GREMLIN Database
USHA - Protein UshA
UniProt: P07024 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11060
Length: 550 (461)
Sequences: 5169 (3685)
Seq/√Len: 171.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
444_I487_P3.7481.00
441_K445_D3.4551.00
437_D490_T3.4491.00
363_K417_D3.2541.00
39_T109_Y3.2021.00
60_K64_D3.1401.00
155_W199_V2.9931.00
439_T442_E2.9611.00
158_F167_V2.9211.00
64_D342_N2.8941.00
469_V477_D2.8941.00
478_L485_V2.8691.00
486_D489_K2.8591.00
80_L167_V2.8481.00
444_I478_L2.7571.00
346_I350_S2.6831.00
350_S354_N2.6091.00
365_G530_I2.6081.00
190_R195_E2.5721.00
111_A167_V2.5651.00
467_S479_K2.5621.00
170_L196_A2.5361.00
166_A203_L2.5101.00
199_V202_E2.4781.00
235_E239_A2.4341.00
197_K201_Q2.3641.00
35_T297_R2.3321.00
237_A248_I2.3011.00
33_K301_E2.2911.00
166_A209_P2.2881.00
341_E346_I2.2611.00
80_L215_A2.1981.00
63_V79_L2.1971.00
437_D492_R2.1141.00
366_E417_D2.0801.00
36_V213_I2.0791.00
79_L109_Y2.0691.00
394_M464_A2.0611.00
160_R165_I2.0381.00
202_E207_E2.0331.00
479_K484_P2.0051.00
105_N134_K1.9921.00
343_Q347_S1.9891.00
204_Q244_S1.9881.00
106_L348_L1.9681.00
157_L164_K1.9581.00
143_Y190_R1.9561.00
241_P244_S1.9231.00
62_L295_V1.9161.00
200_I240_L1.9151.00
139_S171_T1.9021.00
35_T299_D1.8921.00
441_K487_P1.8741.00
79_L107_V1.8651.00
33_K299_D1.8551.00
391_A464_A1.8501.00
247_M298_A1.8501.00
438_M493_M1.8221.00
144_Q147_T1.8051.00
438_M443_V1.7951.00
203_L209_P1.7681.00
157_L209_P1.7591.00
201_Q205_Q1.7511.00
448_T472_D1.7381.00
362_V531_Q1.7341.00
105_N135_F1.7091.00
204_Q212_I1.7081.00
163_L211_I1.7031.00
435_Y492_R1.6891.00
101_F105_N1.6871.00
111_A156_A1.6831.00
80_L111_A1.6821.00
159_K162_D1.6811.00
240_L244_S1.6701.00
422_N425_K1.6511.00
214_A245_L1.6481.00
36_V247_M1.6301.00
66_I297_R1.6261.00
448_T474_K1.6191.00
133_A137_L1.6071.00
439_T490_T1.5921.00
447_L478_L1.5901.00
247_M284_W1.5901.00
145_K186_D1.5831.00
111_A138_L1.5791.00
111_A136_P1.5731.00
284_W312_Y1.5701.00
370_R415_A1.5451.00
401_F443_V1.5361.00
38_H249_V1.5241.00
168_I196_A1.5231.00
39_T81_S1.5171.00
74_G77_V1.5021.00
524_E528_A1.4971.00
190_R198_L1.4941.00
367_T418_I1.4921.00
175_T189_F1.4901.00
159_K164_K1.4851.00
441_K488_A1.4791.00
40_N288_A1.4721.00
247_M300_F1.4681.00
438_M442_E1.4671.00
200_I244_S1.4631.00
395_D533_S1.4531.00
233_D250_G1.4521.00
418_I530_I1.4451.00
248_I285_I1.4431.00
67_R79_L1.4411.00
449_A508_R1.4411.00
364_I423_V1.4401.00
