GREMLIN Database
SYFB - Phenylalanine--tRNA ligase beta subunit
UniProt: P07395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10710
Length: 795 (785)
Sequences: 3847 (2699)
Seq/√Len: 96.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_D330_N6.2091.00
715_A753_Y4.5501.00
594_G682_F4.3721.00
286_T294_E4.3351.00
716_E745_R4.3071.00
52_E66_K4.2161.00
286_T296_K3.9031.00
49_E89_R3.7271.00
218_G332_L3.4581.00
267_F312_A3.4291.00
48_G92_V3.3431.00
556_V595_V3.3411.00
51_V74_L3.1651.00
259_E375_R3.1421.00
49_E68_N3.1261.00
435_C455_M3.0911.00
220_V269_K3.0271.00
88_L136_E3.0251.00
292_G320_E2.9191.00
55_Q63_R2.8611.00
225_N228_A2.8141.00
216_Y267_F2.8071.00
221_V333_L2.8031.00
58_N113_E2.8011.00
283_E299_A2.6871.00
223_G387_E2.6351.00
17_D20_A2.6331.00
51_V68_N2.6121.00
648_Q664_V2.6021.00
50_V84_C2.5841.00
726_E789_F2.5791.00
271_R325_N2.5731.00
221_V386_G2.5721.00
85_R88_L2.5331.00
77_I92_V2.5071.00
85_R136_E2.4991.00
637_R651_A2.4921.00
409_R458_E2.4861.00
301_T349_R2.4851.00
273_E308_N2.4801.00
512_T555_T2.4651.00
716_E752_G2.4601.00
736_V763_Q2.4341.00
518_P542_S2.4111.00
253_T266_A2.3901.00
719_P722_D2.3781.00
230_T234_M2.3771.00
735_V760_L2.3681.00
429_I468_V2.3541.00
311_L322_S2.3391.00
721_A725_S2.3191.00
740_L756_L2.2961.00
412_K458_E2.2941.00
141_A150_Y2.2901.00
10_E237_K2.2701.00
149_E154_D2.2671.00
664_V678_R2.2641.00
711_A757_A2.2451.00
413_L426_V2.2421.00
414_D420_H2.2371.00
281_A297_L2.2141.00
289_L295_A2.2141.00
13_N188_V2.2111.00
216_Y312_A2.2001.00
637_R653_Y2.1931.00
762_L778_V2.1331.00
767_R773_E2.0971.00
69_V75_L2.0661.00
764_D767_R2.0601.00
128_S131_H2.0581.00
52_E86_Q2.0531.00
279_R285_E2.0481.00
272_I311_L2.0171.00
653_Y658_R2.0111.00
89_R141_A2.0001.00
367_A450_S1.9911.00
507_Y620_D1.9791.00
446_A461_L1.9781.00
44_G94_T1.9721.00
510_V569_I1.9691.00
222_K330_N1.9621.00
229_P235_K1.9571.00
217_L373_M1.9511.00
298_N349_R1.9381.00
410_R426_V1.9371.00
19_D23_N1.9301.00
33_D161_S1.9251.00
222_K387_E1.9131.00
408_L461_L1.8921.00
422_A425_Q1.8721.00
428_D432_R1.8701.00
89_R143_I1.8611.00
232_L236_E1.8601.00
549_W681_V1.8581.00
724_L728_K1.8501.00
53_C63_R1.8491.00
288_V294_E1.8461.00
287_L313_M1.8431.00
510_V555_T1.8411.00
219_R374_E1.8371.00
208_E277_V1.8331.00
212_A280_M1.8301.00
600_R610_E1.8271.00
274_G307_H1.8201.00
657_E688_K1.8171.00
378_R382_D1.8091.00
651_A658_R1.8091.00
741_F757_A1.8081.00
145_T149_E1.8041.00
407_T445_Q1.8011.00
69_V94_T1.7881.00
215_R393_D1.7821.00
729_K788_R1.7671.00
408_L413_L1.7571.00
69_V92_V1.7551.00
48_G69_V1.7491.00
