CHER - ECOLI - GREMLIN Contacts

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CHER - Chemotaxis protein methyltransferase

UniProt:	P07364	Sequences: MTSSLPCGQTSLLLQMTERLALSDAHFRRISQLIYQRAGIVLADHKRDMVYNRLVRRLRSLGLTDFGHYLNLLESNQHSGEWQAFINSLTTNLTAFFREAHHFPLLADHARRRSGEYRVWSAAASTGEEPYSIAMTLADTLGTAPGRWKVFASDIDTEVLEKARSGIYRHEELKNLTPQQLQRYFMRGTGPHEGLVRVRQELANYVDFAPLNLLAKQYTVPGPFDAIFCRNVMIYFDQTTQQEILRRFVPLLKPDGLLFAGHSENFSHLERRFTLRGQTVYALSKD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10148
Length:	286 (253)
Sequences:	4592 (3542)
Seq/√Len:	222.7

ECOLI - CHER
BACSU - CHER
HALSA - Q9HQX0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
126_T	159_V	3.324	1.00
274_T	282_A	3.045	1.00
225_D	253_K	2.887	1.00
177_T	180_Q	2.715	1.00
227_I	248_F	2.691	1.00
65_D	68_H	2.682	1.00
249_V	273_F	2.517	1.00
57_R	81_E	2.498	1.00
188_G	197_R	2.444	1.00
186_M	199_R	2.444	1.00
120_W	153_S	2.349	1.00
102_H	259_F	2.343	1.00
69_Y	81_E	2.261	1.00
26_H	67_G	2.251	1.00
128_E	172_E	2.218	1.00
130_P	152_A	2.208	1.00
252_L	256_G	2.181	1.00
167_I	197_R	2.174	1.00
153_S	211_L	2.141	1.00
139_D	180_Q	2.137	1.00
72_L	76_N	2.128	1.00
104_P	108_D	2.075	1.00
106_L	226_A	2.071	1.00
167_I	195_L	2.061	1.00
200_Q	204_N	2.032	1.00
119_V	133_I	1.984	1.00
178_P	182_Q	1.977	1.00
32_Q	36_Q	1.975	1.00
63_L	72_L	1.970	1.00
138_A	202_L	1.938	1.00
149_K	207_D	1.923	1.00
138_A	201_E	1.907	1.00
157_T	210_P	1.897	1.00
133_I	228_F	1.888	1.00
92_N	159_V	1.859	1.00
152_A	206_V	1.859	1.00
132_S	136_T	1.844	1.00
57_R	69_Y	1.815	1.00
139_D	183_R	1.803	1.00
138_A	205_Y	1.799	1.00
58_L	63_L	1.755	1.00
64_T	68_H	1.747	1.00
213_L	232_V	1.743	1.00
24_D	47_R	1.731	1.00
100_A	104_P	1.695	1.00
94_T	126_T	1.694	1.00
160_L	210_P	1.690	1.00
92_N	125_S	1.672	1.00
200_Q	203_A	1.660	1.00
148_W	205_Y	1.652	1.00
227_I	252_L	1.578	1.00
137_L	148_W	1.556	1.00
180_Q	184_Y	1.514	1.00
243_E	247_R	1.504	1.00
135_M	139_D	1.479	1.00
76_N	79_S	1.476	1.00
151_F	209_A	1.474	1.00
107_A	139_D	1.461	1.00
246_R	272_R	1.448	1.00
161_E	165_S	1.422	1.00
229_C	248_F	1.421	1.00
104_P	107_A	1.416	1.00
233_M	244_I	1.408	1.00
37_R	82_W	1.398	1.00
257_L	276_R	1.384	1.00
119_V	137_L	1.373	1.00
173_L	181_L	1.367	1.00
214_L	240_T	1.366	1.00
134_A	150_V	1.361	1.00
166_G	198_V	1.359	1.00
130_P	150_V	1.358	1.00
233_M	245_L	1.352	1.00
151_F	224_F	1.348	1.00
97_F	132_S	1.338	1.00
92_N	156_D	1.332	1.00
202_L	205_Y	1.321	1.00
122_A	213_L	1.316	1.00
188_G	193_E	1.315	1.00
