GREMLIN Database
PUTP - Sodium/proline symporter
UniProt: P07117 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10802
Length: 502 (458)
Sequences: 11508 (7250)
Seq/√Len: 338.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
436_I465_G5.8531.00
367_S370_E4.1051.00
425_M466_I3.9141.00
263_S266_S3.7721.00
363_R370_E3.5891.00
172_I383_A3.3341.00
436_I461_F3.3261.00
20_L24_I3.3131.00
358_Y366_A3.2041.00
433_G466_I3.0421.00
467_V471_L3.0391.00
469_F473_G3.0321.00
426_T473_G2.9891.00
99_V264_H2.9491.00
432_A469_F2.9411.00
203_V207_I2.9221.00
465_G469_F2.9001.00
440_T461_F2.8781.00
205_V291_F2.8651.00
214_D217_E2.6751.00
429_G470_S2.6531.00
369_K373_W2.6221.00
428_N473_G2.6041.00
418_F466_I2.5801.00
159_S162_T2.4861.00
180_F260_A2.4671.00
168_A387_I2.4531.00
373_W377_V2.4031.00
42_L184_S2.3511.00
377_V381_V2.3051.00
292_G313_V2.2951.00
115_T126_R2.2821.00
33_D40_R2.2821.00
426_T429_G2.1741.00
432_A465_G2.1281.00
66_G311_E2.1221.00
13_V17_G2.1101.00
366_A370_E2.1091.00
262_D266_S2.1051.00
422_W425_M2.0451.00
113_Y419_S2.0401.00
384_L388_A1.9591.00
58_G147_A1.9481.00
34_D39_G1.9391.00
165_W169_A1.9331.00
426_T470_S1.9271.00
429_G469_F1.9231.00
428_N432_A1.9221.00
37_L40_R1.9111.00
118_F425_M1.9101.00
415_V430_A1.9011.00
214_D218_V1.8921.00
197_A333_A1.8821.00
16_F20_L1.8811.00
363_R366_A1.8751.00
199_I203_V1.8621.00
296_F320_I1.8611.00
217_E221_Q1.8361.00
464_I468_V1.8311.00
124_I431_L1.8271.00
429_G433_G1.8091.00
355_E359_K1.7721.00
46_V188_T1.7631.00
171_T342_L1.7611.00
422_W467_V1.7541.00
178_G182_A1.7531.00
422_W471_L1.7451.00
265_H269_H1.7451.00
439_L443_V1.7411.00
424_R474_K1.7231.00
21_I189_V1.7121.00
107_A116_G1.7101.00
266_S269_H1.7021.00
265_H268_V1.7011.00
14_Y18_M1.6951.00
373_W376_R1.6871.00
358_Y374_V1.6751.00
217_E220_K1.6661.00
328_G332_S1.6641.00
418_F463_S1.6341.00
353_I378_M1.5951.00
359_K371_L1.5901.00
228_D231_K1.5851.00
424_R471_L1.5811.00
187_D257_R1.5811.00
353_I357_L1.5761.00
149_A164_L1.5761.00
112_D356_D1.5711.00
44_P266_S1.5521.00
49_L188_T1.5491.00
225_E228_D1.5401.00
169_A173_L1.5271.00
115_T123_R1.5201.00
150_R309_N1.5181.00
346_L383_A1.5091.00
226_N230_L1.5081.00
8_L12_C1.4951.00
213_G217_E1.4941.00
316_E320_I1.4941.00
436_I440_T1.4831.00
426_T474_K1.4811.00
47_T261_A1.4651.00
460_I464_I1.4541.00
432_A436_I1.4521.00
358_Y363_R1.4391.00
17_G21_I1.4381.00
161_E391_A1.4231.00
119_E124_I1.4041.00
