GREMLIN Database
MALT - HTH-type transcriptional regulator MalT
UniProt: P06993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10562
Length: 901 (745)
Sequences: 8136 (7387)
Seq/√Len: 270.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
624_D627_N6.8701.00
585_R588_E6.7601.00
665_D668_A6.7141.00
464_N467_E5.8961.00
543_F546_T5.5791.00
703_E706_P5.5041.00
503_E506_R5.3691.00
49_I158_L4.6391.00
424_R427_E4.5951.00
191_A222_L4.4101.00
27_S55_G4.0831.00
344_H363_H3.7191.00
264_D300_E3.5551.00
590_E622_R3.3511.00
130_Y157_V3.3031.00
187_T190_E3.1361.00
743_R746_D3.0551.00
277_L347_A2.8951.00
657_V673_L2.8371.00
26_L52_W2.6901.00
594_R615_L2.6581.00
267_T300_E2.6431.00
552_E576_R2.6281.00
47_T51_Q2.6031.00
188_H209_S2.5801.00
53_A126_V2.5561.00
519_R527_A2.5491.00
548_W552_E2.5211.00
580_L592_S2.5141.00
636_E656_R2.5111.00
128_D158_L2.5071.00
535_S551_Q2.4971.00
590_E594_R2.4921.00
629_R663_T2.4781.00
577_A593_A2.4591.00
389_E392_L2.4391.00
61_W66_E2.4251.00
495_G511_M2.4201.00
267_T301_I2.3631.00
274_S320_Y2.3321.00
660_W672_W2.3141.00
548_W583_W2.3021.00
195_F226_A2.2781.00
580_L585_R2.2601.00
660_W668_A2.2281.00
345_R349_E2.2101.00
619_S631_Q2.1881.00
660_W665_D2.1861.00
538_L550_T2.1771.00
272_L339_E2.1671.00
211_I222_L2.1371.00
580_L588_E2.1121.00
456_A472_A2.0691.00
252_S330_Q2.0621.00
108_L113_F2.0611.00
316_E320_Y2.0581.00
39_S43_Y2.0471.00
37_I49_I2.0081.00
191_A212_C2.0051.00
732_L736_Q1.9631.00
619_S627_N1.9551.00
49_I126_V1.9411.00
531_L550_T1.9331.00
192_K208_S1.9311.00
653_N672_W1.9301.00
381_A397_L1.9271.00
348_A364_A1.9201.00
799_L803_N1.9161.00
20_E190_E1.9111.00
633_N656_R1.9051.00
619_S624_D1.8741.00
559_N569_H1.8731.00
276_I329_R1.8661.00
508_L512_Q1.8601.00
519_R553_K1.8591.00
508_L541_Q1.8581.00
708_E712_E1.8461.00
576_R592_S1.8441.00
467_E470_R1.8271.00
415_Q419_M1.8251.00
23_L51_Q1.7991.00
16_T47_T1.7951.00
597_I615_L1.7871.00
352_M372_M1.7741.00
264_D267_T1.7561.00
491_T510_L1.7211.00
627_N631_Q1.7201.00
275_A329_R1.7091.00
715_N734_L1.7081.00
775_A782_I1.7051.00
429_N433_A1.7041.00
51_Q54_A1.6981.00
573_V592_S1.6811.00
210_R214_D1.6801.00
629_R633_N1.6741.00
798_I802_I1.6701.00
730_N734_L1.6681.00
193_Q197_C1.6571.00
329_R340_L1.6511.00
452_N471_L1.6401.00
190_E193_Q1.6391.00
618_C622_R1.6291.00
268_R272_L1.6261.00
243_L246_I1.6261.00
276_I347_A1.6211.00
587_D622_R1.6181.00
325_G329_R1.6121.00
105_L109_F1.6081.00
473_K494_L1.5921.00
795_A803_N1.5881.00
224_L258_E1.5831.00
408_N412_V1.5781.00
433_A455_R1.5671.00
369_D372_M1.5581.00
159_S163_P1.5561.00
556_Q560_E1.5531.00
38_T178_E1.5511.00
656_R672_W1.5471.00