29_R	74_E	1.311	1.00
110_A	257_L	1.311	1.00
276_R	282_A	1.295	1.00
130_P	206_V	1.294	1.00
124_A	130_P	1.291	1.00
134_A	205_Y	1.289	1.00
72_L	81_E	1.271	1.00
121_S	228_F	1.270	1.00
161_E	164_R	1.266	1.00
73_L	85_F	1.257	1.00
238_Q	241_Q	1.253	1.00
223_P	253_K	1.253	1.00
87_N	156_D	1.247	1.00
242_Q	246_R	1.222	1.00
135_M	184_Y	1.218	1.00
35_Y	237_D	1.210	1.00
87_N	158_E	1.208	1.00
138_A	184_Y	1.206	1.00
123_A	232_V	1.204	1.00
185_F	198_V	1.199	1.00
157_T	161_E	1.185	1.00
198_V	202_L	1.175	1.00
95_A	175_N	1.165	1.00
71_N	75_S	1.163	1.00
68_H	71_N	1.163	1.00
121_S	133_I	1.161	1.00
125_S	159_V	1.150	1.00
90_T	155_I	1.146	1.00
118_R	149_K	1.144	1.00
178_P	181_L	1.142	1.00
186_M	197_R	1.141	1.00
116_E	147_R	1.133	1.00
170_H	187_R	1.132	1.00
170_H	196_V	1.129	1.00
107_A	140_T	1.128	1.00
135_M	185_F	1.123	1.00
33_L	82_W	1.119	1.00
197_R	203_A	1.118	1.00
233_M	260_A	1.109	1.00
169_R	172_E	1.099	1.00
99_E	102_H	1.098	1.00
237_D	240_T	1.091	1.00
121_S	124_A	1.089	1.00
105_L	280_V	1.087	1.00
131_Y	203_A	1.082	1.00
50_V	89_L	1.077	1.00
248_F	273_F	1.076	1.00
202_L	206_V	1.076	1.00
141_L	144_A	1.068	1.00
105_L	259_F	1.060	1.00
153_S	209_A	1.038	1.00
138_A	148_W	1.031	1.00
97_F	180_Q	1.026	1.00
30_I	70_L	1.024	1.00
57_R	60_S	1.022	1.00
106_L	133_I	1.002	1.00
123_A	248_F	0.992	1.00
246_R	250_P	0.990	1.00
29_R	70_L	0.984	1.00
131_Y	208_F	0.981	1.00
101_H	104_P	0.981	1.00
188_G	194_G	0.974	1.00
170_H	181_L	0.969	1.00
57_R	61_L	0.965	1.00
52_N	91_T	0.964	1.00
107_A	136_T	0.962	1.00
135_M	180_Q	0.962	1.00
46_K	53_R	0.960	1.00
70_L	74_E	0.958	1.00
201_E	204_N	0.957	1.00
87_N	157_T	0.957	1.00
228_F	259_F	0.955	1.00
105_L	109_H	0.951	1.00
122_A	232_V	0.949	1.00
61_L	84_A	0.948	1.00
61_L	72_L	0.942	1.00
171_E	174_K	0.936	1.00
188_G	195_L	0.934	1.00
99_E	262_H	0.934	1.00
83_Q	157_T	0.933	1.00
57_R	88_S	0.933	1.00
232_V	236_F	0.928	1.00
57_R	85_F	0.909	0.99
167_I	188_G	0.905	0.99
116_E	149_K	0.903	0.99
162_K	165_S	0.902	0.99
249_V	272_R	0.900	0.99
28_R	31_S	0.898	0.99
156_D	159_V	0.898	0.99
61_L	81_E	0.897	0.99
28_R	32_Q	0.884	0.99
197_R	200_Q	0.883	0.99
212_N	215_A	0.875	0.99
47_R	51_Y	0.869	0.99
243_E	246_R	0.863	0.99
187_R	196_V	0.855	0.99
259_F	280_V	0.849	0.99
140_T	144_A	0.847	0.99
49_M	91_T	0.846	0.99
80_G	84_A	0.841	0.99
179_Q	183_R	0.837	0.99
90_T	156_D	0.837	0.99
142_G	145_P	0.835	0.99
252_L	273_F	0.834	0.99
69_Y	72_L	0.832	0.99
185_F	196_V	0.828	0.99
111_R	114_S	0.826	0.99
97_F	176_L	0.825	0.99
