GREMLIN Database
RSMA - Ribosomal RNA small subunit methyltransferase A
UniProt: P06992 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10523
Length: 273 (252)
Sequences: 4687 (2978)
Seq/√Len: 187.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_M251_N3.6341.00
56_G85_L3.0881.00
253_S256_Q2.9891.00
247_M256_Q2.9301.00
40_A63_T2.7561.00
61_Q86_T2.6251.00
256_Q259_Q2.5971.00
145_V190_A2.5881.00
72_A89_Q2.4151.00
22_D180_A2.4061.00
28_S174_L2.2651.00
63_T88_Y2.2601.00
116_Y189_S2.2041.00
169_N195_V2.1891.00
146_N172_P2.1871.00
171_I193_R2.1731.00
169_N197_H2.1241.00
142_K175_E2.0891.00
217_A257_Y2.0811.00
171_I195_V2.0721.00
96_N99_E2.0621.00
55_V111_F2.0331.00
54_P57_E2.0291.00
178_P188_D2.0221.00
69_R89_Q1.9711.00
149_V170_V1.9541.00
161_S165_Q1.9441.00
18_N184_P1.9371.00
31_S58_R1.9051.00
177_P180_A1.8871.00
224_T246_A1.8731.00
168_C194_L1.8591.00
235_V239_T1.8571.00
39_Q109_R1.8361.00
252_I256_Q1.8321.00
213_I261_A1.8321.00
27_D54_P1.7791.00
59_L62_L1.7701.00
197_H201_P1.7661.00
46_P64_V1.7561.00
205_K262_N1.7531.00
172_P175_E1.7341.00
173_V193_R1.7231.00
175_E190_A1.7021.00
53_E78_H1.6521.00
109_R135_D1.6281.00
65_I95_F1.6081.00
148_L164_A1.5961.00
162_V214_T1.5901.00
21_N182_T1.5751.00
124_F163_M1.5661.00
92_A97_F1.5641.00
36_Q39_Q1.5551.00
135_D193_R1.5541.00
76_Q89_Q1.5491.00
236_E240_G1.5481.00
172_P190_A1.5341.00
139_M176_V1.5151.00
224_T227_N1.5151.00
107_P134_A1.5081.00
123_M140_L1.5031.00
164_A170_V1.5031.00
55_V62_L1.4931.00
162_V254_V1.4821.00
32_A173_V1.4731.00
65_I92_A1.4671.00
142_K146_N1.4461.00
26_I54_P1.4181.00
11_A182_T1.3971.00
125_H129_Y1.3891.00
137_H193_R1.3801.00
92_A122_L1.3681.00
209_V261_A1.3531.00
12_R70_D1.3501.00
204_V262_N1.3501.00
259_Q262_N1.3411.00
240_G263_Y1.3311.00
35_P41_M1.3221.00
15_F67_L1.3201.00
244_D247_M1.3171.00
178_P186_K1.3041.00
72_A76_Q1.3041.00
243_I247_M1.2981.00
110_V126_L1.2911.00
210_L214_T1.2871.00
119_S140_L1.2711.00
217_A249_A1.2691.00
153_N251_N1.2671.00
204_V258_C1.2411.00
241_M263_Y1.2371.00
146_N156_A1.2371.00
148_L192_V1.2251.00
64_V87_I1.2171.00
140_L145_V1.2111.00
142_K188_D1.2091.00
88_Y95_F1.2051.00
114_L138_F1.1961.00
209_V264_L1.1961.00
176_V191_V1.1931.00
166_Y210_L1.1891.00
11_A48_L1.1881.00
175_E188_D1.1791.00
40_A61_Q1.1671.00
127_F168_C1.1641.00
179_S184_P1.1541.00
25_V180_A1.1431.00
137_H191_V1.1381.00
219_N228_S1.1381.00
90_Q95_F1.1351.00
38_G60_D1.1281.00
168_C196_P1.1131.00
226_R235_V1.1071.00
165_Q170_V1.1071.00
23_Q54_P1.1061.00
222_R250_E1.1031.00
119_S144_V1.0951.00
174_L191_V1.0941.00
236_E239_T1.0901.00
91_D94_T1.0891.00
63_T86_T1.0871.00
244_D251_N1.0781.00
64_V85_L1.0691.00
155_K250_E1.0421.00
151_G154_S1.0411.00
33_I112_G1.0401.00
