CHEB - ECOLI - GREMLIN Contacts

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CHEB - Chemotaxis response regulator protein-glutamate methylesterase

UniProt:	P07330	Sequences: MSKIRVLSVDDSALMRQIMTEIINSHSDMEMVATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRLRPMPVVMVSSLTGKGSEVTLRALELGAIDFVTKPQLGIREGMLAYNEMIAEKVRTAAKASLAAHKPLSAPTTLKAGPLLSSEKLIAIGASTGGTEAIRHVLQPLPLSSPALLITQHMPPGFTRSFADRLNKLCQIGVKEAEDGERVLPGHAYIAPGDRHMELSRSGANYQIKIHDGPAVNRHRPSVDVLFHSVAKQAGRNAVGVILTGMGNDGAAGMLAMRQAGAWTLAQNEASCVVFGMPREAINMGGVCEVVDLSQVSQQMLAKISAGQAIRI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10147
Length:	349 (264)
Sequences:	7049 (5280)
Seq/√Len:	324.9

ECOLI - CHEB
BACSU - CHEB
HALSA - CHEB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
63_D	66_D	3.797	1.00
33_A	50_P	3.289	1.00
160_A	267_V	2.957	1.00
37_D	61_R	2.903	1.00
207_C	217_G	2.838	1.00
5_R	30_E	2.774	1.00
39_L	61_R	2.651	1.00
69_E	99_L	2.636	1.00
16_R	36_P	2.616	1.00
46_K	74_L	2.582	1.00
9_V	41_A	2.556	1.00
36_P	40_V	2.553	1.00
20_T	34_T	2.552	1.00
136_A	141_L	2.535	1.00
16_R	34_T	2.524	1.00
38_P	62_M	2.519	1.00
192_P	240_G	2.392	1.00
55_L	67_F	2.335	1.00
138_H	141_L	2.277	1.00
209_I	225_A	2.270	1.00
33_A	48_F	2.215	1.00
162_G	260_V	2.199	1.00
33_A	44_L	2.051	1.00
37_D	40_V	2.048	1.00
212_K	218_E	2.015	1.00
70_K	73_R	1.987	1.00
23_I	29_M	1.978	1.00
102_I	122_M	1.978	1.00
212_K	215_E	1.972	1.00
204_N	210_G	1.961	1.00
70_K	74_L	1.904	1.00
250_G	261_D	1.876	1.00
20_T	24_N	1.845	1.00
95_R	99_L	1.845	1.00
35_A	44_L	1.787	1.00
148_K	171_I	1.765	1.00
68_L	79_V	1.763	1.00
250_G	259_S	1.757	1.00
7_L	35_A	1.740	1.00
38_P	67_F	1.737	1.00
53_L	77_M	1.713	1.00
196_T	237_S	1.689	1.00
232_R	249_D	1.684	1.00
219_R	253_V	1.668	1.00
197_R	201_D	1.663	1.00
45_I	71_L	1.662	1.00
26_H	116_M	1.653	1.00
252_A	259_S	1.625	1.00
26_H	120_N	1.622	1.00
210_G	224_H	1.603	1.00
53_L	71_L	1.585	1.00
62_M	66_D	1.579	1.00
5_R	33_A	1.574	1.00
6_V	29_M	1.547	1.00
42_R	67_F	1.524	1.00
191_M	196_T	1.519	1.00
234_M	245_I	1.512	1.00
95_R	98_E	1.504	1.00
39_L	43_D	1.500	1.00
67_F	71_L	1.492	1.00
212_K	224_H	1.481	1.00
42_R	70_K	1.476	1.00
59_M	62_M	1.452	1.00
216_D	246_K	1.444	1.00
136_A	139_K	1.436	1.00
132_K	135_L	1.430	1.00
44_L	50_P	1.418	1.00
55_L	79_V	1.403	1.00
44_L	47_K	1.399	1.00
263_L	267_V	1.397	1.00
251_P	262_V	1.392	1.00
43_D	46_K	1.378	1.00
69_E	95_R	1.375	1.00
55_L	81_M	1.375	1.00
145_T	148_K	1.368	1.00
65_L	96_A	1.366	1.00
44_L	48_F	1.347	1.00
40_V	44_L	1.342	1.00
10_D	59_M	1.340	1.00
128_R	132_K	1.330	1.00