173_L	176_L	0.824	0.99
33_L	70_L	0.820	0.99
224_F	227_I	0.818	0.99
260_A	266_F	0.814	0.99
134_A	202_L	0.810	0.99
255_D	282_A	0.808	0.99
257_L	280_V	0.803	0.99
58_L	66_F	0.801	0.99
69_Y	85_F	0.796	0.99
220_V	244_I	0.792	0.98
81_E	84_A	0.792	0.98
103_F	132_S	0.788	0.98
76_N	80_G	0.785	0.98
94_T	125_S	0.779	0.98
110_A	226_A	0.778	0.98
139_D	184_Y	0.774	0.98
23_S	26_H	0.773	0.98
58_L	65_D	0.769	0.98
173_L	196_V	0.769	0.98
240_T	244_I	0.769	0.98
145_P	148_W	0.768	0.98
24_D	28_R	0.767	0.98
27_F	50_V	0.767	0.98
151_F	221_P	0.762	0.98
269_L	272_R	0.762	0.98
28_R	44_D	0.762	0.98
60_S	84_A	0.761	0.98
45_H	52_N	0.761	0.98
42_L	50_V	0.757	0.98
38_A	155_I	0.756	0.98
31_S	41_V	0.753	0.98
163_A	208_F	0.750	0.98
142_G	183_R	0.746	0.98
44_D	237_D	0.745	0.98
56_R	88_S	0.745	0.98
162_K	172_E	0.743	0.98
136_T	140_T	0.742	0.98
180_Q	183_R	0.741	0.98
29_R	67_G	0.738	0.98
106_L	228_F	0.735	0.98
54_L	66_F	0.734	0.97
109_H	277_G	0.730	0.97
159_V	163_A	0.730	0.97
102_H	262_H	0.730	0.97
69_Y	73_L	0.730	0.97
90_T	159_V	0.728	0.97
126_T	162_K	0.728	0.97
110_A	259_F	0.724	0.97
236_F	240_T	0.720	0.97
141_L	148_W	0.720	0.97
247_R	250_P	0.720	0.97
115_G	253_K	0.719	0.97
110_A	137_L	0.719	0.97
51_Y	55_V	0.713	0.97
114_S	225_D	0.710	0.97
245_L	269_L	0.709	0.97
138_A	142_G	0.709	0.97
158_E	161_E	0.705	0.97
162_K	168_Y	0.704	0.97
221_P	224_F	0.699	0.97
165_S	197_R	0.695	0.97
31_S	43_A	0.693	0.96
139_D	179_Q	0.688	0.96
26_H	70_L	0.687	0.96
122_A	248_F	0.683	0.96
72_L	75_S	0.678	0.96
223_P	251_L	0.676	0.96
98_R	235_Y	0.672	0.96
239_T	242_Q	0.670	0.96
106_L	136_T	0.670	0.96
66_F	70_L	0.666	0.96
170_H	174_K	0.665	0.96
112_R	115_G	0.661	0.95
231_N	235_Y	0.660	0.95
83_Q	87_N	0.655	0.95
257_L	282_A	0.655	0.95
176_L	185_F	0.654	0.95
176_L	180_Q	0.651	0.95
181_L	185_F	0.649	0.95
118_R	224_F	0.649	0.95
31_S	50_V	0.648	0.95
185_F	188_G	0.647	0.95
31_S	35_Y	0.644	0.95
181_L	196_V	0.641	0.95
242_Q	271_R	0.639	0.94
33_L	74_E	0.638	0.94
118_R	221_P	0.636	0.94
121_S	130_P	0.635	0.94
117_Y	137_L	0.632	0.94
93_L	241_Q	0.630	0.94
42_L	91_T	0.629	0.94
179_Q	182_Q	0.629	0.94
144_A	148_W	0.628	0.94
170_H	194_G	0.627	0.94
53_R	91_T	0.623	0.94
184_Y	188_G	0.622	0.94
157_T	164_R	0.621	0.94
40_I	86_I	0.621	0.94
169_R	173_L	0.618	0.93
169_R	195_L	0.617	0.93
35_Y	41_V	0.615	0.93
29_R	32_Q	0.614	0.93
184_Y	187_R	0.613	0.93
159_V	162_K	0.607	0.93
105_L	277_G	0.605	0.93
168_Y	198_V	0.603	0.93
158_E	162_K	0.603	0.93
46_K	91_T	0.603	0.93
26_H	65_D	0.599	0.92
