GREMLIN Database
TYRA - T-protein
UniProt: P07023 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11039
Length: 373 (367)
Sequences: 261 (163)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_V194_L6.5501.00
318_K332_E5.5311.00
100_P126_R4.3000.99
212_V230_I4.2080.98
101_V118_L3.9940.98
307_I339_F3.7560.97
30_V255_L3.4280.94
103_I115_E3.3950.94
270_E319_R3.2760.93
20_L64_L3.2180.92
74_V78_V3.2120.92
118_L272_V2.8740.87
321_Y325_G2.8500.86
161_K187_V2.8180.86
86_E254_A2.5390.79
254_A360_E2.5120.78
101_V213_V2.4760.77
86_E317_I2.4370.76
219_K222_A2.4120.75
216_D223_Y2.2760.71
15_V29_L2.2680.70
159_I185_M2.2290.69
214_W237_L2.1830.67
126_R142_D2.1000.64
145_M170_I2.0970.64
86_E92_K2.0410.62
30_V86_E1.9760.59
241_S244_E1.9730.59
182_L215_C1.9690.59
23_L78_V1.9660.59
8_L36_V1.9600.59
114_F174_L1.9270.57
104_V213_V1.9260.57
14_E28_E1.9200.57
214_W255_L1.8930.56
110_M266_H1.8870.56
19_L29_L1.8820.55
182_L242_A1.8790.55
251_F316_L1.8670.55
38_S324_F1.8520.54
110_M255_L1.8380.53
67_P206_S1.8140.52
110_M316_L1.8000.52
9_R37_K1.7820.51
204_S346_V1.7800.51
101_V113_L1.7720.51
319_R323_R1.7460.50
250_A310_S1.7240.49
103_I147_I1.7230.49
115_E127_I1.7090.48
145_M172_V1.7080.48
166_P169_C1.7010.48
285_Y291_M1.6980.48
26_R50_E1.6980.48
337_Q341_D1.6780.47
77_R83_Y1.6590.46
171_L285_Y1.6150.44
240_I280_L1.6030.44
118_L205_G1.5790.43
255_L310_S1.5760.42
175_A248_N1.5660.42
344_R348_H1.5650.42
24_A368_A1.5450.41
175_A285_Y1.5360.41
86_E120_L1.5190.40
127_I341_D1.5080.40
96_P102_V1.5030.39
110_M175_A1.5010.39
98_L144_G1.5000.39
115_E147_I1.4960.39
216_D239_R1.4770.38
18_A21_N1.4740.38
284_I291_M1.4650.38
194_L223_Y1.4630.38
250_A255_L1.4580.38
174_L237_L1.4520.37
20_L149_S1.4240.36
207_L353_Y1.4110.36
171_L242_A1.4060.36
270_E323_R1.4000.35
9_R50_E1.3970.35
112_R269_E1.3950.35
197_H201_G1.3920.35
33_V226_F1.3800.35
282_S302_L1.3800.35
121_S229_Q1.3760.34
137_A161_K1.3750.34
163_P320_Y1.3560.34
147_I226_F1.3510.34
186_L218_R1.3380.33
110_M230_I1.3360.33
39_R241_S1.3110.32
16_D82_S1.2960.31
46_V55_A1.2920.31
324_F368_A1.2890.31
131_H341_D1.2890.31
86_E255_L1.2870.31
13_D49_R1.2870.31
118_L226_F1.2860.31
118_L227_L1.2840.31
156_E274_L1.2510.30
30_V53_M1.2470.30
61_A72_E1.2380.29
256_R285_Y1.2380.29
254_A317_I1.2360.29
187_V345_K1.2330.29
34_G79_M1.2190.29
178_K198_P1.2190.29
62_E71_I1.2110.28
144_G168_D1.2100.28
103_I344_R1.2080.28
153_H366_R1.2040.28
297_A350_F1.2020.28
165_L189_H1.2000.28
135_R138_D1.1820.27
173_D198_P1.1820.27
169_C270_E1.1800.27
266_H323_R1.1760.27
180_G355_Q1.1760.27
7_A63_A1.1730.27
100_P145_M1.1650.27
204_S207_L1.1560.27
59_A63_A1.1490.26
101_V341_D1.1490.26
212_V316_L1.1470.26
349_W366_R1.1390.26
137_A164_P1.1360.26
74_V317_I1.1350.26
53_M86_E1.1350.26
159_I298_Q1.1290.26
27_L30_V1.1260.26
177_V180_G1.1190.25
123_Y229_Q1.1190.25
27_L86_E1.1170.25
24_A35_E1.1090.25
103_I110_M1.1080.25
347_E355_Q1.1070.25
