META - ECOLI - GREMLIN Contacts

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META - Homoserine O-succinyltransferase

UniProt:	P07623	Sequences: MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQDQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTEKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQEFFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10581
Length:	309 (300)
Sequences:	1307 (780)
Seq/√Len:	45.0

ECOLI - META
BACSU - META

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
244_A	264_F	4.915	1.00
165_S	257_P	4.750	1.00
162_E	258_D	4.393	1.00
244_A	248_F	4.353	1.00
129_E	151_I	3.892	1.00
68_Q	100_F	3.833	1.00
37_K	66_D	3.334	1.00
99_N	134_H	3.243	1.00
268_D	271_N	3.143	1.00
199_A	213_E	2.911	1.00
198_P	201_L	2.901	1.00
72_I	75_R	2.779	1.00
216_E	261_Y	2.765	1.00
219_A	222_F	2.692	1.00
189_A	220_Y	2.672	1.00
146_Q	195_A	2.624	1.00
73_D	93_E	2.585	1.00
129_E	132_K	2.583	1.00
240_A	275_A	2.534	1.00
103_L	131_S	2.473	1.00
199_A	203_R	2.365	1.00
265_P	273_P	2.308	1.00
75_R	119_A	2.262	1.00
187_F	212_A	2.241	1.00
248_F	264_F	2.234	1.00
37_K	98_Q	2.186	1.00
158_Q	198_P	2.167	1.00
241_Q	245_Q	2.104	1.00
174_H	209_E	2.097	1.00
39_L	103_L	2.091	1.00
220_Y	236_P	2.005	0.99
7_D	26_S	1.996	0.99
140_F	152_L	1.988	0.99
169_E	186_S	1.935	0.99
194_Y	257_P	1.884	0.99
40_I	54_F	1.869	0.99
122_P	125_K	1.844	0.99
70_L	95_I	1.839	0.99
141_V	146_Q	1.838	0.99
179_L	230_A	1.801	0.98
13_N	17_E	1.769	0.98
39_L	70_L	1.737	0.98
112_L	159_T	1.735	0.98
171_H	215_E	1.715	0.98
157_K	195_A	1.707	0.98
12_V	16_R	1.688	0.98
55_L	67_I	1.669	0.98
266_H	271_N	1.645	0.97
46_K	49_E	1.615	0.97
183_F	280_H	1.590	0.97
39_L	95_I	1.580	0.97
136_T	228_R	1.575	0.96
165_S	256_D	1.570	0.96
165_S	194_Y	1.562	0.96
131_S	140_F	1.553	0.96
5_V	12_V	1.544	0.96
54_F	141_V	1.540	0.96
199_A	210_I	1.537	0.96
40_I	67_I	1.529	0.96
128_L	152_L	1.526	0.96
115_F	146_Q	1.525	0.96
46_K	245_Q	1.524	0.96
53_Q	239_D	1.521	0.96
125_K	151_I	1.512	0.96
116_N	150_N	1.507	0.95
183_F	283_L	1.500	0.95
170_H	217_G	1.499	0.95
164_L	168_Y	1.496	0.95
170_H	191_H	1.488	0.95
188_L	276_S	1.472	0.95
194_Y	255_L	1.469	0.95
114_E	117_D	1.459	0.95
96_Q	126_Q	1.459	0.95
124_I	128_L	1.430	0.94
183_F	284_L	1.424	0.94
131_S	152_L	1.423	0.94
136_T	296_I	1.422	0.94
146_Q	157_K	1.417	0.94
248_F	252_E	1.406	0.93
148_A	152_L	1.395	0.93
4_R	130_W	1.376	0.93
111_G	157_K	1.360	0.92
153_Y	224_S	1.357	0.92
140_F	148_A	1.343	0.92
168_Y	261_Y	1.334	0.91
138_T	148_A	1.322	0.91
65_V	289_L	1.301	0.90
156_P	201_L	1.298	0.90
251_V	259_V	1.292	0.90
28_A	31_Q	1.286	0.90
216_E	262_N	1.282	0.90
111_G	195_A	1.264	0.89
210_I	213_E	1.256	0.89
13_N	16_R	1.250	0.88
72_I	127_V	1.244	0.88
160_R	164_L	1.241	0.88
14_F	52_N	1.238	0.88
27_R	30_G	1.235	0.88
141_V	236_P	1.229	0.88
251_V	269_P	1.221	0.87
