GREMLIN Database
OMPC - Outer membrane protein C
UniProt: P06996 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10670
Length: 367 (321)
Sequences: 5575 (3998)
Seq/√Len: 223.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y60_G3.8291.00
292_L323_A3.6491.00
63_G75_G3.4751.00
72_T102_K3.4141.00
298_Y317_K3.3571.00
76_Q98_F3.2331.00
64_E72_T3.1871.00
74_Y100_G3.0951.00
253_I286_Y2.8771.00
154_N166_F2.8621.00
337_Y357_N2.7071.00
216_G242_Y2.5651.00
38_V83_G2.4971.00
120_D151_T2.4141.00
292_L325_Y2.4061.00
259_Y278_Q2.3891.00
152_Y155_T2.3891.00
293_R326_Y2.3661.00
40_G83_G2.3521.00
261_Q278_Q2.3461.00
220_S240_E2.3441.00
300_Q317_K2.3201.00
74_Y108_S2.3051.00
62_K76_Q2.2951.00
327_F333_T2.2491.00
168_V203_G2.2351.00
117_V169_Q2.2301.00
324_T332_S2.1881.00
214_I246_L2.1861.00
74_Y110_D2.1631.00
16_A20_N2.1341.00
166_F205_I2.1221.00
332_S364_V2.1021.00
34_L61_F2.0861.00
288_F294_P2.0421.00
149_F169_Q1.9841.00
102_K108_S1.9731.00
96_V115_Y1.9391.00
117_V167_A1.9281.00
71_L101_L1.9191.00
113_R147_N1.9121.00
35_Y78_E1.9031.00
160_L165_N1.8571.00
71_L105_D1.8271.00
165_N206_T1.8011.00
154_N161_V1.7961.00
84_N174_N1.7901.00
250_A255_L1.7761.00
216_G244_G1.7731.00
35_Y76_Q1.7701.00
37_K58_R1.7391.00
218_I242_Y1.7011.00
111_Y150_A1.6821.00
331_M365_Y1.6771.00
333_T363_L1.6761.00
79_Y92_S1.6591.00
220_S238_R1.6541.00
341_L355_T1.6481.00
109_F150_A1.6431.00
155_T161_V1.6171.00
39_D334_Y1.6121.00
212_F248_Y1.6061.00
74_Y102_K1.5811.00
58_R78_E1.5761.00
67_V73_G1.5681.00
252_N286_Y1.5641.00
91_N147_N1.5531.00
153_R167_A1.5481.00
35_Y62_K1.5431.00
80_Q95_R1.5351.00
294_P323_A1.5271.00
285_Q293_R1.5041.00
332_S366_Q1.4871.00
246_L257_A1.4871.00
288_F292_L1.4751.00
256_A283_V1.4661.00
330_N365_Y1.4431.00
58_R95_R1.4241.00
66_Q70_Q1.4191.00
247_K256_A1.4181.00
110_D151_T1.3961.00
339_I355_T1.3891.00
110_D153_R1.3841.00
255_L284_A1.3841.00
78_E95_R1.3591.00
214_I244_G1.3421.00
34_L59_L1.3391.00
107_G152_Y1.3301.00
106_V152_Y1.3241.00
59_L79_Y1.3221.00
74_Y98_F1.3211.00
72_T104_Q1.3181.00
110_D114_N1.3131.00
125_T213_G1.3081.00
121_V215_G1.2991.00
339_I357_N1.2921.00
82_Q87_E1.2751.00
258_Q281_E1.2691.00
114_N149_F1.2671.00
150_A172_G1.2631.00
10_V14_L1.2601.00
146_G200_G1.2581.00
302_K315_I1.2491.00
65_T328_N1.2461.00
208_D213_G1.2431.00
253_I284_A1.2401.00
55_T364_V1.2321.00
300_Q315_I1.2291.00
253_I257_A1.2271.00
76_Q96_V1.2211.00
171_Q200_G1.2121.00
298_Y319_V1.2061.00
242_Y261_Q1.2031.00
96_V114_N1.2031.00
212_F246_L1.2011.00
297_A320_D1.2001.00
247_K254_Y1.1951.00
170_Y201_V1.1951.00
