0.9900.99
69_L80_V0.9890.99
241_A331_R0.9800.99
333_I343_V0.9800.99
306_G315_Y0.9760.99
39_L54_R0.9750.99
284_Q342_E0.9730.99
78_L81_L0.9720.99
41_T45_L0.9700.99
168_D171_K0.9690.99
270_A273_V0.9680.99
280_E288_A0.9680.99
269_A302_L0.9650.99
204_L299_R0.9640.99
75_Y106_V0.9640.99
228_E231_A0.9630.99
90_Q149_L0.9600.99
86_T148_P0.9600.99
36_Q97_T0.9580.99
42_N75_Y0.9580.99
83_T87_A0.9550.99
18_A24_E0.9550.99
198_N202_E0.9520.99
353_L357_A0.9490.99
41_T68_I0.9470.99
312_A357_A0.9450.99
178_L210_L0.9450.99
100_V127_V0.9370.99
70_P80_V0.9330.99
276_A285_F0.9320.99
38_M65_D0.9310.99
279_S285_F0.9310.99
316_L349_H0.9240.99
75_Y107_V0.9240.99
78_L85_F0.9230.99
20_G23_N0.9220.99
179_A301_G0.9170.99
98_T123_R0.9160.99
9_G12_S0.9140.98
277_R281_R0.9120.98
277_R355_A0.9090.98
250_G268_V0.9050.98
89_L147_H0.9040.98
65_D93_H0.9030.98
211_D214_A0.8990.98
236_E241_A0.8970.98
158_Y235_R0.8920.98
18_A21_L0.8840.98
329_E346_G0.8770.98
194_G337_A0.8770.98
192_L239_L0.8750.98
298_K304_V0.8730.98
54_R64_V0.8690.98
194_G338_I0.8690.98
102_L169_C0.8610.98
351_L354_N0.8610.98
25_P164_V0.8610.98
186_I297_L0.8580.98
39_L50_L0.8580.98
224_E227_A0.8500.98
50_L54_R0.8490.98
281_R351_L0.8480.98
188_Y196_F0.8470.98
257_M262_W0.8470.98
101_A126_Q0.8420.97
143_T156_A0.8380.97
279_S334_L0.8380.97
40_V84_V0.8380.97
288_A291_Q0.8320.97
19_S171_K0.8310.97
55_G58_E0.8280.97
191_I242_L0.8250.97
201_E295_T0.8220.97
44_T75_Y0.8210.97
279_S284_Q0.8180.97
99_L115_A0.8150.97
165_V219_I0.8140.97
49_Y102_L0.8040.97
282_L348_S0.8030.97
146_N177_E0.8020.97
94_G325_V0.8020.97
278_T351_L0.7990.96
131_L178_L0.7980.96
200_L296_L0.7980.96
17_I220_R0.7970.96
42_N45_L0.7960.96
189_G196_F0.7940.96
35_E94_G0.7870.96
206_A211_D0.7830.96
217_Y224_E0.7800.96
350_E354_N0.7780.96
82_D86_T0.7750.96
332_L347_V0.7750.96
41_T50_L0.7740.96
22_F169_C0.7730.96
190_I245_L0.7720.96
102_L127_V0.7710.96
198_N201_E0.7700.96
192_L229_V0.7680.96
179_A208_L0.7660.96
49_Y172_T0.7630.95
71_D75_Y0.7620.95
67_V83_T0.7560.95
275_A279_S0.7560.95
216_A220_R0.7550.95
290_T294_I0.7520.95
178_L215_M0.7500.95
134_Q165_V0.7490.95
77_S80_V0.7470.95
294_I305_N0.7470.95
158_Y161_A0.7470.95
139_V227_A0.7470.95
106_V146_N0.7440.95
94_G328_G0.7420.95
182_L300_A0.7390.95
119_Q153_M0.7380.95
186_I296_L0.7370.94
176_R263_L0.7360.94
183_A269_A0.7340.94
128_P133_S0.7300.94
