MCP4 - ECOLI - GREMLIN Contacts

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MCP4 - Methyl-accepting chemotaxis protein IV

UniProt:	P07018	Sequences: MFNRIRISTTLFLILILCGILQIGSNGMSFWAFRDDLQRLNQVEQSNQQRAALAQTRAVMLQASTALNKAGTLTALSYPADDIKTLMTTARASLTQSTTLFKSFMAMTAGNEHVRGLQKETEKSFARWHNDLEHQATWLESNQLSDFLTAPVQGSQNAFDVNFEAWQLEINHVLEAASAQSQRNYQISALVFISMIIVAAIYISSALWWTRKMIVQPLAIIGSHFDSIAAGNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTATVGQNADNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAATMIDIVSSVTRVNDIMGEIASASEEQQRGIEQVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTLEEHEVARHESVQLQIAPVVS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10987
Length:	533 (499)
Sequences:	20013 (17170)
Seq/√Len:	768.6

ECOLI - MCP4 MCP2 MCP3 MCP1 AER
BACSU - YVAQ TLPB YOAH MCPB MCPA TLPA TLPC MCPC HEMAT YFMS
HALSA - HTR4 HTR2 COST Q9HRA1 Q9HQX8 HMAT HTR7 HTR9 Q9HPA2 Q9HP10 Q9HS86 Q9HRN6 Q9HR88 Q9HPQ5 Q9HQT5 HTR1 Q9HPW6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
333_A	336_G	4.378	1.00
241_G	246_T	3.722	1.00
6_R	9_T	3.435	1.00
227_S	232_N	3.306	1.00
27_G	31_W	3.197	1.00
253_K	256_Q	2.547	1.00
236_P	260_R	2.471	1.00
227_S	235_R	2.445	1.00
10_T	243_N	2.428	1.00
353_S	423_R	2.282	1.00
212_K	216_Q	2.274	1.00
143_Q	146_D	2.209	1.00
221_I	249_F	2.202	1.00
190_L	194_S	2.173	1.00
226_D	247_A	2.158	1.00
314_Q	317_D	2.156	1.00
222_G	247_A	2.110	1.00
331_T	335_A	2.104	1.00
26_N	196_I	2.098	1.00
226_D	254_T	2.050	1.00
352_T	355_Q	2.042	1.00
222_G	251_S	2.013	1.00
349_E	423_R	2.013	1.00
353_S	419_E	1.988	1.00
226_D	230_A	1.987	1.00
29_S	192_F	1.980	1.00
356_K	359_D	1.952	1.00
187_I	191_V	1.931	1.00
236_P	257_Q	1.910	1.00
362_S	366_G	1.894	1.00
225_F	255_M	1.872	1.00
175_E	179_A	1.869	1.00
228_I	256_Q	1.860	1.00
425_Q	429_K	1.845	1.00
243_N	246_T	1.844	1.00
228_I	255_M	1.836	1.00
133_E	137_T	1.828	1.00
211_R	215_V	1.808	1.00
186_Q	190_L	1.802	1.00
164_E	168_L	1.791	1.00
119_K	123_K	1.786	1.00
253_K	257_Q	1.777	1.00
95_T	99_T	1.777	1.00
321_Q	324_E	1.765	1.00
168_L	172_H	1.765	1.00
358_G	421_V	1.763	1.00
88_T	92_A	1.755	1.00
475_Q	478_Q	1.754	1.00
406_S	410_A	1.754	1.00
225_F	252_L	1.741	1.00
342_T	345_H	1.730	1.00
414_K	418_E	1.715	1.00
10_T	213_M	1.705	1.00
134_H	137_T	1.692	1.00
131_D	134_H	1.692	1.00
247_A	250_A	1.688	1.00
351_A	428_S	1.679	1.00
