GREMLIN Database
PLDB - Lysophospholipase L2
UniProt: P07000 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10739
Length: 340 (273)
Sequences: 34467 (29192)
Seq/√Len: 1766.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_R83_D5.0161.00
134_Y158_A4.7721.00
90_R116_D4.3231.00
268_E301_K3.2451.00
73_L319_L3.1901.00
300_I321_A2.9281.00
298_L321_A2.9271.00
118_A148_F2.9251.00
263_L325_F2.6661.00
132_K157_D2.6651.00
134_Y157_D2.6291.00
42_P96_G2.5141.00
80_L323_V2.4741.00
311_K317_V2.4641.00
163_A270_E2.4461.00
46_V67_Y2.4071.00
121_W133_R2.2381.00
282_C295_G2.2141.00
118_A152_H2.2011.00
162_T318_A2.1991.00
148_F152_H2.1711.00
118_A122_Q2.1351.00
122_Q155_V2.1181.00
44_R94_R2.0861.00
268_E299_V2.0791.00
45_F120_F2.0691.00
142_G164_P2.0351.00
296_R328_R2.0151.00
135_I145_S1.9801.00
76_D319_L1.9691.00
118_A155_V1.9691.00
149_L159_I1.9291.00
134_Y326_F1.8941.00
275_N299_V1.8731.00
60_C117_L1.8481.00
303_A311_K1.8011.00
87_I117_L1.7841.00
61_P92_Q1.7771.00
115_D151_R1.7611.00
145_S159_I1.7181.00
56_V85_L1.7021.00
321_A324_D1.6861.00
44_R67_Y1.6801.00
147_L151_R1.6801.00
47_R85_L1.6771.00
48_F86_I1.6711.00
134_Y160_A1.6381.00
292_V295_G1.6281.00
56_V83_D1.6191.00
38_V119_A1.6091.00
117_L148_F1.6021.00
60_C89_H1.5891.00
89_H144_I1.5681.00
263_L298_L1.5621.00
160_A322_I1.5531.00
56_V126_Q1.5481.00
61_P89_H1.5451.00
111_N151_R1.5141.00
320_H324_D1.5091.00
280_R284_L1.4921.00
49_R83_D1.4871.00
48_F74_A1.4631.00
82_F134_Y1.4541.00
148_F156_C1.4051.00
64_I139_S1.3991.00
60_C145_S1.3961.00
160_A263_L1.3461.00
300_I303_A1.3441.00
65_E69_K1.3381.00
76_D323_V1.3321.00
43_V116_D1.3221.00
279_D283_E1.3131.00
161_L164_P1.3091.00
114_V147_L1.2971.00
59_I136_L1.2911.00
109_R112_D1.2901.00
275_N279_D1.2881.00
41_I90_R1.2861.00
317_V321_A1.2801.00
234_G237_T1.2801.00
59_I84_V1.2761.00
44_R88_D1.2731.00
148_F155_V1.2561.00
147_L150_Q1.2561.00
76_D79_H1.2541.00
55_R82_F1.2541.00
55_R134_Y1.2461.00
74_A86_I1.2361.00
85_L120_F1.2361.00
37_G42_P1.2291.00
296_R321_A1.2271.00
146_T161_L1.2171.00
67_Y86_I1.2141.00
152_H155_V1.2041.00
262_T292_V1.2021.00
50_A83_D1.1851.00
58_V121_W1.1841.00
64_I92_Q1.1791.00
317_V320_H1.1791.00
88_D93_G1.1611.00
43_V95_S1.1591.00
87_I120_F1.1591.00
57_V82_F1.1561.00
82_F326_F1.1491.00
280_R283_E1.1481.00
121_W148_F1.1431.00
36_T42_P1.1391.00
62_G139_S1.1371.00
139_S305_H1.1161.00
76_D316_S1.1031.00
136_L162_T1.0991.00
85_L124_E1.0921.00
266_Q278_H1.0861.00
265_L300_I1.0821.00
69_K308_L1.0781.00
126_Q133_R1.0771.00
218_Y221_N1.0601.00
80_L327_N1.0481.00
136_L322_I1.0361.00
121_W126_Q1.0331.00
312_D316_S1.0321.00
137_A145_S1.0311.00
236_P240_W1.0251.00
223_R226_A1.0181.00
316_S320_H1.0141.00
138_H308_L1.0131.00
82_F327_N1.0111.00
78_F84_V1.0101.00
237_T240_W1.0091.00
120_F124_E1.0081.00
239_H242_R1.0041.00
279_D282_C1.0031.00
39_D119_A0.9951.00
318_A322_I0.9891.00
235_G239_H0.9881.00
220_R224_F0.9861.00
67_Y88_D0.9831.00
279_D299_V0.9781.00
122_Q152_H0.9761.00
