GREMLIN Database
CHEB - Chemotaxis response regulator protein-glutamate methylesterase
UniProt: P07330 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10147
Length: 349 (264)
Sequences: 7049 (5280)
Seq/√Len: 324.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_D66_D3.7971.00
33_A50_P3.2891.00
160_A267_V2.9571.00
37_D61_R2.9031.00
207_C217_G2.8381.00
5_R30_E2.7741.00
39_L61_R2.6511.00
69_E99_L2.6361.00
16_R36_P2.6161.00
46_K74_L2.5821.00
9_V41_A2.5561.00
36_P40_V2.5531.00
20_T34_T2.5521.00
136_A141_L2.5351.00
16_R34_T2.5241.00
38_P62_M2.5191.00
192_P240_G2.3921.00
55_L67_F2.3351.00
138_H141_L2.2771.00
209_I225_A2.2701.00
33_A48_F2.2151.00
162_G260_V2.1991.00
33_A44_L2.0511.00
37_D40_V2.0481.00
212_K218_E2.0151.00
70_K73_R1.9871.00
23_I29_M1.9781.00
102_I122_M1.9781.00
212_K215_E1.9721.00
204_N210_G1.9611.00
70_K74_L1.9041.00
250_G261_D1.8761.00
20_T24_N1.8451.00
95_R99_L1.8451.00
35_A44_L1.7871.00
148_K171_I1.7651.00
68_L79_V1.7631.00
250_G259_S1.7571.00
7_L35_A1.7401.00
38_P67_F1.7371.00
53_L77_M1.7131.00
196_T237_S1.6891.00
232_R249_D1.6841.00
219_R253_V1.6681.00
197_R201_D1.6631.00
45_I71_L1.6621.00
26_H116_M1.6531.00
252_A259_S1.6251.00
26_H120_N1.6221.00
210_G224_H1.6031.00
53_L71_L1.5851.00
62_M66_D1.5791.00
5_R33_A1.5741.00
6_V29_M1.5471.00
42_R67_F1.5241.00
191_M196_T1.5191.00
234_M245_I1.5121.00
95_R98_E1.5041.00
39_L43_D1.5001.00
67_F71_L1.4921.00
212_K224_H1.4811.00
42_R70_K1.4761.00
59_M62_M1.4521.00
216_D246_K1.4441.00
136_A139_K1.4361.00
132_K135_L1.4301.00
44_L50_P1.4181.00
55_L79_V1.4031.00
44_L47_K1.3991.00
263_L267_V1.3971.00
251_P262_V1.3921.00
43_D46_K1.3781.00
69_E95_R1.3751.00
55_L81_M1.3751.00
145_T148_K1.3681.00
65_L96_A1.3661.00
44_L48_F1.3471.00
40_V44_L1.3421.00
10_D59_M1.3401.00
128_R132_K1.3301.00
13_A16_R1.3281.00
226_Y245_I1.3211.00
237_S246_K1.2991.00
38_P42_R1.2921.00
221_L224_H1.2811.00
58_E85_L1.2801.00
243_Y271_A1.2481.00
68_L81_M1.2471.00
52_V119_Y1.2461.00
72_M76_P1.2441.00
57_V81_M1.2431.00
5_R48_F1.2411.00
38_P59_M1.2401.00
80_V118_A1.2381.00
115_G123_I1.2371.00
10_D16_R1.2221.00
43_D47_K1.2211.00
11_D56_D1.2181.00
126_K130_A1.2121.00
52_V123_I1.2091.00
218_E226_Y1.1991.00
161_I174_V1.1961.00
45_I53_L1.1951.00
45_I77_M1.1951.00
6_V23_I1.1941.00
23_I119_Y1.1921.00
175_L207_C1.1881.00
207_C256_H1.1861.00
55_L68_L1.1741.00
218_E257_R1.1711.00
66_D70_K1.1681.00
114_E117_L1.1481.00
253_V265_H1.1401.00
263_L266_S1.1351.00
62_M70_K1.1341.00
249_D257_R1.1291.00
114_E118_A1.1221.00
128_R135_L1.1101.00
131_A135_L1.1021.00
91_E95_R1.0901.00
35_A41_A1.0871.00
245_I251_P1.0801.00
146_T149_A1.0741.00
207_C253_V1.0741.00
201_D205_K1.0741.00
184_A223_G1.0681.00
9_V67_F1.0581.00
45_I50_P1.0551.00
4_I123_I1.0341.00
86_T93_T1.0321.00
265_H269_K1.0321.00
54_T82_V1.0261.00
8_S19_M1.0161.00
