GREMLIN Database
SDHB - Succinate dehydrogenase iron-sulfur subunit
UniProt: P07014 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10932
Length: 238 (223)
Sequences: 2533 (1035)
Seq/√Len: 69.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_E24_T4.2481.00
41_Q44_E4.0561.00
6_S90_V3.7081.00
50_S104_V3.7051.00
40_I51_F3.6311.00
5_F38_A3.5251.00
118_K122_L3.5211.00
6_S22_D3.4841.00
6_S88_K3.1521.00
5_F42_L2.8441.00
38_A79_I2.7501.00
175_L229_I2.6411.00
65_L74_A2.5151.00
146_L225_A2.4911.00
21_Q46_D2.4801.00
123_N188_T2.3411.00
11_N14_V2.3241.00
25_L42_L2.2591.00
182_L229_I2.1931.00
26_E41_Q2.1901.00
110_F153_A2.1481.00
171_G225_A2.1031.00
35_L67_M2.0721.00
176_L220_L2.0611.00
160_P209_I2.0531.00
72_G77_T2.0121.00
71_N158_S1.9801.00
41_Q45_K1.9571.00
137_P141_E1.9481.00
4_E88_K1.9341.00
228_H231_S1.9061.00
118_K192_S1.8831.00
67_M72_G1.8761.00
64_G154_C1.8131.00
210_M222_P1.7891.00
33_M41_Q1.7841.00
125_G188_T1.7631.00
112_A115_E1.7451.00
70_K215_V1.6751.00
8_Y18_P1.6680.99
4_E22_D1.6430.99
66_N157_T1.6350.99
6_S20_M1.6290.99
184_D187_D1.6240.99
135_Q185_S1.6120.99
64_G94_L1.5860.99
197_L201_F1.5690.99
5_F89_I1.5540.99
8_Y92_R1.5220.99
20_M90_V1.5130.99
112_A201_F1.4660.99
160_P171_G1.4370.98
83_N87_K1.4300.98
70_K214_S1.4260.98
139_Q185_S1.4160.98
124_N188_T1.3750.98
26_E44_E1.3730.98
8_Y20_M1.3650.98
42_L49_L1.3540.98
30_G33_M1.3430.98
122_L189_E1.3350.97
169_F183_I1.3190.97
7_I49_L1.3170.97
182_L232_M1.2900.97
147_Y153_A1.2880.97
179_Y183_I1.2850.97
197_L200_A1.2610.96
15_D19_R1.2590.96
213_V221_N1.2510.96
28_D79_I1.2500.96
213_V223_T1.2440.96
140_R144_D1.2350.96
11_N19_R1.2340.96
179_Y228_H1.2290.96
82_L87_K1.2080.95
52_R62_S1.1950.95
191_D195_D1.1900.95
123_N133_H1.1880.95
136_M139_Q1.1830.95
12_P16_D1.1540.94
195_D198_S1.1370.94
97_L157_T1.0940.92
127_N130_A1.0880.92
66_N71_N1.0810.92
66_N95_P1.0720.92
170_I174_G1.0710.92
176_L225_A1.0670.91
56_R59_V1.0560.91
16_D19_R1.0550.91
25_L41_Q1.0540.91
107_M110_F1.0540.91
178_A232_M1.0430.90
175_L178_A1.0310.90
176_L222_P1.0310.90
62_S65_L1.0240.90
189_E192_S1.0220.90
36_L56_R1.0200.89
20_M92_R1.0190.89
25_L38_A1.0160.89
98_P109_Q1.0150.89
65_L91_I1.0110.89
59_V76_I1.0050.89
129_P132_E1.0030.89
23_Y46_D0.9960.88
154_C215_V0.9850.88
178_A185_S0.9790.87
82_L89_I0.9780.87
22_D88_K0.9760.87
65_L89_I0.9700.87
43_K50_S0.9700.87
21_Q45_K0.9550.86
206_C212_C0.9550.86
72_G82_L0.9400.85