366_A371_L1.3881.00
370_E373_W1.3821.00
18_M189_V1.3801.00
223_S227_V1.3781.00
119_E427_R1.3711.00
187_D343_S1.3691.00
7_M325_W1.3631.00
132_V438_A1.3561.00
93_V417_L1.3491.00
27_R30_K1.3411.00
12_C16_F1.3401.00
164_L387_I1.3401.00
349_C382_V1.3401.00
171_T339_M1.3331.00
168_A383_A1.3271.00
224_I229_M1.3201.00
162_T166_A1.3091.00
112_D355_E1.3071.00
228_D232_G1.2981.00
218_V221_Q1.2941.00
162_T165_W1.2761.00
461_F465_G1.2651.00
126_R356_D1.2641.00
95_G99_V1.2621.00
117_R419_S1.2601.00
358_Y370_E1.2601.00
131_L135_L1.2561.00
36_I375_G1.2541.00
223_S226_N1.2511.00
186_T343_S1.2451.00
372_V376_R1.2441.00
400_L404_A1.2431.00
123_R360_A1.2411.00
190_Q343_S1.2341.00
440_T465_G1.2291.00
229_M232_G1.2241.00
54_S344_C1.2161.00
353_I358_Y1.2101.00
209_V215_S1.2081.00
148_G167_G1.2061.00
115_T360_A1.2001.00
94_A98_R1.1961.00
145_I168_A1.1961.00
424_R475_A1.1901.00
161_E165_W1.1821.00
113_Y117_R1.1801.00
212_F216_L1.1801.00
218_V294_A1.1791.00
378_M381_V1.1791.00
109_T351_S1.1701.00
433_G437_G1.1651.00
433_G462_G1.1601.00
226_N229_M1.1581.00
354_T375_G1.1581.00
362_L366_A1.1551.00
128_I431_L1.1491.00
96_R99_V1.1461.00
50_S344_C1.1461.00
31_N34_D1.1421.00
17_G20_L1.1381.00
224_I227_V1.1381.00
38_G42_L1.1361.00
427_R431_L1.1331.00
68_V75_E1.1321.00
318_A330_L1.1281.00
443_V447_F1.1261.00
398_L402_S1.1241.00
9_V13_V1.1221.00
210_G214_D1.1211.00
465_G468_V1.1131.00
38_G180_F1.1121.00
426_T469_F1.1101.00
428_N469_F1.1091.00
129_S434_M1.1051.00
125_L431_L1.0971.00
158_M163_A1.0941.00
165_W387_I1.0901.00
174_Y339_M1.0881.00
187_D344_C1.0841.00
463_S467_V1.0831.00
192_S196_F1.0721.00
460_I463_S1.0701.00
425_M429_G1.0681.00
131_L357_L1.0681.00
224_I230_L1.0671.00
375_G379_V1.0631.00
224_I228_D1.0601.00
153_E160_Y1.0601.00
171_T343_S1.0591.00
48_A273_I1.0541.00
411_A462_G1.0541.00
425_M470_S1.0511.00
220_K224_I1.0491.00
424_R476_P1.0481.00
165_W391_A1.0481.00
125_L430_A1.0461.00
141_C386_A1.0451.00
415_V434_M1.0451.00
370_E374_V1.0381.00
213_G216_L1.0331.00
374_V378_M1.0331.00
196_F200_L1.0321.00
17_G189_V1.0301.00
215_S219_I1.0281.00
33_D106_N1.0261.00
14_Y339_M1.0221.00
142_A389_L1.0211.00
397_V401_V1.0201.00
114_F129_S1.0151.00
9_V12_C1.0141.00
200_L204_I1.0111.00
211_G214_D1.0111.00
29_T34_D1.0111.00
52_G277_W1.0101.00
54_S187_D1.0061.00
419_S430_A1.0061.00
128_I434_M1.0041.00
225_E229_M1.0041.00
6_P9_V1.0021.00
368_Q371_L1.0021.00