420_Y527_K1.4371.00
483_E489_K1.4361.00
195_E199_V1.4261.00
443_V485_V1.4211.00
436_A500_A1.4161.00
82_G249_V1.4121.00
191_K194_D1.4041.00
78_L158_F1.4031.00
37_L77_V1.3861.00
368_N537_D1.3821.00
200_I212_I1.3781.00
106_L344_Q1.3691.00
362_V420_Y1.3591.00
395_D532_K1.3571.00
389_I409_I1.3541.00
112_M135_F1.3421.00
155_W202_E1.3321.00
446_Y508_R1.3311.00
136_P156_A1.3231.00
154_P199_V1.3231.00
125_V128_Q1.3021.00
277_P280_Q1.2961.00
437_D513_P1.2921.00
471_K476_N1.2891.00
145_K188_E1.2801.00
81_S109_Y1.2801.00
451_A470_A1.2791.00
393_Q402_A1.2661.00
59_Q295_V1.2611.00
414_E422_N1.2521.00
400_D489_K1.2501.00
253_S287_Q1.2451.00
45_H291_W1.2441.00
442_E511_N1.2431.00
297_R317_V1.2411.00
249_V298_A1.2391.00
301_E311_N1.2381.00
61_T65_G1.2371.00
62_L339_I1.2371.00
86_N129_Q1.2321.00
62_L65_G1.2321.00
403_V443_V1.2281.00
173_D192_P1.2271.00
469_V476_N1.2271.00
143_Y195_E1.2241.00
155_W166_A1.2201.00
64_D344_Q1.2191.00
357_K361_E1.2181.00
197_K241_P1.2091.00
211_I302_F1.2081.00
382_Q387_R1.2061.00
209_P212_I1.2061.00
113_A138_L1.2051.00
57_A346_I1.2051.00
249_V286_V1.2051.00
198_L202_E1.2031.00
47_W353_Q1.1961.00
38_H296_G1.1951.00
42_H56_L1.1901.00
303_R310_V1.1881.00
153_K156_A1.1841.00
300_F309_M1.1811.00
217_H252_H1.1801.00
197_K239_A1.1791.00
34_I165_I1.1731.00
101_F133_A1.1701.00
395_D529_Y1.1641.00
440_G491_Y1.1631.00
117_H120_D1.1531.00
36_V249_V1.1521.00
196_A245_L1.1491.00
98_E102_R1.1481.00
200_I245_L1.1431.00
168_I199_V1.1391.00
59_Q63_V1.1361.00
397_T435_Y1.1331.00
60_K345_M1.1311.00
193_A239_A1.1301.00
112_M137_L1.1301.00
78_L167_V1.1251.00
42_H292_G1.1231.00
235_E238_R1.1061.00
37_L66_I1.1051.00
111_A158_F1.1051.00
290_E293_K1.1021.00
58_A341_E1.1011.00
401_F493_M1.0981.00
106_L345_M1.0951.00
471_K474_K1.0911.00
361_E421_K1.0881.00
467_S482_G1.0861.00
84_D116_N1.0821.00
439_T488_A1.0711.00
168_I214_A1.0661.00
363_K366_E1.0651.00
289_H293_K1.0651.00
105_N133_A1.0651.00
113_A169_G1.0601.00
392_A529_Y1.0601.00
347_S350_S1.0591.00
205_Q208_K1.0571.00
234_V238_R1.0571.00
194_D197_K1.0551.00
203_L212_I1.0530.99
168_I203_L1.0520.99
114_I130_E1.0500.99
31_T301_E1.0500.99
302_F309_M1.0440.99
40_N287_Q1.0440.99
155_W207_E1.0430.99
367_T370_R1.0420.99
433_V494_A1.0410.99
390_L402_A1.0380.99
480_I491_Y1.0360.99
502_G505_G1.0300.99
432_V497_N1.0280.99
463_F466_V1.0260.99
61_T339_I1.0240.99
92_S121_N1.0170.99
63_V67_R1.0120.99
527_K531_Q1.0120.99