359_D	362_S	1.676	1.00
447_R	450_D	1.670	1.00
285_N	289_S	1.669	1.00
502_D	506_S	1.660	1.00
193_I	197_I	1.655	1.00
496_Q	499_N	1.643	1.00
436_A	440_D	1.637	1.00
335_A	338_V	1.637	1.00
438_M	441_I	1.633	1.00
236_P	253_K	1.632	1.00
31_W	35_D	1.630	1.00
503_H	506_S	1.621	1.00
326_A	336_G	1.620	1.00
338_V	342_T	1.618	1.00
446_T	450_D	1.616	1.00
328_N	331_T	1.614	1.00
308_L	319_A	1.609	1.00
408_Q	412_E	1.606	1.00
256_Q	260_R	1.599	1.00
429_K	433_N	1.587	1.00
324_E	327_K	1.583	1.00
161_V	165_A	1.579	1.00
194_S	198_V	1.575	1.00
334_Q	338_V	1.573	1.00
172_H	176_A	1.572	1.00
468_Q	471_Q	1.567	1.00
225_F	251_S	1.561	1.00
236_P	256_Q	1.558	1.00
324_E	328_N	1.558	1.00
485_S	489_E	1.554	1.00
226_D	251_S	1.553	1.00
68_N	72_T	1.542	1.00
436_A	439_I	1.525	1.00
257_Q	261_G	1.523	1.00
275_I	279_E	1.523	1.00
341_S	345_H	1.514	1.00
401_N	404_S	1.513	1.00
356_K	412_E	1.505	1.00
18_C	203_I	1.503	1.00
179_A	183_R	1.503	1.00
115_R	119_K	1.502	1.00
116_G	120_E	1.501	1.00
92_A	96_Q	1.500	1.00
134_H	138_W	1.495	1.00
221_I	248_I	1.484	1.00
286_D	289_S	1.474	1.00
265_D	503_H	1.473	1.00
320_R	324_E	1.468	1.00
499_N	503_H	1.460	1.00
139_L	142_N	1.459	1.00
150_A	154_G	1.454	1.00
99_T	103_S	1.450	1.00
8_S	12_F	1.448	1.00
411_K	415_G	1.443	1.00
260_R	264_S	1.439	1.00
418_E	422_N	1.434	1.00
365_D	414_K	1.433	1.00
296_A	300_Q	1.421	1.00
354_S	424_V	1.420	1.00
478_Q	482_Q	1.418	1.00
327_K	331_T	1.415	1.00
467_E	471_Q	1.412	1.00
404_S	408_Q	1.407	1.00
84_K	88_T	1.405	1.00
322_A	336_G	1.402	1.00
352_T	356_K	1.401	1.00
120_E	124_S	1.400	1.00
112_E	115_R	1.396	1.00
397_G	400_R	1.390	1.00
306_E	310_A	1.390	1.00
332_T	336_G	1.390	1.00
219_A	222_G	1.381	1.00
189_A	193_I	1.375	1.00
165_A	168_L	1.373	1.00
98_T	102_K	1.373	1.00
339_Q	344_T	1.368	1.00
322_A	326_A	1.365	1.00
113_H	116_G	1.365	1.00
87_M	91_R	1.361	1.00
225_F	248_I	1.357	1.00
258_A	261_G	1.350	1.00
102_K	105_M	1.346	1.00
345_H	348_Q	1.346	1.00
300_Q	303_A	1.346	1.00
290_R	479_V	1.342	1.00
93_S	96_Q	1.340	1.00
122_E	126_A	1.340	1.00
296_A	299_A	1.337	1.00
345_H	349_E	1.329	1.00
221_I	252_L	1.326	1.00
91_R	95_T	1.324	1.00
186_Q	189_A	1.323	1.00
96_Q	99_T	1.318	1.00
232_N	235_R	1.316	1.00
440_D	443_S	1.305	1.00
495_E	499_N	1.304	1.00
261_G	265_D	1.302	1.00
348_Q	432_N	1.302	1.00
185_Y	189_A	1.301	1.00
239_V	253_K	1.301	1.00
379_A	397_G	1.299	1.00