315_I318_A1.0001.00
208_S295_Y0.9961.00
174_Y343_S0.9941.00
291_F295_Y0.9941.00
366_A374_V0.9931.00
44_P48_A0.9931.00
50_S53_A0.9881.00
105_N116_G0.9871.00
235_F238_I0.9821.00
118_F419_S0.9751.00
124_I128_I0.9741.00
353_I382_V0.9731.00
307_N310_A0.9731.00
429_G432_A0.9711.00
216_L220_K0.9711.00
118_F466_I0.9681.00
223_S230_L0.9661.00
145_I164_L0.9611.00
388_A392_N0.9551.00
418_F425_M0.9551.00
354_T374_V0.9551.00
190_Q336_A0.9511.00
200_L326_I0.9461.00
24_I28_S0.9451.00
396_R399_G0.9431.00
444_W457_P0.9431.00
20_L23_F0.9391.00
223_S229_M0.9391.00
457_P460_I0.9351.00
224_I231_K0.9341.00
57_S140_Y0.9331.00
123_R127_I0.9301.00
19_I22_G0.9211.00
36_I351_S0.9171.00
309_N312_R0.9121.00
153_E157_G0.9121.00
455_I459_F0.9071.00
81_G85_G0.9061.00
114_F125_L0.9031.00
50_S184_S0.9021.00
340_S343_S0.9021.00
58_G338_V0.9011.00
174_Y340_S0.9011.00
202_P284_G0.9001.00
14_Y336_A0.9001.00
83_T279_I0.8961.00
70_L310_A0.8961.00
176_F380_L0.8951.00
402_S405_W0.8941.00
384_L387_I0.8921.00
402_S406_A0.8911.00
347_L350_S0.8901.00
19_I23_F0.8891.00
426_T475_A0.8881.00
215_S291_F0.8871.00
216_L219_I0.8851.00
428_N472_L0.8841.00
174_Y182_A0.8831.00
358_Y362_L0.8831.00
198_L285_A0.8821.00
140_Y252_P0.8811.00
117_R422_W0.8801.00
53_A257_R0.8801.00
76_S80_I0.8791.00
437_G462_G0.8791.00
422_W470_S0.8771.00
414_P463_S0.8761.00
186_T190_Q0.8761.00
174_Y190_Q0.8761.00
136_F407_G0.8731.00
381_V385_V0.8731.00
443_V446_Q0.8731.00
95_G268_V0.8701.00
299_H307_N0.8651.00
350_S354_T0.8641.00
190_Q340_S0.8631.00
435_I439_L0.8611.00
132_V434_M0.8601.00
288_V317_L0.8581.00
134_L353_I0.8571.00
50_S257_R0.8521.00
6_P10_T0.8511.00
124_I427_R0.8491.00
15_I18_M0.8491.00
437_G441_V0.8491.00
316_E319_Q0.8481.00
422_W429_G0.8481.00
415_V462_G0.8461.00
463_S466_I0.8431.00
92_L96_R0.8421.00
50_S54_S0.8411.00
44_P269_H0.8381.00
160_Y164_L0.8341.00
225_E230_L0.8331.00
43_G266_S0.8321.00
292_G317_L0.8311.00
261_A267_I0.8291.00
38_G260_A0.8281.00
401_V405_W0.8281.00
397_V402_S0.8271.00
29_T372_V0.8251.00
461_F464_I0.8241.00
53_A190_Q0.8231.00
398_L401_V0.8221.00
452_L456_I0.8211.00
190_Q341_T0.8181.00
61_L330_L0.8141.00
85_G89_N0.8121.00
164_L390_A0.8101.00
218_V222_K0.8091.00
49_L191_A0.8061.00
46_V184_S0.8051.00
227_V231_K0.8041.00
227_V230_L0.8031.00
358_Y361_F0.8031.00
68_V290_F0.8011.00
403_Y445_K0.8001.00
379_V383_A0.7991.00
418_F467_V0.7991.00
69_F298_D0.7981.00