437_D514_G1.0080.99
195_E198_L1.0060.99
394_M399_A1.0060.99
219_G253_S1.0020.99
450_V461_P1.0010.99
247_M312_Y0.9950.99
363_K419_S0.9930.99
98_E128_Q0.9920.99
139_S142_I0.9890.99
35_T77_V0.9880.99
110_D160_R0.9880.99
163_L210_D0.9850.99
232_G235_E0.9840.99
401_F480_I0.9820.99
104_M135_F0.9820.99
407_G410_R0.9800.99
156_A167_V0.9790.99
303_R306_E0.9750.99
218_M236_M0.9750.99
240_L245_L0.9730.99
448_T475_L0.9730.99
369_G384_N0.9680.99
78_L160_R0.9680.99
182_E185_T0.9680.99
44_G92_S0.9670.99
370_R414_E0.9660.99
38_H82_G0.9650.99
486_D491_Y0.9630.99
62_L319_L0.9630.99
59_Q292_G0.9630.99
521_I524_E0.9610.99
289_H294_Y0.9560.99
81_S85_I0.9550.99
123_L127_R0.9470.99
396_R528_A0.9460.99
130_E137_L0.9440.99
396_R525_V0.9420.99
104_M109_Y0.9400.99
56_L103_G0.9360.99
211_I300_F0.9350.99
359_Q362_V0.9330.99
256_P294_Y0.9300.99
451_A468_F0.9300.99
190_R194_D0.9280.99
167_V215_A0.9280.99
196_A236_M0.9280.99
196_A214_A0.9240.99
116_N252_H0.9190.99
353_Q357_K0.9180.99
193_A197_K0.9180.99
65_G68_K0.9170.99
286_V298_A0.9170.99
389_I427_Q0.9160.99
466_V480_I0.9100.99
37_L297_R0.9100.99
351_P355_K0.9090.99
354_N358_A0.9090.99
446_Y509_L0.9070.98
410_R429_F0.9060.98
125_V129_Q0.9060.98
31_T304_N0.9040.98
234_V278_D0.9030.98
201_Q241_P0.9000.98
101_F129_Q0.9000.98
140_A195_E0.8990.98
386_G462_Q0.8990.98
297_R315_I0.8990.98
57_A345_M0.8940.98
503_G506_Y0.8910.98
371_L384_N0.8910.98
423_V527_K0.8870.98
345_M348_L0.8870.98
142_I187_I0.8870.98
143_Y150_R0.8860.98
123_L187_I0.8850.98
114_I152_F0.8850.98
530_I536_L0.8820.98
62_L66_I0.8810.98
447_L468_F0.8810.98
423_V523_A0.8810.98
442_E445_D0.8790.98
411_D425_K0.8770.98
61_T340_A0.8770.98
159_K165_I0.8730.98
508_R511_N0.8720.98
404_M408_G0.8670.98
120_D179_G0.8670.98
57_A341_E0.8670.98
217_H254_Q0.8660.98
128_Q131_K0.8650.98
405_S408_G0.8640.98
366_E535_P0.8630.98
390_L404_M0.8610.98
367_T371_L0.8610.98
84_D217_H0.8610.98
520_F528_A0.8590.98
103_G345_M0.8560.98
441_K444_I0.8540.98
447_L475_L0.8530.98
102_R348_L0.8530.98
65_G340_A0.8520.98
212_I244_S0.8480.98
65_G339_I0.8480.98
34_I300_F0.8450.98
113_A139_S0.8440.98
116_N217_H0.8430.98
399_A494_A0.8420.98
35_T66_I0.8420.98
385_M426_V0.8410.98
528_A531_Q0.8370.97
179_G183_Y0.8360.97
43_H254_Q0.8360.97
256_P289_H0.8300.97
220_H257_V0.8300.97
98_E132_W0.8290.97
85_I112_M0.8260.97
388_L392_A0.8250.97
280_Q285_I0.8220.97
39_T59_Q0.8200.97
173_D191_K0.8190.97
36_V78_L0.8170.97
