GREMLIN Database
CHER - Chemotaxis protein methyltransferase
UniProt: P07364 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10148
Length: 286 (253)
Sequences: 4592 (3542)
Seq/√Len: 222.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_T159_V3.3241.00
274_T282_A3.0451.00
225_D253_K2.8871.00
177_T180_Q2.7151.00
227_I248_F2.6911.00
65_D68_H2.6821.00
249_V273_F2.5171.00
57_R81_E2.4981.00
188_G197_R2.4441.00
186_M199_R2.4441.00
120_W153_S2.3491.00
102_H259_F2.3431.00
69_Y81_E2.2611.00
26_H67_G2.2511.00
128_E172_E2.2181.00
130_P152_A2.2081.00
252_L256_G2.1811.00
167_I197_R2.1741.00
153_S211_L2.1411.00
139_D180_Q2.1371.00
72_L76_N2.1281.00
104_P108_D2.0751.00
106_L226_A2.0711.00
167_I195_L2.0611.00
200_Q204_N2.0321.00
119_V133_I1.9841.00
178_P182_Q1.9771.00
32_Q36_Q1.9751.00
63_L72_L1.9701.00
138_A202_L1.9381.00
149_K207_D1.9231.00
138_A201_E1.9071.00
157_T210_P1.8971.00
133_I228_F1.8881.00
92_N159_V1.8591.00
152_A206_V1.8591.00
132_S136_T1.8441.00
57_R69_Y1.8151.00
139_D183_R1.8031.00
138_A205_Y1.7991.00
58_L63_L1.7551.00
64_T68_H1.7471.00
213_L232_V1.7431.00
24_D47_R1.7311.00
100_A104_P1.6951.00
94_T126_T1.6941.00
160_L210_P1.6901.00
92_N125_S1.6721.00
200_Q203_A1.6601.00
148_W205_Y1.6521.00
227_I252_L1.5781.00
137_L148_W1.5561.00
180_Q184_Y1.5141.00
243_E247_R1.5041.00
135_M139_D1.4791.00
76_N79_S1.4761.00
151_F209_A1.4741.00
107_A139_D1.4611.00
246_R272_R1.4481.00
161_E165_S1.4221.00
229_C248_F1.4211.00
104_P107_A1.4161.00
233_M244_I1.4081.00
37_R82_W1.3981.00
257_L276_R1.3841.00
119_V137_L1.3731.00
173_L181_L1.3671.00
214_L240_T1.3661.00
134_A150_V1.3611.00
166_G198_V1.3591.00
130_P150_V1.3581.00
233_M245_L1.3521.00
151_F224_F1.3481.00
97_F132_S1.3381.00
92_N156_D1.3321.00
202_L205_Y1.3211.00
122_A213_L1.3161.00
188_G193_E1.3151.00
29_R74_E1.3111.00
110_A257_L1.3111.00
276_R282_A1.2951.00
130_P206_V1.2941.00
124_A130_P1.2911.00
134_A205_Y1.2891.00
72_L81_E1.2711.00
121_S228_F1.2701.00
161_E164_R1.2661.00
73_L85_F1.2571.00
238_Q241_Q1.2531.00
223_P253_K1.2531.00
87_N156_D1.2471.00
242_Q246_R1.2221.00
135_M184_Y1.2181.00
35_Y237_D1.2101.00
87_N158_E1.2081.00
138_A184_Y1.2061.00
123_A232_V1.2041.00
185_F198_V1.1991.00
157_T161_E1.1851.00
198_V202_L1.1751.00
95_A175_N1.1651.00
71_N75_S1.1631.00
68_H71_N1.1631.00
121_S133_I1.1611.00
125_S159_V1.1501.00
90_T155_I1.1461.00
118_R149_K1.1441.00
178_P181_L1.1421.00
186_M197_R1.1411.00
116_E147_R1.1331.00
170_H187_R1.1321.00
170_H196_V1.1291.00
107_A140_T1.1281.00
135_M185_F1.1231.00
33_L82_W1.1191.00
197_R203_A1.1181.00
233_M260_A1.1091.00
169_R172_E1.0991.00
99_E102_H1.0981.00
237_D240_T1.0911.00
121_S124_A1.0891.00
105_L280_V1.0871.00
131_Y203_A1.0821.00
50_V89_L1.0771.00
248_F273_F1.0761.00
202_L206_V1.0761.00