200_L203_V0.7981.00
23_F177_I0.7951.00
183_V186_T0.7941.00
19_I173_L0.7941.00
11_F335_L0.7901.00
127_I361_F0.7891.00
91_K272_R0.7871.00
88_I92_L0.7871.00
233_L236_V0.7851.00
24_I27_R0.7841.00
468_V472_L0.7831.00
201_T205_V0.7811.00
128_I435_I0.7811.00
437_G440_T0.7801.00
60_L282_L0.7791.00
98_R264_H0.7771.00
61_L198_L0.7761.00
23_F27_R0.7751.00
397_V400_L0.7741.00
23_F26_W0.7741.00
431_L435_I0.7741.00
220_K223_S0.7731.00
422_W426_T0.7721.00
318_A327_A0.7711.00
124_I127_I0.7691.00
312_R316_E0.7691.00
448_G451_G0.7661.00
272_R276_T0.7661.00
226_N231_K0.7651.00
362_L365_H0.7651.00
425_M433_G0.7621.00
462_G466_I0.7611.00
165_W384_L0.7591.00
67_A71_S0.7581.00
158_M166_A0.7581.00
83_T275_M0.7561.00
359_K364_K0.7541.00
440_T444_W0.7531.00
215_S218_V0.7531.00
204_I208_S0.7531.00
7_M10_T0.7531.00
13_V20_L0.7471.00
377_V380_L0.7471.00
123_R126_R0.7471.00
276_T280_L0.7461.00
440_T443_V0.7451.00
163_A167_G0.7420.99
371_L375_G0.7410.99
134_L349_C0.7400.99
358_Y364_K0.7400.99
44_P273_I0.7400.99
430_A437_G0.7390.99
7_M327_A0.7380.99
94_A97_L0.7380.99
57_S61_L0.7360.99
10_T325_W0.7330.99
201_T314_F0.7320.99
24_I185_W0.7310.99
11_F15_I0.7300.99
468_V471_L0.7280.99
180_F184_S0.7270.99
78_I81_G0.7270.99
111_P129_S0.7270.99
418_F422_W0.7260.99
185_W188_T0.7260.99
90_W94_A0.7250.99
209_V214_D0.7250.99
388_A391_A0.7230.99
438_A442_I0.7210.99
208_S321_L0.7200.99
428_N474_K0.7170.99
25_A185_W0.7170.99
183_V344_C0.7160.99
223_S228_D0.7150.99
144_G342_L0.7140.99
225_E231_K0.7130.99
50_S187_D0.7120.99
195_I199_I0.7110.99
190_Q339_M0.7110.99
63_G140_Y0.7090.99
111_P133_I0.7090.99
354_T371_L0.7090.99
10_T328_G0.7090.99
69_F299_H0.7080.99
92_L95_G0.7070.99
206_I287_A0.7060.99
261_A266_S0.7060.99
467_V470_S0.7020.99
183_V257_R0.6990.99
14_Y190_Q0.6990.99
353_I374_V0.6960.99
209_V294_A0.6940.99
436_I469_F0.6940.99
227_V232_G0.6940.99
206_I211_G0.6910.99
341_T345_Q0.6910.99
7_M328_G0.6890.99
42_L47_T0.6880.99
94_A267_I0.6850.99
73_I290_F0.6840.99
78_I82_L0.6830.99
150_R311_E0.6830.99
413_G417_L0.6830.99
55_D405_W0.6810.99
474_K477_S0.6810.99
345_Q348_V0.6790.99
119_E477_S0.6780.99
350_S378_M0.6780.99
346_L379_V0.6770.99
235_F239_I0.6760.99
149_A160_Y0.6760.99
26_W177_I0.6750.99
144_G341_T0.6740.99
119_E125_L0.6740.99
207_I212_F0.6730.99
456_I460_I0.6710.99
222_K226_N0.6680.99
175_T343_S0.6660.99
453_Y457_P0.6640.99
148_G338_V0.6630.99
472_L475_A0.6630.99