18_A347_E1.1060.25
265_L273_Q1.1060.25
118_L147_I1.1020.25
72_E76_R1.1000.25
15_V363_V1.0960.25
118_L212_V1.0910.25
213_V269_E1.0890.24
59_A337_Q1.0860.24
18_A251_F1.0800.24
165_L281_S1.0740.24
44_I349_W1.0710.24
74_V280_L1.0680.24
228_E334_G1.0640.24
130_Q358_Q1.0610.24
181_P285_Y1.0600.24
344_R352_D1.0560.23
160_G183_Q1.0550.23
83_Y209_K1.0530.23
317_I367_Q1.0530.23
169_C331_L1.0520.23
40_F44_I1.0520.23
266_H368_A1.0480.23
264_G283_P1.0460.23
171_L256_R1.0430.23
337_Q344_R1.0390.23
67_P88_D1.0330.23
103_I177_V1.0280.23
77_R81_E1.0270.23
147_I172_V1.0260.23
53_M367_Q1.0260.23
70_L77_R1.0260.23
252_I280_L1.0220.22
37_K50_E1.0190.22
15_V120_L1.0160.22
209_K233_W1.0150.22
272_V320_Y1.0140.22
118_L138_D1.0140.22
147_I237_L1.0140.22
149_S320_Y1.0130.22
229_Q282_S1.0080.22
129_E194_L1.0050.22
90_G357_F0.9970.22
138_D187_V0.9970.22
330_L356_R0.9910.22
253_Q298_Q0.9870.21
197_H245_H0.9830.21
9_R82_S0.9830.21
160_G184_A0.9830.21
72_E75_L0.9800.21
256_R288_E0.9760.21
23_L224_Q0.9730.21
86_E91_F0.9690.21
260_T272_V0.9680.21
46_V52_S0.9650.21
341_D356_R0.9650.21
183_Q228_E0.9650.21
37_K49_R0.9600.21
219_K355_Q0.9580.21
39_R59_A0.9580.21
285_Y297_A0.9550.21
7_A15_V0.9540.20
185_M283_P0.9540.20
239_R275_E0.9540.20
137_A331_L0.9490.20
76_R80_R0.9490.20
312_R355_Q0.9480.20
160_G329_E0.9450.20
92_K369_N0.9450.20
90_G120_L0.9440.20
255_L367_Q0.9420.20
148_V175_A0.9410.20
230_I324_F0.9410.20
108_G245_H0.9390.20
171_L298_Q0.9380.20
63_A160_G0.9360.20
192_P270_E0.9340.20
152_I155_T0.9330.20
118_L221_E0.9300.20
288_E298_Q0.9290.20
6_T28_E0.9290.20
282_S343_F0.9280.20
18_A175_A0.9270.20
170_I183_Q0.9260.20
251_F260_T0.9210.20
153_H259_A0.9200.20
211_V254_A0.9180.20
230_I247_Q0.9180.20
133_W258_F0.9170.19
90_G317_I0.9130.19
9_R49_R0.9060.19
185_M195_G0.9050.19
93_T149_S0.9030.19
234_G253_Q0.9030.19
26_R37_K0.9030.19
30_V49_R0.8930.19
250_A354_A0.8920.19
20_L103_I0.8910.19
215_C354_A0.8910.19
336_K368_A0.8890.19
54_L60_E0.8890.19
277_L368_A0.8890.19
250_A359_S0.8870.19
4_E318_K0.8850.19
107_G129_E0.8850.19
29_L86_E0.8840.19
345_K348_H0.8820.19
296_F343_F0.8820.19
156_E160_G0.8820.19
25_K66_V0.8810.19
44_I56_S0.8790.18
49_R82_S0.8780.18
273_Q347_E0.8740.18
38_S310_S0.8740.18
281_S288_E0.8690.18
155_T351_G0.8680.18
83_Y277_L0.8680.18
186_L217_G0.8660.18
185_M291_M0.8650.18
169_C320_Y0.8640.18
98_L207_L0.8640.18
286_R360_E0.8620.18
284_I351_G0.8610.18
58_R69_D0.8580.18
273_Q341_D0.8560.18
159_I171_L0.8560.18
135_R177_V0.8530.18
176_S198_P0.8510.18
279_A363_V0.8500.18
191_G283_P0.8430.18
6_T23_L0.8420.18
20_L115_E0.8400.18
116_K347_E0.8390.17
191_G217_G0.8380.17
365_L368_A0.8370.17
19_L74_V0.8360.17
151_P298_Q0.8330.17
283_P298_Q0.8320.17
64_L222_A0.8300.17
249_M253_Q0.8300.17
144_G259_A0.8270.17
157_Q333_Q0.8260.17
319_R325_G0.8240.17
37_K82_S0.8160.17
141_A338_A0.8130.17
342_S369_N0.8100.17
14_E273_Q0.8080.17
256_R291_M0.8060.17