141_L144_A1.0681.00
105_L259_F1.0601.00
153_S209_A1.0381.00
138_A148_W1.0311.00
97_F180_Q1.0261.00
30_I70_L1.0241.00
57_R60_S1.0221.00
106_L133_I1.0021.00
123_A248_F0.9921.00
246_R250_P0.9901.00
29_R70_L0.9841.00
131_Y208_F0.9811.00
101_H104_P0.9811.00
188_G194_G0.9741.00
170_H181_L0.9691.00
57_R61_L0.9651.00
52_N91_T0.9641.00
107_A136_T0.9621.00
135_M180_Q0.9621.00
46_K53_R0.9601.00
70_L74_E0.9581.00
201_E204_N0.9571.00
87_N157_T0.9571.00
228_F259_F0.9551.00
105_L109_H0.9511.00
122_A232_V0.9491.00
61_L84_A0.9481.00
61_L72_L0.9421.00
171_E174_K0.9361.00
188_G195_L0.9341.00
99_E262_H0.9341.00
83_Q157_T0.9331.00
57_R88_S0.9331.00
232_V236_F0.9281.00
57_R85_F0.9090.99
167_I188_G0.9050.99
116_E149_K0.9030.99
162_K165_S0.9020.99
249_V272_R0.9000.99
28_R31_S0.8980.99
156_D159_V0.8980.99
61_L81_E0.8970.99
28_R32_Q0.8840.99
197_R200_Q0.8830.99
212_N215_A0.8750.99
47_R51_Y0.8690.99
243_E246_R0.8630.99
187_R196_V0.8550.99
259_F280_V0.8490.99
140_T144_A0.8470.99
49_M91_T0.8460.99
80_G84_A0.8410.99
179_Q183_R0.8370.99
90_T156_D0.8370.99
142_G145_P0.8350.99
252_L273_F0.8340.99
69_Y72_L0.8320.99
185_F196_V0.8280.99
111_R114_S0.8260.99
97_F176_L0.8250.99
173_L176_L0.8240.99
33_L70_L0.8200.99
224_F227_I0.8180.99
260_A266_F0.8140.99
134_A202_L0.8100.99
255_D282_A0.8080.99
257_L280_V0.8030.99
58_L66_F0.8010.99
69_Y85_F0.7960.99
220_V244_I0.7920.98
81_E84_A0.7920.98
103_F132_S0.7880.98
76_N80_G0.7850.98
94_T125_S0.7790.98
110_A226_A0.7780.98
139_D184_Y0.7740.98
23_S26_H0.7730.98
58_L65_D0.7690.98
173_L196_V0.7690.98
240_T244_I0.7690.98
145_P148_W0.7680.98
24_D28_R0.7670.98
27_F50_V0.7670.98
151_F221_P0.7620.98
269_L272_R0.7620.98
28_R44_D0.7620.98
60_S84_A0.7610.98
45_H52_N0.7610.98
42_L50_V0.7570.98
38_A155_I0.7560.98
31_S41_V0.7530.98
163_A208_F0.7500.98
142_G183_R0.7460.98
44_D237_D0.7450.98
56_R88_S0.7450.98
162_K172_E0.7430.98
136_T140_T0.7420.98
180_Q183_R0.7410.98
29_R67_G0.7380.98
106_L228_F0.7350.98
54_L66_F0.7340.97
109_H277_G0.7300.97
159_V163_A0.7300.97
102_H262_H0.7300.97
69_Y73_L0.7300.97
90_T159_V0.7280.97
126_T162_K0.7280.97
110_A259_F0.7240.97
236_F240_T0.7200.97
141_L148_W0.7200.97
247_R250_P0.7200.97
115_G253_K0.7190.97
110_A137_L0.7190.97
51_Y55_V0.7130.97
114_S225_D0.7100.97
245_L269_L0.7090.97
138_A142_G0.7090.97
158_E161_E0.7050.97
162_K168_Y0.7040.97
221_P224_F0.6990.97
165_S197_R0.6950.97
31_S43_A0.6930.96
139_D179_Q0.6880.96
26_H70_L0.6870.96
122_A248_F0.6830.96
72_L75_S0.6780.96
223_P251_L0.6760.96
98_R235_Y0.6720.96
239_T242_Q0.6700.96
106_L136_T0.6700.96
66_F70_L0.6660.96
170_H174_K0.6650.96
112_R115_G0.6610.95
231_N235_Y0.6600.95
83_Q87_N0.6550.95
257_L282_A0.6550.95
176_L185_F0.6540.95
176_L180_Q0.6510.95
181_L185_F0.6490.95
118_R224_F0.6490.95