209_A280_M1.7491.00
66_K74_L1.7261.00
45_V91_A1.7241.00
22_A35_V1.7191.00
264_M376_A1.7181.00
617_L662_V1.7151.00
241_C258_L1.7121.00
720_A756_L1.7121.00
518_P532_L1.7031.00
47_V89_R1.6981.00
786_K792_S1.6831.00
416_L459_E1.6741.00
142_P145_T1.6731.00
235_K245_S1.6671.00
660_G684_L1.6651.00
123_S131_H1.6631.00
425_Q428_D1.6591.00
406_I455_M1.6541.00
98_V104_K1.6491.00
621_L625_L1.6471.00
279_R305_A1.6431.00
91_A147_I1.6321.00
555_T569_I1.6311.00
306_D309_K1.6281.00
301_T346_R1.6251.00
714_V723_I1.6231.00
510_V552_L1.6161.00
273_E309_K1.5971.00
783_E786_K1.5911.00
21_L179_V1.5901.00
252_V376_A1.5861.00
47_V141_A1.5791.00
596_I617_L1.5731.00
380_L386_G1.5651.00
316_I346_R1.5631.00
28_A182_L1.5611.00
301_T350_H1.5601.00
305_A310_A1.5591.00
84_C88_L1.5531.00
64_V113_E1.5521.00
547_S550_T1.5481.00
239_R245_S1.5451.00
91_A134_I1.5411.00
712_V785_L1.5401.00
122_F135_I1.5381.00
221_V380_L1.5311.00
779_A783_E1.5291.00
347_A357_S1.5291.00
784_A788_R1.5281.00
744_Y750_A1.5231.00
54_A113_E1.5151.00
160_I175_V1.5131.00
309_K321_H1.5031.00
713_V750_A1.5011.00
646_P666_H1.4931.00
46_V94_T1.4751.00
645_H667_P1.4721.00
448_A455_M1.4701.00
405_T447_V1.4701.00
53_C84_C1.4701.00
269_K332_L1.4681.00
377_T388_A1.4671.00
317_F354_T1.4581.00
417_I466_A1.4531.00
55_Q61_K1.4511.00
91_A135_I1.4431.00
234_M383_I1.4431.00
138_P141_A1.4421.00
746_G749_V1.4381.00
142_P150_Y1.4351.00
653_Y656_G1.4321.00
654_L659_I1.4311.00
365_D450_S1.4291.00
49_E143_I1.4271.00
55_Q59_A1.4221.00
503_N570_F1.4171.00
98_V102_D1.4140.99
180_A187_L1.4090.99
425_Q473_N1.4070.99
727_C781_C1.4000.99
553_L595_V1.3990.99
171_G261_G1.3960.99
76_D114_P1.3940.99
711_A741_F1.3920.99
252_V380_L1.3860.99
356_A360_Y1.3830.99
645_H666_H1.3810.99
249_V380_L1.3810.99
217_L369_Q1.3790.99
557_V561_N1.3790.99
520_V554_A1.3750.99
775_A779_A1.3740.99
264_M333_L1.3720.99
409_R412_K1.3710.99
414_D419_H1.3700.99
589_D685_E1.3700.99
216_Y276_I1.3640.99
205_I218_G1.3590.99
750_A753_Y1.3570.99
49_E139_A1.3480.99
95_I108_A1.3450.99
644_L649_S1.3410.99
407_T443_E1.3320.99
723_I756_L1.3320.99
252_V383_I1.3310.99
256_V375_R1.3300.99
436_E447_V1.3300.99
59_A63_R1.3280.99
412_K415_R1.3270.99
4_S155_D1.3250.99
427_T431_R1.3230.99
405_T445_Q1.3230.99
302_L314_G1.3210.99
59_A111_R1.3180.99
203_L332_L1.3180.99
410_R423_D1.3100.99
274_G306_D1.3100.99
12_V179_V1.3090.99
664_V680_L1.3070.99
412_K462_V1.3060.99
313_M350_H1.2970.99
73_R116_E1.2900.99
75_L95_I1.2900.99
234_M255_Y1.2890.99
56_H59_A1.2870.99
625_L634_V1.2870.99
107_A114_P1.2870.99
