GREMLIN Database
PPA - Periplasmic AppA protein
UniProt: P07102 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10049
Length: 432 (341)
Sequences: 2409 (1883)
Seq/√Len: 102.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
404_C413_C6.0421.00
77_I118_T5.2391.00
107_I123_A4.9461.00
31_E361_R4.0471.00
302_T419_T3.9131.00
36_V332_L3.3171.00
41_V76_L3.2161.00
414_S417_G3.1301.00
182_Q185_F3.1161.00
333_G355_L2.9781.00
30_L360_W2.9711.00
41_V249_Q2.8821.00
84_Q122_F2.8421.00
296_L300_A2.7771.00
77_I352_G2.6581.00
261_D264_Q2.4801.00
33_V319_V2.4701.00
114_R325_H2.3991.00
357_F372_V2.3841.00
107_I119_G2.3691.00
31_E368_Q2.3151.00
28_L362_R2.3121.00
293_L297_I2.3021.00
74_G121_A2.3021.00
41_V351_P2.2981.00
110_D115_T2.2861.00
301_L359_R2.2801.00
341_T344_G2.2431.00
84_Q356_V2.2421.00
80_L354_E2.1971.00
78_A124_A2.1941.00
38_R114_R2.1941.00
77_I122_F2.1211.00
359_R368_Q2.1131.00
305_P415_L2.1111.00
217_P221_K2.1091.00
42_R114_R2.0931.00
182_Q191_V2.0861.00
37_S80_L2.0791.00
38_R42_R2.0651.00
329_L355_L1.9461.00
115_T325_H1.9381.00
88_L358_E1.8951.00
28_L360_W1.8751.00
297_I357_F1.8561.00
95_A104_Q1.8481.00
75_E79_Y1.8291.00
324_G328_N1.8241.00
39_H114_R1.8111.00
108_I296_L1.7821.00
35_I84_Q1.7391.00
71_P74_G1.7101.00
31_E359_R1.7001.00
39_H42_R1.6921.00
68_W113_E1.6691.00
85_R128_P1.6521.00
35_I356_V1.6491.00
29_K363_L1.6491.00
216_L221_K1.6401.00
111_V153_G1.6201.00
263_H267_T1.5991.00
150_L153_G1.5971.00
104_Q318_S1.5961.00
94_L126_L1.5481.00
253_E256_W1.5331.00
360_W371_Q1.5301.00
43_A70_T1.5241.00
260_T264_Q1.5201.00
217_P222_V1.5071.00
298_K419_T1.4971.00
87_R373_S1.4971.00
32_S301_L1.4941.00
367_S414_S1.4871.00
362_R365_D1.4811.00
262_S266_N1.4751.00
219_E222_V1.4631.00
59_W62_W1.4591.00
417_G420_Q1.4481.00
300_A320_L1.4321.00
37_S321_F1.4161.00
38_R351_P1.4091.00
42_R326_D1.3941.00
269_L273_N1.3831.00
29_K361_R1.3811.00
151_K154_V1.3781.00
110_D325_H1.3710.99
160_A163_T1.3690.99
37_S122_F1.3680.99
240_T265_W1.3540.99
184_A284_E1.3540.99
187_E191_V1.3400.99
378_T399_L1.3270.99
39_H325_H1.3260.99
215_A219_E1.3220.99
369_W412_M1.3140.99
358_E371_Q1.3040.99
301_L370_I1.2900.99
332_L335_A1.2850.99
294_L335_A1.2560.99
40_G76_L1.2350.99
219_E223_S1.2350.99
42_R325_H1.2310.99
76_L352_G1.2170.99
45_T67_G1.2080.99
38_R325_H1.1990.99
182_Q188_L1.1990.99
367_S416_A1.1910.99
276_F279_L1.1910.99
67_G112_D1.1880.99
419_T423_N1.1870.99
159_N162_V1.1680.98
27_E363_L1.1650.98
30_L358_E1.1650.98
113_E117_K1.1590.98
405_E417_G1.1560.98
116_R154_V1.1550.98
184_A187_E1.1530.98
45_T326_D1.1510.98
133_T136_T1.1510.98
41_V248_A1.1490.98
74_G117_K1.1470.98
124_A147_F1.1410.98
217_P220_L1.1380.98
196_Q201_L1.1260.98
40_G77_I1.1260.98
40_G352_G1.1250.98
