GREMLIN Database
HIS2 - Histidine biosynthesis bifunctional protein HisIE
UniProt: P06989 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10451
Length: 203 (193)
Sequences: 1570 (908)
Seq/√Len: 65.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_T74_V4.3731.00
135_T178_Y3.5051.00
22_I34_L3.3401.00
10_L19_M3.2341.00
124_E128_A2.5941.00
60_R66_E2.5691.00
10_L79_P2.3971.00
144_K163_V2.3911.00
13_E16_D2.3541.00
171_N197_N2.3361.00
52_T63_T2.2251.00
11_D14_K2.2071.00
51_V88_V2.1741.00
54_F59_Q2.1731.00
50_K63_T2.1521.00
71_F93_I2.1371.00
170_T197_N2.0621.00
73_N93_I2.0571.00
75_V91_N2.0481.00
92_P95_P2.0461.00
44_K47_E2.0371.00
144_K162_T2.0371.00
73_N91_N1.9361.00
39_P43_D1.9281.00
21_V37_M1.9211.00
43_D47_E1.8941.00
197_N200_K1.8531.00
34_L85_T1.8521.00
101_T106_G1.8451.00
30_E102_S1.8351.00
50_K73_N1.8301.00
119_E185_Q1.8251.00
35_G96_T1.8231.00
155_V158_A1.8191.00
21_V88_V1.7891.00
123_A185_Q1.7881.00
173_A184_L1.7811.00
23_V53_F1.7711.00
151_G155_V1.7671.00
130_P136_A1.7010.99
148_Q155_V1.6950.99
157_T173_A1.6740.99
37_M88_V1.6330.99
173_A180_L1.6130.99
77_I88_V1.6080.99
76_S89_L1.5820.99
99_K106_G1.5720.99
126_K185_Q1.5600.99
129_D136_A1.5570.99
50_K71_F1.5530.99
143_T186_D1.4960.99
21_V41_A1.4690.98
177_M180_L1.4610.98
60_R67_T1.4400.98
169_L189_L1.4300.98
51_V74_V1.4290.98
29_G89_L1.4090.98
44_K61_L1.4070.98
44_K52_T1.3490.97
63_T66_E1.3400.97
157_T176_L1.3240.97
166_R189_L1.3040.97
173_A177_M1.3000.96
142_G146_I1.2730.96
53_F92_P1.2380.95
166_R193_T1.2340.95
174_S194_V1.2250.95
44_K48_S1.2200.95
136_A140_A1.1920.94
33_M85_T1.1910.94
26_A75_V1.1790.94
129_D132_T1.1590.93
126_K139_Y1.1530.93
27_V91_N1.1530.93
164_H187_Q1.1440.93
161_A183_L1.1380.93
33_M87_L1.1380.93
174_S197_N1.1350.93
44_K63_T1.1100.92
115_L191_L1.1090.92
157_T180_L1.1080.92
135_T182_V1.0920.91
160_A168_E1.0890.91
128_A136_A1.0780.91
20_P34_L1.0720.90
70_N92_P1.0700.90
74_V105_F1.0650.90
196_E199_R1.0650.90
143_T187_Q1.0620.90
119_E191_L1.0570.90
190_D193_T1.0480.89
53_F72_L1.0470.89
38_N41_A1.0410.89
122_L139_Y1.0360.89
166_R187_Q1.0300.88
72_L96_T1.0290.88
154_G158_A1.0250.88
137_K145_R1.0220.88
117_Q202_H1.0160.88
145_R159_L1.0140.88
178_Y182_V1.0130.88
114_F202_H1.0120.88
78_A89_L0.9840.86
141_S145_R0.9800.86
23_V90_A0.9740.85
42_L46_L0.9480.84
150_V154_G0.9470.84
53_F88_V0.9440.84
154_G159_L0.9430.84
151_G158_A0.9400.83
160_A169_L0.9310.83
194_V197_N0.9310.83
23_V88_V0.9250.82
12_W42_L0.9210.82
23_V51_V0.9180.82
70_N95_P0.9150.82
49_G73_N0.9090.81
72_L90_A0.9040.81
51_V72_L0.9030.81
51_V90_A0.9010.81
132_T139_Y0.8980.80
10_L42_L0.8930.80
48_S52_T0.8920.80
181_L191_L0.8890.80
50_K66_E0.8740.79
31_V87_L0.8720.78
54_F66_E0.8720.78
72_L92_P0.8570.77
115_L181_L0.8530.77
126_K188_G0.8470.76
143_T161_A0.8430.76
76_S108_T0.8310.75
138_L182_V0.8300.75
70_N93_I0.8300.75
132_T140_A0.8200.74
165_D168_E0.8180.74
128_A132_T0.7940.72
74_V88_V0.7910.71
189_L193_T0.7910.71
161_A169_L0.7860.71
196_E200_K0.7830.71
38_N61_L0.7820.71
92_P102_S0.7790.70
11_D57_T0.7770.70
54_F60_R0.7730.70
123_A127_S0.7670.69
188_G195_I0.7650.69
110_H113_L0.7620.69
46_L77_I0.7480.67
35_G51_V0.7470.67
148_Q151_G0.7400.66
38_N54_F0.7340.66