24_A28_G1.5391.00
596_G611_C1.5321.00
52_W156_V1.5251.00
612_L634_R1.5231.00
798_I805_H1.5201.00
612_L631_Q1.5191.00
615_L619_S1.5141.00
538_L546_T1.5131.00
375_D379_N1.5101.00
559_N595_S1.5081.00
625_L663_T1.5081.00
281_N284_L1.5071.00
188_H212_C1.5021.00
37_I181_S1.5021.00
795_A798_I1.4991.00
802_I805_H1.4971.00
51_Q55_G1.4951.00
629_R660_W1.4891.00
534_Q550_T1.4821.00
235_S240_A1.4751.00
706_P709_I1.4711.00
62_Y66_E1.4641.00
767_F771_G1.4641.00
670_A701_L1.4621.00
135_N138_I1.4621.00
26_L35_A1.4611.00
209_S213_D1.4561.00
41_A160_R1.4541.00
798_I803_N1.4531.00
795_A804_Q1.4471.00
631_Q634_R1.4411.00
144_F148_H1.4391.00
50_S63_S1.4381.00
798_I801_E1.4321.00
25_K177_L1.4291.00
279_S317_W1.4251.00
512_Q534_Q1.4171.00
751_L754_A1.4161.00
242_R245_G1.4131.00
742_G747_A1.4101.00
256_V331_R1.4101.00
753_D757_L1.4071.00
419_M431_L1.4071.00
535_S547_A1.3981.00
588_E592_S1.3971.00
653_N675_H1.3971.00
43_Y219_A1.3941.00
616_I632_L1.3921.00
487_R491_T1.3911.00
538_L543_F1.3871.00
619_S622_R1.3871.00
698_Q706_P1.3811.00
356_F359_E1.3761.00
483_W486_S1.3751.00
362_H366_A1.3751.00
419_M427_E1.3741.00
590_E619_S1.3741.00
634_R637_N1.3671.00
573_V595_S1.3591.00
271_L301_I1.3551.00
626_D663_T1.3521.00
548_W580_L1.3511.00
765_S769_I1.3511.00
712_E734_L1.3501.00
550_T553_K1.3491.00
105_L108_L1.3481.00
270_F289_T1.3471.00
36_L157_V1.3441.00
265_L268_R1.3371.00
627_N630_S1.3361.00
340_L344_H1.3261.00
491_T513_Q1.3251.00
81_A85_A1.3211.00
711_L715_N1.3211.00
274_S280_M1.3201.00
269_H339_E1.3191.00
590_E618_C1.3181.00
671_N675_H1.3081.00
308_L319_C1.2981.00
149_Q153_L1.2981.00
774_M778_L1.2971.00
562_H566_L1.2971.00
494_L510_L1.2941.00
326_N330_Q1.2931.00
371_L375_D1.2931.00
188_H192_K1.2911.00
416_A432_L1.2911.00
795_A802_I1.2901.00
590_E615_L1.2881.00
74_F77_Y1.2871.00
17_V197_C1.2871.00
579_L583_W1.2861.00
36_L159_S1.2841.00
553_K556_Q1.2831.00
732_L735_N1.2811.00
670_A674_R1.2781.00
734_L738_Y1.2771.00
469_E473_K1.2751.00
284_L350_S1.2701.00
306_L324_F1.2691.00
576_R580_L1.2681.00
555_F559_N1.2671.00
224_L227_L1.2661.00
104_S116_L1.2661.00
629_R656_R1.2651.00
280_M318_F1.2651.00
61_W65_D1.2641.00
668_A671_N1.2591.00
615_L631_Q1.2581.00
694_I698_Q1.2581.00
765_S768_V1.2571.00
593_A614_M1.2561.00
674_R678_K1.2531.00
73_R76_S1.2471.00
329_R344_H1.2461.00
415_Q431_L1.2401.00
702_G707_A1.2391.00
74_F81_A1.2391.00
125_L155_L1.2381.00
799_L802_I1.2371.00
288_V347_A1.2331.00
272_L332_C1.2261.00
342_E346_A1.2251.00
753_D756_K1.2221.00
412_V434_R1.2201.00
794_R797_R1.2191.00
459_A467_E1.2191.00
555_F573_V1.2171.00
61_W64_L1.2171.00
743_R747_A1.2161.00
21_R24_A1.2071.00