287_Q293_R1.1921.00
289_D292_L1.1911.00
284_A296_L1.1901.00
218_I240_E1.1881.00
249_D252_N1.1841.00
257_A280_F1.1831.00
106_V109_F1.1831.00
41_L53_D1.1811.00
71_L106_V1.1771.00
211_G248_Y1.1741.00
154_N163_G1.1671.00
91_N94_T1.1601.00
149_F171_Q1.1591.00
43_Y360_A1.1441.00
169_Q202_G1.1371.00
11_P14_L1.1341.00
66_Q72_T1.1231.00
73_G99_A1.1221.00
261_Q276_K1.1201.00
95_R145_R1.1141.00
296_L319_V1.1111.00
64_E74_Y1.1101.00
295_S322_G1.1061.00
118_V217_A1.1051.00
37_K366_Q1.1051.00
98_F110_D1.0971.00
335_V361_L1.0931.00
71_L104_Q1.0651.00
9_L12_A1.0611.00
213_G247_K1.0611.00
334_Y362_G1.0611.00
279_N301_S1.0551.00
38_V81_I1.0551.00
257_A282_A1.0491.00
315_I343_D1.0491.00
243_T260_T1.0481.00
335_V359_V1.0431.00
17_G20_N1.0421.00
32_L75_G1.0371.00
89_E94_T1.0351.00
342_L353_I1.0351.00
64_E102_K1.0331.00
249_D254_Y1.0281.00
77_W97_A1.0241.00
73_G101_L1.0221.00
151_T169_Q1.0221.00
4_K8_L1.0211.00
322_G336_D1.0191.00
46_D357_N1.0181.00
86_A93_W1.0161.00
165_N208_D1.0141.00
295_S324_T1.0121.00
77_W93_W1.0091.00
316_L340_N1.0061.00
146_G149_F1.0061.00
70_Q104_Q0.9971.00
41_L360_A0.9951.00
108_S151_T0.9911.00
31_K64_E0.9891.00
168_V201_V0.9891.00
118_V241_T0.9701.00
155_T160_L0.9641.00
65_T330_N0.9641.00
164_L205_I0.9621.00
319_V339_I0.9621.00
249_D286_Y0.9601.00
167_A204_S0.9581.00
58_R145_R0.9561.00
57_M81_I0.9551.00
114_N151_T0.9541.00
40_G84_N0.9511.00
316_L342_L0.9491.00
331_M363_L0.9441.00
283_V297_A0.9411.00
37_K364_V0.9311.00
249_D287_Q0.9261.00
175_G178_S0.9231.00
254_Y287_Q0.9221.00
164_L209_Y0.9100.99
296_L321_V0.9090.99
60_G78_E0.9070.99
288_F323_A0.9070.99
33_D62_K0.9060.99
88_N94_T0.9050.99
168_V205_I0.9050.99
30_N65_T0.9030.99
118_V243_T0.9020.99
116_G146_G0.9000.99
327_F331_M0.8940.99
7_S10_V0.8930.99
215_G245_G0.8920.99
174_N177_P0.8890.99
54_Q332_S0.8890.99
3_V6_L0.8850.99
254_Y285_Q0.8830.99
55_T332_S0.8820.99
82_Q85_S0.8800.99
326_Y332_S0.8800.99
204_S217_A0.8800.99
252_N287_Q0.8770.99
128_L322_G0.8750.99
55_T366_Q0.8750.99
278_Q304_K0.8730.99
14_L18_A0.8690.99
68_T328_N0.8680.99
128_L297_A0.8660.99
320_D338_K0.8640.99
121_V204_S0.8600.99
281_E299_L0.8580.99
337_Y359_V0.8530.99
117_V204_S0.8500.99
102_K105_D0.8470.99
65_T331_M0.8410.99
280_F302_K0.8390.99
171_Q174_N0.8360.99
5_V8_L0.8360.99
128_L295_S0.8350.99
39_D52_G0.8350.99
88_N91_N0.8330.99
151_T167_A0.8220.99
291_G326_Y0.8200.99
239_A262_T0.8190.99
153_R165_N0.8160.99
121_V206_T0.8150.99
127_V297_A0.8110.99
176_N195_R0.8100.99
41_L55_T0.8080.99
4_K7_S0.8020.99
256_A285_Q0.8010.99
342_L346_Q0.8010.99