13_A	16_R	1.328	1.00
226_Y	245_I	1.321	1.00
237_S	246_K	1.299	1.00
38_P	42_R	1.292	1.00
221_L	224_H	1.281	1.00
58_E	85_L	1.280	1.00
243_Y	271_A	1.248	1.00
68_L	81_M	1.247	1.00
52_V	119_Y	1.246	1.00
72_M	76_P	1.244	1.00
57_V	81_M	1.243	1.00
5_R	48_F	1.241	1.00
38_P	59_M	1.240	1.00
80_V	118_A	1.238	1.00
115_G	123_I	1.237	1.00
10_D	16_R	1.222	1.00
43_D	47_K	1.221	1.00
11_D	56_D	1.218	1.00
126_K	130_A	1.212	1.00
52_V	123_I	1.209	1.00
218_E	226_Y	1.199	1.00
161_I	174_V	1.196	1.00
45_I	53_L	1.195	1.00
45_I	77_M	1.195	1.00
6_V	23_I	1.194	1.00
23_I	119_Y	1.192	1.00
175_L	207_C	1.188	1.00
207_C	256_H	1.186	1.00
55_L	68_L	1.174	1.00
218_E	257_R	1.171	1.00
66_D	70_K	1.168	1.00
114_E	117_L	1.148	1.00
253_V	265_H	1.140	1.00
263_L	266_S	1.135	1.00
62_M	70_K	1.134	1.00
249_D	257_R	1.129	1.00
114_E	118_A	1.122	1.00
128_R	135_L	1.110	1.00
131_A	135_L	1.102	1.00
91_E	95_R	1.090	1.00
35_A	41_A	1.087	1.00
245_I	251_P	1.080	1.00
146_T	149_A	1.074	1.00
207_C	253_V	1.074	1.00
201_D	205_K	1.074	1.00
184_A	223_G	1.068	1.00
9_V	67_F	1.058	1.00
45_I	50_P	1.055	1.00
4_I	123_I	1.034	1.00
86_T	93_T	1.032	1.00
265_H	269_K	1.032	1.00
54_T	82_V	1.026	1.00
8_S	19_M	1.016	1.00
128_R	131_A	1.010	1.00
54_T	119_Y	0.997	1.00
42_R	62_M	0.996	1.00
66_D	69_E	0.994	1.00
235_E	248_H	0.993	1.00
71_L	79_V	0.991	1.00
19_M	82_V	0.989	1.00
118_A	121_E	0.985	1.00
125_E	129_T	0.980	1.00
90_S	93_T	0.979	1.00
256_H	260_V	0.973	1.00
55_L	71_L	0.968	1.00
49_N	75_R	0.968	1.00
26_H	29_M	0.960	1.00
5_R	50_P	0.960	1.00
122_M	126_K	0.958	1.00
39_L	62_M	0.952	1.00
173_H	177_P	0.947	1.00
103_D	118_A	0.946	1.00
139_K	143_A	0.938	1.00
158_L	186_L	0.934	1.00
246_K	266_S	0.931	1.00
29_M	120_N	0.931	1.00
266_S	269_K	0.928	1.00
118_A	122_M	0.926	1.00
181_S	263_L	0.917	1.00
223_G	263_L	0.917	1.00
119_Y	123_I	0.913	1.00
117_L	121_E	0.910	1.00
90_S	94_L	0.903	1.00
42_R	45_I	0.899	1.00
55_L	59_M	0.890	1.00
253_V	256_H	0.888	1.00
124_A	127_V	0.879	1.00
180_L	208_Q	0.878	1.00
267_V	270_Q	0.875	1.00
122_M	125_E	0.869	1.00
8_S	20_T	0.861	1.00
123_I	126_K	0.860	1.00
206_L	254_N	0.859	1.00
9_V	38_P	0.858	1.00
116_M	120_N	0.854	1.00
173_H	188_T	0.852	1.00
9_V	53_L	0.851	1.00
119_Y	125_E	0.850	1.00
115_G	118_A	0.849	1.00
196_T	213_E	0.848	1.00
69_E	73_R	0.840	1.00
72_M	78_P	0.838	1.00
188_T	263_L	0.827	1.00
123_I	127_V	0.827	1.00
141_L	145_T	0.826	1.00
53_L	67_F	0.825	1.00
227_I	269_K	0.822	1.00
186_L	220_V	0.819	1.00
149_A	178_L	0.817	1.00
201_D	206_L	0.816	1.00
92_V	104_F	0.814	1.00
5_R	51_D	0.810	1.00
136_A	140_P	0.808	1.00