79_A86_A0.6630.99
152_F163_A0.6630.99
247_G252_P0.6610.99
25_A29_T0.6590.99
317_L321_L0.6570.99
312_R315_I0.6560.99
35_Y376_R0.6560.99
45_F49_L0.6540.99
34_D181_L0.6520.99
95_G264_H0.6510.99
424_R427_R0.6510.99
187_D340_S0.6500.99
387_I391_A0.6480.99
234_N237_A0.6480.99
475_A478_A0.6470.99
95_G98_R0.6460.99
210_G213_G0.6460.99
459_F462_G0.6450.99
469_F472_L0.6440.99
35_Y379_V0.6420.99
127_I130_A0.6420.99
118_F418_F0.6410.98
269_H273_I0.6410.98
112_D116_G0.6400.98
454_E458_G0.6390.98
145_I182_A0.6380.98
33_D368_Q0.6370.98
150_R153_E0.6360.98
127_I131_L0.6350.98
45_F188_T0.6350.98
85_G245_G0.6340.98
325_W329_I0.6330.98
204_I207_I0.6320.98
54_S257_R0.6320.98
458_G462_G0.6310.98
387_I390_A0.6310.98
253_H256_A0.6310.98
190_Q337_A0.6300.98
235_F240_S0.6290.98
172_I380_L0.6280.98
57_S144_G0.6270.98
108_L112_D0.6230.98
172_I176_F0.6220.98
441_V458_G0.6220.98
434_M437_G0.6220.98
55_D82_L0.6220.98
296_F299_H0.6210.98
322_F326_I0.6200.98
28_S181_L0.6200.98
109_T356_D0.6190.98
69_F313_V0.6160.98
183_V347_L0.6160.98
168_A390_A0.6120.98
293_I313_V0.6120.98
164_L168_A0.6110.98
350_S379_V0.6090.98
206_I210_G0.6080.98
428_N431_L0.6080.98
439_L442_I0.6080.98
222_K293_I0.6070.98
401_V404_A0.6060.98
146_V150_R0.6060.98
350_S375_G0.6060.98
236_V240_S0.6040.98
414_P466_I0.6030.98
275_M279_I0.6030.98
10_T332_S0.6020.98
32_F36_I0.6020.98
241_L244_W0.6020.98
29_T181_L0.6000.98
96_R421_M0.5980.98
43_G46_V0.5980.98
359_K368_Q0.5970.98
43_G47_T0.5950.98
206_I212_F0.5940.98
53_A191_A0.5920.97
248_Y252_P0.5910.97
288_V314_F0.5910.97
257_R344_C0.5900.97
126_R130_A0.5900.97
199_I202_P0.5900.97
224_I232_G0.5880.97
223_S231_K0.5860.97
74_S77_W0.5850.97
257_R340_S0.5850.97
141_C342_L0.5850.97
118_F430_A0.5840.97
47_T50_S0.5840.97
246_L413_G0.5830.97
61_L66_G0.5820.97
133_I352_A0.5820.97
206_I215_S0.5820.97
430_A433_G0.5820.97
293_I297_N0.5810.97
473_G476_P0.5810.97
398_L406_A0.5810.97
401_V406_A0.5800.97
174_Y178_G0.5800.97
55_D278_M0.5800.97
424_R428_N0.5790.97
223_S232_G0.5790.97
181_L185_W0.5780.97
22_G26_W0.5780.97
337_A340_S0.5780.97
153_E159_S0.5760.97
244_W247_G0.5750.97
445_K454_E0.5750.97
140_Y345_Q0.5740.97
339_M343_S0.5740.97
295_Y317_L0.5730.97
67_A75_E0.5730.97
198_L284_G0.5710.97
6_P324_P0.5710.97
429_G465_G0.5700.97
144_G147_A0.5700.97
187_D190_Q0.5690.97
205_V321_L0.5690.97
244_W248_Y0.5690.97
422_W472_L0.5690.97
272_R275_M0.5680.97