236_P	284_L	1.211	0.87
144_A	233_T	1.205	0.87
84_H	88_F	1.203	0.86
156_P	198_P	1.195	0.86
48_I	84_H	1.193	0.86
132_K	151_I	1.190	0.86
170_H	220_Y	1.184	0.86
259_V	269_P	1.181	0.85
178_L	296_I	1.180	0.85
169_E	276_S	1.178	0.85
31_Q	34_R	1.157	0.84
210_I	219_A	1.156	0.84
209_E	225_K	1.156	0.84
221_L	232_V	1.154	0.84
91_N	94_D	1.152	0.84
114_E	156_P	1.149	0.84
131_S	229_I	1.147	0.84
38_V	102_G	1.139	0.83
110_L	144_A	1.135	0.83
251_V	257_P	1.135	0.83
152_L	229_I	1.132	0.83
173_L	213_E	1.130	0.83
158_Q	196_D	1.119	0.82
290_N	295_Q	1.104	0.81
247_F	251_V	1.093	0.81
224_S	229_I	1.090	0.80
57_L	281_G	1.085	0.80
49_E	245_Q	1.068	0.79
248_F	251_V	1.061	0.79
177_A	223_A	1.061	0.79
214_T	217_G	1.059	0.79
90_C	94_D	1.059	0.79
70_L	103_L	1.058	0.78
202_I	219_A	1.056	0.78
209_E	223_A	1.056	0.78
7_D	25_T	1.050	0.78
199_A	219_A	1.049	0.78
8_E	87_N	1.045	0.78
132_K	229_I	1.044	0.78
141_V	195_A	1.034	0.77
208_L	222_F	1.034	0.77
189_A	217_G	1.025	0.76
165_S	169_E	1.025	0.76
28_A	33_I	1.021	0.76
105_V	128_L	1.019	0.76
28_A	34_R	1.019	0.76
191_H	217_G	1.013	0.75
82_A	86_N	1.012	0.75
224_S	228_R	1.009	0.75
111_G	146_Q	1.004	0.75
158_Q	201_L	1.003	0.75
12_V	48_I	1.001	0.74
74_S	123_Q	0.999	0.74
24_T	69_L	0.993	0.74
169_E	188_L	0.988	0.73
200_A	204_D	0.985	0.73
139_L	236_P	0.985	0.73
168_Y	194_Y	0.984	0.73
265_P	271_N	0.982	0.73
31_Q	64_Q	0.982	0.73
130_W	134_H	0.976	0.73
202_I	222_F	0.976	0.73
90_C	98_Q	0.974	0.72
186_S	276_S	0.970	0.72
141_V	157_K	0.950	0.71
197_F	201_L	0.946	0.70
112_L	194_Y	0.941	0.70
110_L	157_K	0.941	0.70
41_L	103_L	0.939	0.70
160_R	196_D	0.938	0.70
179_L	221_L	0.938	0.70
180_T	221_L	0.937	0.69
37_K	301_L	0.936	0.69
4_R	25_T	0.918	0.68
41_L	72_I	0.910	0.67
139_L	284_L	0.906	0.67
13_N	30_G	0.905	0.67
128_L	151_I	0.904	0.67
110_L	195_A	0.903	0.67
41_L	70_L	0.901	0.66
34_R	64_Q	0.899	0.66
191_H	234_G	0.888	0.65
172_I	175_P	0.887	0.65
171_H	262_N	0.881	0.65
189_A	236_P	0.881	0.65
279_S	283_L	0.881	0.65
7_D	24_T	0.874	0.64
141_V	285_F	0.874	0.64
4_R	7_D	0.872	0.64
46_K	242_T	0.864	0.63
171_H	186_S	0.863	0.63
31_Q	294_Y	0.861	0.63
28_A	294_Y	0.842	0.61
68_Q	90_C	0.840	0.61
18_E	56_R	0.839	0.61
251_V	255_L	0.835	0.60
103_L	127_V	0.831	0.60
72_I	77_S	0.826	0.60
196_D	201_L	0.826	0.60
33_I	64_Q	0.826	0.60
55_L	69_L	0.826	0.60
164_L	217_G	0.820	0.59
164_L	194_Y	0.819	0.59
46_K	52_N	0.814	0.58
212_A	220_Y	0.813	0.58
57_L	283_L	0.806	0.58
28_A	64_Q	0.804	0.58
6_P	283_L	0.803	0.57
75_R	78_R	0.802	0.57
87_N	90_C	0.802	0.57
75_R	113_V	0.801	0.57
12_V	24_T	0.796	0.57
199_A	267_N	0.795	0.57
128_L	140_F	0.794	0.57
5_V	48_I	0.793	0.56
172_I	180_T	0.793	0.56
134_H	144_A	0.792	0.56
294_Y	297_T	0.787	0.56
41_L	130_W	0.785	0.56
11_A	52_N	0.782	0.55
110_L	146_Q	0.780	0.55
51_E	89_Y	0.777	0.55
34_R	294_Y	0.777	0.55
156_P	196_D	0.775	0.55