234_H239_S1.2061.00
656_R660_W1.2051.00
24_A27_S1.2051.00
270_F297_R1.2041.00
704_F708_E1.1941.00
432_L454_L1.1921.00
38_T180_G1.1921.00
588_E591_A1.1911.00
795_A799_L1.1891.00
748_Q752_L1.1871.00
333_Q337_A1.1821.00
685_H688_Q1.1791.00
498_L510_L1.1791.00
672_W675_H1.1781.00
23_L52_W1.1771.00
75_A78_L1.1771.00
436_E455_R1.1761.00
397_L400_L1.1751.00
77_Y81_A1.1691.00
141_S145_F1.1651.00
552_E556_Q1.1641.00
668_A672_W1.1591.00
204_E207_E1.1561.00
747_A754_A1.1561.00
360_A364_A1.1511.00
546_T549_E1.1501.00
801_E804_Q1.1471.00
555_F572_L1.1471.00
77_Y80_A1.1431.00
506_R509_A1.1391.00
548_W585_R1.1381.00
775_A779_R1.1371.00
273_K347_A1.1361.00
75_A85_A1.1341.00
358_S383_S1.1341.00
549_E553_K1.1331.00
531_L553_K1.1321.00
620_L625_L1.1311.00
429_N455_R1.1301.00
480_P487_R1.1301.00
398_K427_E1.1261.00
661_Q669_A1.1251.00
345_R369_D1.1241.00
697_A701_L1.1181.00
632_L655_V1.1161.00
459_A464_N1.1151.00
192_K205_A1.1141.00
59_I65_D1.1131.00
288_V350_S1.1131.00
586_L618_C1.1131.00
466_D470_R1.1121.00
746_D749_R1.1071.00
238_K241_R1.1041.00
398_K415_Q1.1041.00
27_S52_W1.1041.00
801_E805_H1.1031.00
660_W663_T1.1011.00
404_S407_E1.1001.00
34_L146_I1.0991.00
385_F418_L1.0991.00
797_R801_E1.0991.00
130_Y133_I1.0981.00
22_L48_L1.0981.00
558_I562_H1.0971.00
416_A435_A1.0961.00
586_L590_E1.0861.00
364_A372_M1.0861.00
412_V431_L1.0841.00
601_S608_Q1.0841.00
215_V222_L1.0831.00
475_A479_L1.0821.00
494_L498_L1.0771.00
106_T110_A1.0721.00
21_R25_K1.0721.00
750_V753_D1.0691.00
45_K160_R1.0681.00
491_T517_M1.0681.00
754_A758_A1.0661.00
128_D131_H1.0651.00
15_H197_C1.0651.00
448_H452_N1.0651.00
59_I62_Y1.0641.00
322_P326_N1.0631.00
435_A438_E1.0621.00
474_L477_E1.0591.00
394_E398_K1.0571.00
595_S598_E1.0571.00
515_E519_R1.0561.00
53_A124_Y1.0541.00
586_L622_R1.0531.00
523_V526_Y1.0511.00
382_W414_L1.0501.00
299_E303_R1.0501.00
107_S111_Q1.0491.00
210_R213_D1.0481.00
630_S634_R1.0471.00
449_A475_A1.0461.00
277_L280_M1.0461.00
535_S554_A1.0431.00
534_Q538_L1.0431.00
448_H478_E1.0401.00
266_A297_R1.0391.00
718_A722_R1.0351.00
339_E342_E1.0351.00
719_R727_L1.0321.00
49_I53_A1.0321.00
40_P43_Y1.0321.00
508_L538_L1.0321.00
774_M777_Q1.0291.00
666_K697_A1.0261.00
419_M424_R1.0221.00
580_L583_W1.0221.00
234_H238_K1.0191.00
636_E640_G1.0181.00
280_M285_I1.0181.00
482_G487_R1.0181.00
266_A293_N1.0151.00
79_I85_A1.0131.00
615_L618_C1.0131.00
385_F414_L1.0121.00
597_I601_S1.0111.00
633_N636_E1.0111.00
738_Y743_R1.0111.00
37_I158_L1.0101.00
528_L531_L1.0081.00
313_D316_E1.0051.00
696_R699_I1.0051.00
38_T159_S1.0051.00
452_N474_L1.0051.00
429_N462_D1.0041.00
78_L141_S1.0001.00
