GREMLIN Database
TYRR - Transcriptional regulatory protein TyrR
UniProt: P07604 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11042
Length: 513 (427)
Sequences: 5343 (4468)
Seq/√Len: 216.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_D371_R3.7571.00
479_N489_R3.7491.00
346_L351_M3.6421.00
345_E349_K3.6391.00
387_R420_K3.5811.00
288_E322_R3.5081.00
264_A309_A3.1471.00
268_E306_R3.0921.00
470_R474_T2.9861.00
469_E500_K2.8591.00
296_L338_A2.7831.00
292_G332_D2.7561.00
222_K431_D2.7171.00
342_N345_E2.5991.00
400_A436_R2.5531.00
341_K346_L2.5461.00
479_N486_L2.5271.00
208_A213_M2.4701.00
403_L407_L2.4391.00
319_T328_E2.4341.00
286_F321_R2.4341.00
320_F331_V2.3911.00
97_D101_K2.3801.00
378_M408_T2.3711.00
485_K488_K2.3171.00
319_T330_H2.2781.00
220_A243_F2.2501.00
253_R332_D2.2461.00
241_D313_R2.2101.00
410_Y413_P2.1821.00
478_R489_R2.1741.00
210_S375_Q2.1521.00
321_R328_E2.1331.00
381_T423_I2.1111.00
378_M404_N2.0951.00
316_N420_K2.0801.00
287_F295_V2.0741.00
110_C117_L2.0321.00
216_V365_L2.0311.00
101_K124_T2.0201.00
412_W422_A1.9761.00
203_F246_A1.9611.00
325_E329_V1.9401.00
492_V497_I1.9401.00
399_L423_I1.9361.00
301_G339_T1.9241.00
94_L102_V1.9201.00
206_I213_M1.9111.00
212_K372_D1.9001.00
166_L170_N1.8991.00
278_H282_G1.8951.00
345_E348_Q1.8871.00
484_R494_H1.8821.00
216_V243_F1.8771.00
381_T399_L1.8761.00
279_A282_G1.8711.00
403_L437_P1.8431.00
346_L349_K1.8421.00
468_F472_V1.7881.00
272_E310_K1.7821.00
287_F314_F1.7711.00
402_D437_P1.7631.00
315_L335_V1.7601.00
209_V379_P1.7591.00
398_K434_E1.7331.00
466_S503_E1.7321.00
385_V427_L1.7181.00
406_V437_P1.7021.00
374_P411_A1.7001.00
374_P377_I1.6991.00
256_K292_G1.6881.00
400_A403_L1.6851.00
123_H127_Q1.6761.00
228_A428_T1.6651.00
400_A434_E1.6621.00
377_I381_T1.6491.00
271_V307_M1.6371.00
228_A424_Y1.6201.00
403_L435_L1.6021.00
233_T366_N1.5961.00
465_T468_F1.5791.00
337_C360_L1.5771.00
295_V335_V1.5631.00
291_N332_D1.5611.00
473_L497_I1.5591.00
238_T367_L1.5431.00
227_S253_R1.4921.00
216_V220_A1.4841.00
107_P111_Q1.4841.00
203_F220_A1.4831.00
476_L486_L1.4821.00
380_L384_F1.4821.00
230_L247_C1.4601.00
108_A111_Q1.4541.00
288_E329_V1.4521.00
485_K489_R1.4521.00
231_L337_C1.4501.00
410_Y418_Q1.4491.00
464_I472_V1.4431.00
348_Q354_E1.4341.00
116_K119_R1.4341.00
105_A120_L1.4321.00
464_I468_F1.4311.00
500_K504_Y1.4261.00
483_T494_H1.4241.00
91_E180_V1.4161.00
207_V383_L1.4161.00
388_F423_I1.4101.00
436_R439_D1.4081.00
343_L352_F1.4071.00
220_A365_L1.4061.00
87_E107_P1.4031.00
287_F333_V1.3931.00
243_F367_L1.3861.00
291_N331_V1.3861.00
378_M381_T1.3821.00
232_I244_A1.3821.00
213_M216_V1.3811.00
405_T409_R1.3761.00
223_L363_L1.3681.00
430_L439_D1.3631.00
495_T498_A1.3621.00
441_L445_Y1.3591.00
