GREMLIN Database
SYV - Valine--tRNA ligase
UniProt: P07118 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11067
Length: 951 (844)
Sequences: 1627 (955)
Seq/√Len: 32.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_Q71_K6.6881.00
109_A112_D5.8641.00
500_H523_T5.4411.00
434_R468_Q5.2351.00
332_F347_A5.0041.00
113_K116_E4.7621.00
675_R790_D4.6431.00
163_E525_H4.6071.00
302_T306_D4.3281.00
246_I263_G4.1101.00
233_V250_V4.0571.00
573_S576_E3.9731.00
391_K395_E3.6471.00
290_G295_L3.5871.00
249_Y258_R3.5841.00
403_Q540_T3.4531.00
679_A794_L3.4281.00
407_K410_E3.3811.00
335_L343_A3.3791.00
398_E418_R3.3391.00
331_E347_A3.3161.00
149_L485_S3.3071.00
553_Q559_K3.2201.00
492_N497_R3.1771.00
207_G215_D3.1561.00
56_Q134_N3.1221.00
155_E159_R3.0861.00
251_I256_N3.0571.00
162_K457_E3.0231.00
649_S761_I2.9341.00
680_E711_Q2.9231.00
309_E333_Q2.8671.00
201_R216_Y2.8271.00
131_R570_D2.7741.00
346_A349_D2.7611.00
347_A350_A2.7581.00
85_A369_R2.6901.00
98_E113_K2.6811.00
330_A333_Q2.6671.00
162_K449_R2.6501.00
307_I311_A2.6331.00
454_V458_N2.6101.00
217_L275_C2.5891.00
480_A522_M2.5831.00
592_D595_R2.5801.00
394_V414_F2.5771.00
448_G454_V2.5681.00
155_E449_R2.5631.00
194_K361_D2.5631.00
61_T692_L2.5201.00
15_Y24_F2.5181.00
204_L215_D2.5111.00
93_K97_E2.4470.99
690_E694_S2.4380.99
234_A278_I2.4230.99
267_A271_K2.3700.99
578_L599_E2.3600.99
708_T746_L2.3550.99
19_E130_R2.3520.99
750_A754_I2.3440.99
129_M134_N2.3430.99
674_D716_Y2.3160.99
775_T778_L2.3040.99
683_Q794_L2.3020.99
197_M271_K2.2800.99
56_Q129_M2.2790.99
216_Y355_E2.2720.99
451_E455_R2.2670.99
166_I425_I2.2630.99
14_L760_T2.2620.99
33_E71_K2.2330.99
302_T308_R2.2130.99
595_R599_E2.2050.99
288_E291_K2.2010.99
651_F720_T2.1840.99
106_G109_A2.1740.99
180_R304_D2.1460.99
551_E601_Q2.1300.99
251_I258_R2.1100.98
449_R453_E2.1090.98
347_A351_L2.1030.98
201_R218_V2.0970.98
387_D391_K2.0950.98
200_I348_V2.0930.98
384_V425_I2.0760.98
151_N491_E2.0720.98
298_I308_R2.0710.98
459_N464_V2.0630.98
200_I227_L2.0620.98
76_Q486_T2.0560.98
395_E399_N2.0450.98
410_E414_F2.0440.98
409_Y412_M2.0330.98
700_A753_I2.0240.98
192_E361_D2.0110.98
461_G464_V2.0080.98
193_S366_Y2.0000.98
512_I543_M1.9750.98
39_I129_M1.9740.98
671_S674_D1.9700.98
22_G25_K1.9610.98
66_Q69_Q1.9590.97
388_V391_K1.9500.97
507_S516_I1.9480.97
587_Q590_L1.9450.97
205_A258_R1.9410.97
238_E265_E1.9370.97
467_R470_E1.9320.97
441_E467_R1.9290.97
453_E457_E1.9210.97
