OMPC - ECOLI - GREMLIN Contacts

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OMPC - Outer membrane protein C

UniProt:	P06996	Sequences: MKVKVLSLLVPALLVAGAANAAEVYNKDGNKLDLYGKVDGLHYFSDNKDVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNSAENENNSWTRVAFAGLKFQDVGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYGSDNFMQQRGNGFATYRNTDFFGLVDGLNFAVQYQGKNGNPSGEGFTSGVTNNGRDALRQNGDGVGGSITYDYEGFGIGGAISSSKRTDAQNTAAYIGNGDRAETYTGGLKYDANNIYLAAQYTQTYNATRVGSLGWANKAQNFEAVAQYQFDFGLRPSLAYLQSKGKNLGRGYDDEDILKYVDVGATYYFNKNMSTYVDYKINLLDDNQFTRDAGINTDNIVALGLVYQF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10670
Length:	367 (321)
Sequences:	5575 (3998)
Seq/√Len:	223.2

ECOLI - OMPC YEDS OMPN NMPC PHOE OMPF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_Y	60_G	3.829	1.00
292_L	323_A	3.649	1.00
63_G	75_G	3.475	1.00
72_T	102_K	3.414	1.00
298_Y	317_K	3.357	1.00
76_Q	98_F	3.233	1.00
64_E	72_T	3.187	1.00
74_Y	100_G	3.095	1.00
253_I	286_Y	2.877	1.00
154_N	166_F	2.862	1.00
337_Y	357_N	2.707	1.00
216_G	242_Y	2.565	1.00
38_V	83_G	2.497	1.00
120_D	151_T	2.414	1.00
292_L	325_Y	2.406	1.00
259_Y	278_Q	2.389	1.00
152_Y	155_T	2.389	1.00
293_R	326_Y	2.366	1.00
40_G	83_G	2.352	1.00
261_Q	278_Q	2.346	1.00
220_S	240_E	2.344	1.00
300_Q	317_K	2.320	1.00
74_Y	108_S	2.305	1.00
62_K	76_Q	2.295	1.00
327_F	333_T	2.249	1.00
168_V	203_G	2.235	1.00
117_V	169_Q	2.230	1.00
324_T	332_S	2.188	1.00
214_I	246_L	2.186	1.00
74_Y	110_D	2.163	1.00
16_A	20_N	2.134	1.00
166_F	205_I	2.122	1.00
332_S	364_V	2.102	1.00
34_L	61_F	2.086	1.00
288_F	294_P	2.042	1.00
149_F	169_Q	1.984	1.00
102_K	108_S	1.973	1.00
96_V	115_Y	1.939	1.00
117_V	167_A	1.928	1.00
71_L	101_L	1.919	1.00
113_R	147_N	1.912	1.00
35_Y	78_E	1.903	1.00
160_L	165_N	1.857	1.00
71_L	105_D	1.827	1.00
165_N	206_T	1.801	1.00
154_N	161_V	1.796	1.00
84_N	174_N	1.790	1.00
250_A	255_L	1.776	1.00
216_G	244_G	1.773	1.00
35_Y	76_Q	1.770	1.00
37_K	58_R	1.739	1.00
218_I	242_Y	1.701	1.00
111_Y	150_A	1.682	1.00
331_M	365_Y	1.677	1.00
333_T	363_L	1.676	1.00
79_Y	92_S	1.659	1.00
220_S	238_R	1.654	1.00
341_L	355_T	1.648	1.00
109_F	150_A	1.643	1.00
155_T	161_V	1.617	1.00
39_D	334_Y	1.612	1.00
212_F	248_Y	1.606	1.00
74_Y	102_K	1.581	1.00
58_R	78_E	1.576	1.00
67_V	73_G	1.568	1.00
252_N	286_Y	1.564	1.00
91_N	147_N	1.553	1.00
153_R	167_A	1.548	1.00
35_Y	62_K	1.543	1.00
80_Q	95_R	1.535	1.00
294_P	323_A	1.527	1.00
285_Q	293_R	1.504	1.00
332_S	366_Q	1.487	1.00
246_L	257_A	1.487	1.00