205_V208_S0.5680.97
397_V405_W0.5680.97
54_S175_T0.5670.97
55_D401_V0.5670.97
52_G191_A0.5650.97
245_G252_P0.5650.97
215_S294_A0.5650.97
48_A52_G0.5640.97
40_R98_R0.5640.97
184_S187_D0.5640.97
97_L255_L0.5630.97
202_P287_A0.5630.97
464_I467_V0.5620.97
32_F371_L0.5620.97
114_F415_V0.5610.97
87_W91_K0.5610.97
52_G281_C0.5600.97
406_A441_V0.5600.97
432_A435_I0.5600.97
380_L384_L0.5590.96
46_V185_W0.5580.96
62_M147_A0.5580.96
140_Y144_G0.5570.96
81_G86_A0.5560.96
226_N232_G0.5560.96
201_T330_L0.5550.96
125_L129_S0.5540.96
127_I357_L0.5530.96
7_M22_G0.5520.96
196_F199_I0.5510.96
307_N316_E0.5500.96
54_S253_H0.5500.96
433_G436_I0.5490.96
345_Q412_F0.5490.96
258_F271_R0.5480.96
169_A380_L0.5470.96
18_M22_G0.5470.96
442_I446_Q0.5460.96
42_L260_A0.5440.96
110_L416_V0.5440.96
365_H370_E0.5410.96
449_W457_P0.5380.96
352_A356_D0.5370.96
432_A473_G0.5350.95
132_V411_A0.5350.95
426_T430_A0.5340.95
219_I222_K0.5320.95
286_V290_F0.5310.95
79_A82_L0.5310.95
209_V218_V0.5310.95
84_L242_M0.5290.95
201_T318_A0.5290.95
146_V160_Y0.5280.95
353_I381_V0.5270.95
117_R423_S0.5270.95
133_I412_F0.5270.95
59_W405_W0.5270.95
354_T358_Y0.5260.95
243_G252_P0.5260.95
43_G185_W0.5250.95
262_D265_H0.5230.95
87_W272_R0.5230.95
94_A264_H0.5220.95
233_L237_A0.5220.95
107_A112_D0.5210.95
165_W168_A0.5200.95
324_P327_A0.5200.95
140_Y405_W0.5200.95
30_K34_D0.5200.95
15_I19_I0.5200.95
214_D294_A0.5190.95
125_L427_R0.5190.95
385_V388_A0.5180.95
28_S41_S0.5150.94
310_A313_V0.5150.94
56_M274_S0.5150.94
186_T257_R0.5140.94
459_F463_S0.5140.94
77_W81_G0.5140.94
66_G310_A0.5140.94
319_Q327_A0.5120.94
59_W140_Y0.5110.94
68_V289_G0.5090.94
21_I25_A0.5090.94
376_R379_V0.5080.94
126_R360_A0.5070.94
129_S133_I0.5060.94
67_A70_L0.5060.94
150_R154_S0.5050.94
425_M430_A0.5040.94
294_A297_N0.5030.94
204_I321_L0.5030.94
361_F364_K0.5030.94
365_H377_V0.5020.94
165_W390_A0.5010.94
399_G402_S0.5010.94
424_R470_S0.5010.94
243_G413_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9243 100 0.234 Contact Map
3dh4A 3 0.8805 100 0.277 Contact Map
3l1lA 2 0.8028 99.3 0.857 Contact Map
3giaA 1 0.8347 99.3 0.858 Contact Map
4wgvA 2 0.7291 99.1 0.874 Contact Map
2jlnA 1 0.8227 99 0.878 Contact Map
4djkA 2 0.7988 98.8 0.885 Contact Map
4c7rA 3 0.8426 97.5 0.918 Contact Map
2wswA 3 0.7948 95.8 0.934 Contact Map
4us3A 1 0.7809 95.4 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0127 seconds.