254_L347_A1.9190.97
142_R482_W1.9180.97
201_R355_E1.9110.97
403_Q407_K1.8850.97
235_V261_I1.8730.97
398_E414_F1.8730.97
750_A758_T1.8700.97
395_E398_E1.8700.97
459_N462_A1.8640.97
233_V275_C1.8640.97
72_N498_Q1.8500.96
215_D244_D1.8430.96
204_L207_G1.8280.96
205_A249_Y1.8280.96
677_I707_F1.8190.96
232_G262_V1.8140.96
398_E410_E1.8060.96
829_C855_V1.7800.96
689_R693_D1.7790.96
197_M267_A1.7760.95
691_A700_A1.7730.95
685_I749_L1.7550.95
63_I73_T1.7490.95
190_N363_T1.7440.95
505_M519_M1.7410.95
685_I741_T1.7400.95
483_T500_H1.7330.95
160_L522_M1.7300.95
250_V261_I1.7290.95
142_R148_G1.7220.95
402_I520_I1.7200.95
686_K690_E1.7190.95
300_I307_I1.7180.95
688_Y700_A1.7180.95
192_E363_T1.7070.94
191_R366_Y1.6980.94
16_E20_K1.6850.94
460_L464_V1.6800.94
689_R781_F1.6670.94
681_F745_G1.6650.94
207_G214_K1.6630.94
159_R163_E1.6610.94
206_D248_K1.6600.94
23_Y778_L1.6580.93
61_T619_A1.6560.93
101_T104_D1.6540.93
670_L678_L1.6470.93
66_Q693_D1.6420.93
345_V357_I1.6400.93
158_V449_R1.6390.93
763_Q776_I1.6380.93
346_A350_A1.6380.93
306_D336_E1.6330.93
856_L863_P1.6320.93
337_R375_E1.6280.93
302_T309_E1.6250.93
340_A344_V1.6180.93
678_L685_I1.6150.93
827_R874_E1.6140.93
417_M520_I1.6040.92
575_P579_E1.5950.92
199_H356_E1.5900.92
179_L370_G1.5860.92
178_K372_V1.5750.92
266_H289_V1.5750.92
859_D863_P1.5700.91
224_P345_V1.5680.91
129_M136_V1.5660.91
680_E683_Q1.5610.91
616_F701_A1.5600.91
619_A753_I1.5590.91
100_K104_D1.5570.91
156_V526_F1.5470.91
494_D497_R1.5450.91
235_V246_I1.5430.91
57_T619_A1.5420.91
527_I534_P1.5400.91
796_D839_E1.5400.91
331_E343_A1.5390.91
727_G731_E1.5320.90
55_Q544_T1.5310.90
808_R811_R1.5260.90
585_M590_L1.5260.90
692_L700_A1.5240.90
441_E465_V1.5110.90
792_A796_D1.5100.90
487_L502_T1.4980.89
544_T547_I1.4970.89
56_Q544_T1.4960.89
460_L463_D1.4940.89
678_L741_T1.4920.89
402_I536_V1.4850.89
343_A346_A1.4840.89
159_R492_N1.4800.89
217_L261_I1.4790.89
414_F418_R1.4750.89
728_T731_E1.4750.89
69_Q689_R1.4720.89
385_R388_V1.4690.88
824_L875_L1.4650.88
94_I105_Y1.4580.88
550_D601_Q1.4510.88
176_D367_G1.4310.87
25_K139_E1.4100.86
229_G233_V1.4090.86
111_I114_I1.4090.86
308_R311_A1.4080.86
568_M609_H1.4070.86
206_D214_K1.4070.86
810_I877_I1.4050.86
790_D793_A1.4040.86
568_M630_W1.3970.86
307_I340_A1.3880.85
576_E579_E1.3850.85
170_K380_D1.3830.85
844_L848_A1.3780.85
356_E363_T1.3750.85
17_H21_Q1.3700.85
811_R816_I1.3700.85
860_D863_P1.3680.85