475_Q478_R1.3591.00
482_S494_H1.3531.00
228_A392_Q1.3481.00
344_V348_Q1.3371.00
302_E341_K1.3331.00
136_R140_S1.3301.00
388_F427_L1.3271.00
320_F330_H1.3151.00
89_L93_V1.3121.00
233_T364_T1.3061.00
374_P378_M1.3021.00
235_D369_P1.2951.00
493_S496_A1.2871.00
426_A435_L1.2871.00
384_F423_I1.2801.00
221_Q250_A1.2671.00
382_E404_N1.2631.00
471_S475_Q1.2561.00
486_L489_R1.2531.00
271_V275_L1.2491.00
291_N333_V1.2461.00
322_R325_E1.2441.00
494_H498_A1.2401.00
496_A499_N1.2361.00
473_L500_K1.2321.00
383_L387_R1.2271.00
208_A217_V1.2201.00
404_N408_T1.2201.00
314_F320_F1.2161.00
484_R488_K1.2131.00
384_F388_F1.2081.00
389_A395_P1.2061.00
286_F289_Q1.1901.00
473_L486_L1.1891.00
189_G193_Q1.1801.00
283_K326_D1.1791.00
460_S463_E1.1691.00
473_L501_L1.1671.00
467_R471_S1.1661.00
205_Q249_Q1.1631.00
268_E304_S1.1631.00
483_T497_I1.1601.00
441_L444_D1.1591.00
217_V221_Q1.1511.00
278_H283_K1.1501.00
482_S485_K1.1491.00
422_A426_A1.1451.00
389_A396_R1.1341.00
206_I242_L1.1331.00
217_V243_F1.1281.00
483_T498_A1.1271.00
165_Y172_Q1.1261.00
366_N372_D1.1221.00
233_T344_V1.1211.00
495_T499_N1.1141.00
206_I243_F1.1091.00
289_Q325_E1.1081.00
248_H294_S1.1061.00
399_L404_N1.1061.00
295_V314_F1.1061.00
284_K326_D1.1051.00
96_V175_L1.1031.00
225_M252_P1.0941.00
245_Y249_Q1.0941.00
92_P106_N1.0931.00
405_T408_T1.0921.00
199_D249_Q1.0921.00
471_S474_T1.0871.00
465_T472_V1.0861.00
110_C116_K1.0851.00
435_L440_I1.0841.00
389_A427_L1.0811.00
384_F420_K1.0741.00
476_L479_N1.0641.00
264_A302_E1.0641.00
246_A250_A1.0621.00
392_Q428_T1.0591.00
476_L480_Y1.0551.00
219_Q429_Q1.0541.00
402_D436_R1.0521.00
227_S252_P1.0521.00
192_L195_V1.0511.00
137_W140_S1.0501.00
399_L403_L1.0491.00
469_E473_L1.0481.00
322_R329_V1.0361.00
284_K322_R1.0301.00
425_R429_Q1.0281.00
228_A362_V1.0281.00
208_A379_P1.0271.00
218_E221_Q1.0261.00
474_T506_L1.0261.00
253_R333_V1.0231.00
201_S245_Y1.0221.00
259_L289_Q1.0131.00
92_P112_L1.0121.00
80_L83_S1.0111.00
97_D103_D1.0101.00
301_G341_K1.0091.00
227_S391_E1.0081.00
244_A258_Y1.0051.00
226_L428_T1.0051.00
260_A313_R1.0041.00
481_P486_L1.0001.00
370_L419_L1.0001.00
394_V397_P1.0001.00
474_T477_Y0.9981.00
344_V443_P0.9971.00
401_A405_T0.9971.00
115_Q120_L0.9941.00
302_E340_Q0.9941.00
440_I444_D0.9901.00
213_M217_V0.9871.00
79_H83_S0.9851.00
271_V303_M0.9831.00
135_L139_E0.9821.00
83_S87_E0.9821.00
220_A250_A0.9811.00
397_P433_Y0.9791.00
425_R441_L0.9781.00
335_V360_L0.9701.00
213_M243_F0.9691.00
492_V496_A0.9691.00
318_G330_H0.9671.00
426_A430_L0.9571.00
105_A110_C0.9531.00
410_Y444_D0.9531.00
212_K215_H0.9531.00
432_G439_D0.9531.00
476_L481_P0.9521.00
466_S504_Y0.9491.00
464_I467_R0.9350.99
107_P110_C0.9340.99
262_N265_S0.9330.99
486_L497_I0.9320.99
301_G340_Q0.9310.99