114_R326_D1.1220.98
210_C214_Q1.1110.98
369_W414_S1.1100.98
107_I321_F1.1050.98
117_K120_E1.1030.98
332_L336_L1.1030.98
199_L202_K1.1000.98
415_L419_T1.1000.98
418_F422_V1.0940.97
28_L412_M1.0930.97
248_A351_P1.0920.97
361_R368_Q1.0860.97
72_R76_L1.0730.97
360_W412_M1.0640.97
241_E280_Q1.0540.97
185_F191_V1.0530.97
198_N202_K1.0440.97
34_V301_L1.0410.97
81_G358_E1.0260.96
67_G114_R1.0210.96
333_G374_L1.0180.96
122_F126_L1.0160.96
361_R416_A1.0150.96
116_R120_E1.0140.96
83_Y376_F1.0130.96
123_A128_P1.0090.96
188_L191_V1.0080.96
110_D353_G1.0050.96
125_G128_P1.0010.96
158_D162_V0.9980.96
243_F254_P0.9930.96
163_T324_G0.9930.96
298_K302_T0.9920.95
59_W63_P0.9920.95
85_R126_L0.9910.95
40_G69_L0.9910.95
263_H266_N0.9900.95
332_L357_F0.9850.95
110_D324_G0.9780.95
270_S273_N0.9770.95
354_E358_E0.9740.95
276_F327_T0.9710.95
345_Q349_T0.9700.95
111_V351_P0.9670.95
349_T374_L0.9650.95
81_G85_R0.9550.94
325_H328_N0.9510.94
121_A125_G0.9480.94
353_G374_L0.9460.94
112_D115_T0.9460.94
270_S274_A0.9440.94
218_S222_V0.9410.94
371_Q412_M0.9410.94
295_D426_R0.9410.94
81_G88_L0.9400.94
33_V87_R0.9370.94
37_S323_A0.9270.94
85_R89_V0.9220.93
325_H336_L0.9210.93
401_L418_F0.9130.93
44_P404_C0.9120.93
278_L281_R0.9110.93
133_T137_Q0.9090.93
216_L219_E0.9040.93
37_S77_I0.9010.93
228_S231_G0.8910.92
123_A127_A0.8910.92
245_L351_P0.8880.92
106_A111_V0.8860.92
89_V127_A0.8830.92
253_E261_D0.8820.92
42_R241_E0.8790.92
34_V322_I0.8770.92
58_A62_W0.8750.91
47_A66_L0.8740.91
211_S215_A0.8720.91
28_L369_W0.8700.91
32_S320_L0.8690.91
237_S271_L0.8680.91
30_L33_V0.8640.91
101_Q417_G0.8640.91
375_V378_T0.8610.91
155_C159_N0.8590.91
220_L231_G0.8590.91
267_T271_L0.8560.91
30_L93_L0.8560.91
275_Q279_L0.8540.90
45_T48_T0.8530.90
20_A24_S0.8530.90
70_T249_Q0.8500.90
34_V127_A0.8460.90
98_G127_A0.8460.90
109_A115_T0.8460.90
75_E86_Q0.8430.90
215_A218_S0.8410.90
104_Q127_A0.8410.90
232_A235_L0.8380.90
69_L73_G0.8350.89
373_S398_K0.8350.89
53_D58_A0.8350.89
256_W260_T0.8350.89
67_G326_D0.8340.89
182_Q186_R0.8320.89
214_Q218_S0.8300.89
370_I415_L0.8290.89
181_R190_R0.8250.89
302_T415_L0.8240.89
122_F323_A0.8230.89
59_W64_V0.8220.89
197_S200_C0.8210.89
131_A134_V0.8160.88
305_P368_Q0.8150.88
215_A220_L0.8150.88
212_L215_A0.8130.88
297_I332_L0.8130.88
336_L422_V0.8110.88
126_L319_V0.8010.87
274_A278_L0.7990.87
302_T423_N0.7970.87
209_S213_T0.7920.87
157_L162_V0.7910.87
211_S214_Q0.7870.86
214_Q217_P0.7860.86
109_A245_L0.7830.86
264_Q267_T0.7810.86
186_R190_R0.7800.86
327_T330_A0.7790.86
156_Q160_A0.7740.86
41_V72_R0.7720.85
344_G347_D0.7720.85
343_P349_T0.7720.85
293_L322_I0.7710.85
111_V115_T0.7690.85
81_G125_G0.7690.85
243_F246_Q0.7660.85
87_R358_E0.7660.85
293_L332_L0.7650.85
34_V300_A0.7630.85