394_V418_R1.3660.84
38_M502_T1.3650.84
681_F742_V1.3630.84
93_K120_E1.3590.84
100_K109_A1.3550.84
578_L595_R1.3550.84
682_N789_V1.3550.84
95_A99_G1.3470.84
684_T749_L1.3350.83
47_S124_T1.3320.83
100_K105_Y1.3230.82
302_T307_I1.3190.82
29_D32_Q1.3180.82
437_A447_V1.3080.82
835_R839_E1.3070.82
101_T106_G1.2980.81
38_M482_W1.2980.81
658_G736_R1.2950.81
678_L788_Q1.2940.81
838_N841_R1.2930.81
404_F512_I1.2870.81
266_H363_T1.2870.81
483_T523_T1.2820.80
32_Q71_K1.2800.80
219_V295_L1.2800.80
505_M516_I1.2790.80
65_Y692_L1.2750.80
687_A690_E1.2730.80
105_Y109_A1.2710.80
343_A347_A1.2690.80
834_E838_N1.2530.79
79_T126_T1.2520.79
196_S359_P1.2500.79
21_Q774_D1.2470.78
670_L734_G1.2400.78
232_G278_I1.2380.78
856_L862_G1.2380.78
203_P216_Y1.2380.78
23_Y777_M1.2380.78
413_Y520_I1.2370.78
123_G126_T1.2360.78
199_H220_A1.2340.78
234_A275_C1.2320.78
236_N267_A1.2280.77
401_D535_Q1.2280.77
336_E339_A1.2250.77
53_A56_Q1.2220.77
189_E368_D1.2160.77
332_F335_L1.2160.77
685_I745_G1.2150.77
12_Q16_E1.2120.76
445_V448_G1.2100.76
454_V457_E1.2080.76
58_I506_V1.2060.76
301_L307_I1.2040.76
729_E732_L1.1990.76
198_W227_L1.1950.75
594_I598_T1.1890.75
39_I56_Q1.1870.75
572_I576_E1.1860.75
35_F63_I1.1860.75
685_I689_R1.1810.75
540_T695_F1.1810.75
23_Y774_D1.1780.74
204_L233_V1.1700.74
205_A251_I1.1690.74
37_I63_I1.1660.74
551_E597_R1.1650.74
440_D462_A1.1620.73
399_N524_M1.1620.73
67_R135_S1.1600.73
545_G622_A1.1600.73
677_I742_V1.1580.73
39_I75_W1.1580.73
65_Y689_R1.1550.73
55_Q77_V1.1540.73
592_D596_K1.1530.73
567_D572_I1.1490.72
289_V292_R1.1470.72
154_K158_V1.1460.72
581_R598_T1.1460.72
453_E456_K1.1420.72
238_E269_M1.1410.72
674_D734_G1.1410.72
732_L736_R1.1400.72
411_N415_S1.1390.72
126_T141_E1.1390.72
844_L850_L1.1360.72
575_P599_E1.1330.71
415_S418_R1.1320.71
475_T478_S1.1300.71
159_R162_K1.1280.71
218_V355_E1.1260.71
645_L757_I1.1250.71
64_R755_P1.1240.71
482_W486_T1.1240.71
392_P395_E1.1230.71
65_Y69_Q1.1220.71
33_E66_Q1.1190.70
306_D339_A1.1150.70
72_N499_F1.1140.70
588_P591_A1.1140.70
158_V453_E1.1140.70
575_P578_L1.1120.70
744_E748_R1.1060.70
140_R495_A1.1050.69
634_R638_Y1.1050.69
42_P46_G1.1050.69
196_S357_I1.1030.69
858_A861_K1.1030.69
759_E763_Q1.0990.69
830_S872_G1.0990.69
547_I618_L1.0990.69
254_L348_V1.0950.69
204_L214_K1.0940.69
129_M544_T1.0940.69
33_E72_N1.0900.68
411_N417_M1.0890.68
262_V267_A1.0890.68
527_I535_Q1.0800.68
724_M727_G1.0790.68
493_T496_L1.0790.68
