GREMLIN Database
PROA - Gamma-glutamyl phosphate reductase
UniProt: P07004 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10767
Length: 417 (385)
Sequences: 38413 (22879)
Seq/√Len: 1166.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_K324_S5.4061.00
263_K322_I3.2871.00
266_A322_I3.2291.00
236_A272_A3.1901.00
231_E262_N2.8361.00
10_K193_Y2.7831.00
231_E264_N2.7821.00
240_K276_Q2.7651.00
154_A157_A2.7381.00
346_T352_A2.7001.00
38_Q41_I2.6801.00
36_E81_R2.6421.00
270_L320_V2.6191.00
291_L295_Q2.5981.00
31_I159_I2.4251.00
302_V306_A2.3521.00
10_K195_D2.3501.00
354_R358_E2.2731.00
160_Q170_A2.2221.00
39_S74_K2.1831.00
326_L351_N2.1671.00
303_A307_E2.1671.00
227_I242_I2.1051.00
274_S278_A2.0931.00
110_V406_K2.0711.00
34_E165_S2.0591.00
232_S351_N2.0441.00
298_P302_V2.0331.00
337_G383_E2.0331.00
29_E81_R2.0071.00
41_I154_A2.0031.00
109_R400_E1.9591.00
260_L332_H1.9261.00
268_S272_A1.9261.00
109_R403_T1.9251.00
34_E37_A1.9041.00
27_V168_L1.9011.00
326_L354_R1.8641.00
34_E158_V1.8581.00
207_K383_E1.8491.00
7_I193_Y1.8391.00
324_S328_D1.8351.00
260_L329_A1.8241.00
186_E190_M1.8191.00
309_Y321_K1.8191.00
190_M212_Q1.8141.00
208_L211_E1.8071.00
20_S23_E1.8061.00
262_N323_V1.8021.00
360_D382_A1.7851.00
40_E70_P1.7451.00
156_V175_A1.6911.00
247_T277_M1.6901.00
230_D351_N1.6871.00
342_D361_S1.6831.00
328_D331_A1.6681.00
241_V345_L1.6651.00
33_D37_A1.6551.00
266_A270_L1.6551.00
80_V131_S1.6531.00
45_A154_A1.6461.00
259_L318_L1.6431.00
231_E351_N1.6251.00
13_S17_A1.6191.00
272_A275_K1.6161.00
30_K33_D1.5891.00
271_P275_K1.5891.00
23_E26_R1.5781.00
139_A172_A1.5681.00
262_N325_D1.5671.00
260_L323_V1.5631.00
235_I272_A1.5571.00
18_Q358_E1.5571.00
327_D358_E1.5361.00
40_E44_N1.5331.00
276_Q279_E1.5321.00
267_D322_I1.5221.00
239_L272_A1.5161.00
227_I256_V1.5131.00
108_R357_N1.5101.00
242_I269_F1.5001.00
3_E187_M1.4911.00
3_E7_I1.4691.00
38_Q165_S1.4501.00
44_N48_Q1.4481.00
300_K313_F1.4361.00
3_E191_D1.4291.00
261_V269_F1.4261.00
230_D323_V1.4231.00
36_E77_A1.4221.00
210_R386_V1.4161.00
328_D332_H1.4111.00
268_S271_P1.3981.00
302_V305_K1.3901.00
34_E166_C1.3891.00
294_L298_P1.3841.00
196_M218_I1.3831.00
117_V140_V1.3811.00
38_Q154_A1.3771.00
242_I259_L1.3711.00
281_G289_A1.3711.00
86_L89_P1.3711.00
80_V128_D1.3641.00
180_D183_L1.3631.00
356_V408_I1.3321.00
323_V332_H1.3251.00
19_L23_E1.3231.00
13_S139_A1.3221.00
327_D354_R1.3191.00
275_K278_A1.3131.00
33_D81_R1.2991.00