80_Q94_T0.8000.99
324_T364_V0.7920.98
117_V217_A0.7920.98
121_V153_R0.7920.98
6_L10_V0.7810.98
127_V285_Q0.7770.98
47_N356_D0.7730.98
277_A301_S0.7670.98
15_V20_N0.7630.98
15_V18_A0.7600.98
117_V202_G0.7580.98
98_F114_N0.7540.98
120_D153_R0.7510.98
146_G169_Q0.7460.98
263_Y276_K0.7440.98
127_V281_E0.7430.98
108_S153_R0.7400.98
321_V337_Y0.7390.98
250_A253_I0.7390.98
154_N168_V0.7380.98
278_Q302_K0.7380.98
127_V283_V0.7370.98
315_I341_L0.7370.98
70_Q105_D0.7370.98
59_L92_S0.7310.97
113_R145_R0.7310.97
131_F134_D0.7270.97
279_N299_L0.7250.97
281_E297_A0.7240.97
242_Y278_Q0.7220.97
80_Q93_W0.7210.97
293_R324_T0.7200.97
262_T277_A0.7190.97
259_Y280_F0.7150.97
155_T163_G0.7120.97
126_D129_P0.7110.97
65_T68_T0.7060.97
202_G219_S0.7050.97
148_G174_N0.7020.97
336_D360_A0.7010.97
16_A19_A0.7000.97
66_Q69_D0.6980.97
115_Y119_Y0.6940.97
118_V202_G0.6920.96
290_F325_Y0.6910.96
131_F135_T0.6900.96
124_W206_T0.6880.96
154_N162_D0.6810.96
84_N148_G0.6770.96
29_G33_D0.6760.96
210_E248_Y0.6740.96
285_Q295_S0.6740.96
5_V9_L0.6730.96
116_G202_G0.6710.96
58_R80_Q0.6640.96
361_L365_Y0.6610.95
318_Y340_N0.6610.95
30_N66_Q0.6600.95
45_S358_I0.6580.95
341_L354_N0.6580.95
126_D136_Y0.6560.95
115_Y145_R0.6550.95
59_L81_I0.6550.95
60_G95_R0.6550.95
133_G136_Y0.6550.95
201_V205_I0.6550.95
4_K11_P0.6550.95
166_F203_G0.6540.95
134_D137_G0.6520.95
65_T73_G0.6500.95
303_G314_D0.6490.95
8_L12_A0.6470.95
211_G250_A0.6460.95
173_K178_S0.6420.95
323_A335_V0.6410.95
11_P16_A0.6400.95
126_D131_F0.6360.94
65_T365_Y0.6350.94
46_D353_I0.6340.94
122_T243_T0.6330.94
320_D336_D0.6320.94
287_Q326_Y0.6310.94
79_Y93_W0.6300.94
104_Q152_Y0.6250.94
211_G249_D0.6220.94
170_Y199_D0.6200.94
346_Q353_I0.6190.94
111_Y114_N0.6170.93
239_A264_N0.6160.93
206_T215_G0.6160.93
242_Y259_Y0.6160.93
244_G259_Y0.6150.93
44_F339_I0.6150.93
328_N331_M0.6120.93
51_D83_G0.6120.93
177_P195_R0.6110.93
146_G171_Q0.6110.93
155_T165_N0.6100.93
301_S316_L0.6080.93
8_L11_P0.6080.93
345_N348_T0.6080.93
104_Q109_F0.6070.93
106_V155_T0.6060.93
14_L17_G0.6060.93
126_D132_G0.6020.93
29_G66_Q0.6020.93
276_K302_K0.6010.93
12_A15_V0.6000.92
44_F359_V0.5980.92
196_Q222_K0.5970.92
67_V70_Q0.5960.92
160_L208_D0.5950.92
161_V165_N0.5920.92
125_T256_A0.5920.92
15_V19_A0.5920.92
43_Y358_I0.5920.92
125_T245_G0.5890.92
12_A20_N0.5880.92
80_Q145_R0.5880.92
163_G207_Y0.5830.91
154_N160_L0.5810.91
9_L15_V0.5800.91
44_F357_N0.5780.91
57_M83_G0.5780.91
195_R199_D0.5780.91
99_A328_N0.5760.91
56_Y80_Q0.5750.91
138_S141_F0.5730.91
209_Y214_I0.5730.91
252_N288_F0.5730.91