368_N535_P0.8170.97
194_D198_L0.8120.97
399_A492_R0.8120.97
123_L186_D0.8110.97
299_D313_Q0.8110.97
176_A189_F0.8110.97
192_P236_M0.8100.97
444_I485_V0.8070.97
43_H88_G0.8050.97
369_G538_V0.8010.97
67_R108_G0.8010.97
143_Y188_E0.7990.97
408_G429_F0.7980.97
160_R167_V0.7980.97
199_V203_L0.7970.97
39_T79_L0.7950.97
62_L317_V0.7940.97
279_Q282_G0.7940.97
34_I302_F0.7930.96
43_H252_H0.7920.96
73_E76_S0.7900.96
387_R464_A0.7890.96
461_P506_Y0.7890.96
497_N501_T0.7890.96
402_A494_A0.7870.96
110_D158_F0.7860.96
401_F491_Y0.7860.96
41_D254_Q0.7840.96
136_P153_K0.7810.96
373_G412_S0.7740.96
117_H217_H0.7740.96
155_W203_L0.7740.96
96_D121_N0.7730.96
116_N254_Q0.7710.96
392_A525_V0.7700.96
394_M402_A0.7690.96
60_K107_V0.7680.96
461_P468_F0.7680.96
406_G458_G0.7680.96
368_N538_V0.7660.96
34_I163_L0.7650.96
84_D254_Q0.7640.96
445_D508_R0.7630.96
250_G287_Q0.7610.96
484_P487_P0.7600.96
142_I189_F0.7590.95
79_L295_V0.7580.95
397_T494_A0.7560.95
429_F498_F0.7550.95
232_G236_M0.7500.95
157_L207_E0.7500.95
84_D117_H0.7490.95
391_A395_D0.7480.95
102_R352_F0.7460.95
303_R308_K0.7420.95
447_L466_V0.7410.95
157_L166_A0.7400.95
216_T233_D0.7380.95
495_T500_A0.7380.95
442_E512_K0.7370.95
138_L156_A0.7350.95
166_A212_I0.7340.95
142_I171_T0.7330.95
219_G252_H0.7310.94
48_R341_E0.7310.94
445_D511_N0.7300.94
165_I213_I0.7270.94
64_D68_K0.7270.94
447_L463_F0.7260.94
216_T250_G0.7260.94
174_D177_K0.7260.94
403_V493_M0.7260.94
234_V285_I0.7240.94
401_F466_V0.7230.94
201_Q209_P0.7220.94
170_L216_T0.7210.94
394_M492_R0.7210.94
37_L79_L0.7200.94
347_S351_P0.7200.94
456_D459_A0.7190.94
43_H219_G0.7170.94
373_G385_M0.7170.94
212_I245_L0.7170.94
45_H89_V0.7170.94
277_P281_N0.7160.94
102_R351_P0.7160.94
340_A343_Q0.7160.94
436_A495_T0.7160.94
158_F165_I0.7150.94
348_L352_F0.7150.94
48_R54_Y0.7140.94
393_Q496_L0.7090.94
84_D252_H0.7080.93
129_Q132_W0.7060.93
200_I204_Q0.7050.93
438_M512_K0.7000.93
280_Q283_I0.6970.93
487_P491_Y0.6970.93
184_F189_F0.6970.93
399_A435_Y0.6960.93
497_N522_D0.6960.93
95_Q352_F0.6960.93
529_Y533_S0.6930.93
442_E508_R0.6930.93
32_Y161_Q0.6920.93
144_Q148_G0.6920.93
483_E486_D0.6920.93
146_S188_E0.6920.93
431_N496_L0.6920.93
32_Y163_L0.6910.93
443_V446_Y0.6910.93
216_T248_I0.6910.93
237_A285_I0.6900.93
168_I200_I0.6900.93
66_I295_V0.6880.93
232_G237_A0.6880.93
432_V517_N0.6870.92
203_L208_K0.6860.92
396_R520_F0.6860.92
35_T74_G0.6860.92
288_A296_G0.6840.92