128_R131_A1.0101.00
54_T119_Y0.9971.00
42_R62_M0.9961.00
66_D69_E0.9941.00
235_E248_H0.9931.00
71_L79_V0.9911.00
19_M82_V0.9891.00
118_A121_E0.9851.00
125_E129_T0.9801.00
90_S93_T0.9791.00
256_H260_V0.9731.00
55_L71_L0.9681.00
49_N75_R0.9681.00
26_H29_M0.9601.00
5_R50_P0.9601.00
122_M126_K0.9581.00
39_L62_M0.9521.00
173_H177_P0.9471.00
103_D118_A0.9461.00
139_K143_A0.9381.00
158_L186_L0.9341.00
246_K266_S0.9311.00
29_M120_N0.9311.00
266_S269_K0.9281.00
118_A122_M0.9261.00
181_S263_L0.9171.00
223_G263_L0.9171.00
119_Y123_I0.9131.00
117_L121_E0.9101.00
90_S94_L0.9031.00
42_R45_I0.8991.00
55_L59_M0.8901.00
253_V256_H0.8881.00
124_A127_V0.8791.00
180_L208_Q0.8781.00
267_V270_Q0.8751.00
122_M125_E0.8691.00
8_S20_T0.8611.00
123_I126_K0.8601.00
206_L254_N0.8591.00
9_V38_P0.8581.00
116_M120_N0.8541.00
173_H188_T0.8521.00
9_V53_L0.8511.00
119_Y125_E0.8501.00
115_G118_A0.8491.00
196_T213_E0.8481.00
69_E73_R0.8401.00
72_M78_P0.8381.00
188_T263_L0.8271.00
123_I127_V0.8271.00
141_L145_T0.8261.00
53_L67_F0.8251.00
227_I269_K0.8221.00
186_L220_V0.8191.00
149_A178_L0.8171.00
201_D206_L0.8161.00
92_V104_F0.8141.00
5_R51_D0.8101.00
136_A140_P0.8081.00
268_A271_A0.8081.00
174_V178_L0.8051.00
215_E218_E0.8041.00
175_L225_A0.8041.00
57_V92_V0.8031.00
35_A38_P0.8011.00
38_P61_R0.8001.00
13_A17_Q0.7961.00
127_V131_A0.7951.00
93_T104_F0.7931.00
51_D126_K0.7911.00
41_A67_F0.7891.00
201_D204_N0.7891.00
35_A40_V0.7871.00
192_P233_H0.7861.00
56_D59_M0.7751.00
140_P143_A0.7721.00
53_L79_V0.7701.00
206_L211_V0.7691.00
124_A129_T0.7661.00
187_I225_A0.7641.00
92_V95_R0.7611.00
147_L150_G0.7611.00
72_M102_I0.7611.00
40_V43_D0.7590.99
119_Y126_K0.7460.99
121_E125_E0.7440.99
187_I227_I0.7380.99
54_T80_V0.7380.99
22_I116_M0.7340.99
131_A134_S0.7330.99
143_A146_T0.7330.99
28_D120_N0.7320.99
153_L180_L0.7300.99
256_H259_S0.7270.99
163_A166_G0.7260.99
86_T90_S0.7250.99
65_L99_L0.7210.99
11_D59_M0.7190.99
37_D59_M0.7190.99
148_K151_P0.7140.99
6_V52_V0.7120.99
172_R176_Q0.7100.99
98_E172_R0.7080.99
219_R242_N0.7050.99
169_E244_Q0.7040.99
81_M86_T0.7030.99
62_M67_F0.6990.99
217_G258_P0.6980.99
127_V130_A0.6970.99
199_F238_R0.6950.99
222_P262_V0.6950.99
86_T89_G0.6930.99
56_D107_K0.6900.99
220_V257_R0.6900.99
239_S244_Q0.6870.99
11_D64_G0.6850.99
82_V105_V0.6840.99
119_Y122_M0.6830.99
42_R46_K0.6830.99
145_T171_I0.6820.99
54_T115_G0.6790.99
178_L182_S0.6780.99
57_V63_D0.6770.99
125_E128_R0.6740.99
212_K226_Y0.6730.99
251_P261_D0.6710.99
261_D266_S0.6690.99
210_G221_L0.6680.99
7_L41_A0.6660.99
45_I75_R0.6660.99
37_D60_P0.6640.99
136_A145_T0.6630.99
126_K129_T0.6610.99
211_V214_A0.6580.99
265_H270_Q0.6510.98
17_Q20_T0.6500.98
45_I67_F0.6460.98
160_A171_I0.6460.98
170_A174_V0.6450.98
174_V177_P0.6440.98
39_L70_K0.6420.98
136_A148_K0.6410.98
59_M64_G0.6370.98
263_L269_K0.6350.98