32_A36_E1.2931.00
275_K279_E1.2921.00
265_I268_S1.2921.00
127_V142_L1.2901.00
269_F273_L1.2811.00
397_M400_E1.2731.00
325_D328_D1.2701.00
156_V173_V1.2691.00
230_D355_F1.2691.00
330_I355_F1.2631.00
44_N286_A1.2621.00
208_L212_Q1.2591.00
159_I173_V1.2561.00
291_L294_L1.2561.00
171_G174_Q1.2511.00
267_D271_P1.2501.00
30_K34_E1.2401.00
39_S70_P1.2401.00
270_L274_S1.2401.00
8_A171_G1.2381.00
295_Q299_A1.2371.00
42_I154_A1.2341.00
6_G191_D1.2251.00
297_G315_S1.2251.00
284_L287_D1.2201.00
352_A366_V1.2191.00
228_Y329_A1.2141.00
272_A276_Q1.2081.00
8_A174_Q1.2061.00
47_A285_H1.1981.00
273_L318_L1.1971.00
262_N265_I1.1951.00
31_I158_V1.1941.00
106_E353_Q1.1931.00
234_E347_R1.1881.00
396_P400_E1.1861.00
6_G193_Y1.1851.00
157_A165_S1.1711.00
19_L27_V1.1671.00
112_L196_M1.1651.00
299_A303_A1.1631.00
29_E85_N1.1621.00
342_D364_V1.1611.00
224_V257_E1.1571.00
109_R405_Y1.1541.00
7_I11_Q1.1541.00
117_V198_I1.1491.00
48_Q150_R1.1481.00
153_A177_D1.1461.00
237_E347_R1.1411.00
348_D351_N1.1351.00
243_V276_Q1.1311.00
310_D337_G1.1241.00
205_L208_L1.1211.00
116_G194_I1.1181.00
38_Q158_V1.1171.00
6_G194_I1.1161.00
310_D335_E1.1131.00
31_I80_V1.1111.00
287_D290_A1.1011.00
330_I358_E1.1001.00
44_N54_R1.0971.00
187_M191_D1.0961.00
122_R252_T1.0941.00
327_D331_A1.0921.00
14_Y331_A1.0921.00
234_E237_E1.0921.00
232_S348_D1.0881.00
228_Y355_F1.0881.00
146_K180_D1.0821.00
210_R217_V1.0801.00
130_A173_V1.0751.00
204_G208_L1.0731.00
326_L355_F1.0711.00
146_K182_A1.0701.00
31_I168_L1.0691.00
54_R70_P1.0691.00
93_V396_P1.0671.00
21_S25_N1.0561.00
42_I158_V1.0551.00
227_I345_L1.0551.00
12_A139_A1.0531.00
397_M405_Y1.0501.00
305_K308_E1.0491.00
106_E410_I1.0431.00
228_Y333_I1.0421.00
245_A256_V1.0391.00
330_I334_R1.0371.00
230_D262_N1.0311.00
207_K211_E1.0301.00
36_E74_K1.0251.00
108_R408_I1.0251.00
323_V329_A1.0211.00
300_K303_A1.0131.00
283_T290_A1.0121.00
112_L216_P1.0111.00
93_V397_M1.0111.00
379_G388_T1.0051.00
41_I44_N1.0011.00
38_Q157_A0.9991.00
246_K257_E0.9921.00
130_A140_V0.9901.00
388_T404_T0.9871.00
343_A369_S0.9871.00
210_R214_T0.9861.00
14_Y360_D0.9851.00
297_G317_D0.9851.00
235_I239_L0.9821.00
195_D360_D0.9811.00
115_I196_M0.9801.00
153_A175_A0.9791.00
226_H342_D0.9791.00
29_E33_D0.9761.00
114_V194_I0.9761.00
381_G404_T0.9741.00
37_A165_S0.9711.00
114_V139_A0.9661.00
298_P301_V0.9651.00
186_E208_L0.9571.00
14_Y18_Q0.9541.00
47_A69_T0.9531.00
331_A335_E0.9501.00
26_R30_K0.9501.00