211_N215_V0.9370.85
139_Q142_K0.9360.85
35_L79_I0.9330.85
145_G148_E0.9120.83
76_I146_L0.9110.83
56_R63_D0.8970.82
165_N229_I0.8950.82
97_L107_M0.8930.82
94_L171_G0.8880.82
142_K224_R0.8870.82
77_T82_L0.8830.81
35_L38_A0.8810.81
23_Y50_S0.8810.81
27_A33_M0.8800.81
34_M56_R0.8800.81
213_V222_P0.8770.81
25_L49_L0.8760.81
107_M153_A0.8650.80
107_M111_Y0.8600.80
189_E193_R0.8440.78
148_E220_L0.8400.78
110_F173_A0.8390.78
190_T232_M0.8390.78
124_N189_E0.8380.78
175_L197_L0.8350.78
7_I91_I0.8270.77
28_D33_M0.8250.77
125_G130_A0.8230.77
15_D18_P0.8170.76
158_S215_V0.8090.75
113_Q162_F0.8090.75
214_S223_T0.8090.75
89_I191_D0.8080.75
49_L103_L0.8080.75
5_F35_L0.8070.75
83_N88_K0.8030.75
42_L227_G0.7960.74
210_M214_S0.7930.74
73_L187_D0.7880.73
10_Y14_V0.7870.73
39_L65_L0.7790.73
140_R143_L0.7770.72
100_I104_V0.7770.72
125_G128_P0.7730.72
35_L91_I0.7720.72
135_Q139_Q0.7700.72
63_D96_G0.7690.72
95_P157_T0.7680.71
17_A21_Q0.7670.71
142_K179_Y0.7660.71
68_N82_L0.7650.71
50_S101_R0.7640.71
198_S233_L0.7600.71
12_P15_D0.7570.70
208_S227_G0.7560.70
51_F56_R0.7550.70
14_V17_A0.7520.70
210_M213_V0.7510.70
21_Q68_N0.7480.69
227_G231_S0.7460.69
66_N209_I0.7430.69
17_A101_R0.7430.69
226_I229_I0.7410.69
39_L51_F0.7390.69
20_M169_F0.7370.68
138_E189_E0.7370.68
174_G229_I0.7340.68
83_N100_I0.7340.68
35_L77_T0.7320.68
143_L147_Y0.7310.68
128_P133_H0.7300.68
129_P133_H0.7290.68
110_F156_S0.7210.67
221_N224_R0.7210.67
62_S73_L0.7200.67
112_A197_L0.7150.66
160_P211_N0.7120.66
20_M99_V0.7110.66
140_R148_E0.7100.65
16_D81_A0.7040.65
46_D184_D0.7000.64
110_F147_Y0.6990.64
220_L223_T0.6960.64
161_S209_I0.6950.64
97_L153_A0.6910.63
10_Y15_D0.6910.63
144_D148_E0.6870.63
71_N154_C0.6860.63
114_Y207_H0.6820.62
143_L176_L0.6810.62
122_L192_S0.6800.62
72_G111_Y0.6780.62
79_I169_F0.6770.62
54_S173_A0.6770.62
67_M89_I0.6750.62
123_N189_E0.6740.61
29_E116_K0.6720.61
7_I42_L0.6710.61
177_A181_F0.6710.61
106_D109_Q0.6680.61
145_G222_P0.6670.61
104_V167_D0.6620.60
109_Q162_F0.6600.60
71_N211_N0.6590.60
7_I25_L0.6580.60
73_L180_R0.6580.60
34_M78_P0.6570.59
92_R215_V0.6560.59
118_K196_G0.6540.59
197_L229_I0.6530.59
14_V22_D0.6500.59
195_D200_A0.6490.59
144_D151_L0.6480.58
17_A98_P0.6480.58
95_P218_K0.6470.58
109_Q113_Q0.6460.58
148_E222_P0.6440.58
28_D41_Q0.6420.58
12_P18_P0.6410.58
26_E87_K0.6380.57
7_I127_N0.6360.57
82_L88_K0.6350.57
112_A116_K0.6310.56