200_G221_S0.5710.91
286_Y292_L0.5680.90
53_D360_A0.5680.90
264_N277_A0.5680.90
6_L9_L0.5670.90
116_G219_S0.5660.90
67_V331_M0.5660.90
35_Y95_R0.5640.90
41_L334_Y0.5610.90
107_G155_T0.5610.90
40_G44_F0.5590.90
205_I216_G0.5580.89
324_T366_Q0.5570.89
319_V341_L0.5570.89
178_S195_R0.5570.89
221_S239_A0.5560.89
85_S93_W0.5550.89
316_L348_T0.5550.89
299_L318_Y0.5550.89
53_D56_Y0.5550.89
105_D109_F0.5530.89
199_D222_K0.5520.89
348_T353_I0.5510.89
255_L282_A0.5470.89
58_R96_V0.5470.89
265_A274_A0.5470.89
174_N178_S0.5460.88
209_Y246_L0.5460.88
2_K5_V0.5450.88
319_V355_T0.5450.88
128_L134_D0.5440.88
121_V167_A0.5430.88
276_K304_K0.5430.88
176_N196_Q0.5430.88
32_L65_T0.5420.88
209_Y216_G0.5390.88
56_Y115_Y0.5380.88
258_Q283_V0.5380.88
100_G110_D0.5380.88
305_N314_D0.5370.88
269_G275_N0.5370.88
41_L362_G0.5340.87
152_Y161_V0.5330.87
339_I359_V0.5320.87
292_L296_L0.5310.87
317_K343_D0.5300.87
162_D209_Y0.5300.87
321_V335_V0.5280.87
117_V120_D0.5280.87
222_K238_R0.5260.87
132_G135_T0.5260.87
133_G137_G0.5250.86
200_G219_S0.5250.86
290_F294_P0.5250.86
122_T258_Q0.5240.86
101_L104_Q0.5220.86
164_L207_Y0.5220.86
32_L63_G0.5220.86
318_Y338_K0.5220.86
140_N143_Q0.5200.86
3_V7_S0.5200.86
119_Y142_M0.5190.86
175_G197_N0.5190.86
43_Y338_K0.5180.86
125_T131_F0.5180.86
6_L12_A0.5180.86
160_L164_L0.5170.86
143_Q219_S0.5170.86
65_T75_G0.5170.86
342_L345_N0.5160.86
92_S97_A0.5160.86
56_Y130_E0.5160.86
173_K177_P0.5160.86
29_G32_L0.5160.86
72_T108_S0.5140.85
169_Q200_G0.5140.85
65_T70_Q0.5140.85
12_A17_G0.5130.85
100_G108_S0.5130.85
233_I268_V0.5130.85
120_D167_A0.5130.85
52_G57_M0.5110.85
42_H52_G0.5110.85
5_V14_L0.5110.85
209_Y212_F0.5100.85
322_G360_A0.5090.85
154_N164_L0.5080.85
10_V105_D0.5080.85
75_G93_W0.5080.85
280_F284_A0.5080.85
5_V12_A0.5070.85
135_T144_Q0.5050.84
31_K34_L0.5050.84
338_K358_I0.5050.84
77_W86_A0.5050.84
136_Y143_Q0.5040.84
280_F300_Q0.5030.84
317_K341_L0.5030.84
132_G136_Y0.5020.84
213_G249_D0.5020.84
260_T279_N0.5010.84
263_Y278_Q0.5010.84
203_G218_I0.5000.84
68_T329_K0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j1nA 3 0.9319 100 0.255 Contact Map
3nsgA 3 0.8883 100 0.269 Contact Map
1phoA 3 0.8774 100 0.276 Contact Map
2zfgA 3 0.8774 100 0.285 Contact Map
2fgqX 3 0.8256 100 0.311 Contact Map
3vy8X 3 0.8529 100 0.33 Contact Map
3wi5A 3 0.812 100 0.361 Contact Map
2porA 3 0.7657 100 0.394 Contact Map
3prnA 3 0.7357 100 0.412 Contact Map
2o4vA 3 0.8801 99.5 0.76 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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