288_F	292_L	1.475	1.00
256_A	283_V	1.466	1.00
330_N	365_Y	1.443	1.00
58_R	95_R	1.424	1.00
66_Q	70_Q	1.419	1.00
247_K	256_A	1.418	1.00
110_D	151_T	1.396	1.00
339_I	355_T	1.389	1.00
110_D	153_R	1.384	1.00
255_L	284_A	1.384	1.00
78_E	95_R	1.359	1.00
214_I	244_G	1.342	1.00
34_L	59_L	1.339	1.00
107_G	152_Y	1.330	1.00
106_V	152_Y	1.324	1.00
59_L	79_Y	1.322	1.00
74_Y	98_F	1.321	1.00
72_T	104_Q	1.318	1.00
110_D	114_N	1.313	1.00
125_T	213_G	1.308	1.00
121_V	215_G	1.299	1.00
339_I	357_N	1.292	1.00
82_Q	87_E	1.275	1.00
258_Q	281_E	1.269	1.00
114_N	149_F	1.267	1.00
150_A	172_G	1.263	1.00
10_V	14_L	1.260	1.00
146_G	200_G	1.258	1.00
302_K	315_I	1.249	1.00
65_T	328_N	1.246	1.00
208_D	213_G	1.243	1.00
253_I	284_A	1.240	1.00
55_T	364_V	1.232	1.00
300_Q	315_I	1.229	1.00
253_I	257_A	1.227	1.00
76_Q	96_V	1.221	1.00
171_Q	200_G	1.212	1.00
298_Y	319_V	1.206	1.00
242_Y	261_Q	1.203	1.00
96_V	114_N	1.203	1.00
212_F	246_L	1.201	1.00
297_A	320_D	1.200	1.00
247_K	254_Y	1.195	1.00
170_Y	201_V	1.195	1.00
287_Q	293_R	1.192	1.00
289_D	292_L	1.191	1.00
284_A	296_L	1.190	1.00
218_I	240_E	1.188	1.00
249_D	252_N	1.184	1.00
257_A	280_F	1.183	1.00
106_V	109_F	1.183	1.00
41_L	53_D	1.181	1.00
71_L	106_V	1.177	1.00
211_G	248_Y	1.174	1.00
154_N	163_G	1.167	1.00
91_N	94_T	1.160	1.00
149_F	171_Q	1.159	1.00
43_Y	360_A	1.144	1.00
169_Q	202_G	1.137	1.00
11_P	14_L	1.134	1.00
66_Q	72_T	1.123	1.00
73_G	99_A	1.122	1.00
261_Q	276_K	1.120	1.00
95_R	145_R	1.114	1.00
296_L	319_V	1.111	1.00
64_E	74_Y	1.110	1.00
295_S	322_G	1.106	1.00
118_V	217_A	1.105	1.00
37_K	366_Q	1.105	1.00
98_F	110_D	1.097	1.00
335_V	361_L	1.093	1.00
71_L	104_Q	1.065	1.00
9_L	12_A	1.061	1.00
213_G	247_K	1.061	1.00
334_Y	362_G	1.061	1.00
279_N	301_S	1.055	1.00
38_V	81_I	1.055	1.00
257_A	282_A	1.049	1.00
315_I	343_D	1.049	1.00
243_T	260_T	1.048	1.00
335_V	359_V	1.043	1.00
17_G	20_N	1.042	1.00
32_L	75_G	1.037	1.00
89_E	94_T	1.035	1.00
342_L	353_I	1.035	1.00
64_E	102_K	1.033	1.00
249_D	254_Y	1.028	1.00
77_W	97_A	1.024	1.00
73_G	101_L	1.022	1.00
151_T	169_Q	1.022	1.00
4_K	8_L	1.021	1.00
322_G	336_D	1.019	1.00
46_D	357_N	1.018	1.00
86_A	93_W	1.016	1.00
165_N	208_D	1.014	1.00
295_S	324_T	1.012	1.00
77_W	93_W	1.009	1.00
316_L	340_N	1.006	1.00
146_G	149_F	1.006	1.00
70_Q	104_Q	0.997	1.00
41_L	360_A	0.995	1.00
108_S	151_T	0.991	1.00
31_K	64_E	0.989	1.00
168_V	201_V	0.989	1.00
118_V	241_T	0.970	1.00
155_T	160_L	0.964	1.00
65_T	330_N	0.964	1.00