232_G260_P1.0770.67
481_L484_F1.0750.67
681_F685_I1.0740.67
440_D446_Y1.0720.67
691_A703_I1.0720.67
8_Q12_Q1.0710.67
832_D835_R1.0660.67
656_T659_Q1.0660.67
303_F377_M1.0650.67
440_D444_N1.0580.66
46_G49_H1.0560.66
629_N633_K1.0550.66
660_D733_R1.0550.66
688_Y703_I1.0510.66
280_P290_G1.0500.65
590_L593_K1.0480.65
287_Y403_Q1.0480.65
555_M561_N1.0480.65
110_F114_I1.0470.65
645_L743_L1.0450.65
412_M415_S1.0450.65
763_Q775_T1.0430.65
405_V695_F1.0420.65
254_L351_L1.0400.65
804_I808_R1.0390.65
687_A703_I1.0370.64
582_T595_R1.0370.64
509_F543_M1.0350.64
831_A835_R1.0350.64
291_K294_A1.0350.64
174_N376_P1.0330.64
824_L850_L1.0330.64
440_D459_N1.0320.64
198_W224_P1.0310.64
275_C278_I1.0230.63
46_G51_G1.0230.63
6_N9_D1.0220.63
682_N685_I1.0210.63
77_V544_T1.0210.63
586_M594_I1.0200.63
683_Q791_E1.0200.63
660_D663_F1.0130.63
858_A863_P1.0130.63
42_P49_H1.0120.63
89_V92_R1.0120.63
176_D370_G1.0120.63
308_R333_Q1.0120.63
586_M590_L1.0100.62
657_E660_D1.0100.62
801_K811_R1.0070.62
582_T591_A1.0060.62
331_E351_L1.0050.62
14_L704_L1.0040.62
23_Y26_P1.0030.62
770_G773_A1.0020.62
497_R535_Q0.9970.61
175_W182_A0.9950.61
200_I254_L0.9920.61
228_L307_I0.9910.61
867_T874_E0.9910.61
446_Y460_L0.9900.61
236_N266_H0.9880.61
55_Q134_N0.9860.60
856_L860_D0.9830.60
13_P760_T0.9820.60
42_P51_G0.9800.60
304_D308_R0.9800.60
200_I345_V0.9790.60
302_T377_M0.9770.60
405_V540_T0.9750.60
176_D179_L0.9750.60
39_I136_V0.9720.59
634_R637_G0.9720.59
715_W801_K0.9720.59
219_V256_N0.9720.59
733_R737_H0.9720.59
17_H23_Y0.9710.59
177_P305_G0.9700.59
453_E458_N0.9650.59
490_P493_T0.9650.59
231_T280_P0.9630.59
300_I308_R0.9630.59
103_H106_G0.9600.58
701_A753_I0.9580.58
392_P525_H0.9560.58
194_K359_P0.9550.58
229_G300_I0.9550.58
403_Q539_H0.9500.58
549_D561_N0.9480.57
40_P45_T0.9470.57
62_M66_Q0.9470.57
401_D524_M0.9470.57
751_H758_T0.9460.57
502_T505_M0.9440.57
488_G493_T0.9420.57
556_S561_N0.9410.57
602_F605_G0.9410.57
75_W129_M0.9370.57
15_Y23_Y0.9360.56
707_F742_V0.9350.56
87_Q91_E0.9340.56
54_F59_M0.9280.56
544_T550_D0.9250.56
856_L859_D0.9250.56
332_F344_V0.9240.55
841_R845_Q0.9230.55
295_L568_M0.9230.55
217_L295_L0.9210.55
231_T295_L0.9200.55
273_T280_P0.9180.55
735_T738_T0.9150.55
392_P534_P0.9130.55
583_G592_D0.9060.54
547_I691_A0.9050.54
27_N499_F0.9040.54
854_T860_D0.9020.54
424_C428_Q0.9000.54
808_R814_M0.8990.53
573_S578_L0.8980.53
472_V475_T0.8970.53
287_Y425_I0.8960.53
799_W836_R0.8960.53
