GREMLIN Database
META - Homoserine O-succinyltransferase
UniProt: P07623 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10581
Length: 309 (300)
Sequences: 1307 (780)
Seq/√Len: 45.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_A264_F4.9151.00
165_S257_P4.7501.00
162_E258_D4.3931.00
244_A248_F4.3531.00
129_E151_I3.8921.00
68_Q100_F3.8331.00
37_K66_D3.3341.00
99_N134_H3.2431.00
268_D271_N3.1431.00
199_A213_E2.9111.00
198_P201_L2.9011.00
72_I75_R2.7791.00
216_E261_Y2.7651.00
219_A222_F2.6921.00
189_A220_Y2.6721.00
146_Q195_A2.6241.00
73_D93_E2.5851.00
129_E132_K2.5831.00
240_A275_A2.5341.00
103_L131_S2.4731.00
199_A203_R2.3651.00
265_P273_P2.3081.00
75_R119_A2.2621.00
187_F212_A2.2411.00
248_F264_F2.2341.00
37_K98_Q2.1861.00
158_Q198_P2.1671.00
241_Q245_Q2.1041.00
174_H209_E2.0971.00
39_L103_L2.0911.00
220_Y236_P2.0050.99
7_D26_S1.9960.99
140_F152_L1.9880.99
169_E186_S1.9350.99
194_Y257_P1.8840.99
40_I54_F1.8690.99
122_P125_K1.8440.99
70_L95_I1.8390.99
141_V146_Q1.8380.99
179_L230_A1.8010.98
13_N17_E1.7690.98
39_L70_L1.7370.98
112_L159_T1.7350.98
171_H215_E1.7150.98
157_K195_A1.7070.98
12_V16_R1.6880.98
55_L67_I1.6690.98
266_H271_N1.6450.97
46_K49_E1.6150.97
183_F280_H1.5900.97
39_L95_I1.5800.97
136_T228_R1.5750.96
165_S256_D1.5700.96
165_S194_Y1.5620.96
131_S140_F1.5530.96
5_V12_V1.5440.96
54_F141_V1.5400.96
199_A210_I1.5370.96
40_I67_I1.5290.96
128_L152_L1.5260.96
115_F146_Q1.5250.96
46_K245_Q1.5240.96
53_Q239_D1.5210.96
125_K151_I1.5120.96
116_N150_N1.5070.95
183_F283_L1.5000.95
170_H217_G1.4990.95
164_L168_Y1.4960.95
170_H191_H1.4880.95
188_L276_S1.4720.95
194_Y255_L1.4690.95
114_E117_D1.4590.95
96_Q126_Q1.4590.95
124_I128_L1.4300.94
183_F284_L1.4240.94
131_S152_L1.4230.94
136_T296_I1.4220.94
146_Q157_K1.4170.94
248_F252_E1.4060.93
148_A152_L1.3950.93
4_R130_W1.3760.93
111_G157_K1.3600.92
153_Y224_S1.3570.92
140_F148_A1.3430.92
168_Y261_Y1.3340.91
138_T148_A1.3220.91
65_V289_L1.3010.90
156_P201_L1.2980.90
251_V259_V1.2920.90
28_A31_Q1.2860.90
216_E262_N1.2820.90
111_G195_A1.2640.89
210_I213_E1.2560.89
13_N16_R1.2500.88
72_I127_V1.2440.88
160_R164_L1.2410.88
14_F52_N1.2380.88
27_R30_G1.2350.88
141_V236_P1.2290.88
251_V269_P1.2210.87
236_P284_L1.2110.87
144_A233_T1.2050.87
84_H88_F1.2030.86
156_P198_P1.1950.86
48_I84_H1.1930.86
132_K151_I1.1900.86
170_H220_Y1.1840.86
259_V269_P1.1810.85
178_L296_I1.1800.85