374_P408_T0.9290.99
94_L109_S0.9280.99
460_S491_G0.9270.99
284_K289_Q0.9250.99
209_V214_K0.9240.99
479_N485_K0.9210.99
166_L169_E0.9190.99
385_V389_A0.9140.99
136_R139_E0.9140.99
267_P323_V0.9140.99
425_R428_T0.9080.99
95_S103_D0.9080.99
214_K217_V0.9070.99
385_V399_L0.9030.99
241_D260_A0.8960.99
232_I243_F0.8930.99
258_Y293_G0.8930.99
279_A283_K0.8920.99
391_E424_Y0.8920.99
497_I501_L0.8900.99
493_S499_N0.8870.99
386_A390_D0.8810.99
341_K351_M0.8800.99
187_R191_Q0.8770.99
287_F331_V0.8770.99
217_V220_A0.8730.99
211_P215_H0.8710.99
389_A394_V0.8710.99
232_I367_L0.8670.99
245_Y260_A0.8660.99
388_F424_Y0.8640.99
124_T127_Q0.8620.99
185_T188_M0.8610.99
477_Y480_Y0.8580.99
141_E165_Y0.8530.99
381_T404_N0.8520.99
226_L363_L0.8500.99
241_D317_D0.8490.99
289_Q326_D0.8480.99
487_A497_I0.8470.99
215_H219_Q0.8460.99
501_L506_L0.8450.99
362_V421_N0.8450.99
223_L365_L0.8430.99
465_T469_E0.8430.99
400_A437_P0.8380.99
381_T407_L0.8380.99
203_F217_V0.8360.99
291_N329_V0.8360.99
220_A247_C0.8350.99
229_P337_C0.8320.99
374_P409_R0.8310.99
302_E339_T0.8300.99
141_E172_Q0.8250.99
288_E320_F0.8210.99
498_A502_R0.8180.99
470_R506_L0.8160.99
101_K122_N0.8130.99
399_L435_L0.8120.99
94_L105_A0.8070.99
218_E431_D0.8050.98
229_P318_G0.8050.98
163_P167_Q0.8040.98
215_H218_E0.8040.98
137_W144_D0.7990.98
223_L230_L0.7970.98
483_T501_L0.7930.98
232_I365_L0.7910.98
186_I190_R0.7830.98
270_A273_S0.7830.98
484_R498_A0.7810.98
477_Y481_P0.7790.98
473_L490_L0.7780.98
273_S278_H0.7780.98
283_K286_F0.7760.98
203_F250_A0.7730.98
389_A397_P0.7720.98
233_T340_Q0.7700.98
267_P272_E0.7690.98
312_L359_R0.7690.98
220_A246_A0.7690.98
163_P166_L0.7680.98
397_P430_L0.7670.98
191_Q194_N0.7600.98
89_L92_P0.7570.98
214_K218_E0.7560.98
470_R504_Y0.7550.98
151_V154_G0.7530.98
131_G134_F0.7530.98
459_G467_R0.7500.98
260_A319_T0.7480.98
228_A363_L0.7480.98
406_V444_D0.7470.98
208_A214_K0.7450.97
219_Q425_R0.7410.97
204_S221_Q0.7390.97
494_H497_I0.7390.97
378_M382_E0.7390.97
140_S144_D0.7380.97
266_I275_L0.7370.97
493_S498_A0.7350.97
499_N503_E0.7350.97
361_N425_R0.7350.97
392_Q427_L0.7340.97
166_L173_H0.7340.97
79_H82_L0.7330.97
216_V367_L0.7310.97
397_P427_L0.7310.97
165_Y170_N0.7310.97
300_I303_M0.7300.97
109_S113_F0.7280.97
388_F420_K0.7270.97
287_F320_F0.7270.97
501_L504_Y0.7260.97
382_E386_A0.7260.97
253_R256_K0.7240.97
184_S189_G0.7210.97
177_G180_V0.7200.97
105_A109_S0.7200.97
476_L483_T0.7180.97
356_L360_L0.7180.97
498_A501_L0.7170.97
461_L464_I0.7170.97
344_V347_V0.7160.97
260_A317_D0.7140.97
227_S334_R0.7130.97
313_R316_N0.7130.97
126_A130_N0.7130.97
394_V427_L0.7110.97
233_T339_T0.7100.97
270_A340_Q0.7100.97
292_G333_V0.7070.97
115_Q119_R0.7060.97
241_D316_N0.7060.97
247_C336_I0.7040.96