98_E105_Y0.8950.53
40_P43_N0.8950.53
618_L621_L0.8940.53
24_F27_N0.8920.53
725_N732_L0.8910.53
873_A876_L0.8910.53
381_Q428_Q0.8900.53
811_R815_N0.8850.52
132_L592_D0.8850.52
455_R458_N0.8850.52
373_V445_V0.8840.52
811_R814_M0.8840.52
228_L344_V0.8830.52
590_L594_I0.8830.52
835_R838_N0.8830.52
508_G554_K0.8810.52
250_V275_C0.8790.52
266_H271_K0.8790.52
737_H741_T0.8780.52
250_V289_V0.8780.52
176_D183_I0.8770.52
612_D615_R0.8770.52
579_E582_T0.8760.52
447_V451_E0.8720.51
630_W635_L0.8700.51
504_V542_Y0.8680.51
796_D836_R0.8660.51
685_I788_Q0.8620.50
568_M633_K0.8610.50
723_V735_T0.8590.50
448_G451_E0.8570.50
688_Y749_L0.8560.50
385_R422_D0.8550.50
669_T730_A0.8540.50
870_I873_A0.8540.50
36_C149_L0.8540.50
76_Q142_R0.8540.50
844_L847_L0.8530.50
734_G738_T0.8520.50
868_K871_D0.8510.49
271_K363_T0.8490.49
57_T61_T0.8480.49
266_H364_V0.8480.49
236_N269_M0.8470.49
23_Y27_N0.8450.49
122_G126_T0.8440.49
281_A300_I0.8440.49
386_A402_I0.8440.49
524_M534_P0.8430.49
190_N365_P0.8420.49
41_P60_D0.8410.49
180_R303_F0.8400.49
287_Y291_K0.8380.48
35_F289_V0.8380.48
396_A524_M0.8370.48
587_Q591_A0.8350.48
50_M562_V0.8350.48
584_N590_L0.8330.48
246_I260_P0.8320.48
674_D723_V0.8290.48
278_I294_A0.8280.48
476_W479_S0.8280.48
299_N308_R0.8270.47
149_L383_Y0.8260.47
257_R298_I0.8250.47
61_T753_I0.8250.47
354_L357_I0.8250.47
290_G296_P0.8240.47
199_H358_K0.8240.47
133_G756_F0.8230.47
200_I219_V0.8210.47
168_R175_W0.8190.47
65_Y693_D0.8190.47
237_P263_G0.8150.46
380_D383_Y0.8090.46
589_Q592_D0.8090.46
636_E640_N0.8090.46
334_K337_R0.8080.46
584_N591_A0.8070.46
727_G732_L0.8060.46
339_A343_A0.8050.46
567_D580_K0.8040.46
492_N607_E0.8040.46
544_T635_L0.8030.45
9_D13_P0.8030.45
14_L17_H0.8010.45
121_S181_T0.7990.45
379_T627_D0.7980.45
423_W432_G0.7930.45
674_D717_L0.7930.45
262_V289_V0.7920.45
443_G704_L0.7920.45
448_G458_N0.7910.44
645_L708_T0.7900.44
500_H527_I0.7880.44
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428_Q435_I0.5290.25
45_T59_M0.5280.25
304_D651_F0.5280.25
797_T816_I0.5280.25
577_L605_G0.5280.25
549_D558_S0.5280.25
38_M624_T0.5270.25
265_E292_R0.5270.25
667_E670_L0.5260.25
203_P254_L0.5250.25
792_A838_N0.5250.25
35_F656_T0.5240.25
840_N843_F0.5240.25
160_L661_C0.5240.25
707_F756_F0.5240.25
723_V731_E0.5240.25
702_G750_A0.5240.25
395_E831_A0.5230.25
386_A520_I0.5230.25
39_I482_W0.5230.25
473_L478_S0.5220.25
683_Q789_V0.5220.25
108_E434_R0.5220.25