400_T403_G0.7590.84
272_H275_Q0.7590.84
118_T152_T0.7560.84
398_K412_M0.7560.84
149_P152_T0.7560.84
273_N278_L0.7530.84
357_F402_A0.7490.84
123_A321_F0.7470.83
118_T352_G0.7450.83
300_A322_I0.7450.83
295_D299_T0.7450.83
242_I246_Q0.7450.83
107_I152_T0.7440.83
45_T112_D0.7440.83
282_T285_V0.7400.83
296_L322_I0.7400.83
298_K422_V0.7380.83
350_P375_V0.7380.83
241_E244_L0.7370.83
82_H366_N0.7370.83
333_G338_L0.7370.83
150_L154_V0.7350.82
274_A277_Y0.7340.82
354_E375_V0.7290.82
298_K301_L0.7290.82
221_K230_T0.7230.81
122_F321_F0.7210.81
155_C160_A0.7210.81
159_N163_T0.7200.81
416_A419_T0.7200.81
242_I268_L0.7200.81
78_A125_G0.7190.81
241_E351_P0.7190.81
130_C137_Q0.7140.81
105_V127_A0.7130.81
202_K208_E0.7120.80
338_L399_L0.7120.80
21_F24_S0.7110.80
301_L415_L0.7090.80
179_G185_F0.7090.80
241_E326_D0.7070.80
262_S265_W0.7060.80
114_R413_C0.7050.80
207_D210_C0.7050.80
109_A323_A0.7030.80
40_G118_T0.7010.79
76_L118_T0.7010.79
119_G323_A0.7010.79
115_T323_A0.7000.79
188_L234_S0.6990.79
20_A23_Q0.6980.79
256_W413_C0.6960.79
371_Q378_T0.6950.79
157_L161_N0.6940.79
209_S267_T0.6930.79
113_E153_G0.6920.79
305_P359_R0.6920.79
200_C233_V0.6880.78
106_A299_T0.6870.78
290_A294_L0.6870.78
403_G421_I0.6840.78
277_Y282_T0.6820.78
83_Y375_V0.6820.78
219_E260_T0.6820.78
217_P223_S0.6810.77
356_V373_S0.6810.77
179_G186_R0.6800.77
75_E78_A0.6760.77
39_H326_D0.6760.77
32_S356_V0.6730.77
417_G421_I0.6730.77
41_V80_L0.6720.76
134_V137_Q0.6650.76
220_L313_V0.6650.76
243_F260_T0.6640.76
119_G122_F0.6610.75
154_V160_A0.6590.75
273_N281_R0.6580.75
245_L323_A0.6580.75
110_D163_T0.6560.75
58_A61_T0.6560.75
361_R426_R0.6550.75
209_S212_L0.6510.74
421_I425_A0.6490.74
241_E249_Q0.6480.74
184_A191_V0.6470.74
401_L421_I0.6460.74
298_K426_R0.6460.74
339_N352_G0.6430.73
149_P162_V0.6430.73
57_D60_P0.6420.73
293_L350_P0.6410.73
277_Y281_R0.6410.73
187_E190_R0.6410.73
243_F362_R0.6400.73
47_A328_N0.6390.73
275_Q280_Q0.6380.73
329_L333_G0.6380.73
216_L222_V0.6370.73
250_G370_I0.6360.72
255_G258_R0.6360.72
76_L249_Q0.6350.72
286_A330_A0.6340.72
79_Y82_H0.6320.72
333_G347_D0.6310.72
32_S304_H0.6300.72
398_K411_G0.6300.72
41_V376_F0.6300.72
116_R153_G0.6290.72
43_A66_L0.6290.72
220_L223_S0.6290.72
189_E195_P0.6280.72
29_K368_Q0.6270.71
180_H185_F0.6260.71
73_G88_L0.6240.71
41_V77_I0.6230.71
185_F189_E0.6220.71
38_R326_D0.6220.71
57_D61_T0.6210.71
290_A331_N0.6200.71
294_L298_K0.6190.70
45_T327_T0.6190.70
253_E265_W0.6180.70
362_R412_M0.6170.70
271_L275_Q0.6160.70
113_E150_L0.6110.69
45_T110_D0.6110.69
343_P346_P0.6100.69
95_A98_G0.6100.69
420_Q424_E0.6090.69
36_V293_L0.6080.69
282_T286_A0.6080.69
70_T241_E0.6060.69
261_D267_T0.6060.69
256_W404_C0.6040.69
275_Q278_L0.6010.68
346_P349_T0.5990.68