31_S50_V0.6480.95
185_F188_G0.6470.95
31_S35_Y0.6440.95
181_L196_V0.6410.95
242_Q271_R0.6390.94
33_L74_E0.6380.94
118_R221_P0.6360.94
121_S130_P0.6350.94
117_Y137_L0.6320.94
93_L241_Q0.6300.94
42_L91_T0.6290.94
179_Q182_Q0.6290.94
144_A148_W0.6280.94
170_H194_G0.6270.94
53_R91_T0.6230.94
184_Y188_G0.6220.94
157_T164_R0.6210.94
40_I86_I0.6210.94
169_R173_L0.6180.93
169_R195_L0.6170.93
35_Y41_V0.6150.93
29_R32_Q0.6140.93
184_Y187_R0.6130.93
159_V162_K0.6070.93
105_L277_G0.6050.93
168_Y198_V0.6030.93
158_E162_K0.6030.93
46_K91_T0.6030.93
26_H65_D0.5990.92
123_A229_C0.5970.92
61_L69_Y0.5960.92
188_G196_V0.5950.92
135_M138_A0.5930.92
84_A87_N0.5930.92
26_H29_R0.5930.92
120_W123_A0.5910.92
119_V226_A0.5910.92
46_K263_S0.5880.92
122_A228_F0.5880.92
123_A153_S0.5840.91
150_V205_Y0.5820.91
109_H257_L0.5810.91
187_R195_L0.5800.91
119_V150_V0.5740.91
137_L150_V0.5730.91
249_V283_L0.5710.90
111_R115_G0.5690.90
152_A229_C0.5690.90
57_R72_L0.5670.90
144_A147_R0.5660.90
51_Y66_F0.5660.90
275_L281_Y0.5600.90
67_G70_L0.5600.90
135_M202_L0.5600.90
234_I263_S0.5590.90
147_R205_Y0.5580.89
27_F66_F0.5570.89
241_Q245_L0.5550.89
140_T143_T0.5530.89
135_M176_L0.5520.89
98_R231_N0.5520.89
187_R193_E0.5500.89
48_D51_Y0.5500.89
123_A244_I0.5500.89
42_L46_K0.5470.89
152_A163_A0.5470.89
40_I212_N0.5450.88
85_F156_D0.5450.88
227_I251_L0.5440.88
131_Y168_Y0.5430.88
96_F168_Y0.5420.88
131_Y206_V0.5420.88
211_L221_P0.5380.88
211_L215_A0.5380.88
34_I89_L0.5380.88
34_I43_A0.5340.87
79_S83_Q0.5330.87
95_A241_Q0.5310.87
50_V279_T0.5290.87
210_P215_A0.5280.87
135_M198_V0.5280.87
212_N216_K0.5270.87
89_L212_N0.5260.87
107_A180_Q0.5250.86
227_I244_I0.5250.86
246_R270_E0.5240.86
80_G83_Q0.5240.86
238_Q242_Q0.5220.86
33_L37_R0.5210.86
31_S70_L0.5210.86
91_T235_Y0.5210.86
234_I261_G0.5200.86
71_N74_E0.5190.86
214_L244_I0.5190.86
63_L68_H0.5190.86
95_A174_K0.5190.86
55_V59_R0.5180.86
244_I248_F0.5180.86
125_S234_I0.5180.86
170_H173_L0.5160.85
157_T160_L0.5160.85
67_G71_N0.5150.85
118_R209_A0.5150.85
103_F106_L0.5140.85
31_S44_D0.5140.85
103_F119_V0.5130.85
275_L278_Q0.5110.85
49_M241_Q0.5080.85
30_I283_L0.5080.85
171_E175_N0.5080.85
126_T163_A0.5070.84
46_K49_M0.5040.84
245_L273_F0.5010.84
124_A163_A0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1af7A 1 0.958 100 0.301 Contact Map
4qnuA 2 0.7483 99.9 0.753 Contact Map
3i53A 2 0.8357 99.8 0.763 Contact Map
3gwzA 3 0.8462 99.8 0.773 Contact Map
4gqbA 4 0.8042 99.8 0.774 Contact Map
4z2yA 2 0.7832 99.7 0.787 Contact Map
2ip2A 2 0.8322 99.7 0.794 Contact Map
1qzzA 2 0.8252 99.7 0.801 Contact Map
2r3sA 4 0.8462 99.6 0.803 Contact Map
3lstA 2 0.8287 99.6 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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