123_A	229_C	0.597	0.92
61_L	69_Y	0.596	0.92
188_G	196_V	0.595	0.92
135_M	138_A	0.593	0.92
84_A	87_N	0.593	0.92
26_H	29_R	0.593	0.92
120_W	123_A	0.591	0.92
119_V	226_A	0.591	0.92
46_K	263_S	0.588	0.92
122_A	228_F	0.588	0.92
123_A	153_S	0.584	0.91
150_V	205_Y	0.582	0.91
109_H	257_L	0.581	0.91
187_R	195_L	0.580	0.91
119_V	150_V	0.574	0.91
137_L	150_V	0.573	0.91
249_V	283_L	0.571	0.90
111_R	115_G	0.569	0.90
152_A	229_C	0.569	0.90
57_R	72_L	0.567	0.90
144_A	147_R	0.566	0.90
51_Y	66_F	0.566	0.90
275_L	281_Y	0.560	0.90
67_G	70_L	0.560	0.90
135_M	202_L	0.560	0.90
234_I	263_S	0.559	0.90
147_R	205_Y	0.558	0.89
27_F	66_F	0.557	0.89
241_Q	245_L	0.555	0.89
140_T	143_T	0.553	0.89
135_M	176_L	0.552	0.89
98_R	231_N	0.552	0.89
187_R	193_E	0.550	0.89
48_D	51_Y	0.550	0.89
123_A	244_I	0.550	0.89
42_L	46_K	0.547	0.89
152_A	163_A	0.547	0.89
40_I	212_N	0.545	0.88
85_F	156_D	0.545	0.88
227_I	251_L	0.544	0.88
131_Y	168_Y	0.543	0.88
96_F	168_Y	0.542	0.88
131_Y	206_V	0.542	0.88
211_L	221_P	0.538	0.88
211_L	215_A	0.538	0.88
34_I	89_L	0.538	0.88
34_I	43_A	0.534	0.87
79_S	83_Q	0.533	0.87
95_A	241_Q	0.531	0.87
50_V	279_T	0.529	0.87
210_P	215_A	0.528	0.87
135_M	198_V	0.528	0.87
212_N	216_K	0.527	0.87
89_L	212_N	0.526	0.87
107_A	180_Q	0.525	0.86
227_I	244_I	0.525	0.86
246_R	270_E	0.524	0.86
80_G	83_Q	0.524	0.86
238_Q	242_Q	0.522	0.86
33_L	37_R	0.521	0.86
31_S	70_L	0.521	0.86
91_T	235_Y	0.521	0.86
234_I	261_G	0.520	0.86
71_N	74_E	0.519	0.86
214_L	244_I	0.519	0.86
63_L	68_H	0.519	0.86
95_A	174_K	0.519	0.86
55_V	59_R	0.518	0.86
244_I	248_F	0.518	0.86
125_S	234_I	0.518	0.86
170_H	173_L	0.516	0.85
157_T	160_L	0.516	0.85
67_G	71_N	0.515	0.85
118_R	209_A	0.515	0.85
103_F	106_L	0.514	0.85
31_S	44_D	0.514	0.85
103_F	119_V	0.513	0.85
275_L	278_Q	0.511	0.85
49_M	241_Q	0.508	0.85
30_I	283_L	0.508	0.85
171_E	175_N	0.508	0.85
126_T	163_A	0.507	0.84
46_K	49_M	0.504	0.84
245_L	273_F	0.501	0.84
124_A	163_A	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1af7A	1	0.958	100	0.301	Contact Map
4qnuA	2	0.7483	99.9	0.753	Contact Map
3i53A	2	0.8357	99.8	0.763	Contact Map
3gwzA	3	0.8462	99.8	0.773	Contact Map
4gqbA	4	0.8042	99.8	0.774	Contact Map
4z2yA	2	0.7832	99.7	0.787	Contact Map
2ip2A	2	0.8322	99.7	0.794	Contact Map
1qzzA	2	0.8252	99.7	0.801	Contact Map
2r3sA	4	0.8462	99.6	0.803	Contact Map
3lstA	2	0.8287	99.6	0.81	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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