164_L	205_I	0.962	1.00
319_V	339_I	0.962	1.00
249_D	286_Y	0.960	1.00
167_A	204_S	0.958	1.00
58_R	145_R	0.956	1.00
57_M	81_I	0.955	1.00
114_N	151_T	0.954	1.00
40_G	84_N	0.951	1.00
316_L	342_L	0.949	1.00
331_M	363_L	0.944	1.00
283_V	297_A	0.941	1.00
37_K	364_V	0.931	1.00
249_D	287_Q	0.926	1.00
175_G	178_S	0.923	1.00
254_Y	287_Q	0.922	1.00
164_L	209_Y	0.910	0.99
296_L	321_V	0.909	0.99
60_G	78_E	0.907	0.99
288_F	323_A	0.907	0.99
33_D	62_K	0.906	0.99
88_N	94_T	0.905	0.99
168_V	205_I	0.905	0.99
30_N	65_T	0.903	0.99
118_V	243_T	0.902	0.99
116_G	146_G	0.900	0.99
327_F	331_M	0.894	0.99
7_S	10_V	0.893	0.99
215_G	245_G	0.892	0.99
174_N	177_P	0.889	0.99
54_Q	332_S	0.889	0.99
3_V	6_L	0.885	0.99
254_Y	285_Q	0.883	0.99
55_T	332_S	0.882	0.99
82_Q	85_S	0.880	0.99
326_Y	332_S	0.880	0.99
204_S	217_A	0.880	0.99
252_N	287_Q	0.877	0.99
128_L	322_G	0.875	0.99
55_T	366_Q	0.875	0.99
278_Q	304_K	0.873	0.99
14_L	18_A	0.869	0.99
68_T	328_N	0.868	0.99
128_L	297_A	0.866	0.99
320_D	338_K	0.864	0.99
121_V	204_S	0.860	0.99
281_E	299_L	0.858	0.99
337_Y	359_V	0.853	0.99
117_V	204_S	0.850	0.99
102_K	105_D	0.847	0.99
65_T	331_M	0.841	0.99
280_F	302_K	0.839	0.99
171_Q	174_N	0.836	0.99
5_V	8_L	0.836	0.99
128_L	295_S	0.835	0.99
39_D	52_G	0.835	0.99
88_N	91_N	0.833	0.99
151_T	167_A	0.822	0.99
291_G	326_Y	0.820	0.99
239_A	262_T	0.819	0.99
153_R	165_N	0.816	0.99
121_V	206_T	0.815	0.99
127_V	297_A	0.811	0.99
176_N	195_R	0.810	0.99
41_L	55_T	0.808	0.99
4_K	7_S	0.802	0.99
256_A	285_Q	0.801	0.99
342_L	346_Q	0.801	0.99
80_Q	94_T	0.800	0.99
324_T	364_V	0.792	0.98
117_V	217_A	0.792	0.98
121_V	153_R	0.792	0.98
6_L	10_V	0.781	0.98
127_V	285_Q	0.777	0.98
47_N	356_D	0.773	0.98
277_A	301_S	0.767	0.98
15_V	20_N	0.763	0.98
15_V	18_A	0.760	0.98
117_V	202_G	0.758	0.98
98_F	114_N	0.754	0.98
120_D	153_R	0.751	0.98
146_G	169_Q	0.746	0.98
263_Y	276_K	0.744	0.98
127_V	281_E	0.743	0.98
108_S	153_R	0.740	0.98
321_V	337_Y	0.739	0.98
250_A	253_I	0.739	0.98
154_N	168_V	0.738	0.98
278_Q	302_K	0.738	0.98
127_V	283_V	0.737	0.98
315_I	341_L	0.737	0.98
70_Q	105_D	0.737	0.98
59_L	92_S	0.731	0.97
113_R	145_R	0.731	0.97
131_F	134_D	0.727	0.97
279_N	299_L	0.725	0.97
281_E	297_A	0.724	0.97
242_Y	278_Q	0.722	0.97
80_Q	93_W	0.721	0.97
293_R	324_T	0.720	0.97
262_T	277_A	0.719	0.97
259_Y	280_F	0.715	0.97
155_T	163_G	0.712	0.97
126_D	129_P	0.711	0.97
65_T	68_T	0.706	0.97
202_G	219_S	0.705	0.97
148_G	174_N	0.702	0.97
336_D	360_A	0.701	0.97
16_A	19_A	0.700	0.97