408_Q	411_K	1.298	1.00
429_K	432_N	1.293	1.00
268_K	271_Q	1.292	1.00
207_L	211_R	1.285	1.00
140_E	143_Q	1.280	1.00
439_I	443_S	1.278	1.00
289_S	292_E	1.276	1.00
8_S	212_K	1.275	1.00
353_S	356_K	1.275	1.00
348_Q	352_T	1.262	1.00
172_H	175_E	1.256	1.00
222_G	226_D	1.255	1.00
460_E	464_R	1.254	1.00
24_G	28_M	1.254	1.00
443_S	447_R	1.254	1.00
441_I	452_M	1.253	1.00
37_L	185_Y	1.252	1.00
331_T	334_Q	1.252	1.00
267_R	271_Q	1.251	1.00
326_A	329_A	1.249	1.00
32_A	35_D	1.242	1.00
121_T	125_F	1.239	1.00
102_K	106_A	1.236	1.00
164_E	167_Q	1.236	1.00
313_G	317_D	1.235	1.00
478_Q	481_Q	1.235	1.00
6_R	247_A	1.232	1.00
223_S	226_D	1.227	1.00
220_I	238_A	1.223	1.00
81_D	84_K	1.221	1.00
489_E	492_V	1.214	1.00
474_S	478_Q	1.210	1.00
105_M	122_E	1.207	1.00
239_V	249_F	1.207	1.00
64_S	68_N	1.206	1.00
297_S	475_Q	1.201	1.00
356_K	419_E	1.199	1.00
95_T	98_T	1.198	1.00
332_T	440_D	1.198	1.00
81_D	85_T	1.198	1.00
351_A	355_Q	1.197	1.00
155_S	158_A	1.195	1.00
8_S	211_R	1.189	1.00
322_A	329_A	1.188	1.00
190_L	193_I	1.187	1.00
485_S	488_E	1.185	1.00
363_V	409_A	1.184	1.00
139_L	143_Q	1.184	1.00
422_N	426_Q	1.183	1.00
508_V	511_F	1.182	1.00
224_H	237_I	1.179	1.00
79_P	82_D	1.179	1.00
237_I	253_K	1.178	1.00
346_T	426_Q	1.175	1.00
307_Q	310_A	1.174	1.00
365_D	410_A	1.174	1.00
351_A	425_Q	1.172	1.00
86_L	89_T	1.171	1.00
355_Q	425_Q	1.169	1.00
282_A	286_D	1.167	1.00
119_K	122_E	1.166	1.00
5_I	9_T	1.165	1.00
347_M	427_G	1.161	1.00
457_S	461_E	1.160	1.00
94_L	98_T	1.160	1.00
230_A	254_T	1.158	1.00
279_E	282_A	1.146	1.00
82_D	85_T	1.146	1.00
126_A	130_N	1.143	1.00
411_K	414_K	1.142	1.00
412_E	415_G	1.141	1.00
96_Q	100_L	1.141	1.00
346_T	427_G	1.138	1.00
57_R	61_L	1.137	1.00
191_V	194_S	1.135	1.00
332_T	335_A	1.134	1.00
289_S	293_Q	1.133	1.00
338_V	341_S	1.131	1.00
293_Q	296_A	1.131	1.00
112_E	116_G	1.131	1.00
349_E	352_T	1.128	1.00
227_S	230_A	1.125	1.00
461_E	464_R	1.124	1.00
208_W	212_K	1.123	1.00
322_A	452_M	1.119	1.00
268_K	272_E	1.115	1.00
116_G	119_K	1.110	1.00
130_N	134_H	1.106	1.00
219_A	223_S	1.101	1.00
415_G	419_E	1.101	1.00
482_Q	485_S	1.095	1.00
92_A	95_T	1.094	1.00
419_E	423_R	1.093	1.00
424_V	427_G	1.091	1.00
52_A	55_Q	1.090	1.00
120_E	123_K	1.090	1.00
58_A	61_L	1.089	1.00
488_E	492_V	1.088	1.00
278_A	282_A	1.085	1.00
59_V	63_A	1.078	1.00
379_A	400_R	1.073	1.00
220_I	223_S	1.073	1.00