169_E276_S1.1780.85
31_Q34_R1.1570.84
210_I219_A1.1560.84
209_E225_K1.1560.84
221_L232_V1.1540.84
91_N94_D1.1520.84
114_E156_P1.1490.84
131_S229_I1.1470.84
38_V102_G1.1390.83
110_L144_A1.1350.83
251_V257_P1.1350.83
152_L229_I1.1320.83
173_L213_E1.1300.83
158_Q196_D1.1190.82
290_N295_Q1.1040.81
247_F251_V1.0930.81
224_S229_I1.0900.80
57_L281_G1.0850.80
49_E245_Q1.0680.79
248_F251_V1.0610.79
177_A223_A1.0610.79
214_T217_G1.0590.79
90_C94_D1.0590.79
70_L103_L1.0580.78
202_I219_A1.0560.78
209_E223_A1.0560.78
7_D25_T1.0500.78
199_A219_A1.0490.78
8_E87_N1.0450.78
132_K229_I1.0440.78
141_V195_A1.0340.77
208_L222_F1.0340.77
189_A217_G1.0250.76
165_S169_E1.0250.76
28_A33_I1.0210.76
105_V128_L1.0190.76
28_A34_R1.0190.76
191_H217_G1.0130.75
82_A86_N1.0120.75
224_S228_R1.0090.75
111_G146_Q1.0040.75
158_Q201_L1.0030.75
12_V48_I1.0010.74
74_S123_Q0.9990.74
24_T69_L0.9930.74
169_E188_L0.9880.73
200_A204_D0.9850.73
139_L236_P0.9850.73
168_Y194_Y0.9840.73
265_P271_N0.9820.73
31_Q64_Q0.9820.73
130_W134_H0.9760.73
202_I222_F0.9760.73
90_C98_Q0.9740.72
186_S276_S0.9700.72
141_V157_K0.9500.71
197_F201_L0.9460.70
112_L194_Y0.9410.70
110_L157_K0.9410.70
41_L103_L0.9390.70
160_R196_D0.9380.70
179_L221_L0.9380.70
180_T221_L0.9370.69
37_K301_L0.9360.69
4_R25_T0.9180.68
41_L72_I0.9100.67
139_L284_L0.9060.67
13_N30_G0.9050.67
128_L151_I0.9040.67
110_L195_A0.9030.67
41_L70_L0.9010.66
34_R64_Q0.8990.66
191_H234_G0.8880.65
172_I175_P0.8870.65
171_H262_N0.8810.65
189_A236_P0.8810.65
279_S283_L0.8810.65
7_D24_T0.8740.64
141_V285_F0.8740.64
4_R7_D0.8720.64
46_K242_T0.8640.63
171_H186_S0.8630.63
31_Q294_Y0.8610.63
28_A294_Y0.8420.61
68_Q90_C0.8400.61
18_E56_R0.8390.61
251_V255_L0.8350.60
103_L127_V0.8310.60
72_I77_S0.8260.60
196_D201_L0.8260.60
33_I64_Q0.8260.60
55_L69_L0.8260.60
164_L217_G0.8200.59
164_L194_Y0.8190.59
46_K52_N0.8140.58
212_A220_Y0.8130.58
57_L283_L0.8060.58
28_A64_Q0.8040.58
6_P283_L0.8030.57
75_R78_R0.8020.57
87_N90_C0.8020.57
75_R113_V0.8010.57
12_V24_T0.7960.57
199_A267_N0.7950.57
128_L140_F0.7940.57
5_V48_I0.7930.56
172_I180_T0.7930.56
134_H144_A0.7920.56
294_Y297_T0.7870.56
41_L130_W0.7850.56
11_A52_N0.7820.55
110_L146_Q0.7800.55
51_E89_Y0.7770.55
34_R294_Y0.7770.55
156_P196_D0.7750.55
73_D91_N0.7750.55
220_Y284_L0.7750.55
180_T211_L0.7700.54
138_T229_I0.7680.54
28_A32_E0.7620.53
21_F291_Y0.7620.53
265_P272_T0.7610.53