73_D	91_N	0.775	0.55
220_Y	284_L	0.775	0.55
180_T	211_L	0.770	0.54
138_T	229_I	0.768	0.54
28_A	32_E	0.762	0.53
21_F	291_Y	0.762	0.53
265_P	272_T	0.761	0.53
165_S	168_Y	0.760	0.53
165_S	251_V	0.758	0.53
105_V	148_A	0.757	0.53
122_P	126_Q	0.755	0.53
236_P	282_N	0.755	0.53
3_I	16_R	0.754	0.53
111_G	141_V	0.753	0.53
253_A	257_P	0.752	0.53
24_T	48_I	0.749	0.52
40_I	55_L	0.749	0.52
105_V	229_I	0.749	0.52
48_I	52_N	0.749	0.52
191_H	211_L	0.746	0.52
3_I	239_D	0.745	0.52
220_Y	232_V	0.740	0.51
223_A	227_K	0.738	0.51
159_T	194_Y	0.725	0.50
83_E	86_N	0.723	0.50
39_L	100_F	0.720	0.49
138_T	152_L	0.716	0.49
76_E	82_A	0.716	0.49
111_G	123_Q	0.714	0.49
204_D	210_I	0.714	0.49
220_Y	280_H	0.714	0.49
64_Q	294_Y	0.713	0.49
78_R	210_I	0.710	0.48
72_I	119_A	0.706	0.48
258_D	261_Y	0.704	0.48
228_R	300_D	0.704	0.48
125_K	129_E	0.700	0.47
21_F	27_R	0.698	0.47
153_Y	231_F	0.692	0.47
121_W	147_A	0.691	0.47
11_A	48_I	0.687	0.46
207_D	224_S	0.687	0.46
115_F	195_A	0.686	0.46
254_G	257_P	0.685	0.46
213_E	219_A	0.684	0.46
130_W	284_L	0.683	0.46
128_L	148_A	0.682	0.46
68_Q	98_Q	0.680	0.46
202_I	208_L	0.677	0.45
39_L	69_L	0.677	0.45
112_L	144_A	0.677	0.45
171_H	212_A	0.673	0.45
26_S	30_G	0.672	0.45
223_A	230_A	0.666	0.44
203_R	210_I	0.666	0.44
236_P	286_T	0.666	0.44
140_F	144_A	0.664	0.44
46_K	301_L	0.662	0.44
112_L	281_G	0.660	0.44
57_L	282_N	0.660	0.44
155_I	206_T	0.660	0.44
49_E	52_N	0.658	0.43
178_L	185_D	0.655	0.43
203_R	222_F	0.654	0.43
35_P	278_R	0.650	0.43
69_L	124_I	0.649	0.43
33_I	294_Y	0.644	0.42
2_P	28_A	0.641	0.42
110_L	113_V	0.641	0.42
217_G	236_P	0.641	0.42
178_L	299_Y	0.634	0.41
174_H	285_F	0.632	0.41
115_F	157_K	0.630	0.41
60_N	291_Y	0.629	0.41
75_R	123_Q	0.629	0.41
46_K	57_L	0.629	0.41
177_A	211_L	0.627	0.40
209_E	221_L	0.626	0.40
170_H	289_L	0.625	0.40
197_F	222_F	0.620	0.40
8_E	13_N	0.618	0.40
45_P	192_S	0.616	0.39
110_L	152_L	0.616	0.39
280_H	284_L	0.615	0.39
8_E	12_V	0.615	0.39
8_E	177_A	0.614	0.39
59_S	282_N	0.614	0.39
200_A	251_V	0.614	0.39
27_R	295_Q	0.614	0.39
149_L	233_T	0.612	0.39
167_V	251_V	0.609	0.39
77_S	85_L	0.609	0.39
156_P	205_Y	0.608	0.39
115_F	281_G	0.608	0.39
148_A	151_I	0.607	0.39
219_A	233_T	0.607	0.39
21_F	293_V	0.607	0.39
115_F	124_I	0.606	0.39
236_P	285_F	0.606	0.39
172_I	276_S	0.606	0.39
168_Y	262_N	0.604	0.38
66_D	177_A	0.600	0.38
237_E	249_R	0.599	0.38
39_L	131_S	0.599	0.38
132_K	227_K	0.597	0.38
189_A	232_V	0.596	0.38
14_F	17_E	0.593	0.37
224_S	227_K	0.590	0.37
203_R	266_H	0.587	0.37
37_K	68_Q	0.587	0.37
31_Q	35_P	0.587	0.37
111_G	115_F	0.586	0.37
124_I	148_A	0.586	0.37
30_G	119_A	0.585	0.37
19_N	291_Y	0.585	0.37
6_P	83_E	0.584	0.37
197_F	202_I	0.584	0.37
93_E	96_Q	0.582	0.36
77_S	119_A	0.581	0.36
275_A	281_G	0.580	0.36
54_F	284_L	0.580	0.36
71_R	85_L	0.578	0.36
136_T	297_T	0.576	0.36
5_V	68_Q	0.575	0.36