53_R154_C0.6310.56
8_Y99_V0.6300.56
184_D232_M0.6260.56
121_L181_F0.6250.56
159_C212_C0.6240.56
109_Q112_A0.6150.55
28_D38_A0.6110.54
34_M57_E0.6110.54
81_A89_I0.6100.54
193_R218_K0.6080.54
4_E203_V0.6080.54
117_I174_G0.6070.54
138_E141_E0.6060.53
25_L44_E0.6050.53
152_C159_C0.5980.52
224_R227_G0.5970.52
6_S21_Q0.5970.52
43_K59_V0.5950.52
187_D193_R0.5930.52
206_C216_C0.5920.52
112_A233_L0.5900.52
63_D181_F0.5900.52
59_V63_D0.5900.52
139_Q193_R0.5880.51
11_N15_D0.5860.51
165_N226_I0.5780.50
27_A30_G0.5760.50
10_Y18_P0.5760.50
160_P215_V0.5740.50
52_R73_L0.5710.49
167_D224_R0.5710.49
112_A191_D0.5700.49
68_N89_I0.5690.49
37_D52_R0.5690.49
175_L225_A0.5650.48
158_S162_F0.5630.48
146_L183_I0.5630.48
7_I65_L0.5620.48
83_N89_I0.5620.48
190_T195_D0.5610.48
63_D223_T0.5610.48
65_L72_G0.5600.48
137_P169_F0.5580.48
33_M38_A0.5570.48
90_V192_S0.5570.48
55_C75_C0.5570.48
71_N205_R0.5550.47
24_T138_E0.5550.47
178_A196_G0.5540.47
26_E45_K0.5540.47
78_P81_A0.5540.47
55_C60_C0.5540.47
123_N129_P0.5520.47
159_C206_C0.5520.47
60_C75_C0.5520.47
149_C159_C0.5510.47
15_D112_A0.5510.47
172_P175_L0.5500.47
34_M153_A0.5500.47
160_P225_A0.5490.47
58_G76_I0.5490.47
33_M64_G0.5480.46
72_G91_I0.5460.46
161_S164_W0.5450.46
145_G225_A0.5440.46
154_C163_W0.5430.46
58_G150_I0.5410.46
19_R22_D0.5400.45
156_S173_A0.5380.45
160_P177_A0.5380.45
195_D199_D0.5370.45
212_C216_C0.5360.45
57_E151_L0.5350.45
183_I232_M0.5340.45
111_Y177_A0.5310.44
165_N205_R0.5280.44
96_G145_G0.5260.44
67_M74_A0.5260.44
152_C155_C0.5260.44
194_L233_L0.5210.43
176_L229_I0.5200.43
6_S101_R0.5200.43
15_D20_M0.5180.43
5_F88_K0.5170.43
142_K192_S0.5170.43
63_D207_H0.5150.43
169_F208_S0.5140.42
136_M185_S0.5140.42
159_C171_G0.5130.42
110_F170_I0.5130.42
82_L125_G0.5120.42
14_V101_R0.5100.42
163_W211_N0.5090.42
119_P135_Q0.5060.41
9_R21_Q0.5050.41
66_N160_P0.5030.41
87_K196_G0.5020.41
140_R147_Y0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8277 100 0.359 Contact Map
2h88B 1 0.979 100 0.419 Contact Map
2wdqB 1 0.9916 100 0.419 Contact Map
4ysxB 1 0.9832 100 0.421 Contact Map
1kf6B 1 0.9748 100 0.434 Contact Map
2bs2B 1 0.9748 100 0.455 Contact Map
3c8yA 1 0.8613 99.9 0.751 Contact Map
1ffvA 1 0.6471 99.9 0.755 Contact Map
3i9v3 1 0.8193 99.8 0.762 Contact Map
1t3qA 1 0.6681 99.8 0.768 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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