268_E302_G0.9731.00
323_V327_N0.9711.00
239_H243_E0.9701.00
238_Y241_V0.9691.00
35_F38_V0.9661.00
55_R132_K0.9641.00
48_F78_F0.9581.00
219_R223_R0.9561.00
192_D196_I0.9541.00
67_Y94_R0.9481.00
254_G257_D0.9471.00
55_R157_D0.9451.00
50_A53_H0.9441.00
221_N224_F0.9431.00
112_D115_D0.9291.00
114_V144_I0.9291.00
263_L296_R0.9271.00
51_Q83_D0.9261.00
178_R182_N0.9261.00
256_G284_L0.9211.00
238_Y242_R0.9201.00
266_Q297_P0.9161.00
133_R156_C0.9141.00
43_V90_R0.9141.00
298_L317_V0.9071.00
266_Q299_V0.8961.00
266_Q275_N0.8941.00
303_A310_E0.8911.00
265_L318_A0.8871.00
241_V244_S0.8871.00
240_W245_I0.8851.00
159_I262_T0.8761.00
75_Y79_H0.8761.00
250_Q254_G0.8681.00
60_C135_I0.8681.00
219_R222_L0.8671.00
184_A188_P0.8671.00
45_F124_E0.8621.00
279_D297_P0.8601.00
193_G196_I0.8571.00
119_A122_Q0.8541.00
41_I96_G0.8511.00
119_A123_Q0.8501.00
135_I156_C0.8501.00
126_Q132_K0.8501.00
58_V117_L0.8471.00
89_H140_M0.8421.00
58_V133_R0.8411.00
265_L321_A0.8411.00
72_E75_Y0.8341.00
296_R324_D0.8281.00
221_N225_Y0.8281.00
181_L185_E0.8271.00
303_A307_I0.8211.00
282_C297_P0.8211.00
236_P239_H0.8191.00
223_R227_D0.8171.00
81_G323_V0.8161.00
57_V84_V0.8121.00
237_T241_V0.8121.00
118_A151_R0.8111.00
235_G238_Y0.8101.00
304_Y310_E0.8091.00
60_C87_I0.8091.00
158_A325_F0.8091.00
138_H306_E0.8071.00
149_L156_C0.8061.00
125_V131_R0.8051.00
88_D94_R0.8011.00
114_V151_R0.7991.00
137_A142_G0.7941.00
220_R223_R0.7931.00
160_A326_F0.7851.00
300_I317_V0.7831.00
240_W243_E0.7821.00
181_L184_A0.7801.00
71_A86_I0.7771.00
46_V71_A0.7751.00
71_A75_Y0.7751.00
136_L160_A0.7751.00
324_D328_R0.7741.00
118_A121_W0.7721.00
224_F227_D0.7711.00
75_Y78_F0.7711.00
182_N185_E0.7691.00
192_D197_G0.7651.00
78_F81_G0.7631.00
133_R155_V0.7631.00
298_L324_D0.7611.00
177_A181_L0.7601.00
74_A84_V0.7551.00
276_R279_D0.7551.00
135_I148_F0.7491.00
234_G241_V0.7491.00
56_V133_R0.7491.00
278_H297_P0.7461.00
259_A293_E0.7461.00
57_V136_L0.7461.00
39_D112_D0.7441.00
156_C260_T0.7391.00
241_V245_I0.7381.00
58_V135_I0.7371.00
139_S306_E0.7331.00
55_R158_A0.7291.00
235_G240_W0.7291.00
113_Y140_M0.7261.00
76_D80_L0.7261.00
224_F228_D0.7241.00
269_E302_G0.7231.00
180_I184_A0.7221.00
53_H56_V0.7221.00
138_H163_A0.7221.00
180_I183_W0.7211.00
234_G240_W0.7191.00
185_E188_P0.7181.00
89_H113_Y0.7161.00
58_V87_I0.7161.00
115_D119_A0.7141.00
56_V82_F0.7121.00
65_E309_F0.7071.00
178_R181_L0.7051.00
162_T308_L0.7041.00
300_I311_K0.7021.00
179_Q182_N0.7001.00
236_P241_V0.6981.00
206_F211_L0.6971.00
59_I70_Y0.6971.00
162_T307_I0.6961.00
59_I86_I0.6951.00
267_A307_I0.6941.00
222_L225_Y0.6911.00
211_L214_S0.6911.00
115_D118_A0.6911.00
228_D232_R0.6901.00
176_M179_Q0.6861.00
249_E253_A0.6861.00
193_G197_G0.6851.00
64_I140_M0.6841.00
240_W244_S0.6791.00
250_Q253_A0.6791.00
214_S217_R0.6751.00
111_N147_L0.6721.00
158_A326_F0.6701.00
182_N186_A0.6661.00
311_K316_S0.6641.00
82_F323_V0.6631.00
163_A266_Q0.6631.00
61_P87_I0.6581.00
146_T166_F0.6561.00