89_L118_Y0.7300.94
44_T130_T0.7280.94
277_R290_T0.7280.94
39_L64_V0.7280.94
285_F293_I0.7260.94
285_F335_P0.7230.94
217_Y220_R0.7200.94
273_V304_V0.7190.94
198_N292_R0.7120.93
19_S216_A0.7110.93
45_L49_Y0.7100.93
275_A334_L0.7090.93
185_V188_Y0.7090.93
77_S146_N0.7090.93
274_M355_A0.7080.93
29_L34_G0.7080.93
334_L342_E0.7070.93
89_L153_M0.7060.93
197_F296_L0.7040.93
41_T66_S0.7000.93
18_A166_D0.6990.93
244_N323_K0.6960.93
119_Q144_A0.6940.93
276_A335_P0.6940.93
93_H118_Y0.6930.92
11_R161_A0.6910.92
53_V57_L0.6900.92
291_Q294_I0.6890.92
284_Q336_L0.6880.92
204_L207_L0.6870.92
180_S266_E0.6840.92
281_R355_A0.6840.92
126_Q137_S0.6830.92
52_K55_G0.6820.92
43_E68_I0.6820.92
58_E64_V0.6810.92
28_F164_V0.6800.92
240_R244_N0.6790.92
282_L346_G0.6780.92
276_A290_T0.6770.92
347_V352_V0.6760.92
108_G133_S0.6750.91
257_M261_N0.6690.91
19_S167_L0.6680.91
199_W214_A0.6670.91
256_E315_Y0.6670.91
218_C222_C0.6640.91
354_N357_A0.6630.91
275_A332_L0.6630.91
79_A83_T0.6610.91
197_F293_I0.6600.91
270_A274_M0.6580.90
150_G259_Y0.6540.90
273_V277_R0.6540.90
307_P310_M0.6510.90
313_Q349_H0.6490.90
286_S337_A0.6490.90
44_T47_P0.6470.90
101_A108_G0.6400.89
222_C225_L0.6390.89
147_H150_G0.6390.89
85_F154_I0.6380.89
191_I225_L0.6350.89
201_E296_L0.6350.89
298_K305_N0.6350.89
36_Q94_G0.6320.89
295_T298_K0.6280.88
35_E98_T0.6260.88
245_L335_P0.6260.88
75_Y110_L0.6260.88
119_Q321_R0.6240.88
100_V125_I0.6240.88
41_T72_G0.6210.88
270_A303_P0.6190.88
36_Q93_H0.6180.87
280_E286_S0.6180.87
77_S81_L0.6160.87
253_I270_A0.6150.87
284_Q344_R0.6140.87
53_V127_V0.6140.87
253_I262_W0.6140.87
123_R158_Y0.6140.87
280_E285_F0.6130.87
194_G292_R0.6130.87
241_A326_L0.6120.87
272_M293_I0.6110.87
92_P317_P0.6090.87
205_D209_R0.6060.86
284_Q334_L0.6060.86
108_G138_S0.6040.86
199_W221_R0.6040.86
96_D327_A0.6030.86
39_L53_V0.6020.86
17_I223_C0.6020.86
228_E239_L0.6020.86
89_L149_L0.6000.86
119_Q325_V0.6000.86
234_E237_T0.6000.86
295_T299_R0.5990.86
193_D225_L0.5990.86
140_G244_N0.5990.86
25_P127_V0.5980.86
124_F159_Q0.5980.86
119_Q122_V0.5970.86
95_R157_F0.5970.86
17_I216_A0.5960.86
38_M97_T0.5950.85
255_A259_Y0.5920.85
315_Y319_M0.5920.85
43_E75_Y0.5910.85
191_I272_M0.5910.85
141_G244_N0.5900.85
201_E299_R0.5900.85
44_T48_L0.5900.85
65_D87_A0.5900.85
35_E327_A0.5890.85
197_F201_E0.5870.85
18_A165_V0.5860.85