156_P	204_D	0.575	0.36
24_T	174_H	0.573	0.36
23_M	27_R	0.570	0.35
139_L	230_A	0.570	0.35
187_F	220_Y	0.569	0.35
85_L	140_F	0.567	0.35
102_G	284_L	0.567	0.35
214_T	220_Y	0.564	0.35
103_L	130_W	0.563	0.35
38_V	139_L	0.557	0.34
172_I	189_A	0.557	0.34
48_I	275_A	0.556	0.34
12_V	25_T	0.556	0.34
118_V	143_W	0.556	0.34
60_N	286_T	0.555	0.34
76_E	119_A	0.554	0.34
132_K	226_D	0.553	0.34
85_L	105_V	0.553	0.34
55_L	226_D	0.553	0.34
27_R	60_N	0.551	0.34
185_D	275_A	0.550	0.34
139_L	232_V	0.548	0.33
19_N	60_N	0.547	0.33
31_Q	297_T	0.546	0.33
56_R	239_D	0.546	0.33
109_P	143_W	0.544	0.33
184_D	291_Y	0.544	0.33
177_A	227_K	0.543	0.33
46_K	264_F	0.543	0.33
96_Q	266_H	0.543	0.33
170_H	189_A	0.541	0.33
196_D	233_T	0.540	0.33
24_T	223_A	0.540	0.33
275_A	278_R	0.540	0.33
102_G	196_D	0.540	0.33
167_V	245_Q	0.539	0.33
170_H	214_T	0.539	0.33
146_Q	149_L	0.538	0.32
221_L	236_P	0.538	0.32
4_R	66_D	0.537	0.32
171_H	213_E	0.536	0.32
105_V	152_L	0.535	0.32
111_G	160_R	0.534	0.32
92_F	130_W	0.533	0.32
16_R	173_L	0.532	0.32
6_P	275_A	0.531	0.32
178_L	223_A	0.531	0.32
56_R	130_W	0.530	0.32
265_P	268_D	0.529	0.32
157_K	160_R	0.528	0.32
19_N	184_D	0.528	0.32
153_Y	194_Y	0.527	0.32
162_E	251_V	0.527	0.32
51_E	218_D	0.527	0.32
139_L	301_L	0.526	0.31
203_R	213_E	0.526	0.31
20_V	78_R	0.524	0.31
46_K	53_Q	0.524	0.31
5_V	232_V	0.524	0.31
38_V	230_A	0.523	0.31
197_F	233_T	0.523	0.31
79_N	112_L	0.522	0.31
6_P	87_N	0.521	0.31
99_N	198_P	0.521	0.31
220_Y	233_T	0.520	0.31
126_Q	129_E	0.520	0.31
148_A	156_P	0.520	0.31
240_A	272_T	0.520	0.31
21_F	60_N	0.519	0.31
121_W	150_N	0.519	0.31
45_P	51_E	0.518	0.31
25_T	239_D	0.518	0.31
8_E	24_T	0.516	0.31
67_I	177_A	0.516	0.31
50_T	287_N	0.516	0.31
89_Y	250_D	0.515	0.31
90_C	96_Q	0.514	0.30
61_S	286_T	0.514	0.30
85_L	91_N	0.514	0.30
278_R	282_N	0.511	0.30
198_P	202_I	0.510	0.30
236_P	289_L	0.509	0.30
207_D	225_K	0.508	0.30
25_T	29_S	0.508	0.30
105_V	140_F	0.508	0.30
233_T	280_H	0.507	0.30
117_D	134_H	0.506	0.30
45_P	89_Y	0.506	0.30
71_R	77_S	0.506	0.30
72_I	78_R	0.505	0.30
232_V	236_P	0.504	0.30
34_R	295_Q	0.504	0.30
17_E	241_Q	0.504	0.30
36_L	208_L	0.504	0.30
24_T	29_S	0.503	0.30
146_Q	181_R	0.503	0.30
125_K	285_F	0.503	0.30
20_V	59_S	0.502	0.29
72_I	91_N	0.502	0.29
64_Q	184_D	0.500	0.29
202_I	210_I	0.500	0.29
35_P	64_Q	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vdjA	2	0.8673	100	0.417	Contact Map
2h2wA	2	0.932	100	0.429	Contact Map
3m3pA	1	0.767	100	0.756	Contact Map
3l7nA	1	0.7411	99.8	0.852	Contact Map
1o1yA	2	0.7411	99.8	0.853	Contact Map
1qdlB	2	0.6149	99.7	0.864	Contact Map
2lxnA	1	0.5922	99.6	0.87	Contact Map
1wl8A	1	0.5922	99.6	0.871	Contact Map
2vpiA	1	0.5922	99.6	0.872	Contact Map
2a9vA	1	0.6408	99.5	0.877	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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