63_T71_F0.7300.65
170_T189_L0.7290.65
19_M86_L0.7250.65
129_D140_A0.7230.64
116_Y120_Q0.7220.64
51_V63_T0.7210.64
163_V168_E0.7200.64
122_L185_Q0.7170.64
169_L187_Q0.7170.64
159_L163_V0.7110.63
12_W19_M0.7100.63
119_E190_D0.7100.63
151_G159_L0.7090.63
147_A155_V0.7090.63
157_T194_V0.7080.63
166_R170_T0.7000.62
71_F75_V0.6980.62
26_A91_N0.6950.61
25_H102_S0.6910.61
193_T196_E0.6890.61
139_Y146_I0.6880.61
74_V77_I0.6880.61
192_T196_E0.6830.60
192_T199_R0.6780.60
126_K129_D0.6750.59
143_T154_G0.6750.59
132_T136_A0.6710.59
157_T174_S0.6700.59
137_K141_S0.6690.58
116_Y119_E0.6670.58
137_K140_A0.6660.58
170_T193_T0.6630.58
176_L191_L0.6610.58
58_K67_T0.6610.58
146_I186_D0.6590.57
162_T168_E0.6580.57
95_P102_S0.6560.57
51_V96_T0.6550.57
63_T72_L0.6520.57
144_K168_E0.6510.56
36_Y85_T0.6490.56
122_L181_L0.6470.56
143_T162_T0.6460.56
145_R155_V0.6460.56
191_L195_I0.6460.56
121_L202_H0.6450.56
51_V77_I0.6420.55
150_V176_L0.6370.55
20_P36_Y0.6340.54
192_T195_I0.6320.54
124_E129_D0.6270.54
119_E123_A0.6240.53
13_E17_G0.6230.53
43_D167_F0.6180.53
35_G72_L0.6150.52
48_S63_T0.6070.51
25_H28_S0.6060.51
35_G58_K0.6050.51
145_R168_E0.6050.51
137_K148_Q0.6030.51
64_K98_H0.6000.50
197_N201_R0.6000.50
41_A51_V0.5920.50
144_K159_L0.5880.49
46_L49_G0.5870.49
45_T51_V0.5830.48
22_I87_L0.5820.48
22_I31_V0.5770.48
126_K136_A0.5760.48
21_V29_G0.5750.48
52_T61_L0.5740.47
53_F90_A0.5740.47
164_H186_D0.5720.47
133_S136_A0.5700.47
57_T85_T0.5700.47
178_Y183_L0.5700.47
83_N107_D0.5690.47
185_Q188_G0.5670.47
168_E171_N0.5650.46
28_S102_S0.5640.46
13_E108_T0.5630.46
143_T169_L0.5580.46
28_S192_T0.5570.45
106_G109_A0.5560.45
99_K107_D0.5550.45
164_H168_E0.5540.45
37_M41_A0.5540.45
115_L195_I0.5530.45
11_D58_K0.5520.45
13_E18_L0.5500.45
123_A128_A0.5490.45
33_M92_P0.5470.44
85_T105_F0.5470.44
122_L130_P0.5470.44
157_T160_A0.5470.44
37_M51_V0.5460.44
20_P85_T0.5450.44
95_P202_H0.5420.44
37_M45_T0.5420.44
31_V201_R0.5400.43
39_P83_N0.5390.43
41_A45_T0.5380.43
67_T135_T0.5380.43
147_A151_G0.5370.43
170_T174_S0.5360.43
89_L178_Y0.5350.43
91_N200_K0.5350.43
57_T96_T0.5350.43
137_K168_E0.5300.42
16_D59_Q0.5290.42
148_Q157_T0.5290.42
114_F195_I0.5260.42
35_G63_T0.5260.42
112_W116_Y0.5240.42
170_T200_K0.5230.42
70_N128_A0.5230.42
121_L139_Y0.5230.42
139_Y185_Q0.5220.41
145_R151_G0.5220.41
30_E105_F0.5200.41
144_K148_Q0.5170.41
143_T147_A0.5170.41
66_E120_Q0.5160.41
33_M62_W0.5160.41
147_A162_T0.5140.41
16_D108_T0.5120.40
158_A163_V0.5110.40
101_T107_D0.5110.40
103_S109_A0.5100.40
171_N200_K0.5080.40
25_H91_N0.5060.40
64_K68_S0.5060.40
10_L86_L0.5060.40
47_E127_S0.5060.40
137_K178_Y0.5050.40
17_G142_G0.5040.39
123_A190_D0.5030.39
25_H92_P0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zpsA 2 0.6158 100 0.421 Contact Map
2a7wA 4 0.4483 100 0.636 Contact Map
1yvwA 4 0.4433 100 0.646 Contact Map
1yxbA 4 0.4089 100 0.653 Contact Map
1y6xA 3 0.4286 100 0.653 Contact Map
2yxhA 2 0.4138 99 0.86 Contact Map
2gtaA 4 0.4236 98.7 0.878 Contact Map
1vmgA 4 0.4039 98 0.898 Contact Map
2q5zA 4 0.4039 97.6 0.908 Contact Map
2oieA 3 0.4581 97.6 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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