256_P316_P0.6810.92
44_G100_D0.6810.92
393_Q433_V0.6780.92
498_F503_G0.6780.92
163_L302_F0.6770.92
241_P283_I0.6750.92
386_G409_I0.6750.92
427_Q526_L0.6750.92
164_K210_D0.6730.92
150_R199_V0.6720.92
140_A154_P0.6710.92
82_G113_A0.6710.92
449_A452_Q0.6690.91
103_G349_L0.6690.91
445_D449_A0.6680.91
192_P195_E0.6670.91
463_F468_F0.6670.91
150_R195_E0.6660.91
528_A532_K0.6640.91
81_S113_A0.6630.91
213_I247_M0.6600.91
393_Q427_Q0.6580.91
94_L359_Q0.6580.91
402_A464_A0.6570.91
423_V530_I0.6570.91
60_K342_N0.6570.91
140_A196_A0.6550.91
43_H84_D0.6530.90
193_A240_L0.6520.90
350_S353_Q0.6500.90
95_Q99_P0.6500.90
220_H234_V0.6480.90
81_S112_M0.6460.90
43_H217_H0.6450.90
56_L349_L0.6450.90
178_I252_H0.6420.90
461_P499_N0.6420.90
470_A475_L0.6400.90
165_I211_I0.6390.89
394_M400_D0.6380.89
203_L207_E0.6370.89
164_K208_K0.6360.89
168_I245_L0.6360.89
348_L351_P0.6300.89
444_I473_G0.6290.89
367_T413_I0.6290.89
344_Q347_S0.6280.89
81_S104_M0.6280.89
448_T471_K0.6270.89
31_T310_V0.6260.89
56_L59_Q0.6240.88
419_S422_N0.6220.88
404_M496_L0.6220.88
35_T75_G0.6210.88
78_L165_I0.6200.88
67_R110_D0.6190.88
66_I73_E0.6160.88
496_L499_N0.6150.88
431_N497_N0.6140.88
449_A459_A0.6130.87
196_A240_L0.6130.87
394_M465_N0.6110.87
43_H287_Q0.6110.87
87_T118_E0.6110.87
401_F465_N0.6100.87
405_S431_N0.6080.87
400_D492_R0.6070.87
95_Q355_K0.6070.87
443_V493_M0.6050.87
85_I109_Y0.6050.87
394_M494_A0.6040.87
411_D426_V0.6040.87
76_S161_Q0.6040.87
355_K358_A0.6040.87
520_F525_V0.6030.87
116_N120_D0.6030.87
364_I527_K0.6020.87
114_I126_L0.6020.87
438_M446_Y0.6010.86
175_T179_G0.6010.86
390_L464_A0.6010.86
117_H429_F0.6000.86
176_A184_F0.5990.86
387_R391_A0.5970.86
430_G523_A0.5960.86
80_L249_V0.5960.86
288_A294_Y0.5960.86
406_G462_Q0.5960.86
440_G485_V0.5950.86
144_Q149_E0.5930.86
200_I241_P0.5910.86
34_I211_I0.5910.86
114_I137_L0.5900.85
485_V491_Y0.5890.85
46_F100_D0.5880.85
40_N82_G0.5870.85
154_P168_I0.5870.85
39_T295_V0.5860.85
63_V295_V0.5840.85
80_L158_F0.5820.85
421_K425_K0.5810.85
396_R433_V0.5800.84
470_A476_N0.5800.84
369_G415_A0.5800.84
128_Q132_W0.5790.84
366_E534_S0.5790.84
249_V296_G0.5790.84
124_T128_Q0.5790.84
378_V383_T0.5780.84
154_P202_E0.5780.84
46_F349_L0.5780.84
398_G492_R0.5770.84
42_H81_S0.5760.84
202_E205_Q0.5750.84
42_H85_I0.5740.84
201_Q244_S0.5740.84
214_A248_I0.5740.84
427_Q522_D0.5740.84
109_Y112_M0.5740.84
117_H252_H0.5730.84
42_H100_D0.5710.84