126_A135_L0.7030.96
369_P372_D0.7020.96
373_C376_D0.7000.96
271_V310_K0.7000.96
361_N364_T0.6990.96
359_R417_R0.6970.96
362_V424_Y0.6950.96
496_A500_K0.6920.96
466_S470_R0.6910.96
94_L177_G0.6900.96
274_E278_H0.6900.96
316_N359_R0.6900.96
298_D313_R0.6880.96
318_G332_D0.6880.96
100_S124_T0.6840.96
424_Y428_T0.6830.96
403_L436_R0.6820.96
313_R317_D0.6810.96
301_G343_L0.6810.96
318_G333_V0.6800.96
320_F328_E0.6750.96
367_L416_V0.6730.95
211_P214_K0.6730.95
388_F391_E0.6700.95
92_P109_S0.6690.95
212_K375_Q0.6670.95
354_E418_Q0.6670.95
207_V379_P0.6670.95
224_A250_A0.6670.95
426_A439_D0.6650.95
140_S143_Q0.6650.95
125_A134_F0.6640.95
426_A440_I0.6630.95
484_R495_T0.6630.95
163_P168_D0.6620.95
303_M307_M0.6600.95
340_Q359_R0.6600.95
481_P494_H0.6600.95
92_P113_F0.6580.95
208_A376_D0.6580.95
388_F392_Q0.6550.95
299_E340_Q0.6540.95
95_S109_S0.6540.95
473_L504_Y0.6530.95
85_L95_S0.6530.95
89_L178_A0.6520.95
284_K288_E0.6510.95
210_S213_M0.6510.95
188_M195_V0.6500.95
161_I165_Y0.6490.94
266_I272_E0.6480.94
95_S104_M0.6480.94
476_L501_L0.6470.94
137_W161_I0.6470.94
188_M191_Q0.6460.94
294_S334_R0.6460.94
381_T385_V0.6450.94
267_P270_A0.6450.94
482_S498_A0.6450.94
352_F356_L0.6410.94
264_A310_K0.6400.94
225_M250_A0.6390.94
440_I443_P0.6350.94
236_T359_R0.6350.94
403_L426_A0.6330.94
299_E359_R0.6330.94
207_V384_F0.6300.94
298_D359_R0.6290.94
150_V154_G0.6290.94
395_P433_Y0.6280.93
341_K350_G0.6280.93
483_T492_V0.6260.93
396_R399_L0.6260.93
182_L186_I0.6250.93
486_L490_L0.6250.93
343_L347_V0.6250.93
235_D238_T0.6240.93
431_D439_D0.6230.93
344_V357_Y0.6230.93
163_P172_Q0.6210.93
165_Y169_E0.6200.93
422_A425_R0.6200.93
209_V375_Q0.6190.93
278_H323_V0.6190.93
203_F221_Q0.6190.93
291_N330_H0.6180.93
211_P375_Q0.6150.93
318_G331_V0.6130.93
174_V179_V0.6120.93
175_L179_V0.6120.93
117_L121_R0.6100.92
377_I408_T0.6090.92
161_I177_G0.6090.92
273_S340_Q0.6080.92
109_S179_V0.6080.92
270_A323_V0.6080.92
227_S332_D0.6080.92
317_D330_H0.6070.92
269_D272_E0.6060.92
200_V245_Y0.6050.92
385_V398_K0.6030.92
286_F498_A0.6010.92
261_L275_L0.6010.92
298_D340_Q0.6010.92
251_S334_R0.6000.92
96_V102_V0.5980.92
273_S283_K0.5980.92
483_T495_T0.5970.92
222_K394_V0.5960.92
238_T242_L0.5960.92
147_N150_V0.5930.91
92_P179_V0.5930.91
148_E151_V0.5920.91
325_E328_E0.5910.91
274_E352_F0.5900.91
462_D466_S0.5900.91
314_F317_D0.5860.91
243_F246_A0.5860.91
425_R495_T0.5860.91
403_L441_L0.5860.91
284_K320_F0.5850.91
261_L295_V0.5840.91
407_L412_W0.5840.91
282_G325_E0.5830.91
355_D359_R0.5820.91
291_N320_F0.5810.91
212_K216_V0.5800.90
87_E117_L0.5800.90
96_V100_S0.5790.90
202_A205_Q0.5760.90
276_F285_G0.5750.90
473_L506_L0.5750.90
294_S376_D0.5740.90
298_D417_R0.5740.90
375_Q408_T0.5720.90