144_P151_P0.6340.98
68_L99_L0.6330.98
34_T44_L0.6320.98
206_L210_G0.6320.98
57_V86_T0.6290.98
10_D107_K0.6290.98
138_H142_S0.6280.98
61_R67_F0.6260.98
129_T132_K0.6260.98
23_I32_V0.6240.98
8_S54_T0.6240.98
110_L114_E0.6230.98
193_P231_D0.6210.98
19_M115_G0.6200.98
22_I111_G0.6200.98
7_L50_P0.6200.98
8_S32_V0.6190.98
199_F203_L0.6180.98
15_M109_Q0.6170.98
261_D265_H0.6160.98
65_L95_R0.6150.98
38_P63_D0.6150.98
58_E63_D0.6130.98
214_A217_G0.6120.98
197_R215_E0.6110.98
142_S145_T0.6100.98
186_L234_M0.6070.98
263_L268_A0.6040.97
9_V59_M0.6040.97
235_E246_K0.6020.97
56_D64_G0.6000.97
126_K131_A0.5990.97
155_S180_L0.5980.97
186_L224_H0.5960.97
4_I52_V0.5960.97
7_L45_I0.5950.97
81_M96_A0.5950.97
141_L144_P0.5940.97
104_F114_E0.5930.97
72_M77_M0.5930.97
24_N30_E0.5930.97
78_P125_E0.5930.97
137_A142_S0.5920.97
68_L101_A0.5910.97
122_M130_A0.5910.97
200_A241_A0.5900.97
196_T235_E0.5900.97
58_E89_G0.5890.97
249_D261_D0.5880.97
14_L18_I0.5860.97
253_V262_V0.5850.97
160_A263_L0.5840.97
94_L98_E0.5840.97
125_E132_K0.5830.97
72_M75_R0.5730.97
145_T174_V0.5730.97
222_P263_L0.5720.97
231_D249_D0.5700.96
57_V65_L0.5690.96
52_V78_P0.5680.96
157_K249_D0.5680.96
21_E25_S0.5670.96
118_A126_K0.5650.96
9_V35_A0.5650.96
46_K70_K0.5640.96
124_A135_L0.5640.96
220_V252_A0.5640.96
233_H272_G0.5610.96
197_R213_E0.5600.96
21_E24_N0.5600.96
160_A186_L0.5570.96
147_L151_P0.5520.96
97_L101_A0.5510.96
139_K142_S0.5500.96
144_P148_K0.5460.95
116_M119_Y0.5460.95
30_E48_F0.5450.95
117_L128_R0.5440.95
4_I29_M0.5440.95
118_A123_I0.5440.95
98_E103_D0.5440.95
41_A45_I0.5420.95
11_D107_K0.5410.95
52_V102_I0.5390.95
226_Y266_S0.5360.95
7_L44_L0.5360.95
235_E269_K0.5350.95
136_A142_S0.5350.95
125_E133_A0.5330.95
121_E124_A0.5310.95
236_L243_Y0.5310.95
10_D15_M0.5270.95
86_T106_T0.5270.95
15_M18_I0.5250.94
32_V48_F0.5240.94
116_M123_I0.5230.94
268_A272_G0.5200.94
266_S270_Q0.5200.94
190_H233_H0.5180.94
102_I125_E0.5160.94
89_G95_R0.5160.94
190_H234_M0.5160.94
89_G92_V0.5150.94
120_N124_A0.5140.94
220_V236_L0.5140.94
232_R270_Q0.5130.94
102_I118_A0.5120.94
162_G167_G0.5110.94
125_E130_A0.5110.94
255_R265_H0.5100.94
144_P147_L0.5100.94
13_A36_P0.5090.93
130_A134_S0.5090.93
113_R117_L0.5080.93
124_A128_R0.5070.93
229_P247_I0.5060.93
236_L240_G0.5000.93
71_L76_P0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a2oA 1 0.9713 100 0.147 Contact Map
1chdA 1 0.5673 100 0.452 Contact Map
3sftA 1 0.5387 100 0.464 Contact Map
4g97A 1 0.3754 100 0.642 Contact Map
3n0rA 1 0.3524 100 0.646 Contact Map
4l4uA 2 0.8825 100 0.657 Contact Map
3dzdA 2 0.9513 100 0.663 Contact Map
3breA 4 0.8395 100 0.665 Contact Map
4gvpA 1 0.5931 100 0.668 Contact Map
1s8nA 1 0.5415 99.9 0.67 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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