86_E90_G0.8050.17
209_K229_Q0.8000.17
310_S320_Y0.8000.17
111_G246_D0.7990.17
9_R26_R0.7990.17
255_L262_A0.7980.17
263_Y354_A0.7970.16
44_I369_N0.7910.16
131_H336_K0.7900.16
132_D244_E0.7870.16
247_Q366_R0.7830.16
362_R366_R0.7780.16
189_H192_P0.7780.16
283_P295_L0.7760.16
30_V92_K0.7740.16
113_L116_K0.7720.16
341_D355_Q0.7720.16
53_M109_Q0.7670.16
143_A146_V0.7660.16
11_Q167_K0.7610.16
32_E40_F0.7600.16
41_G300_P0.7580.16
357_F368_A0.7580.16
145_M194_L0.7560.16
339_F351_G0.7560.16
229_Q233_W0.7540.16
107_G131_H0.7540.16
161_K311_E0.7520.15
172_V226_F0.7520.15
16_D26_R0.7520.15
104_V164_P0.7520.15
290_A349_W0.7500.15
256_R284_I0.7500.15
25_K213_V0.7480.15
128_L139_I0.7460.15
334_G345_K0.7450.15
272_V366_R0.7450.15
187_V269_E0.7440.15
252_I324_F0.7430.15
30_V120_L0.7420.15
108_G197_H0.7400.15
73_D209_K0.7370.15
218_R264_G0.7370.15
6_T214_W0.7320.15
119_T312_R0.7310.15
42_L362_R0.7310.15
171_L291_M0.7310.15
255_L317_I0.7300.15
231_Q315_A0.7300.15
253_Q343_F0.7260.15
87_N251_F0.7240.15
157_Q187_V0.7240.15
178_K257_H0.7240.15
347_E358_Q0.7190.15
183_Q187_V0.7170.15
123_Y209_K0.7170.15
17_K331_L0.7170.15
106_G245_H0.7160.15
187_V320_Y0.7160.15
220_P228_E0.7140.15
97_S104_V0.7130.15
19_L320_Y0.7130.15
135_R140_V0.7130.15
118_L230_I0.7120.15
30_V254_A0.7120.15
27_L317_I0.7110.15
16_D49_R0.7100.15
177_V246_D0.7100.15
250_A324_F0.7090.15
159_I288_E0.7080.15
263_Y320_Y0.7070.15
159_I304_A0.7060.14
205_G363_V0.7060.14
94_L248_N0.7050.14
359_S366_R0.7030.14
231_Q341_D0.7020.14
152_I267_L0.7000.14
318_K352_D0.6990.14
329_E333_Q0.6990.14
168_D300_P0.6980.14
78_V207_L0.6960.14
154_V177_V0.6930.14
110_M356_R0.6920.14
170_I179_N0.6890.14
238_H250_A0.6890.14
289_L293_G0.6880.14
139_I347_E0.6880.14
17_K60_E0.6880.14
117_M354_A0.6870.14
241_S355_Q0.6850.14
239_R341_D0.6830.14
114_F148_V0.6790.14
31_A366_R0.6790.14
284_I303_Y0.6780.14
175_A232_V0.6780.14
185_M256_R0.6770.14
193_V302_L0.6750.14
235_A299_D0.6730.14
148_V163_P0.6720.14
121_S233_W0.6710.14
74_V300_P0.6700.14
46_V355_Q0.6690.14
148_V335_D0.6690.14
210_Q260_T0.6660.14
32_E67_P0.6640.14
250_A367_Q0.6620.14
105_G193_V0.6600.14
34_G37_K0.6570.13
130_Q354_A0.6560.13
119_T180_G0.6540.13
171_L288_E0.6530.13
149_S170_I0.6530.13
31_A74_V0.6500.13
155_T185_M0.6470.13
199_M302_L0.6460.13
28_E156_E0.6460.13
327_A331_L0.6430.13
23_L114_F0.6430.13
11_Q156_E0.6430.13
366_R369_N0.6430.13
48_E56_S0.6420.13
138_D348_H0.6410.13
173_D234_G0.6400.13
275_E333_Q0.6400.13
208_A367_Q0.6370.13
185_M298_Q0.6360.13
25_K101_V0.6360.13
310_S321_Y0.6360.13
199_M305_D0.6350.13
172_V175_A0.6350.13
14_E168_D0.6350.13
73_D165_L0.6340.13
85_S369_N0.6330.13
269_E326_E0.6320.13
46_V138_D0.6300.13
134_D167_K0.6290.13
75_L81_E0.6290.13
6_T10_D0.6280.13
120_L144_G0.6270.13
160_G187_V0.6270.13
135_R329_E0.6240.13
351_G360_E0.6240.13
311_E355_Q0.6230.13
93_T96_P0.6230.13
341_D345_K0.6220.13
268_A273_Q0.6210.13