181_R184_A0.5990.68
93_L96_K0.5970.68
53_D136_T0.5970.68
214_Q420_Q0.5970.68
45_T280_Q0.5950.67
241_E246_Q0.5950.67
161_N164_D0.5940.67
353_G361_R0.5940.67
336_L372_V0.5910.67
299_T303_P0.5890.67
88_L182_Q0.5890.67
74_G118_T0.5860.66
158_D299_T0.5840.66
33_V88_L0.5830.66
214_Q295_D0.5830.66
306_P313_V0.5830.66
237_S240_T0.5810.66
40_G80_L0.5800.65
212_L219_E0.5800.65
323_A327_T0.5780.65
134_V336_L0.5780.65
75_E367_S0.5780.65
336_L416_A0.5770.65
67_G327_T0.5770.65
195_P200_C0.5770.65
242_I271_L0.5750.65
46_K238_M0.5750.65
46_K279_L0.5750.65
43_A245_L0.5740.65
401_L404_C0.5740.65
36_V415_L0.5740.65
330_A352_G0.5740.65
302_T422_V0.5730.65
329_L370_I0.5720.64
131_A135_H0.5710.64
333_G372_V0.5710.64
294_L336_L0.5690.64
269_L346_P0.5680.64
43_A64_V0.5680.64
130_C136_T0.5680.64
216_L220_L0.5680.64
32_S359_R0.5670.64
132_I136_T0.5660.64
34_V297_I0.5660.64
110_D326_D0.5660.64
41_V323_A0.5650.63
162_V261_D0.5650.63
26_P218_S0.5650.63
182_Q192_L0.5650.63
197_S229_L0.5640.63
60_P64_V0.5640.63
195_P298_K0.5640.63
42_R351_P0.5610.63
21_F25_E0.5600.63
114_R118_T0.5600.63
189_E230_T0.5590.63
34_V351_P0.5590.63
301_L305_P0.5580.63
86_Q89_V0.5570.62
280_Q331_N0.5560.62
215_A222_V0.5560.62
272_H276_F0.5550.62
235_L238_M0.5550.62
365_D369_W0.5540.62
216_L223_S0.5540.62
301_L419_T0.5520.62
202_K258_R0.5490.61
111_V116_R0.5480.61
135_H149_P0.5460.61
227_V231_G0.5450.61
245_L248_A0.5450.61
301_L304_H0.5450.61
114_R404_C0.5440.61
191_V366_N0.5440.61
398_K401_L0.5430.60
400_T411_G0.5390.60
34_V320_L0.5360.59
370_I418_F0.5330.59
260_T266_N0.5330.59
76_L323_A0.5330.59
23_Q416_A0.5320.59
22_A183_T0.5290.58
338_L401_L0.5260.58
119_G153_G0.5250.58
337_E340_W0.5240.58
89_V124_A0.5210.57
128_P148_N0.5210.57
179_G182_Q0.5210.57
213_T218_S0.5210.57
262_S271_L0.5190.57
306_P314_T0.5170.57
163_T285_V0.5160.57
31_E304_H0.5150.56
326_D330_A0.5120.56
228_S418_F0.5100.56
244_L248_A0.5090.56
416_A420_Q0.5080.55
78_A82_H0.5080.55
77_I327_T0.5070.55
326_D329_L0.5060.55
368_Q372_V0.5050.55
103_G364_S0.5040.55
189_E192_L0.5030.55
303_P315_L0.5030.55
184_A189_E0.5020.55
45_T374_L0.5010.54
45_T246_Q0.5010.54
184_A202_K0.5010.54
41_V250_G0.5000.54
106_A300_A0.5000.54
23_Q156_Q0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zhcA 2 0.8657 100 0.29 Contact Map
4arvA 1 0.9259 100 0.297 Contact Map
1dkqA 1 0.9213 100 0.312 Contact Map
1nd6A 4 0.7731 100 0.313 Contact Map
3it3A 2 0.7662 100 0.33 Contact Map
4aruA 1 0.8542 100 0.335 Contact Map
2wnhA 3 0.8519 100 0.338 Contact Map
4jobA 1 0.7593 100 0.355 Contact Map
3ntlA 2 0.8333 100 0.359 Contact Map
1qwoA 1 0.8542 100 0.398 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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