232_A238_G0.5830.84
34_G98_T0.5830.84
344_R347_V0.5820.84
273_V290_T0.5820.84
53_V100_V0.5810.84
47_P71_D0.5810.84
318_H321_R0.5800.84
58_E63_N0.5800.84
77_S110_L0.5790.84
210_L215_M0.5780.84
36_Q65_D0.5770.84
185_V218_C0.5750.83
240_R323_K0.5750.83
41_T102_L0.5690.83
314_A318_H0.5690.83
141_G240_R0.5690.83
135_V222_C0.5690.83
21_L164_V0.5670.83
98_T125_I0.5670.83
137_S250_G0.5630.82
35_E97_T0.5610.82
52_K56_V0.5600.82
11_R235_R0.5590.82
125_I162_S0.5580.82
262_W266_E0.5580.82
39_L66_S0.5580.82
131_L185_V0.5560.81
88_L114_A0.5560.81
98_T161_A0.5520.81
129_T169_C0.5510.81
352_V355_A0.5510.81
235_R239_L0.5500.81
179_A266_E0.5500.81
24_E28_F0.5480.80
110_L114_A0.5470.80
20_G166_D0.5460.80
131_L219_I0.5450.80
203_N207_L0.5450.80
255_A321_R0.5440.80
194_G289_E0.5420.80
118_Y150_G0.5390.79
183_A272_M0.5370.79
50_L102_L0.5370.79
208_L301_G0.5360.79
16_T31_L0.5350.79
25_P29_L0.5330.79
203_N214_A0.5310.78
175_P301_G0.5310.78
69_L84_V0.5310.78
313_Q317_P0.5300.78
67_V91_K0.5300.78
47_P50_L0.5290.78
213_P217_Y0.5270.78
230_V244_N0.5270.78
96_D237_T0.5270.78
250_G272_M0.5260.78
117_S144_A0.5260.78
182_L186_I0.5250.78
204_L208_L0.5250.78
293_I297_L0.5250.78
128_P132_L0.5240.77
38_M91_K0.5230.77
296_L299_R0.5220.77
93_H119_Q0.5220.77
78_L117_S0.5220.77
97_T123_R0.5200.77
312_A356_I0.5200.77
52_K168_D0.5180.77
11_R234_E0.5170.77
151_K251_H0.5160.76
179_A182_L0.5150.76
312_A352_V0.5150.76
55_G59_Q0.5140.76
220_R228_E0.5140.76
77_S145_V0.5140.76
124_F138_S0.5130.76
118_Y153_M0.5130.76
147_H153_M0.5130.76
23_N55_G0.5130.76
241_A343_V0.5110.76
135_V219_I0.5080.75
282_L344_R0.5070.75
22_F52_K0.5060.75
178_L182_L0.5060.75
278_T282_L0.5060.75
146_N267_A0.5060.75
94_G119_Q0.5050.75
42_N107_V0.5050.75
333_I341_S0.5040.75
23_N56_V0.5040.75
49_Y52_K0.5030.75
92_P320_L0.5030.75
173_L177_E0.5030.75
192_L242_L0.5030.75
80_V84_V0.5010.74
244_N324_K0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zokA 4 0.9972 100 0.267 Contact Map
2gruA 2 0.9862 100 0.272 Contact Map
3okfA 3 0.9972 100 0.28 Contact Map
3qbeA 1 0.9696 100 0.301 Contact Map
1ujnA 2 0.9144 100 0.315 Contact Map
4p53A 2 0.9724 100 0.318 Contact Map
1sg6A 1 0.9503 100 0.323 Contact Map
1xahA 1 0.9088 100 0.326 Contact Map
3clhA 2 0.8508 100 0.354 Contact Map
3ce9A 3 0.9006 100 0.528 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.