302_G311_K0.6551.00
63_R140_M0.6551.00
225_Y229_P0.6541.00
191_R197_G0.6511.00
147_L254_G0.6501.00
251_V254_G0.6491.00
158_A261_P0.6461.00
319_L323_V0.6461.00
67_Y87_I0.6451.00
149_L260_T0.6411.00
111_N115_D0.6401.00
208_I212_T0.6391.00
68_V71_A0.6391.00
229_P232_R0.6371.00
222_L226_A0.6341.00
74_A78_F0.6341.00
107_V112_D0.6341.00
208_I211_L0.6341.00
163_A267_A0.6321.00
191_R194_Y0.6301.00
243_E246_L0.6261.00
195_A198_T0.6251.00
137_A141_G0.6221.00
150_Q257_D0.6151.00
57_V134_Y0.6121.00
212_T215_R0.6101.00
185_E189_R0.6101.00
178_R184_A0.6081.00
89_H92_Q0.6071.00
88_D95_S0.6011.00
143_A165_M0.6001.00
70_Y73_L0.6001.00
234_G238_Y0.5991.00
242_R245_I0.5981.00
184_A190_F0.5971.00
57_V326_F0.5961.00
120_F123_Q0.5951.00
44_R95_S0.5931.00
175_F179_Q0.5901.00
194_Y197_G0.5891.00
207_A210_V0.5891.00
81_G84_V0.5881.00
179_Q183_W0.5881.00
59_I77_L0.5841.00
204_L207_A0.5831.00
72_E319_L0.5831.00
37_G119_A0.5821.00
180_I185_E0.5821.00
235_G241_V0.5801.00
264_L295_G0.5791.00
186_A189_R0.5761.00
133_R157_D0.5741.00
183_W187_H0.5741.00
266_Q273_V0.5731.00
47_R50_A0.5721.00
89_H117_L0.5711.00
228_D231_I0.5701.00
207_A211_L0.5701.00
237_T243_E0.5691.00
268_E275_N0.5681.00
160_A265_L0.5621.00
191_R195_A0.5611.00
276_R280_R0.5601.00
190_F193_G0.5591.00
179_Q187_H0.5581.00
176_M182_N0.5571.00
57_V77_L0.5571.00
49_R53_H0.5561.00
236_P243_E0.5561.00
159_I260_T0.5531.00
131_R155_V0.5501.00
236_P244_S0.5461.00
187_H190_F0.5451.00
270_E305_H0.5451.00
46_V68_V0.5441.00
182_N188_P0.5431.00
264_L297_P0.5421.00
62_G138_H0.5421.00
202_R205_P0.5401.00
175_F178_R0.5391.00
217_R221_N0.5391.00
114_V148_F0.5391.00
177_A180_I0.5351.00
306_E309_F0.5341.00
121_W155_V0.5331.00
142_G163_A0.5321.00
277_M280_R0.5321.00
126_Q131_R0.5311.00
320_H323_V0.5281.00
237_T244_S0.5271.00
146_T164_P0.5271.00
217_R220_R0.5261.00
180_I188_P0.5251.00
229_P233_V0.5231.00
186_A190_F0.5231.00
114_V118_A0.5201.00
237_T242_R0.5191.00
113_Y144_I0.5181.00
121_W156_C0.5171.00
160_A325_F0.5171.00
39_D116_D0.5171.00
255_A258_D0.5161.00
192_D195_A0.5151.00
238_Y244_S0.5151.00
63_R92_Q0.5131.00
278_H282_C0.5131.00
206_F209_N0.5121.00
68_V94_R0.5121.00
163_A307_I0.5111.00
194_Y198_T0.5101.00
176_M180_I0.5091.00
209_N213_H0.5071.00
138_H162_T0.5071.00
188_P192_D0.5071.00
188_P191_R0.5061.00
60_C144_I0.5051.00
184_A187_H0.5041.00
79_H323_V0.5041.00
140_M144_I0.5041.00
73_L76_D0.5011.00
234_G239_H0.5001.00
104_L107_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3om8A 4 0.7735 100 0.321 Contact Map
1zoiA 3 0.7971 100 0.325 Contact Map
3oosA 1 0.7912 100 0.329 Contact Map
4psuA 1 0.8294 100 0.333 Contact Map
2pujA 4 0.8088 100 0.333 Contact Map
1ehyA 1 0.7941 100 0.335 Contact Map
4inzA 1 0.7853 100 0.337 Contact Map
2wueA 4 0.7971 100 0.338 Contact Map
2xuaA 2 0.7618 100 0.338 Contact Map
1q0rA 1 0.8176 100 0.34 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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