692_R695_A1.0001.00
749_R753_D0.9981.00
256_V261_D0.9951.00
287_R353_A0.9931.00
758_A761_T0.9901.00
473_K477_E0.9891.00
220_T321_H0.9891.00
747_A751_L0.9891.00
372_M375_D0.9881.00
378_L410_Q0.9861.00
487_R513_Q0.9861.00
276_I343_I0.9841.00
470_R474_L0.9801.00
49_I156_V0.9791.00
771_G801_E0.9771.00
632_L656_R0.9761.00
47_T223_Q0.9741.00
59_I64_L0.9741.00
524_W560_E0.9731.00
434_R437_H0.9711.00
675_H678_K0.9681.00
459_A471_L0.9661.00
215_V225_I0.9651.00
795_A801_E0.9641.00
186_F190_E0.9631.00
361_I364_A0.9621.00
546_T550_T0.9611.00
455_R459_A0.9601.00
718_A721_L0.9571.00
74_F83_Q0.9561.00
261_D268_R0.9561.00
62_Y65_D0.9561.00
515_E531_L0.9551.00
29_A35_A0.9541.00
59_I124_Y0.9541.00
16_T51_Q0.9511.00
518_A526_Y0.9481.00
772_E775_A0.9471.00
632_L636_E0.9471.00
333_Q339_E0.9471.00
755_L758_A0.9461.00
512_Q516_Q0.9461.00
66_E77_Y0.9441.00
364_A376_I0.9431.00
191_A226_A0.9421.00
559_N562_H0.9401.00
659_Y663_T0.9401.00
573_V599_V0.9381.00
43_Y218_W0.9371.00
766_H769_I0.9361.00
64_L69_N0.9341.00
506_R510_L0.9331.00
667_A701_L0.9331.00
795_A805_H0.9321.00
191_A215_V0.9311.00
537_I541_Q0.9291.00
111_Q114_I0.9291.00
734_L737_L0.9271.00
363_H366_A0.9261.00
126_V158_L0.9261.00
759_N762_G0.9221.00
775_A781_L0.9221.00
389_E393_L0.9211.00
744_K747_A0.9211.00
752_L756_K0.9211.00
670_A698_Q0.9211.00
698_Q703_E0.9201.00
593_A615_L0.9191.00
256_V327_F0.9191.00
731_L750_V0.9191.00
634_R638_L0.9171.00
105_L110_A0.9161.00
110_A114_I0.9161.00
196_D208_S0.9131.00
270_F294_G0.9131.00
124_Y154_T0.9121.00
434_R438_E0.9121.00
485_Y488_I0.9091.00
765_S771_G0.9081.00
360_A363_H0.9081.00
794_R798_I0.9081.00
709_I713_E0.9071.00
142_M155_L0.9051.00
712_E715_N0.9041.00
728_N758_A0.9031.00
214_D326_N0.9021.00
761_T764_I0.9021.00
491_T498_L0.9011.00
555_F576_R0.9001.00
674_R694_I0.8991.00
695_A733_L0.8991.00
629_R659_Y0.8991.00
78_L138_I0.8981.00
432_L436_E0.8981.00
273_K343_I0.8971.00
192_K196_D0.8961.00
332_C343_I0.8951.00
594_R627_N0.8951.00
555_F569_H0.8941.00
400_L411_L0.8931.00
592_S595_S0.8931.00
35_A154_T0.8921.00
133_I139_H0.8911.00
727_L731_L0.8891.00
220_T251_L0.8881.00
107_S110_A0.8871.00
433_A437_H0.8861.00
347_A351_W0.8841.00
76_S81_A0.8841.00
76_S80_A0.8811.00
216_S322_P0.8791.00
365_L377_L0.8771.00
195_F208_S0.8771.00
235_S238_K0.8771.00
34_L157_V0.8751.00
300_E304_Q0.8711.00
770_E774_M0.8711.00
734_L750_V0.8711.00
733_L736_Q0.8711.00
260_L328_L0.8711.00
598_E602_S0.8711.00
723_L726_D0.8701.00
380_H384_L0.8691.00
518_A530_S0.8681.00
569_H573_V0.8671.00
554_A558_I0.8671.00
273_K289_T0.8661.00
394_E415_Q0.8661.00
771_G797_R0.8661.00
527_A531_L0.8621.00
108_L117_A0.8621.00