137_T	141_S	1.072	1.00
426_Q	429_K	1.072	1.00
41_N	45_Q	1.072	1.00
127_R	130_N	1.067	1.00
254_T	257_Q	1.064	1.00
505_S	509_A	1.062	1.00
325_L	329_A	1.061	1.00
221_I	225_F	1.060	1.00
339_Q	433_N	1.056	1.00
65_T	69_K	1.055	1.00
15_L	207_L	1.055	1.00
499_N	502_D	1.053	1.00
350_I	427_G	1.053	1.00
33_F	188_S	1.051	1.00
171_N	175_E	1.050	1.00
30_F	189_A	1.046	1.00
85_T	88_T	1.045	1.00
254_T	258_A	1.045	1.00
204_S	208_W	1.043	1.00
481_Q	485_S	1.042	1.00
28_M	32_A	1.036	1.00
350_I	420_S	1.033	1.00
100_L	104_F	1.033	1.00
506_S	509_A	1.032	1.00
464_R	468_Q	1.029	1.00
12_F	16_I	1.027	1.00
34_R	189_A	1.026	1.00
292_E	296_A	1.024	1.00
222_G	248_I	1.022	1.00
7_I	245_I	1.022	1.00
137_T	140_E	1.020	1.00
80_A	84_K	1.019	1.00
223_S	227_S	1.011	1.00
317_D	321_Q	1.008	1.00
22_Q	25_S	1.007	1.00
8_S	215_V	1.007	1.00
249_F	253_K	1.001	1.00
310_A	314_Q	1.000	1.00
183_R	187_I	1.000	1.00
220_I	224_H	1.000	1.00
330_A	334_Q	0.989	1.00
242_R	246_T	0.989	1.00
205_S	209_W	0.987	1.00
239_V	250_A	0.986	1.00
339_Q	342_T	0.985	1.00
89_T	92_A	0.985	1.00
322_A	333_A	0.984	1.00
136_A	140_E	0.982	1.00
103_S	106_A	0.980	1.00
69_K	72_T	0.980	1.00
405_R	408_Q	0.979	1.00
252_L	256_Q	0.978	1.00
360_I	416_L	0.977	1.00
282_A	285_N	0.975	1.00
275_I	278_A	0.970	1.00
218_L	248_I	0.968	1.00
274_H	278_A	0.968	1.00
323_S	327_K	0.967	1.00
497_L	511_F	0.967	1.00
305_M	308_L	0.966	1.00
114_V	117_L	0.963	1.00
19_G	203_I	0.962	1.00
23_I	27_G	0.961	1.00
304_S	479_V	0.957	1.00
448_V	452_M	0.956	1.00
151_P	154_G	0.956	1.00
407_A	411_K	0.954	1.00
85_T	89_T	0.952	1.00
33_F	37_L	0.951	1.00
365_D	369_F	0.948	1.00
182_Q	186_Q	0.947	1.00
434_A	438_M	0.947	1.00
492_V	496_Q	0.946	1.00
149_T	153_Q	0.945	1.00
218_L	245_I	0.945	1.00
40_L	43_V	0.944	1.00
237_I	249_F	0.942	1.00
21_L	199_A	0.942	1.00
507_R	510_V	0.941	1.00
239_V	243_N	0.941	1.00
152_V	156_Q	0.940	1.00
28_M	31_W	0.936	1.00
87_M	94_L	0.932	1.00
271_Q	275_I	0.931	1.00
31_W	34_R	0.930	1.00
264_S	268_K	0.929	1.00
144_L	147_F	0.929	1.00
101_F	104_F	0.927	1.00
123_K	127_R	0.925	1.00
156_Q	160_D	0.922	1.00
415_G	418_E	0.920	1.00
34_R	38_Q	0.919	1.00
319_A	322_A	0.917	1.00
197_I	201_I	0.916	1.00
457_S	460_E	0.915	1.00
356_K	416_L	0.912	1.00
477_D	481_Q	0.912	1.00
100_L	103_S	0.912	1.00
454_E	457_S	0.911	1.00
224_H	235_R	0.910	1.00
217_P	241_G	0.906	1.00
44_E	47_N	0.905	1.00