66_Q	69_D	0.698	0.97
115_Y	119_Y	0.694	0.97
118_V	202_G	0.692	0.96
290_F	325_Y	0.691	0.96
131_F	135_T	0.690	0.96
124_W	206_T	0.688	0.96
154_N	162_D	0.681	0.96
84_N	148_G	0.677	0.96
29_G	33_D	0.676	0.96
210_E	248_Y	0.674	0.96
285_Q	295_S	0.674	0.96
5_V	9_L	0.673	0.96
116_G	202_G	0.671	0.96
58_R	80_Q	0.664	0.96
361_L	365_Y	0.661	0.95
318_Y	340_N	0.661	0.95
30_N	66_Q	0.660	0.95
45_S	358_I	0.658	0.95
341_L	354_N	0.658	0.95
126_D	136_Y	0.656	0.95
115_Y	145_R	0.655	0.95
59_L	81_I	0.655	0.95
60_G	95_R	0.655	0.95
133_G	136_Y	0.655	0.95
201_V	205_I	0.655	0.95
4_K	11_P	0.655	0.95
166_F	203_G	0.654	0.95
134_D	137_G	0.652	0.95
65_T	73_G	0.650	0.95
303_G	314_D	0.649	0.95
8_L	12_A	0.647	0.95
211_G	250_A	0.646	0.95
173_K	178_S	0.642	0.95
323_A	335_V	0.641	0.95
11_P	16_A	0.640	0.95
126_D	131_F	0.636	0.94
65_T	365_Y	0.635	0.94
46_D	353_I	0.634	0.94
122_T	243_T	0.633	0.94
320_D	336_D	0.632	0.94
287_Q	326_Y	0.631	0.94
79_Y	93_W	0.630	0.94
104_Q	152_Y	0.625	0.94
211_G	249_D	0.622	0.94
170_Y	199_D	0.620	0.94
346_Q	353_I	0.619	0.94
111_Y	114_N	0.617	0.93
239_A	264_N	0.616	0.93
206_T	215_G	0.616	0.93
242_Y	259_Y	0.616	0.93
244_G	259_Y	0.615	0.93
44_F	339_I	0.615	0.93
328_N	331_M	0.612	0.93
51_D	83_G	0.612	0.93
177_P	195_R	0.611	0.93
146_G	171_Q	0.611	0.93
155_T	165_N	0.610	0.93
301_S	316_L	0.608	0.93
8_L	11_P	0.608	0.93
345_N	348_T	0.608	0.93
104_Q	109_F	0.607	0.93
106_V	155_T	0.606	0.93
14_L	17_G	0.606	0.93
126_D	132_G	0.602	0.93
29_G	66_Q	0.602	0.93
276_K	302_K	0.601	0.93
12_A	15_V	0.600	0.92
44_F	359_V	0.598	0.92
196_Q	222_K	0.597	0.92
67_V	70_Q	0.596	0.92
160_L	208_D	0.595	0.92
161_V	165_N	0.592	0.92
125_T	256_A	0.592	0.92
15_V	19_A	0.592	0.92
43_Y	358_I	0.592	0.92
125_T	245_G	0.589	0.92
12_A	20_N	0.588	0.92
80_Q	145_R	0.588	0.92
163_G	207_Y	0.583	0.91
154_N	160_L	0.581	0.91
9_L	15_V	0.580	0.91
44_F	357_N	0.578	0.91
57_M	83_G	0.578	0.91
195_R	199_D	0.578	0.91
99_A	328_N	0.576	0.91
56_Y	80_Q	0.575	0.91
138_S	141_F	0.573	0.91
209_Y	214_I	0.573	0.91
252_N	288_F	0.573	0.91
200_G	221_S	0.571	0.91
286_Y	292_L	0.568	0.90
53_D	360_A	0.568	0.90
264_N	277_A	0.568	0.90
6_L	9_L	0.567	0.90
116_G	219_S	0.566	0.90
67_V	331_M	0.566	0.90
35_Y	95_R	0.564	0.90
41_L	334_Y	0.561	0.90
107_G	155_T	0.561	0.90
40_G	44_F	0.559	0.90
205_I	216_G	0.558	0.89
324_T	366_Q	0.557	0.89
319_V	341_L	0.557	0.89
178_S	195_R	0.557	0.89
221_S	239_A	0.556	0.89
85_S	93_W	0.555	0.89
316_L	348_T	0.555	0.89
299_L	318_Y	0.555	0.89