594_G617_L1.2820.99
353_H358_H1.2810.99
243_I355_D1.2800.99
405_T448_A1.2790.99
635_E725_S1.2790.99
206_T277_V1.2750.99
51_V86_Q1.2680.99
746_G750_A1.2650.99
226_V248_A1.2620.99
217_L370_H1.2620.99
93_A97_A1.2600.99
276_I312_A1.2560.99
34_G159_E1.2500.99
753_Y792_S1.2490.99
119_L136_E1.2480.99
98_V103_F1.2460.99
621_L682_F1.2440.99
277_V307_H1.2390.99
408_L462_V1.2380.99
18_S156_N1.2380.99
303_V310_A1.2370.99
5_E18_S1.2360.99
281_A285_E1.2360.99
411_S442_D1.2330.99
431_R437_V1.2250.99
505_K623_S1.2150.98
413_L465_V1.2150.98
50_V53_C1.2150.98
248_A384_C1.2140.98
762_L777_T1.2140.98
435_C448_A1.2110.98
212_A342_S1.2100.98
785_L791_A1.2090.98
312_A356_A1.2070.98
569_I595_V1.2070.98
722_D725_S1.2000.98
783_E787_E1.1950.98
502_L592_L1.1940.98
76_D116_E1.1930.98
416_L462_V1.1930.98
64_V76_D1.1910.98
226_V249_V1.1890.98
177_R451_W1.1880.98
203_L272_I1.1870.98
146_D149_E1.1870.98
644_L681_V1.1860.98
53_C85_R1.1840.98
381_I388_A1.1830.98
288_V320_E1.1790.98
427_T444_W1.1770.98
498_V686_W1.1720.98
225_N329_Q1.1720.98
147_I151_L1.1670.98
377_T381_I1.1650.98
24_Q183_N1.1630.98
235_K239_R1.1620.98
253_T333_L1.1590.98
440_G443_E1.1580.98
747_K751_E1.1580.98
560_Q677_G1.1560.98
219_R377_T1.1550.98
30_L169_C1.1550.98
353_H362_R1.1540.98
438_T447_V1.1490.98
223_G329_Q1.1480.98
572_S686_W1.1450.98
370_H374_E1.1420.98
48_G77_I1.1420.98
522_Q528_V1.1410.98
224_I249_V1.1410.98
342_S346_R1.1400.98
69_V77_I1.1380.98
762_L774_I1.1360.98
47_V150_Y1.1360.98
316_I343_I1.1310.98
270_D329_Q1.1290.98
358_H362_R1.1280.97
410_R444_W1.1270.97
393_D396_N1.1260.97
591_M683_E1.1260.97
283_E296_K1.1250.97
732_V735_V1.1230.97
84_C136_E1.1230.97
147_I150_Y1.1210.97
279_R287_L1.1200.97
298_N301_T1.1190.97
747_K750_A1.1190.97
710_I778_V1.1180.97
3_F175_V1.1180.97
635_E656_G1.1180.97
89_R140_D1.1170.97
771_E775_A1.1120.97
726_E730_V1.1120.97
109_K114_P1.1100.97
280_M300_D1.1090.97
714_V791_A1.1080.97
764_D773_E1.1070.97
45_V125_L1.1030.97
507_Y594_G1.0980.97
237_K255_Y1.0970.97
60_D111_R1.0940.97
75_L116_E1.0940.97
184_Q428_D1.0910.97
223_G330_N1.0910.97
230_T235_K1.0900.97
56_H111_R1.0900.97
269_K330_N1.0900.97
107_A116_E1.0870.97
2_K159_E1.0870.97
714_V754_K1.0870.97
398_A402_K1.0850.97
119_L134_I1.0830.97
552_L595_V1.0830.97
37_P40_G1.0800.97
501_L623_S1.0800.97
266_A333_L1.0800.97
430_L461_L1.0800.97
781_C785_L1.0800.97
137_L141_A1.0790.97
324_V331_V1.0780.97
737_G761_I1.0720.97
707_R759_S1.0690.97
425_Q429_I1.0680.97
49_E86_Q1.0670.96
9_R14_P1.0650.96
438_T445_Q1.0650.96
214_P337_F1.0640.96
63_R84_C1.0610.96