509_F546_L0.5220.25
220_A271_K0.5220.25
339_A342_K0.5220.25
423_W427_R0.5210.25
66_Q692_L0.5210.25
633_K636_E0.5210.25
170_K378_L0.5210.25
176_D377_M0.5210.25
682_N686_K0.5200.25
339_A730_A0.5190.24
411_N523_T0.5180.24
82_A86_T0.5180.24
440_D452_D0.5180.24
568_M632_M0.5180.24
134_N544_T0.5180.24
429_L434_R0.5180.24
712_F715_W0.5170.24
413_Y417_M0.5160.24
789_V794_L0.5160.24
136_V149_L0.5160.24
77_V89_V0.5160.24
348_V534_P0.5150.24
331_E335_L0.5150.24
687_A691_A0.5150.24
146_D237_P0.5150.24
279_T519_M0.5150.24
75_W138_W0.5140.24
190_N364_V0.5140.24
200_I351_L0.5130.24
115_W143_F0.5130.24
772_T784_Y0.5130.24
848_A851_E0.5130.24
261_I376_P0.5130.24
442_A462_A0.5130.24
20_K550_D0.5130.24
32_Q780_P0.5130.24
503_S539_H0.5130.24
620_A638_Y0.5130.24
161_Y457_E0.5130.24
447_V450_N0.5130.24
523_T535_Q0.5120.24
639_R643_N0.5120.24
641_F709_W0.5120.24
223_R230_D0.5120.24
671_S716_Y0.5120.24
91_E114_I0.5120.24
38_M505_M0.5110.24
683_Q798_E0.5110.24
42_P48_L0.5110.24
168_R571_G0.5100.24
156_V480_A0.5100.24
159_R449_R0.5090.24
553_Q590_L0.5090.24
231_T250_V0.5090.24
257_R438_W0.5090.24
574_L578_L0.5090.24
524_M593_K0.5090.24
831_A841_R0.5070.24
399_N875_L0.5070.24
4_T645_L0.5070.24
475_T518_R0.5070.24
165_L570_D0.5070.24
436_P755_P0.5060.24
5_Y189_E0.5060.24
581_R595_R0.5060.24
152_A564_D0.5060.24
36_C877_I0.5060.24
62_M371_G0.5060.24
475_T513_F0.5060.24
455_R463_D0.5050.24
190_N366_Y0.5050.24
726_G729_E0.5040.24
549_D554_K0.5040.24
282_H381_Q0.5040.24
55_Q58_I0.5040.24
197_M220_A0.5040.24
816_I824_L0.5040.24
227_L234_A0.5030.24
162_K844_L0.5030.24
522_M732_L0.5030.24
842_G858_A0.5030.24
137_D453_E0.5020.23
386_A590_L0.5020.23
18_W24_F0.5020.23
189_E412_M0.5020.23
779_Q837_V0.5020.23
40_P511_I0.5010.23
182_A187_E0.5010.23
772_T860_D0.5010.23
196_S342_K0.5010.23
678_L771_I0.5010.23
254_L344_V0.5010.23
6_N725_N0.5000.23
844_L853_I0.5000.23
690_E791_E0.5000.23
391_K399_N0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gaxA 1 0.8991 100 0.217 Contact Map
1ffyA 1 0.8665 100 0.303 Contact Map
1ileA 1 0.7886 100 0.373 Contact Map
1wz2A 1 0.8654 100 0.405 Contact Map
2v0cA 1 0.6688 100 0.467 Contact Map
1wkbA 1 0.714 100 0.469 Contact Map
4arcA 1 0.7077 100 0.484 Contact Map
3ziuA 1 0.6015 100 0.586 Contact Map
4qreA 1 0.53 100 0.682 Contact Map
1rqgA 2 0.5615 100 0.683 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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