268_A	271_A	0.808	1.00
174_V	178_L	0.805	1.00
215_E	218_E	0.804	1.00
175_L	225_A	0.804	1.00
57_V	92_V	0.803	1.00
35_A	38_P	0.801	1.00
38_P	61_R	0.800	1.00
13_A	17_Q	0.796	1.00
127_V	131_A	0.795	1.00
93_T	104_F	0.793	1.00
51_D	126_K	0.791	1.00
41_A	67_F	0.789	1.00
201_D	204_N	0.789	1.00
35_A	40_V	0.787	1.00
192_P	233_H	0.786	1.00
56_D	59_M	0.775	1.00
140_P	143_A	0.772	1.00
53_L	79_V	0.770	1.00
206_L	211_V	0.769	1.00
124_A	129_T	0.766	1.00
187_I	225_A	0.764	1.00
92_V	95_R	0.761	1.00
147_L	150_G	0.761	1.00
72_M	102_I	0.761	1.00
40_V	43_D	0.759	0.99
119_Y	126_K	0.746	0.99
121_E	125_E	0.744	0.99
187_I	227_I	0.738	0.99
54_T	80_V	0.738	0.99
22_I	116_M	0.734	0.99
131_A	134_S	0.733	0.99
143_A	146_T	0.733	0.99
28_D	120_N	0.732	0.99
153_L	180_L	0.730	0.99
256_H	259_S	0.727	0.99
163_A	166_G	0.726	0.99
86_T	90_S	0.725	0.99
65_L	99_L	0.721	0.99
11_D	59_M	0.719	0.99
37_D	59_M	0.719	0.99
148_K	151_P	0.714	0.99
6_V	52_V	0.712	0.99
172_R	176_Q	0.710	0.99
98_E	172_R	0.708	0.99
219_R	242_N	0.705	0.99
169_E	244_Q	0.704	0.99
81_M	86_T	0.703	0.99
62_M	67_F	0.699	0.99
217_G	258_P	0.698	0.99
127_V	130_A	0.697	0.99
199_F	238_R	0.695	0.99
222_P	262_V	0.695	0.99
86_T	89_G	0.693	0.99
56_D	107_K	0.690	0.99
220_V	257_R	0.690	0.99
239_S	244_Q	0.687	0.99
11_D	64_G	0.685	0.99
82_V	105_V	0.684	0.99
119_Y	122_M	0.683	0.99
42_R	46_K	0.683	0.99
145_T	171_I	0.682	0.99
54_T	115_G	0.679	0.99
178_L	182_S	0.678	0.99
57_V	63_D	0.677	0.99
125_E	128_R	0.674	0.99
212_K	226_Y	0.673	0.99
251_P	261_D	0.671	0.99
261_D	266_S	0.669	0.99
210_G	221_L	0.668	0.99
7_L	41_A	0.666	0.99
45_I	75_R	0.666	0.99
37_D	60_P	0.664	0.99
136_A	145_T	0.663	0.99
126_K	129_T	0.661	0.99
211_V	214_A	0.658	0.99
265_H	270_Q	0.651	0.98
17_Q	20_T	0.650	0.98
45_I	67_F	0.646	0.98
160_A	171_I	0.646	0.98
170_A	174_V	0.645	0.98
174_V	177_P	0.644	0.98
39_L	70_K	0.642	0.98
136_A	148_K	0.641	0.98
59_M	64_G	0.637	0.98
263_L	269_K	0.635	0.98
144_P	151_P	0.634	0.98
68_L	99_L	0.633	0.98
34_T	44_L	0.632	0.98
206_L	210_G	0.632	0.98
57_V	86_T	0.629	0.98
10_D	107_K	0.629	0.98
138_H	142_S	0.628	0.98
61_R	67_F	0.626	0.98
129_T	132_K	0.626	0.98
23_I	32_V	0.624	0.98
8_S	54_T	0.624	0.98
110_L	114_E	0.623	0.98
193_P	231_D	0.621	0.98
19_M	115_G	0.620	0.98
22_I	111_G	0.620	0.98
7_L	50_P	0.620	0.98
8_S	32_V	0.619	0.98
199_F	203_L	0.618	0.98
15_M	109_Q	0.617	0.98
261_D	265_H	0.616	0.98
65_L	95_R	0.615	0.98
38_P	63_D	0.615	0.98
58_E	63_D	0.613	0.98
214_A	217_G	0.612	0.98
197_R	215_E	0.611	0.98
142_S	145_T	0.610	0.98
186_L	234_M	0.607	0.98
263_L	268_A	0.604	0.97