437_V444_W1.0600.96
404_A448_A1.0570.96
551_G573_G1.0530.96
639_E651_A1.0500.96
18_S22_A1.0460.96
207_V214_P1.0440.96
22_A158_I1.0430.96
256_V379_L1.0420.96
66_K76_D1.0420.96
427_T437_V1.0400.96
88_L119_L1.0400.96
65_T84_C1.0380.96
599_N611_T1.0340.96
47_V145_T1.0340.96
333_L380_L1.0330.96
82_P88_L1.0330.96
710_I760_L1.0320.96
264_M356_A1.0300.96
180_A186_P1.0290.96
459_E462_V1.0290.96
427_T439_E1.0240.96
30_L160_I1.0210.95
5_E9_R1.0190.95
726_E784_A1.0180.95
295_A352_L1.0170.95
71_G94_T1.0160.95
621_L652_I1.0160.95
435_C446_A1.0160.95
720_A758_I1.0150.95
20_A23_N1.0120.95
216_Y338_F1.0110.95
167_A453_F1.0110.95
333_L376_A1.0110.95
283_E298_N1.0070.95
425_Q469_Y1.0050.95
63_R82_P1.0050.95
426_V465_V1.0040.95
644_L661_F1.0030.95
744_Y748_G1.0010.95
170_L358_H1.0010.95
122_F128_S0.9980.95
181_V468_V0.9970.95
648_Q680_L0.9970.95
253_T264_M0.9950.95
68_N74_L0.9920.95
646_P667_P0.9890.95
232_L235_K0.9880.95
375_R379_L0.9870.95
53_C86_Q0.9870.95
617_L682_F0.9860.95
76_D113_E0.9860.95
236_E239_R0.9850.95
579_D587_R0.9830.94
252_V384_C0.9830.94
276_I311_L0.9830.94
256_V259_E0.9820.94
532_L543_A0.9810.94
6_L9_R0.9810.94
248_A383_I0.9810.94
489_R492_D0.9800.94
53_C88_L0.9790.94
458_E462_V0.9760.94
335_C373_M0.9740.94
572_S592_L0.9720.94
24_Q182_L0.9720.94
404_A456_E0.9710.94
284_G296_K0.9700.94
621_L662_V0.9690.94
312_A338_F0.9690.94
271_R327_E0.9680.94
80_G119_L0.9650.94
162_V170_L0.9600.94
721_A724_L0.9530.93
63_R79_C0.9490.93
652_I660_G0.9460.93
337_F340_P0.9450.93
591_M685_E0.9450.93
291_D295_A0.9450.93
370_H393_D0.9450.93
31_E161_S0.9450.93
750_A792_S0.9440.93
421_I426_V0.9440.93
184_Q432_R0.9430.93
730_V784_A0.9420.93
229_P248_A0.9410.93
123_S128_S0.9370.93
395_T398_A0.9340.93
701_S763_Q0.9340.93
92_V119_L0.9320.93
46_V69_V0.9310.93
304_I338_F0.9250.92
734_Q777_T0.9230.92
28_A468_V0.9220.92
15_A20_A0.9220.92
548_L551_G0.9190.92
507_Y596_I0.9190.92
705_A761_I0.9180.92
749_V752_G0.9180.92
51_V66_K0.9180.92
390_P393_D0.9160.92
324_V328_T0.9160.92
64_V78_V0.9120.92
190_P375_R0.9110.92
727_C738_V0.9090.92
760_L781_C0.9090.92
590_L687_N0.9080.92
95_I107_A0.9080.92
743_V754_K0.9080.92
276_I338_F0.9040.92
279_R303_V0.9040.92
743_V756_L0.9010.91
723_I758_I0.9000.91
596_I620_D0.8970.91
625_L630_K0.8970.91
56_H60_D0.8950.91
530_A543_A0.8950.91
722_D789_F0.8950.91
423_D444_W0.8940.91
403_R436_E0.8940.91
553_L665_V0.8930.91
301_T313_M0.8880.91
212_A339_S0.8880.91
27_M472_N0.8870.91
469_Y473_N0.8850.91
419_H475_P0.8810.90
197_A222_K0.8810.90
635_E653_Y0.8800.90
29_G169_C0.8800.90
