GREMLIN Database
THGA - Galactoside O-acetyltransferase
UniProt: P07464 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10524
Length: 203 (179)
Sequences: 4248 (3065)
Seq/√Len: 229.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_I96_V4.2621.00
110_L132_I3.4271.00
155_N171_N3.2271.00
135_G154_D2.9861.00
81_N101_N2.8971.00
87_N107_N2.6351.00
154_D170_P2.5931.00
159_G175_A2.5731.00
25_K74_S2.5421.00
136_N154_D2.5251.00
77_H97_T2.5221.00
147_N160_A2.4991.00
57_T77_H2.4031.00
168_I174_A2.4021.00
111_S142_S2.3001.00
175_A182_I2.2971.00
80_R100_D2.2931.00
43_E46_K2.1901.00
140_I146_I2.1171.00
156_S170_P2.0501.00
137_N155_N2.0181.00
34_Y38_H1.9801.00
97_T133_T1.8641.00
156_S172_V1.8541.00
34_Y41_P1.8451.00
93_D129_S1.8111.00
158_I168_I1.8071.00
78_I82_F1.7911.00
101_N137_N1.7611.00
59_G80_R1.7581.00
48_E52_K1.7211.00
133_T151_T1.6671.00
77_H95_T1.6151.00
110_L134_I1.6141.00
94_Y129_S1.6071.00
58_V62_A1.5691.00
32_L53_E1.5491.00
140_I144_V1.5411.00
156_S168_I1.5091.00
117_V157_V1.4991.00
104_I110_L1.4911.00
82_F100_D1.4651.00
172_V184_E1.4561.00
100_D136_N1.4551.00
28_R32_L1.4481.00
123_K137_N1.4341.00
174_A179_C1.4191.00
61_N81_N1.4181.00
117_V173_V1.3851.00
31_T42_S1.3821.00
158_I174_A1.3471.00
172_V181_V1.3381.00
151_T167_D1.3361.00
31_T40_H1.3101.00
118_H121_L1.3031.00
79_G100_D1.3021.00
7_E11_A1.3001.00
162_S179_C1.2721.00
89_T107_N1.2711.00
46_K49_S1.2671.00
56_A77_H1.2601.00
84_A88_L1.2561.00
135_G151_T1.2401.00
82_F102_V1.2241.00
65_E83_Y1.2001.00
35_E40_H1.1941.00
98_I104_I1.1831.00
70_F76_I1.1661.00
109_T143_H1.1521.00
62_A78_I1.1501.00
29_G54_M1.1441.00
34_Y40_H1.1331.00
147_N165_T1.1301.00
181_V184_E1.1181.00
109_T142_S1.1111.00
169_P181_V1.1031.00
78_I84_A1.0981.00
135_G156_S1.0971.00
29_G33_M1.0861.00
52_K58_V1.0821.00
51_I55_F1.0801.00
50_L54_M1.0481.00
169_P174_A1.0441.00
144_V162_S1.0421.00
60_E80_R1.0341.00
104_I140_I1.0311.00
36_F51_I1.0191.00
76_I90_I1.0131.00
114_G130_F1.0131.00
162_S177_V1.0041.00
84_A104_I0.9971.00
20_E24_E0.9871.00
163_I177_V0.9871.00
61_N80_R0.9851.00
14_L128_Y0.9781.00
78_I98_I0.9761.00
102_V136_N0.9731.00
134_I140_I0.9711.00
99_G136_N0.9591.00
14_L126_E0.9571.00
82_F136_N0.9561.00
109_T145_V0.9531.00
110_L146_I0.9461.00
84_A90_I0.9431.00
98_I134_I0.9361.00
102_V154_D0.9251.00
114_G128_Y0.9181.00
107_N143_H0.9171.00
98_I110_L0.9040.99
68_V76_I0.8970.99
169_P172_V0.8850.99
154_D171_N0.8790.99
119_H122_R0.8760.99
49_S53_E0.8740.99
35_E46_K0.8730.99
173_V185_I0.8590.99
76_I96_V0.8550.99
32_L54_M0.8430.99
174_A181_V0.8430.99
138_V154_D0.8420.99
138_V170_P0.8400.99
157_V173_V0.8400.99
108_V144_V0.8330.99
55_F59_G0.8270.99
146_I152_I0.8250.99
39_S46_K0.8140.99
73_G76_I0.8120.99
112_V131_P0.7990.99
120_E124_N0.7980.99
32_L50_L0.7960.99
30_K65_E0.7810.98
114_G117_V0.7800.98
152_I167_D0.7800.98
152_I174_A0.7690.98
71_S93_D0.7560.98
69_Y86_F0.7530.98
36_F66_P0.7450.98
113_T129_S0.7360.98
47_R66_P0.7350.98
39_S47_R0.7300.98