303_A306_A0.9501.00
321_K332_H0.9491.00
25_N29_E0.9451.00
216_P404_T0.9451.00
186_E212_Q0.9431.00
36_E39_S0.9421.00
237_E241_V0.9351.00
239_L276_Q0.9311.00
353_Q357_N0.9291.00
232_S346_T0.9291.00
236_A268_S0.9281.00
17_A360_D0.9271.00
329_A332_H0.9251.00
304_V308_E0.9251.00
230_D326_L0.9231.00
202_G205_L0.9211.00
10_K14_Y0.9191.00
16_L172_A0.9141.00
110_V381_G0.9121.00
50_V148_T0.9121.00
238_A242_I0.9121.00
34_E38_Q0.9121.00
153_A157_A0.9061.00
76_I128_D0.9041.00
105_L376_G0.9031.00
9_A174_Q0.9031.00
342_D359_V0.9021.00
267_D270_L0.9021.00
310_D336_H0.9021.00
156_V160_Q0.9001.00
181_R185_S0.8931.00
18_Q357_N0.8921.00
48_Q286_A0.8921.00
225_C257_E0.8901.00
206_H219_T0.8891.00
41_I157_A0.8851.00
266_A320_V0.8841.00
112_L404_T0.8821.00
230_D346_T0.8811.00
29_E84_C0.8791.00
32_A81_R0.8781.00
323_V328_D0.8781.00
229_V269_F0.8741.00
157_A160_Q0.8701.00
116_G197_L0.8691.00
110_V357_N0.8691.00
197_L213_S0.8671.00
112_L138_N0.8671.00
206_H221_G0.8651.00
132_L398_G0.8611.00
210_R213_S0.8581.00
168_L172_A0.8571.00
32_A77_A0.8551.00
349_M353_Q0.8501.00
197_L209_C0.8381.00
297_G313_F0.8381.00
353_Q410_I0.8371.00
344_I355_F0.8371.00
116_G188_L0.8351.00
376_G407_W0.8351.00
349_M352_A0.8331.00
184_V187_M0.8321.00
133_C140_V0.8301.00
361_S364_V0.8281.00
30_K166_C0.8271.00
226_H333_I0.8251.00
295_Q298_P0.8211.00
9_A139_A0.8171.00
52_D72_R0.8171.00
199_P205_L0.8161.00
239_L273_L0.8141.00
127_V130_A0.8131.00
235_I265_I0.8131.00
104_R353_Q0.8121.00
160_Q171_G0.8021.00
142_L152_N0.8011.00
300_K311_D0.8001.00
4_Q8_A0.7981.00
27_V166_C0.7951.00
283_T287_D0.7921.00
147_E292_A0.7911.00
12_A172_A0.7911.00
239_L269_F0.7901.00
238_A269_F0.7901.00
28_L135_K0.7871.00
239_L243_V0.7871.00
11_Q14_Y0.7871.00
144_G177_D0.7861.00
128_D155_T0.7861.00
211_E214_T0.7851.00
154_A158_V0.7851.00
76_I124_N0.7831.00
105_L407_W0.7811.00
299_A302_V0.7811.00
47_A54_R0.7771.00
277_M280_S0.7751.00
138_N403_T0.7741.00
326_L330_I0.7731.00
46_N49_D0.7721.00
11_Q15_K0.7711.00
261_V265_I0.7691.00
35_L76_I0.7681.00
356_V366_V0.7661.00
43_L47_A0.7621.00
182_A186_E0.7611.00
14_Y17_A0.7601.00
33_D36_E0.7551.00
243_V280_S0.7541.00
136_T403_T0.7511.00
349_M410_I0.7491.00
271_P274_S0.7481.00
262_N326_L0.7481.00
4_Q7_I0.7461.00
74_K77_A0.7431.00
298_P305_K0.7431.00
45_A150_R0.7411.00
127_V155_T0.7381.00
332_H335_E0.7361.00
146_K181_R0.7341.00
330_I354_R0.7301.00
54_R286_A0.7281.00
293_Q296_A0.7261.00
43_L54_R0.7251.00