124_S	127_R	0.905	1.00
320_R	460_E	0.900	1.00
227_S	255_M	0.898	1.00
245_I	249_F	0.898	1.00
40_L	44_E	0.897	1.00
53_L	56_T	0.897	1.00
250_A	253_K	0.895	1.00
294_Q	304_S	0.892	1.00
293_Q	297_S	0.892	1.00
60_M	63_A	0.888	1.00
228_I	252_L	0.888	1.00
89_T	93_S	0.885	1.00
32_A	188_S	0.885	1.00
255_M	259_L	0.883	1.00
153_Q	158_A	0.881	1.00
99_T	102_K	0.881	1.00
334_Q	337_G	0.880	1.00
168_L	171_N	0.880	1.00
315_N	459_S	0.879	1.00
66_A	69_K	0.876	1.00
162_N	165_A	0.876	1.00
343_M	431_V	0.875	1.00
265_D	268_K	0.875	1.00
88_T	91_R	0.872	1.00
90_A	94_L	0.872	1.00
83_I	90_A	0.871	1.00
216_Q	220_I	0.871	1.00
359_D	363_V	0.868	1.00
366_G	405_R	0.866	1.00
397_G	401_N	0.866	1.00
224_H	227_S	0.864	1.00
154_G	158_A	0.863	1.00
91_R	94_L	0.863	1.00
213_M	217_P	0.863	1.00
157_N	161_V	0.861	1.00
15_L	18_C	0.858	1.00
61_L	64_S	0.858	1.00
125_F	129_H	0.852	1.00
217_P	245_I	0.851	1.00
26_N	30_F	0.850	1.00
25_S	29_S	0.850	1.00
471_Q	474_S	0.849	1.00
308_L	312_V	0.848	1.00
94_L	97_S	0.846	1.00
252_L	255_M	0.842	1.00
113_H	117_L	0.842	1.00
65_T	68_N	0.839	1.00
258_A	510_V	0.837	1.00
471_Q	475_Q	0.835	1.00
427_G	431_V	0.835	1.00
36_D	40_L	0.834	1.00
346_T	430_L	0.830	1.00
422_N	425_Q	0.829	1.00
51_A	54_A	0.828	1.00
224_H	252_L	0.828	1.00
132_L	135_Q	0.825	1.00
344_T	435_A	0.823	1.00
176_A	179_A	0.822	1.00
238_A	253_K	0.822	1.00
271_Q	505_S	0.819	1.00
355_Q	359_D	0.819	1.00
187_I	190_L	0.818	1.00
492_V	495_E	0.817	1.00
5_I	13_L	0.815	1.00
69_K	73_L	0.814	1.00
63_A	66_A	0.813	1.00
136_A	139_L	0.811	1.00
366_G	369_F	0.811	1.00
303_A	307_Q	0.808	1.00
219_A	247_A	0.806	1.00
303_A	306_E	0.804	1.00
209_W	212_K	0.803	1.00
14_I	21_L	0.802	1.00
441_I	448_V	0.802	1.00
326_A	333_A	0.799	1.00
70_A	139_L	0.799	1.00
42_Q	46_S	0.797	1.00
173_V	176_A	0.796	1.00
233_L	259_L	0.794	1.00
342_T	433_N	0.794	1.00
453_G	457_S	0.793	1.00
464_R	467_E	0.793	1.00
308_L	315_N	0.793	1.00
450_D	453_G	0.792	1.00
162_N	169_E	0.789	1.00
215_V	219_A	0.787	1.00
299_A	303_A	0.783	1.00
434_A	441_I	0.778	1.00
191_V	195_M	0.778	1.00
322_A	330_A	0.777	1.00
286_D	290_R	0.776	1.00
67_L	70_A	0.775	1.00
163_F	166_W	0.773	1.00
216_Q	219_A	0.769	1.00
132_L	136_A	0.769	1.00
180_Q	184_N	0.769	1.00
443_S	446_T	0.768	1.00
264_S	267_R	0.768	1.00
225_F	228_I	0.768	1.00
405_R	412_E	0.762	1.00
500_Q	503_H	0.759	1.00
502_D	505_S	0.759	1.00