53_D	56_Y	0.555	0.89
105_D	109_F	0.553	0.89
199_D	222_K	0.552	0.89
348_T	353_I	0.551	0.89
255_L	282_A	0.547	0.89
58_R	96_V	0.547	0.89
265_A	274_A	0.547	0.89
174_N	178_S	0.546	0.88
209_Y	246_L	0.546	0.88
2_K	5_V	0.545	0.88
319_V	355_T	0.545	0.88
128_L	134_D	0.544	0.88
121_V	167_A	0.543	0.88
276_K	304_K	0.543	0.88
176_N	196_Q	0.543	0.88
32_L	65_T	0.542	0.88
209_Y	216_G	0.539	0.88
56_Y	115_Y	0.538	0.88
258_Q	283_V	0.538	0.88
100_G	110_D	0.538	0.88
305_N	314_D	0.537	0.88
269_G	275_N	0.537	0.88
41_L	362_G	0.534	0.87
152_Y	161_V	0.533	0.87
339_I	359_V	0.532	0.87
292_L	296_L	0.531	0.87
317_K	343_D	0.530	0.87
162_D	209_Y	0.530	0.87
321_V	335_V	0.528	0.87
117_V	120_D	0.528	0.87
222_K	238_R	0.526	0.87
132_G	135_T	0.526	0.87
133_G	137_G	0.525	0.86
200_G	219_S	0.525	0.86
290_F	294_P	0.525	0.86
122_T	258_Q	0.524	0.86
101_L	104_Q	0.522	0.86
164_L	207_Y	0.522	0.86
32_L	63_G	0.522	0.86
318_Y	338_K	0.522	0.86
140_N	143_Q	0.520	0.86
3_V	7_S	0.520	0.86
119_Y	142_M	0.519	0.86
175_G	197_N	0.519	0.86
43_Y	338_K	0.518	0.86
125_T	131_F	0.518	0.86
6_L	12_A	0.518	0.86
160_L	164_L	0.517	0.86
143_Q	219_S	0.517	0.86
65_T	75_G	0.517	0.86
342_L	345_N	0.516	0.86
92_S	97_A	0.516	0.86
56_Y	130_E	0.516	0.86
173_K	177_P	0.516	0.86
29_G	32_L	0.516	0.86
72_T	108_S	0.514	0.85
169_Q	200_G	0.514	0.85
65_T	70_Q	0.514	0.85
12_A	17_G	0.513	0.85
100_G	108_S	0.513	0.85
233_I	268_V	0.513	0.85
120_D	167_A	0.513	0.85
52_G	57_M	0.511	0.85
42_H	52_G	0.511	0.85
5_V	14_L	0.511	0.85
209_Y	212_F	0.510	0.85
322_G	360_A	0.509	0.85
154_N	164_L	0.508	0.85
10_V	105_D	0.508	0.85
75_G	93_W	0.508	0.85
280_F	284_A	0.508	0.85
5_V	12_A	0.507	0.85
135_T	144_Q	0.505	0.84
31_K	34_L	0.505	0.84
338_K	358_I	0.505	0.84
77_W	86_A	0.505	0.84
136_Y	143_Q	0.504	0.84
280_F	300_Q	0.503	0.84
317_K	341_L	0.503	0.84
132_G	136_Y	0.502	0.84
213_G	249_D	0.502	0.84
260_T	279_N	0.501	0.84
263_Y	278_Q	0.501	0.84
203_G	218_I	0.500	0.84
68_T	329_K	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j1nA	3	0.9319	100	0.255	Contact Map
3nsgA	3	0.8883	100	0.269	Contact Map
1phoA	3	0.8774	100	0.276	Contact Map
2zfgA	3	0.8774	100	0.285	Contact Map
2fgqX	3	0.8256	100	0.311	Contact Map
3vy8X	3	0.8529	100	0.33	Contact Map
3wi5A	3	0.812	100	0.361	Contact Map
2porA	3	0.7657	100	0.394	Contact Map
3prnA	3	0.7357	100	0.412	Contact Map
2o4vA	3	0.8801	99.5	0.76	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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