124_N151_T0.7251.00
10_K13_S0.7251.00
229_V238_A0.7241.00
87_A135_K0.7241.00
43_L70_P0.7241.00
213_S217_V0.7231.00
168_L173_V0.7231.00
260_L309_Y0.7231.00
178_N184_V0.7191.00
203_A383_E0.7181.00
274_S277_M0.7171.00
243_V273_L0.7171.00
142_L173_V0.7151.00
237_E240_K0.7151.00
15_K19_L0.7121.00
15_K18_Q0.7081.00
252_T255_T0.7081.00
70_P74_K0.7021.00
203_A207_K0.7011.00
42_I124_N0.7001.00
347_R350_R0.6991.00
284_L290_A0.6971.00
232_S347_R0.6971.00
14_Y358_E0.6921.00
74_K78_D0.6921.00
301_V317_D0.6911.00
189_R212_Q0.6911.00
189_R209_C0.6911.00
183_L186_E0.6881.00
236_A276_Q0.6881.00
127_V152_N0.6881.00
39_S43_L0.6881.00
160_Q165_S0.6841.00
242_I273_L0.6831.00
292_A295_Q0.6831.00
300_K304_V0.6831.00
218_I401_A0.6831.00
185_S189_R0.6821.00
292_A296_A0.6811.00
346_T351_N0.6811.00
216_P401_A0.6781.00
227_I343_A0.6771.00
188_L197_L0.6771.00
352_A356_V0.6761.00
325_D331_A0.6741.00
16_L27_V0.6731.00
29_E88_D0.6731.00
210_R219_T0.6711.00
41_I45_A0.6691.00
141_I174_Q0.6681.00
106_E408_I0.6671.00
112_L195_D0.6671.00
105_L409_G0.6671.00
21_S135_K0.6651.00
35_L77_A0.6641.00
32_A84_C0.6631.00
159_I168_L0.6611.00
17_A111_P0.6601.00
17_A358_E0.6591.00
119_Y127_V0.6581.00
146_K296_A0.6561.00
52_D122_R0.6541.00
5_M176_I0.6511.00
341_S365_Y0.6511.00
360_D381_G0.6461.00
139_A174_Q0.6421.00
44_N47_A0.6411.00
285_H317_D0.6411.00
296_A299_A0.6411.00
304_V313_F0.6401.00
350_R353_Q0.6391.00
16_L134_L0.6381.00
259_L269_F0.6381.00
186_E189_R0.6361.00
17_A110_V0.6341.00
229_V233_V0.6331.00
116_G187_M0.6311.00
343_A370_T0.6301.00
12_A15_K0.6291.00
22_R26_R0.6291.00
46_N151_T0.6291.00
7_I10_K0.6281.00
181_R187_M0.6281.00
236_A240_K0.6281.00
108_R406_K0.6261.00
326_L358_E0.6251.00
3_E193_Y0.6251.00
235_I268_S0.6241.00
330_I359_V0.6241.00
344_I352_A0.6201.00
130_A142_L0.6201.00
23_E27_V0.6191.00
115_I138_N0.6161.00
301_V305_K0.6141.00
273_L277_M0.6131.00
350_R354_R0.6101.00
235_I269_F0.6101.00
304_V307_E0.6091.00
309_Y319_N0.6091.00
119_Y126_T0.6091.00
293_Q297_G0.6081.00
25_N135_K0.6071.00
35_L124_N0.6061.00
69_T72_R0.6061.00
146_K204_G0.6041.00
366_V410_I0.6031.00
400_E403_T0.6031.00
313_F317_D0.6021.00
6_G141_I0.6011.00
90_V399_L0.5971.00
73_L77_A0.5961.00
309_Y332_H0.5951.00
107_R405_Y0.5951.00
136_T399_L0.5951.00
261_V320_V0.5931.00
35_L42_I0.5921.00
364_V406_K0.5911.00
9_A141_I0.5911.00
246_K318_L0.5911.00
31_I34_E0.5901.00
25_N84_C0.5891.00
125_V129_V0.5881.00
400_E405_Y0.5871.00