201_S205_Q0.5720.90
202_A249_Q0.5710.90
190_R194_N0.5710.90
310_K321_R0.5710.90
98_M170_N0.5700.90
364_T425_R0.5690.90
278_H281_E0.5670.89
260_A321_R0.5670.89
374_P379_P0.5660.89
304_S496_A0.5640.89
123_H128_L0.5620.89
208_A212_K0.5600.89
100_S125_A0.5590.89
353_R359_R0.5580.89
189_G192_L0.5580.89
188_M192_L0.5580.89
96_V177_G0.5560.89
469_E504_Y0.5550.88
186_I195_V0.5550.88
375_Q378_M0.5520.88
406_V409_R0.5510.88
432_G436_R0.5500.88
385_V396_R0.5500.88
313_R319_T0.5500.88
493_S500_K0.5500.88
347_V352_F0.5480.88
152_I157_F0.5480.88
273_S338_A0.5470.88
202_A250_A0.5470.88
224_A334_R0.5460.88
184_S187_R0.5460.88
382_E398_K0.5460.88
380_L383_L0.5450.88
222_K429_Q0.5440.87
267_P303_M0.5440.87
98_M173_H0.5440.87
464_I475_Q0.5430.87
423_I426_A0.5420.87
387_R391_E0.5410.87
318_G391_E0.5400.87
350_G354_E0.5390.87
377_I407_L0.5370.87
480_Y494_H0.5350.87
268_E272_E0.5340.87
311_L314_F0.5330.86
459_G464_I0.5330.86
353_R417_R0.5330.86
199_D245_Y0.5320.86
339_T343_L0.5320.86
410_Y441_L0.5320.86
174_V178_A0.5320.86
303_M309_A0.5310.86
147_N152_I0.5310.86
494_H499_N0.5310.86
172_Q175_L0.5300.86
304_S307_M0.5300.86
215_H438_Q0.5300.86
363_L428_T0.5300.86
320_F329_V0.5290.86
110_C114_G0.5280.86
383_L386_A0.5280.86
476_L482_S0.5270.86
274_E282_G0.5270.86
177_G181_M0.5260.86
242_L313_R0.5260.86
220_A336_I0.5260.86
125_A135_L0.5250.86
486_L501_L0.5250.86
251_S294_S0.5250.86
113_F179_V0.5250.86
231_L343_L0.5240.85
418_Q443_P0.5240.85
206_I367_L0.5230.85
299_E417_R0.5230.85
277_G285_G0.5220.85
461_L469_E0.5210.85
144_D154_G0.5200.85
271_V304_S0.5200.85
420_K424_Y0.5190.85
146_H150_V0.5180.85
363_L429_Q0.5160.85
110_C115_Q0.5150.85
299_E338_A0.5150.85
186_I189_G0.5140.84
102_V128_L0.5130.84
106_N109_S0.5120.84
148_E152_I0.5120.84
344_V364_T0.5120.84
289_Q328_E0.5120.84
150_V156_N0.5100.84
249_Q254_A0.5090.84
236_T312_L0.5080.84
379_P383_L0.5080.84
215_H442_L0.5080.84
492_V500_K0.5080.84
146_H149_H0.5070.84
301_G352_F0.5070.84
135_L138_L0.5070.84
403_L406_V0.5070.84
238_T244_A0.5060.83
406_V443_P0.5060.83
112_L179_V0.5050.83
181_M185_T0.5050.83
406_V445_Y0.5050.83
82_L85_L0.5050.83
477_Y482_S0.5040.83
381_T426_A0.5010.83
190_R193_Q0.5010.83
278_H340_Q0.5000.83
320_F323_V0.5000.83
461_L465_T0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.7427 100 0.349 Contact Map
1ojlA 3 0.5712 100 0.487 Contact Map
3dzdA 2 0.692 100 0.511 Contact Map
4fwgA 3 0.6023 100 0.658 Contact Map
4qosA 1 0.4678 100 0.686 Contact Map
4qhsA 3 0.462 100 0.686 Contact Map
1qvrA 3 0.8635 100 0.7 Contact Map
1r6bX 1 0.8031 100 0.71 Contact Map
4d2uA 3 0.8207 100 0.713 Contact Map
4ciuA 1 0.8226 100 0.717 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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