531_L557_L0.8621.00
410_Q414_L0.8611.00
673_L693_N0.8601.00
597_I612_L0.8601.00
267_T304_Q0.8571.00
60_G64_L0.8571.00
545_Q583_W0.8541.00
513_Q516_Q0.8521.00
591_A595_S0.8501.00
426_G462_D0.8481.00
171_R178_E0.8481.00
472_A476_L0.8461.00
474_L478_E0.8461.00
733_L737_L0.8461.00
427_E430_T0.8451.00
769_I772_E0.8451.00
498_L503_E0.8451.00
495_G514_T0.8421.00
640_G649_I0.8421.00
731_L753_D0.8411.00
601_S634_R0.8411.00
205_A209_S0.8391.00
475_A478_E0.8391.00
696_R700_L0.8381.00
513_Q517_M0.8381.00
704_F707_A0.8361.00
755_L759_N0.8330.99
146_I155_L0.8320.99
22_L179_I0.8310.99
128_D322_P0.8310.99
252_S327_F0.8310.99
122_P152_N0.8280.99
548_W579_L0.8270.99
690_Q694_I0.8270.99
105_L113_F0.8270.99
715_N719_R0.8260.99
776_Q779_R0.8240.99
198_R223_Q0.8230.99
123_L153_L0.8230.99
73_R80_A0.8230.99
778_L782_I0.8210.99
751_L755_L0.8190.99
286_T294_G0.8180.99
735_N742_G0.8180.99
110_A113_F0.8180.99
124_Y156_V0.8170.99
428_V458_V0.8170.99
53_A63_S0.8170.99
22_L182_Q0.8160.99
581_W586_L0.8160.99
467_E471_L0.8160.99
407_E410_Q0.8150.99
201_S204_E0.8130.99
553_K557_L0.8130.99
554_A572_L0.8110.99
510_L513_Q0.8110.99
636_E653_N0.8110.99
360_A376_I0.8090.99
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402_W411_L0.5130.90
228_S232_N0.5130.90
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80_A83_Q0.5120.90
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755_L767_F0.5120.90
613_A618_C0.5120.90
731_L757_L0.5120.90
617_Q620_L0.5120.90
309_Q318_F0.5110.90
106_T109_F0.5110.90
16_T190_E0.5100.90
456_A475_A0.5100.90
524_W527_A0.5090.90
394_E419_M0.5080.90
568_M571_F0.5070.90
544_L579_L0.5070.90
302_E318_F0.5070.90
507_S537_I0.5070.90
714_L722_R0.5060.90
22_L25_K0.5060.90
276_I332_C0.5060.90
487_R490_A0.5060.90
418_L421_S0.5050.89
370_A373_L0.5050.89
718_A723_L0.5040.89
731_L734_L0.5040.89
773_A778_L0.5040.89
385_F393_L0.5040.89
409_P413_L0.5040.89
198_R226_A0.5030.89
63_S67_G0.5020.89
218_W222_L0.5020.89
487_R492_S0.5020.89
433_A436_E0.5010.89
724_M728_N0.5010.89
635_L652_A0.5010.89
22_L181_S0.5010.89
557_L560_E0.5010.89
746_D758_A0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z6tA 1 0.4761 100 0.712 Contact Map
2a5yB 2 0.3807 100 0.769 Contact Map
2qenA 1 0.3441 100 0.799 Contact Map
1hz4A 2 0.4062 100 0.801 Contact Map
1w3bA 2 0.4295 99.9 0.816 Contact Map
3sf4A 1 0.3718 99.9 0.818 Contact Map
2fnaA 1 0.3352 99.9 0.819 Contact Map
4ui9O 1 0.6204 99.9 0.821 Contact Map
3sfzA 1 0.7192 99.9 0.827 Contact Map
3ro2A 1 0.3407 99.9 0.829 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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