354_S	420_S	0.756	1.00
467_E	470_A	0.756	1.00
317_D	320_R	0.754	1.00
365_D	411_K	0.754	1.00
217_P	244_E	0.751	1.00
361_I	414_K	0.751	1.00
361_I	365_D	0.751	1.00
33_F	36_D	0.747	1.00
153_Q	157_N	0.746	1.00
49_Q	52_A	0.745	1.00
167_Q	170_I	0.745	1.00
158_A	162_N	0.744	1.00
37_L	41_N	0.743	1.00
214_I	217_P	0.743	1.00
142_N	146_D	0.738	1.00
306_E	470_A	0.732	1.00
334_Q	446_T	0.730	1.00
138_W	143_Q	0.728	1.00
158_A	161_V	0.727	1.00
38_Q	41_N	0.725	1.00
19_G	207_L	0.723	1.00
323_S	326_A	0.723	1.00
506_S	510_V	0.723	1.00
421_V	425_Q	0.722	1.00
333_A	337_G	0.722	1.00
149_T	152_V	0.721	1.00
468_Q	472_A	0.720	1.00
62_Q	65_T	0.720	1.00
54_A	58_A	0.718	1.00
59_V	62_Q	0.718	1.00
101_F	105_M	0.717	1.00
450_D	454_E	0.716	1.00
80_A	83_I	0.715	1.00
504_L	511_F	0.715	1.00
63_A	67_L	0.715	1.00
159_F	163_F	0.713	1.00
35_D	39_R	0.711	1.00
229_A	254_T	0.711	1.00
86_L	90_A	0.709	1.00
55_Q	59_V	0.708	1.00
313_G	467_E	0.707	1.00
14_I	18_C	0.706	1.00
435_A	439_I	0.705	1.00
461_E	465_G	0.705	1.00
336_G	441_I	0.704	1.00
442_V	446_T	0.702	1.00
90_A	97_S	0.702	1.00
148_L	151_P	0.701	1.00
39_R	42_Q	0.701	1.00
140_E	144_L	0.701	1.00
7_I	214_I	0.699	1.00
344_T	348_Q	0.699	1.00
498_A	502_D	0.697	1.00
337_G	442_V	0.697	1.00
497_L	501_A	0.696	1.00
340_V	343_M	0.695	1.00
156_Q	159_F	0.692	1.00
329_A	336_G	0.690	1.00
272_E	275_I	0.690	1.00
26_N	192_F	0.690	1.00
130_N	133_E	0.687	1.00
97_S	101_F	0.685	1.00
165_A	169_E	0.684	1.00
325_L	328_N	0.683	1.00
360_I	417_I	0.682	1.00
298_L	301_T	0.682	1.00
38_Q	42_Q	0.682	1.00
61_L	65_T	0.682	1.00
142_N	145_S	0.681	1.00
304_S	307_Q	0.681	1.00
337_G	341_S	0.681	1.00
376_L	384_R	0.680	1.00
328_N	332_T	0.679	1.00
97_S	100_L	0.678	1.00
350_I	424_V	0.677	1.00
114_V	121_T	0.676	1.00
342_T	346_T	0.675	1.00
122_E	125_F	0.675	1.00
265_D	507_R	0.674	1.00
29_S	33_F	0.672	1.00
161_V	164_E	0.671	1.00
176_A	180_Q	0.670	1.00
435_A	438_M	0.670	1.00
211_R	214_I	0.669	1.00
297_S	304_S	0.669	1.00
241_G	245_I	0.667	1.00
50_R	54_A	0.667	1.00
125_F	128_W	0.666	1.00
479_V	483_N	0.666	1.00
179_A	182_Q	0.664	1.00
359_D	412_E	0.664	1.00
230_A	258_A	0.663	1.00
181_S	185_Y	0.660	1.00
466_I	470_A	0.659	1.00
349_E	426_Q	0.658	1.00
340_V	344_T	0.656	1.00
12_F	211_R	0.655	1.00
123_K	126_A	0.655	1.00
30_F	185_Y	0.653	1.00
424_V	428_S	0.653	1.00
354_S	360_I	0.651	1.00
235_R	256_Q	0.649	1.00