75_G79_D0.5861.00
8_A170_A0.5841.00
220_G340_H0.5821.00
30_K165_S0.5811.00
124_N155_T0.5791.00
245_A369_S0.5781.00
263_K266_A0.5771.00
47_A286_A0.5771.00
146_K208_L0.5751.00
365_Y368_A0.5751.00
34_E167_G0.5751.00
196_M401_A0.5731.00
45_A48_Q0.5721.00
227_I259_L0.5721.00
8_A11_Q0.5711.00
259_L320_V0.5681.00
32_A74_K0.5671.00
35_L155_T0.5661.00
103_L368_A0.5651.00
248_Q252_T0.5651.00
247_T280_S0.5641.00
46_N72_R0.5631.00
198_I402_L0.5621.00
5_M174_Q0.5611.00
121_A314_L0.5601.00
333_I359_V0.5591.00
144_G152_N0.5591.00
116_G185_S0.5551.00
129_V394_R0.5541.00
114_V195_D0.5541.00
363_A378_F0.5531.00
250_P316_L0.5521.00
70_P288_A0.5521.00
217_V386_V0.5511.00
363_A372_F0.5501.00
189_R197_L0.5501.00
344_I366_V0.5501.00
150_R153_A0.5491.00
286_A290_A0.5481.00
155_T159_I0.5481.00
10_K114_V0.5461.00
231_E323_V0.5451.00
26_R29_E0.5441.00
27_V167_G0.5441.00
360_D404_T0.5441.00
237_E345_L0.5441.00
9_A114_V0.5431.00
27_V31_I0.5401.00
90_V403_T0.5391.00
50_V248_Q0.5371.00
273_L320_V0.5371.00
233_V238_A0.5341.00
94_I107_R0.5341.00
3_E6_G0.5341.00
182_A208_L0.5341.00
178_N185_S0.5341.00
329_A333_I0.5321.00
225_C341_S0.5321.00
46_N50_V0.5311.00
30_K167_G0.5301.00
204_G292_A0.5271.00
256_V343_A0.5271.00
253_C312_E0.5261.00
236_A275_K0.5261.00
117_V130_A0.5261.00
355_F359_V0.5241.00
183_L187_M0.5221.00
14_Y334_R0.5211.00
160_Q167_G0.5211.00
386_V404_T0.5191.00
53_A67_A0.5191.00
54_R67_A0.5191.00
265_I269_F0.5181.00
73_L76_I0.5171.00
43_L73_L0.5171.00
313_F319_N0.5151.00
294_L301_V0.5151.00
116_G141_I0.5151.00
271_P278_A0.5141.00
118_I209_C0.5141.00
110_V360_D0.5131.00
83_V132_L0.5131.00
85_N88_D0.5131.00
203_A222_I0.5131.00
235_I238_A0.5121.00
148_T152_N0.5111.00
26_R81_R0.5111.00
35_L80_V0.5111.00
39_S77_A0.5101.00
245_A255_T0.5101.00
115_I140_V0.5091.00
257_E319_N0.5051.00
261_V266_A0.5051.00
115_I198_I0.5051.00
83_V131_S0.5021.00
296_A300_K0.5021.00
134_L173_V0.5021.00
246_K259_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ek1A 5 0.94 100 0.095 Contact Map
1a4sA 4 0.9424 100 0.096 Contact Map
4pz2A 4 0.9448 100 0.099 Contact Map
4pxlA 4 0.9448 100 0.1 Contact Map
4qf6A 4 0.9353 100 0.101 Contact Map
4wj9A 4 0.9448 100 0.102 Contact Map
2d4eA 4 0.9448 100 0.102 Contact Map
4yweA 5 0.9329 100 0.103 Contact Map
4o5hA 4 0.94 100 0.103 Contact Map
3prlA 4 0.9472 100 0.104 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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