121_L126_E0.7280.98
172_V175_A0.7280.98
35_E53_E0.7250.98
93_D113_T0.7250.98
28_R53_E0.7240.98
22_L26_R0.7160.97
30_K86_F0.7140.97
171_N184_E0.7090.97
31_T35_E0.7080.97
152_I168_I0.7060.97
58_V80_R0.7060.97
40_H43_E0.7050.97
140_I152_I0.7040.97
137_N154_D0.7040.97
56_A59_G0.7020.97
102_V138_V0.6940.97
104_I108_V0.6930.97
121_L124_N0.6920.97
62_A82_F0.6900.97
69_Y87_N0.6840.96
82_F104_I0.6840.96
135_G170_P0.6790.96
161_G177_V0.6790.96
104_I134_I0.6770.96
45_E49_S0.6750.96
14_L121_L0.6710.96
134_I146_I0.6680.96
167_D174_A0.6670.96
13_K16_T0.6650.96
82_F98_I0.6650.96
85_N103_L0.6640.96
28_R31_T0.6600.96
73_G92_D0.6580.96
168_I179_C0.6560.96
158_I179_C0.6560.96
10_R94_Y0.6490.95
21_G24_E0.6490.95
98_I102_V0.6450.95
39_S50_L0.6450.95
101_N123_K0.6430.95
16_T124_N0.6430.95
59_G62_A0.6430.95
134_I138_V0.6420.95
25_K28_R0.6410.95
23_P26_R0.6410.95
85_N139_W0.6380.95
24_E27_L0.6350.95
97_T131_P0.6290.94
115_H139_W0.6270.94
113_T127_M0.6240.94
28_R74_S0.6240.94
173_V183_R0.6180.94
55_F58_V0.6180.94
58_V78_I0.6130.94
145_V160_A0.6030.93
63_W83_Y0.5980.93
31_T34_Y0.5970.93
26_R65_E0.5960.93
27_L44_V0.5960.93
38_H41_P0.5960.93
109_T132_I0.5950.93
82_F99_G0.5870.92
33_M70_F0.5870.92
21_G25_K0.5830.92
57_T78_I0.5790.92
99_G133_T0.5780.92
83_Y103_L0.5750.91
68_V88_L0.5750.91
106_P142_S0.5750.91
155_N170_P0.5750.91
54_M70_F0.5740.91
175_A179_C0.5710.91
116_P121_L0.5690.91
144_V174_A0.5660.91
85_N115_H0.5660.91
46_K50_L0.5660.91
117_V183_R0.5620.90
108_V140_I0.5610.90
145_V163_I0.5600.90
138_V156_S0.5600.90
91_V113_T0.5530.90
112_V148_P0.5520.90
132_I148_P0.5510.90
88_L108_V0.5510.90
79_G82_F0.5510.90
90_I110_L0.5500.89
10_R95_T0.5490.89
78_I102_V0.5480.89
159_G165_T0.5480.89
24_E28_R0.5470.89
177_V182_I0.5450.89
114_G148_P0.5440.89
105_A135_G0.5440.89
26_R29_G0.5440.89
22_L25_K0.5420.89
142_S145_V0.5410.89
88_L104_I0.5390.89
101_N125_G0.5380.88
27_L30_K0.5360.88
175_A180_R0.5360.88
85_N91_V0.5330.88
32_L35_E0.5330.88
119_H171_N0.5320.88
132_I150_V0.5310.88
95_T133_T0.5290.88
18_M26_R0.5270.87
131_P151_T0.5230.87
81_N100_D0.5200.87
64_V84_A0.5190.87
29_G32_L0.5160.86
22_L74_S0.5140.86
36_F39_S0.5140.86
44_V48_E0.5130.86
15_F113_T0.5110.86
35_E39_S0.5110.86
75_N95_T0.5090.86
8_R19_C0.5070.85
39_S43_E0.5070.85
17_D125_G0.5070.85
111_S145_V0.5050.85
117_V185_I0.5050.85
116_P122_R0.5050.85
75_N92_D0.5040.85
159_G173_V0.5030.85
50_L53_E0.5030.85
119_H123_K0.5030.85
30_K72_Y0.5000.85
105_A151_T0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1krrA 3 0.9852 100 0.266 Contact Map
3fttA 3 0.9212 100 0.287 Contact Map
3srtA 3 0.9212 100 0.291 Contact Map
3nz2A 4 0.9113 100 0.293 Contact Map
3hjjA 3 0.9212 100 0.299 Contact Map
2p2oA 3 0.9064 100 0.303 Contact Map
1ocxA 3 0.8966 100 0.328 Contact Map
3vbiA 3 0.7783 100 0.484 Contact Map
4g3qA 3 0.9901 100 0.493 Contact Map
2v0hA 3 0.9113 100 0.5 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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