315_N	319_A	0.647	1.00
316_A	319_A	0.647	1.00
418_E	421_V	0.647	1.00
7_I	244_E	0.646	1.00
9_T	12_F	0.645	1.00
169_E	173_V	0.644	1.00
277_I	494_T	0.643	1.00
30_F	34_R	0.642	1.00
49_Q	53_L	0.641	1.00
369_F	380_V	0.641	1.00
229_A	251_S	0.640	1.00
308_L	466_I	0.640	1.00
168_L	175_E	0.640	1.00
93_S	98_T	0.639	1.00
348_Q	351_A	0.638	1.00
357_I	417_I	0.638	1.00
135_Q	139_L	0.636	1.00
310_A	313_G	0.635	1.00
55_Q	58_A	0.634	1.00
330_A	333_A	0.634	1.00
160_D	164_E	0.632	1.00
54_A	57_R	0.632	1.00
333_A	442_V	0.632	1.00
239_V	246_T	0.631	1.00
346_T	349_E	0.631	1.00
360_I	409_A	0.629	1.00
284_N	487_V	0.628	1.00
166_W	170_I	0.626	1.00
213_M	216_Q	0.624	1.00
287_L	291_T	0.624	1.00
297_S	300_Q	0.623	1.00
93_S	100_L	0.623	1.00
419_E	422_N	0.622	1.00
294_Q	308_L	0.620	1.00
40_L	181_S	0.619	1.00
490_A	493_A	0.616	1.00
82_D	86_L	0.614	1.00
94_L	101_F	0.613	1.00
182_Q	185_Y	0.612	1.00
263_V	266_V	0.611	1.00
117_L	120_E	0.610	1.00
224_H	228_I	0.607	1.00
184_N	187_I	0.606	1.00
482_Q	486_L	0.603	1.00
272_E	496_Q	0.602	1.00
406_S	416_L	0.602	1.00
67_L	71_G	0.602	1.00
256_Q	259_L	0.602	1.00
369_F	407_A	0.602	1.00
445_V	452_M	0.601	1.00
427_G	430_L	0.600	1.00
41_N	44_E	0.600	1.00
215_V	245_I	0.598	1.00
375_A	400_R	0.595	1.00
19_G	200_A	0.594	1.00
131_D	135_Q	0.593	1.00
139_L	144_L	0.593	1.00
312_V	315_N	0.592	1.00
49_Q	170_I	0.592	1.00
167_Q	171_N	0.590	1.00
476_M	483_N	0.589	1.00
266_V	508_V	0.588	1.00
360_I	363_V	0.587	1.00
34_R	185_Y	0.587	1.00
70_A	73_L	0.586	1.00
315_N	318_N	0.586	1.00
372_N	400_R	0.586	1.00
403_A	406_S	0.586	1.00
484_A	487_V	0.583	1.00
29_S	32_A	0.583	1.00
246_T	250_A	0.583	1.00
43_V	47_N	0.582	1.00
83_I	86_L	0.581	1.00
294_Q	301_T	0.580	1.00
270_S	274_H	0.580	1.00
489_E	493_A	0.580	1.00
169_E	172_H	0.576	1.00
198_V	202_Y	0.575	1.00
309_T	312_V	0.574	1.00
58_A	62_Q	0.574	1.00
9_T	13_L	0.573	1.00
148_L	154_G	0.572	1.00
93_S	97_S	0.571	1.00
133_E	136_A	0.571	1.00
456_A	459_S	0.570	1.00
347_M	431_V	0.567	1.00
308_L	322_A	0.567	1.00
7_I	218_L	0.566	1.00
266_V	269_G	0.565	1.00
56_T	60_M	0.565	1.00
447_R	451_I	0.564	1.00
154_G	157_N	0.564	1.00
278_A	498_A	0.562	1.00
118_Q	121_T	0.562	1.00
347_M	351_A	0.562	1.00
44_E	174_L	0.562	1.00
48_Q	174_L	0.561	1.00
233_L	263_V	0.560	1.00
35_D	38_Q	0.560	1.00
163_F	167_Q	0.560	1.00
255_M	258_A	0.559	1.00
117_L	121_T	0.558	1.00