9_V	59_M	0.604	0.97
235_E	246_K	0.602	0.97
56_D	64_G	0.600	0.97
126_K	131_A	0.599	0.97
155_S	180_L	0.598	0.97
186_L	224_H	0.596	0.97
4_I	52_V	0.596	0.97
7_L	45_I	0.595	0.97
81_M	96_A	0.595	0.97
141_L	144_P	0.594	0.97
104_F	114_E	0.593	0.97
72_M	77_M	0.593	0.97
24_N	30_E	0.593	0.97
78_P	125_E	0.593	0.97
137_A	142_S	0.592	0.97
68_L	101_A	0.591	0.97
122_M	130_A	0.591	0.97
200_A	241_A	0.590	0.97
196_T	235_E	0.590	0.97
58_E	89_G	0.589	0.97
249_D	261_D	0.588	0.97
14_L	18_I	0.586	0.97
253_V	262_V	0.585	0.97
160_A	263_L	0.584	0.97
94_L	98_E	0.584	0.97
125_E	132_K	0.583	0.97
72_M	75_R	0.573	0.97
145_T	174_V	0.573	0.97
222_P	263_L	0.572	0.97
231_D	249_D	0.570	0.96
57_V	65_L	0.569	0.96
52_V	78_P	0.568	0.96
157_K	249_D	0.568	0.96
21_E	25_S	0.567	0.96
118_A	126_K	0.565	0.96
9_V	35_A	0.565	0.96
46_K	70_K	0.564	0.96
124_A	135_L	0.564	0.96
220_V	252_A	0.564	0.96
233_H	272_G	0.561	0.96
197_R	213_E	0.560	0.96
21_E	24_N	0.560	0.96
160_A	186_L	0.557	0.96
147_L	151_P	0.552	0.96
97_L	101_A	0.551	0.96
139_K	142_S	0.550	0.96
144_P	148_K	0.546	0.95
116_M	119_Y	0.546	0.95
30_E	48_F	0.545	0.95
117_L	128_R	0.544	0.95
4_I	29_M	0.544	0.95
118_A	123_I	0.544	0.95
98_E	103_D	0.544	0.95
41_A	45_I	0.542	0.95
11_D	107_K	0.541	0.95
52_V	102_I	0.539	0.95
226_Y	266_S	0.536	0.95
7_L	44_L	0.536	0.95
235_E	269_K	0.535	0.95
136_A	142_S	0.535	0.95
125_E	133_A	0.533	0.95
121_E	124_A	0.531	0.95
236_L	243_Y	0.531	0.95
10_D	15_M	0.527	0.95
86_T	106_T	0.527	0.95
15_M	18_I	0.525	0.94
32_V	48_F	0.524	0.94
116_M	123_I	0.523	0.94
268_A	272_G	0.520	0.94
266_S	270_Q	0.520	0.94
190_H	233_H	0.518	0.94
102_I	125_E	0.516	0.94
89_G	95_R	0.516	0.94
190_H	234_M	0.516	0.94
89_G	92_V	0.515	0.94
120_N	124_A	0.514	0.94
220_V	236_L	0.514	0.94
232_R	270_Q	0.513	0.94
102_I	118_A	0.512	0.94
162_G	167_G	0.511	0.94
125_E	130_A	0.511	0.94
255_R	265_H	0.510	0.94
144_P	147_L	0.510	0.94
13_A	36_P	0.509	0.93
130_A	134_S	0.509	0.93
113_R	117_L	0.508	0.93
124_A	128_R	0.507	0.93
229_P	247_I	0.506	0.93
236_L	240_G	0.500	0.93
71_L	76_P	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a2oA	1	0.9713	100	0.147	Contact Map
1chdA	1	0.5673	100	0.452	Contact Map
3sftA	1	0.5387	100	0.464	Contact Map
4g97A	1	0.3754	100	0.642	Contact Map
3n0rA	1	0.3524	100	0.646	Contact Map
4l4uA	2	0.8825	100	0.657	Contact Map
3dzdA	2	0.9513	100	0.663	Contact Map
3breA	4	0.8395	100	0.665	Contact Map
4gvpA	1	0.5931	100	0.668	Contact Map
1s8nA	1	0.5415	99.9	0.67	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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