165_S168_Y0.7600.53
165_S251_V0.7580.53
105_V148_A0.7570.53
122_P126_Q0.7550.53
236_P282_N0.7550.53
3_I16_R0.7540.53
111_G141_V0.7530.53
253_A257_P0.7520.53
24_T48_I0.7490.52
40_I55_L0.7490.52
105_V229_I0.7490.52
48_I52_N0.7490.52
191_H211_L0.7460.52
3_I239_D0.7450.52
220_Y232_V0.7400.51
223_A227_K0.7380.51
159_T194_Y0.7250.50
83_E86_N0.7230.50
39_L100_F0.7200.49
138_T152_L0.7160.49
76_E82_A0.7160.49
111_G123_Q0.7140.49
204_D210_I0.7140.49
220_Y280_H0.7140.49
64_Q294_Y0.7130.49
78_R210_I0.7100.48
72_I119_A0.7060.48
258_D261_Y0.7040.48
228_R300_D0.7040.48
125_K129_E0.7000.47
21_F27_R0.6980.47
153_Y231_F0.6920.47
121_W147_A0.6910.47
11_A48_I0.6870.46
207_D224_S0.6870.46
115_F195_A0.6860.46
254_G257_P0.6850.46
213_E219_A0.6840.46
130_W284_L0.6830.46
128_L148_A0.6820.46
68_Q98_Q0.6800.46
202_I208_L0.6770.45
39_L69_L0.6770.45
112_L144_A0.6770.45
171_H212_A0.6730.45
26_S30_G0.6720.45
223_A230_A0.6660.44
203_R210_I0.6660.44
236_P286_T0.6660.44
140_F144_A0.6640.44
46_K301_L0.6620.44
112_L281_G0.6600.44
57_L282_N0.6600.44
155_I206_T0.6600.44
49_E52_N0.6580.43
178_L185_D0.6550.43
203_R222_F0.6540.43
35_P278_R0.6500.43
69_L124_I0.6490.43
33_I294_Y0.6440.42
2_P28_A0.6410.42
110_L113_V0.6410.42
217_G236_P0.6410.42
178_L299_Y0.6340.41
174_H285_F0.6320.41
115_F157_K0.6300.41
60_N291_Y0.6290.41
75_R123_Q0.6290.41
46_K57_L0.6290.41
177_A211_L0.6270.40
209_E221_L0.6260.40
170_H289_L0.6250.40
197_F222_F0.6200.40
8_E13_N0.6180.40
45_P192_S0.6160.39
110_L152_L0.6160.39
280_H284_L0.6150.39
8_E12_V0.6150.39
8_E177_A0.6140.39
59_S282_N0.6140.39
200_A251_V0.6140.39
27_R295_Q0.6140.39
149_L233_T0.6120.39
167_V251_V0.6090.39
77_S85_L0.6090.39
156_P205_Y0.6080.39
115_F281_G0.6080.39
148_A151_I0.6070.39
219_A233_T0.6070.39
21_F293_V0.6070.39
115_F124_I0.6060.39
236_P285_F0.6060.39
172_I276_S0.6060.39
168_Y262_N0.6040.38
66_D177_A0.6000.38
237_E249_R0.5990.38
39_L131_S0.5990.38
132_K227_K0.5970.38
189_A232_V0.5960.38
14_F17_E0.5930.37
224_S227_K0.5900.37
203_R266_H0.5870.37
37_K68_Q0.5870.37
31_Q35_P0.5870.37
111_G115_F0.5860.37
124_I148_A0.5860.37
30_G119_A0.5850.37
19_N291_Y0.5850.37
6_P83_E0.5840.37
197_F202_I0.5840.37
93_E96_Q0.5820.36
77_S119_A0.5810.36
275_A281_G0.5800.36
54_F284_L0.5800.36
71_R85_L0.5780.36
136_T297_T0.5760.36
5_V68_Q0.5750.36
156_P204_D0.5750.36
24_T174_H0.5730.36
23_M27_R0.5700.35
139_L230_A0.5700.35
187_F220_Y0.5690.35
85_L140_F0.5670.35