239_T245_P1.0351.00
148_L170_V1.0351.00
24_F180_A1.0321.00
217_A225_I1.0301.00
135_D195_V1.0261.00
149_V172_P1.0191.00
242_G259_Q1.0181.00
30_V111_F1.0161.00
217_A228_S1.0101.00
52_T62_L1.0081.00
35_P59_L1.0060.99
24_F27_D1.0030.99
33_I111_F0.9930.99
72_A87_I0.9910.99
235_V245_P0.9860.99
16_G117_N0.9830.99
15_F70_D0.9810.99
42_V101_A0.9800.99
197_H200_M0.9790.99
30_V35_P0.9770.99
168_C197_H0.9760.99
167_Y211_S0.9710.99
27_D31_S0.9680.99
56_G84_K0.9600.99
33_I41_M0.9590.99
79_P82_G0.9560.99
90_Q94_T0.9560.99
35_P39_Q0.9550.99
112_G138_F0.9510.99
255_A259_Q0.9460.99
130_T207_V0.9450.99
166_Y207_V0.9360.99
40_A60_D0.9340.99
142_K190_A0.9320.99
42_V65_I0.9300.99
73_A76_Q0.9260.99
93_M118_I0.9120.99
44_I110_V0.9090.99
48_L71_L0.9070.99
23_Q53_E0.9060.99
228_S249_A0.9060.99
26_I50_A0.9010.99
32_A174_L0.8980.99
48_L74_R0.8980.99
237_V264_L0.8970.99
206_D262_N0.8920.99
46_P75_L0.8900.99
166_Y254_V0.8800.99
79_P84_K0.8750.99
123_M148_L0.8660.98
33_I137_H0.8650.98
207_V211_S0.8640.98
200_M258_C0.8590.98
258_C262_N0.8590.98
206_D209_V0.8550.98
150_A154_S0.8510.98
40_A106_Q0.8460.98
26_I30_V0.8310.98
216_E249_A0.8220.98
118_I122_L0.8150.98
64_V75_L0.8140.98
41_M59_L0.8130.98
24_F28_S0.8130.98
209_V213_I0.8120.98
159_R215_T0.8110.98
75_L87_I0.8100.98
207_V210_L0.8090.98
178_P184_P0.8020.98
92_A114_L0.8010.97
142_K172_P0.7990.97
65_I100_L0.7980.97
213_I217_A0.7940.97
12_R15_F0.7900.97
136_M196_P0.7880.97
77_T80_F0.7870.97
157_Y257_Y0.7870.97
29_I139_M0.7840.97
210_L261_A0.7810.97
109_R134_A0.7800.97
157_Y161_S0.7800.97
109_R137_H0.7720.97
23_Q27_D0.7720.97
35_P109_R0.7690.97
26_I139_M0.7640.97
259_Q263_Y0.7520.96
159_R163_M0.7500.96
80_F83_P0.7490.96
29_I191_V0.7490.96
128_S211_S0.7470.96
158_G250_E0.7470.96
101_A108_L0.7460.96
114_L122_L0.7420.96
92_A118_I0.7300.96
163_M211_S0.7300.96
9_H70_D0.7220.95
149_V190_A0.7210.95
28_S179_S0.7200.95
237_V263_Y0.7190.95
209_V212_R0.7190.95
162_V257_Y0.7190.95
123_M164_A0.7170.95
33_I109_R0.7130.95
40_A105_G0.7100.95
37_K60_D0.7090.95
212_R216_E0.7060.95
66_E72_A0.7050.95
169_N201_P0.7050.95
48_L78_H0.7040.95
133_I136_M0.7020.95
98_G131_D0.6970.94
166_Y211_S0.6960.94
11_A19_F0.6960.94
92_A125_H0.6930.94
74_R77_T0.6920.94
213_I232_L0.6910.94
97_F125_H0.6900.94
54_P58_R0.6900.94
176_V187_V0.6840.94
212_R232_L0.6810.94
39_Q134_A0.6780.94
10_L70_D0.6770.94
124_F128_S0.6720.93
42_V108_L0.6720.93
208_R212_R0.6710.93
166_Y204_V0.6710.93
129_Y133_I0.6700.93
97_F122_L0.6660.93
177_P188_D0.6630.93
73_A77_T0.6620.93
124_F159_R0.6590.93
98_G129_Y0.6580.93
198_A201_P0.6570.93
167_Y207_V0.6540.92
149_V192_V0.6540.92
90_Q99_E0.6530.92
62_L112_G0.6470.92
107_P198_A0.6470.92
28_S31_S0.6470.92
108_L133_I0.6410.92
9_H48_L0.6390.91