114_I119_F0.5690.83
56_L292_G0.5690.83
241_P281_N0.5680.83
454_K459_A0.5630.83
472_D475_L0.5620.83
282_G308_K0.5620.83
408_G431_N0.5620.83
117_H254_Q0.5610.82
38_H250_G0.5590.82
393_Q522_D0.5590.82
119_F126_L0.5580.82
444_I448_T0.5570.82
204_Q246_A0.5560.82
389_I426_V0.5560.82
459_A462_Q0.5550.82
458_G461_P0.5530.82
126_L142_I0.5530.82
42_H104_M0.5520.81
120_D175_T0.5520.81
35_T73_E0.5520.81
82_G251_G0.5520.81
36_V300_F0.5510.81
220_H250_G0.5510.81
67_R107_V0.5500.81
247_M309_M0.5500.81
169_G215_A0.5490.81
343_Q346_I0.5490.81
143_Y147_T0.5460.81
63_V107_V0.5460.81
64_D67_R0.5460.81
382_Q460_Y0.5450.81
38_H286_V0.5440.81
43_H291_W0.5430.80
150_R198_L0.5420.80
372_E384_N0.5400.80
403_V461_P0.5400.80
455_P459_A0.5400.80
220_H287_Q0.5390.80
404_M522_D0.5390.80
143_Y146_S0.5380.80
448_T473_G0.5370.80
113_A215_A0.5330.79
47_W91_E0.5320.79
479_K482_G0.5320.79
39_T42_H0.5310.79
117_H431_N0.5300.79
210_D244_S0.5300.79
192_P218_M0.5290.79
195_E201_Q0.5290.79
438_M509_L0.5290.79
487_P490_T0.5280.79
388_L530_I0.5280.79
477_D484_P0.5270.78
84_D115_G0.5270.78
389_I404_M0.5270.78
42_H109_Y0.5270.78
217_H251_G0.5270.78
82_G288_A0.5260.78
82_G215_A0.5250.78
400_D481_K0.5250.78
250_G253_S0.5250.78
119_F142_I0.5250.78
172_T175_T0.5240.78
433_V525_V0.5240.78
196_A203_L0.5240.78
371_L413_I0.5230.78
386_G390_L0.5230.78
302_F307_M0.5230.78
43_H87_T0.5220.78
459_A464_A0.5220.78
403_V446_Y0.5210.78
355_K359_Q0.5210.78
28_Q31_T0.5190.77
67_R77_V0.5180.77
140_A199_V0.5180.77
373_G384_N0.5170.77
443_V463_F0.5150.77
31_T303_R0.5150.77
468_F477_D0.5140.77
166_A208_K0.5130.77
405_S499_N0.5130.77
220_H255_D0.5110.76
364_I530_I0.5090.76
113_A171_T0.5090.76
391_A394_M0.5090.76
392_A526_L0.5060.76
360_L421_K0.5040.75
167_V213_I0.5040.75
408_G496_L0.5040.75
48_R58_A0.5030.75
385_M413_I0.5030.75
197_K240_L0.5030.75
139_S150_R0.5030.75
413_I426_V0.5030.75
164_K207_E0.5020.75
354_N357_K0.5020.75
172_T287_Q0.5000.75
390_L393_Q0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z1aA 1 0.8764 100 0.245 Contact Map
1hp1A 1 0.9327 100 0.249 Contact Map
4h2gA 2 0.8727 100 0.263 Contact Map
3ztvA 2 0.9109 100 0.268 Contact Map
3iveA 1 0.8582 100 0.269 Contact Map
4q7fA 1 0.8491 100 0.292 Contact Map
2wdcA 1 0.8455 100 0.313 Contact Map
3c9fA 2 0.8636 100 0.452 Contact Map
3gveA 2 0.5545 100 0.571 Contact Map
3jyfA 2 0.5655 100 0.576 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0141 seconds.