449_N	453_G	0.557	1.00
180_Q	183_R	0.556	1.00
90_A	93_S	0.555	1.00
203_I	207_L	0.554	1.00
201_I	205_S	0.553	1.00
138_W	142_N	0.552	1.00
143_Q	147_F	0.551	1.00
347_M	428_S	0.551	1.00
280_I	284_N	0.551	1.00
138_W	141_S	0.551	1.00
68_N	73_L	0.548	1.00
362_S	365_D	0.548	1.00
217_P	243_N	0.547	1.00
510_V	513_L	0.547	1.00
14_I	203_I	0.546	1.00
34_R	37_L	0.545	1.00
231_G	255_M	0.545	1.00
151_P	155_S	0.544	1.00
501_A	511_F	0.543	1.00
25_S	192_F	0.542	1.00
94_L	100_L	0.542	1.00
33_F	185_Y	0.541	1.00
346_T	423_R	0.541	1.00
486_L	489_E	0.541	1.00
373_I	380_V	0.539	1.00
117_L	125_F	0.537	1.00
27_G	30_F	0.537	1.00
320_R	323_S	0.534	1.00
495_E	498_A	0.533	1.00
226_D	229_A	0.532	1.00
150_A	153_Q	0.532	1.00
114_V	118_Q	0.532	1.00
290_R	294_Q	0.531	1.00
400_R	404_S	0.529	1.00
327_K	330_A	0.528	1.00
388_Q	399_V	0.525	1.00
360_I	406_S	0.524	1.00
336_G	344_T	0.524	1.00
242_R	250_A	0.523	1.00
46_S	49_Q	0.522	1.00
462_Q	465_G	0.521	1.00
194_S	197_I	0.521	1.00
47_N	173_V	0.520	1.00
370_Q	398_E	0.520	1.00
205_S	208_W	0.520	1.00
473_V	477_D	0.519	1.00
311_T	314_Q	0.519	1.00
503_H	507_R	0.518	1.00
53_L	57_R	0.517	1.00
491_A	494_T	0.517	1.00
221_I	224_H	0.517	1.00
441_I	444_S	0.517	1.00
64_S	67_L	0.516	1.00
159_F	166_W	0.516	1.00
159_F	162_N	0.515	1.00
124_S	162_N	0.515	1.00
228_I	233_L	0.514	1.00
301_T	305_M	0.514	1.00
121_T	127_R	0.512	1.00
97_S	104_F	0.512	1.00
129_H	133_E	0.512	1.00
337_G	439_I	0.511	1.00
42_Q	45_Q	0.511	1.00
448_V	462_Q	0.511	1.00
287_L	290_R	0.510	1.00
124_S	128_W	0.510	1.00
322_A	325_L	0.509	1.00
288_S	291_T	0.508	1.00
434_A	437_T	0.508	1.00
294_Q	297_S	0.508	1.00
68_N	71_G	0.507	1.00
99_T	105_M	0.507	1.00
37_L	182_Q	0.506	1.00
269_G	272_E	0.506	1.00
485_S	492_V	0.505	1.00
326_A	330_A	0.504	1.00
339_Q	346_T	0.503	1.00
149_T	159_F	0.503	1.00
22_Q	29_S	0.500	1.00
355_Q	358_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.5685	100	0.364	Contact Map
1qu7A	2	0.4259	100	0.502	Contact Map
2ch7A	2	0.5535	100	0.514	Contact Map
3g67A	2	0.3996	100	0.58	Contact Map
4i3mA	2	0.2758	99.9	0.734	Contact Map
4cq4A	4	0.1614	99.5	0.829	Contact Map
2f95B	2	0.0976	99.4	0.844	Contact Map
4gycB	2	0.1126	99.2	0.856	Contact Map
3zccA	2	0.197	98.8	0.874	Contact Map
4i5sA	2	0.5591	98.6	0.883	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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