50_A54_P0.6370.91
114_L119_S0.6370.91
110_V138_F0.6370.91
225_I229_L0.6360.91
56_G82_G0.6360.91
222_R248_R0.6360.91
110_V133_I0.6330.91
178_P187_V0.6330.91
120_T136_M0.6330.91
146_N175_E0.6300.91
249_A257_Y0.6230.90
9_H74_R0.6190.90
32_A193_R0.6170.90
166_Y258_C0.6160.90
220_Q228_S0.6130.90
116_Y139_M0.6110.90
238_L245_P0.6060.89
25_V174_L0.6040.89
44_I126_L0.6030.89
30_V58_R0.6030.89
18_N186_K0.5990.89
53_E79_P0.5990.89
81_L84_K0.5980.89
65_I228_S0.5980.89
243_I251_N0.5960.88
147_R150_A0.5930.88
140_L164_A0.5930.88
128_S208_R0.5930.88
157_Y254_V0.5920.88
213_I257_Y0.5910.88
225_I252_I0.5890.88
69_R72_A0.5880.88
121_P125_H0.5870.88
79_P85_L0.5840.87
26_I51_L0.5830.87
26_I111_F0.5830.87
25_V176_V0.5760.87
239_T242_G0.5760.87
53_E82_G0.5760.87
226_R230_G0.5760.87
148_L161_S0.5740.86
44_I138_F0.5730.86
238_L242_G0.5730.86
67_L89_Q0.5730.86
200_M204_V0.5720.86
140_L159_R0.5720.86
174_L190_A0.5690.86
216_E232_L0.5660.86
39_Q106_Q0.5650.86
252_I257_Y0.5620.85
79_P83_P0.5610.85
241_M260_M0.5600.85
19_F71_L0.5590.85
38_G106_Q0.5590.85
11_A71_L0.5580.85
238_L243_I0.5580.85
170_V192_V0.5570.85
8_G11_A0.5570.85
169_N198_A0.5570.85
139_M189_S0.5560.85
42_V97_F0.5540.84
126_L136_M0.5540.84
217_A229_L0.5540.84
120_T124_F0.5530.84
159_R214_T0.5520.84
243_I256_Q0.5520.84
140_L148_L0.5520.84
129_Y132_A0.5510.84
30_V55_V0.5470.84
30_V54_P0.5470.84
41_M62_L0.5460.84
46_P56_G0.5460.84
136_M194_L0.5450.84
224_T228_S0.5440.83
221_R250_E0.5430.83
70_D73_A0.5410.83
95_F99_E0.5400.83
159_R211_S0.5390.83
255_A258_C0.5380.83
98_G132_A0.5350.82
139_M191_V0.5340.82
206_D258_C0.5340.82
206_D210_L0.5340.82
119_S124_F0.5330.82
119_S123_M0.5330.82
11_A14_R0.5320.82
241_M245_P0.5320.82
219_N249_A0.5310.82
25_V177_P0.5290.82
41_M58_R0.5270.81
233_F238_L0.5260.81
41_M109_R0.5260.81
243_I260_M0.5260.81
35_P60_D0.5250.81
28_S32_A0.5250.81
20_L25_V0.5230.81
49_A56_G0.5200.81
210_L213_I0.5190.80
55_V59_L0.5180.80
12_R69_R0.5140.80
241_M259_Q0.5110.79
234_S237_V0.5100.79
165_Q254_V0.5090.79
178_P190_A0.5090.79
145_V194_L0.5080.79
113_N139_M0.5080.79
18_N71_L0.5070.79
50_A112_G0.5070.79
254_V258_C0.5070.79
246_A251_N0.5040.79
136_M140_L0.5000.78
213_I260_M0.5000.78
237_V260_M0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i4wA 1 0.967 100 0.246 Contact Map
4gc5A 2 0.9963 100 0.261 Contact Map
4jxjA 1 0.8901 100 0.282 Contact Map
3uzuA 1 0.9414 100 0.29 Contact Map
3tqsA 1 0.9011 100 0.294 Contact Map
1qyrA 1 0.9231 100 0.298 Contact Map
3futA 1 0.9267 100 0.319 Contact Map
3gruA 1 0.9048 100 0.322 Contact Map
3ftdA 1 0.8755 100 0.336 Contact Map
1zq9A 2 0.9011 100 0.374 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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