255_L364_L0.6210.13
87_N101_V0.6200.13
17_K56_S0.6190.13
18_A356_R0.6170.13
94_L301_Q0.6170.13
208_A280_L0.6150.13
323_R354_A0.6150.13
149_S260_T0.6140.13
90_G208_A0.6120.13
327_A349_W0.6100.13
109_Q116_K0.6100.13
179_N275_E0.6100.13
283_P343_F0.6070.13
146_V159_I0.6030.12
232_V250_A0.6030.12
302_L343_F0.6020.12
173_D178_K0.5990.12
259_A300_P0.5980.12
211_V258_F0.5980.12
207_L309_S0.5970.12
29_L41_G0.5950.12
204_S347_E0.5950.12
20_L30_V0.5950.12
91_F254_A0.5940.12
329_E335_D0.5930.12
120_L317_I0.5930.12
214_W325_G0.5910.12
176_S200_F0.5910.12
129_E239_R0.5890.12
11_Q32_E0.5880.12
180_G239_R0.5870.12
201_G245_H0.5870.12
9_R16_D0.5860.12
154_V271_N0.5860.12
250_A316_L0.5850.12
208_A317_I0.5810.12
362_R367_Q0.5810.12
161_K359_S0.5800.12
251_F270_E0.5790.12
240_I364_L0.5780.12
103_I269_E0.5780.12
171_L185_M0.5770.12
152_I303_Y0.5770.12
155_T277_L0.5760.12
126_R366_R0.5750.12
39_R274_L0.5750.12
134_D142_D0.5740.12
25_K207_L0.5740.12
130_Q154_V0.5730.12
30_V206_S0.5720.12
128_L136_A0.5710.12
221_E224_Q0.5700.12
279_A334_G0.5690.12
285_Y296_F0.5660.12
171_L175_A0.5650.12
252_I288_E0.5640.12
150_V249_M0.5640.12
113_L148_V0.5640.12
152_I203_D0.5620.12
124_Q322_K0.5620.12
30_V91_F0.5580.12
4_E338_A0.5580.12
337_Q345_K0.5570.12
333_Q338_A0.5570.12
148_V320_Y0.5500.12
81_E370_D0.5490.11
333_Q345_K0.5490.11
254_A310_S0.5490.11
117_M323_R0.5470.11
25_K62_E0.5470.11
338_A356_R0.5440.11
194_L324_F0.5440.11
210_Q296_F0.5440.11
328_I365_L0.5430.11
71_I208_A0.5400.11
11_Q39_R0.5370.11
196_L295_L0.5360.11
174_L265_L0.5360.11
133_W136_A0.5350.11
310_S319_R0.5340.11
127_I243_V0.5330.11
78_V82_S0.5310.11
338_A363_V0.5300.11
86_E367_Q0.5300.11
179_N231_Q0.5290.11
15_V46_V0.5290.11
124_Q231_Q0.5290.11
58_R72_E0.5290.11
153_H301_Q0.5270.11
10_D36_V0.5270.11
229_Q293_G0.5260.11
152_I206_S0.5250.11
48_E140_V0.5240.11
335_D338_A0.5210.11
240_I357_F0.5210.11
48_E252_I0.5200.11
61_A303_Y0.5190.11
103_I240_I0.5190.11
147_I356_R0.5180.11
14_E355_Q0.5180.11
162_L252_I0.5170.11
106_G197_H0.5160.11
243_V247_Q0.5140.11
308_M349_W0.5140.11
263_Y292_V0.5140.11
15_V314_L0.5140.11
21_N323_R0.5110.11
14_E25_K0.5100.11
16_D50_E0.5080.11
75_L370_D0.5080.11
104_V228_E0.5070.11
137_A140_V0.5070.11
93_T362_R0.5070.11
200_F292_V0.5060.11
100_P110_M0.5060.11
111_G178_K0.5060.11
15_V22_L0.5060.11
344_R347_E0.5050.11
57_R60_E0.5010.11
181_P291_M0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pv7A 2 0.748 100 0.598 Contact Map
3b1fA 2 0.6783 100 0.722 Contact Map
3ktdA 2 0.7131 100 0.728 Contact Map
2g5cA 2 0.6729 100 0.73 Contact Map
3ggoA 2 0.6863 100 0.733 Contact Map
4wjiA 2 0.6997 100 0.742 Contact Map
2f1kA 2 0.6702 100 0.748 Contact Map
4xdzA 2 0.7534 99.9 0.825 Contact Map
4kqwA 2 0.748 99.9 0.834 Contact Map
3triA 2 0.6273 99.9 0.839 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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