102_G284_L0.5670.35
214_T220_Y0.5640.35
103_L130_W0.5630.35
38_V139_L0.5570.34
172_I189_A0.5570.34
48_I275_A0.5560.34
12_V25_T0.5560.34
118_V143_W0.5560.34
60_N286_T0.5550.34
76_E119_A0.5540.34
132_K226_D0.5530.34
85_L105_V0.5530.34
55_L226_D0.5530.34
27_R60_N0.5510.34
185_D275_A0.5500.34
139_L232_V0.5480.33
19_N60_N0.5470.33
31_Q297_T0.5460.33
56_R239_D0.5460.33
109_P143_W0.5440.33
184_D291_Y0.5440.33
177_A227_K0.5430.33
46_K264_F0.5430.33
96_Q266_H0.5430.33
170_H189_A0.5410.33
196_D233_T0.5400.33
24_T223_A0.5400.33
275_A278_R0.5400.33
102_G196_D0.5400.33
167_V245_Q0.5390.33
170_H214_T0.5390.33
146_Q149_L0.5380.32
221_L236_P0.5380.32
4_R66_D0.5370.32
171_H213_E0.5360.32
105_V152_L0.5350.32
111_G160_R0.5340.32
92_F130_W0.5330.32
16_R173_L0.5320.32
6_P275_A0.5310.32
178_L223_A0.5310.32
56_R130_W0.5300.32
265_P268_D0.5290.32
157_K160_R0.5280.32
19_N184_D0.5280.32
153_Y194_Y0.5270.32
162_E251_V0.5270.32
51_E218_D0.5270.32
139_L301_L0.5260.31
203_R213_E0.5260.31
20_V78_R0.5240.31
46_K53_Q0.5240.31
5_V232_V0.5240.31
38_V230_A0.5230.31
197_F233_T0.5230.31
79_N112_L0.5220.31
6_P87_N0.5210.31
99_N198_P0.5210.31
220_Y233_T0.5200.31
126_Q129_E0.5200.31
148_A156_P0.5200.31
240_A272_T0.5200.31
21_F60_N0.5190.31
121_W150_N0.5190.31
45_P51_E0.5180.31
25_T239_D0.5180.31
8_E24_T0.5160.31
67_I177_A0.5160.31
50_T287_N0.5160.31
89_Y250_D0.5150.31
90_C96_Q0.5140.30
61_S286_T0.5140.30
85_L91_N0.5140.30
278_R282_N0.5110.30
198_P202_I0.5100.30
236_P289_L0.5090.30
207_D225_K0.5080.30
25_T29_S0.5080.30
105_V140_F0.5080.30
233_T280_H0.5070.30
117_D134_H0.5060.30
45_P89_Y0.5060.30
71_R77_S0.5060.30
72_I78_R0.5050.30
232_V236_P0.5040.30
34_R295_Q0.5040.30
17_E241_Q0.5040.30
36_L208_L0.5040.30
24_T29_S0.5030.30
146_Q181_R0.5030.30
125_K285_F0.5030.30
20_V59_S0.5020.29
72_I91_N0.5020.29
64_Q184_D0.5000.29
202_I210_I0.5000.29
35_P64_Q0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vdjA 2 0.8673 100 0.417 Contact Map
2h2wA 2 0.932 100 0.429 Contact Map
3m3pA 1 0.767 100 0.756 Contact Map
3l7nA 1 0.7411 99.8 0.852 Contact Map
1o1yA 2 0.7411 99.8 0.853 Contact Map
1qdlB 2 0.6149 99.7 0.864 Contact Map
2lxnA 1 0.5922 99.6 0.87 Contact Map
1wl8A 1 0.5922 99.6 0.871 Contact Map
2vpiA 1 0.5922 99.6 0.872 Contact Map
2a9vA 1 0.6408 99.5 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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