333_L377_T0.8790.90
728_K738_V0.8790.90
32_V160_I0.8790.90
495_L590_L0.8790.90
505_K620_D0.8790.90
412_K416_L0.8780.90
285_E305_A0.8750.90
685_E688_K0.8740.90
320_E325_N0.8700.90
428_D431_R0.8690.90
722_D788_R0.8690.90
3_F172_I0.8680.90
104_K107_A0.8680.90
381_I384_C0.8670.90
228_A385_G0.8650.90
48_G67_V0.8650.90
173_I260_L0.8640.90
466_A471_Y0.8640.90
23_N27_M0.8620.90
499_K572_S0.8600.89
287_L305_A0.8580.89
45_V99_L0.8580.89
300_D349_R0.8580.89
297_L303_V0.8570.89
407_T440_G0.8560.89
594_G621_L0.8550.89
669_L672_K0.8540.89
285_E303_V0.8540.89
723_I789_F0.8520.89
431_R436_E0.8510.89
633_E655_K0.8510.89
782_V793_L0.8510.89
211_E339_S0.8490.89
16_I183_N0.8480.89
715_A754_K0.8480.89
518_P522_Q0.8460.89
498_V624_V0.8450.89
272_I332_L0.8440.89
636_F652_I0.8430.88
123_S129_D0.8430.88
215_R395_T0.8420.88
731_G738_V0.8400.88
736_V765_T0.8390.88
216_Y335_C0.8380.88
173_I190_P0.8380.88
77_I90_V0.8340.88
610_E616_D0.8330.88
270_D327_E0.8310.88
421_I469_Y0.8300.88
731_G781_C0.8290.88
735_V762_L0.8290.88
736_V761_I0.8290.88
53_C82_P0.8260.87
64_V110_L0.8260.87
79_C119_L0.8240.87
311_L321_H0.8230.87
530_A546_L0.8220.87
204_P275_G0.8220.87
522_Q527_G0.8220.87
411_S415_R0.8210.87
81_A133_G0.8210.87
99_L103_F0.8190.87
727_C758_I0.8180.87
265_H318_G0.8180.87
2_K36_E0.8170.87
566_R599_N0.8170.87
222_K269_K0.8150.87
466_A474_I0.8140.87
56_H64_V0.8140.87
727_C785_L0.8080.86
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82_P136_E0.5080.53
652_I662_V0.5080.53
578_P585_G0.5080.53
289_L293_T0.5080.53
706_N771_E0.5080.53
59_A82_P0.5070.53
373_M391_V0.5070.53
615_Y622_E0.5070.53
213_C278_V0.5060.53
711_A794_R0.5060.53
43_H97_A0.5060.53
391_V396_N0.5060.53
45_V97_A0.5060.53
727_C760_L0.5060.53
266_A324_V0.5050.53
54_A59_A0.5040.53
218_G312_A0.5040.53
207_V210_P0.5040.53
199_I202_T0.5040.53
274_G305_A0.5030.53
108_A116_E0.5030.53
601_Y610_E0.5020.52
282_K286_T0.5020.52
281_A303_V0.5010.52
92_V134_I0.5010.52
265_H317_F0.5010.52
272_I322_S0.5010.52
777_T780_K0.5000.52
161_S164_P0.5000.52
292_G786_K0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pcoB 2 0.9975 100 0.077 Contact Map
4p72A 2 0.9937 100 0.081 Contact Map
2rhqB 2 0.9761 100 0.09 Contact Map
1b7yB 2 0.9623 100 0.1 Contact Map
3l4gB 2 0.673 100 0.517 Contact Map
2cxiA 3 0.3925 100 0.732 Contact Map
3cmqA 1 0.4151 100 0.758 Contact Map
2odrA 4 0.3522 100 0.785 Contact Map
2odrD 4 0.3522 100 0.785 Contact Map
2odrB 3 0.3535 100 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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