GREMLIN Database
HISX - Histidinol dehydrogenase
UniProt: P06988 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10447
Length: 434 (409)
Sequences: 3840 (2141)
Seq/√Len: 105.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_N46_R4.1361.00
56_A62_T4.0811.00
46_R53_E3.5431.00
67_K180_D3.2901.00
40_L191_A3.1311.00
126_S156_K3.0971.00
160_C193_L3.0861.00
135_S264_P3.0461.00
295_A299_R2.9301.00
250_D284_A2.9171.00
242_I320_S2.7891.00
334_N337_E2.7811.00
95_I143_L2.7601.00
129_L146_A2.7181.00
96_E100_T2.7091.00
336_R394_E2.5571.00
156_K180_D2.5321.00
79_R167_D2.5041.00
90_V406_T2.4971.00
311_K315_Q2.4731.00
314_A341_S2.4721.00
275_A279_R2.4661.00
42_N54_Y2.4221.00
284_A287_R2.3591.00
77_S174_Q2.3331.00
412_A424_T2.3051.00
125_A343_T2.2561.00
150_S179_Q2.2541.00
310_T316_C2.1301.00
89_A175_L2.1221.00
73_I181_V2.1131.00
278_A309_V2.0941.00
278_A307_L2.0821.00
245_S274_A2.0591.00
53_E57_K2.0551.00
299_R303_N2.0371.00
404_A427_V2.0341.00
48_D197_T2.0221.00
92_V96_E2.0151.00
412_A417_T2.0001.00
240_L320_S1.9881.00
216_E220_Q1.9861.00
408_E424_T1.9851.00
46_R49_E1.9781.00
155_K343_T1.9441.00
38_D42_N1.9421.00
263_G266_S1.9371.00
92_V147_T1.9311.00
317_V342_I1.9301.00
146_A178_V1.9211.00
204_D376_A1.9141.00
42_N53_E1.9111.00
35_T213_F1.8981.00
74_A174_Q1.8951.00
242_I316_C1.8741.00
41_D45_A1.8701.00
282_A307_L1.8651.00
239_V258_S1.8611.00
74_A78_E1.8581.00
276_D280_R1.8481.00
289_L298_A1.7891.00
125_A344_S1.7851.00
246_G333_R1.7631.00
272_T278_A1.7521.00
85_K89_A1.7381.00
421_N424_T1.7361.00
293_P417_T1.7261.00
125_A155_K1.7151.00
357_S422_A1.7001.00
96_E150_S1.7001.00
397_K401_S1.6831.00
317_V338_L1.6651.00
69_S72_E1.6581.00
67_K182_F1.6581.00
358_A407_I1.6381.00
72_E183_N1.6251.00
37_N220_Q1.6181.00
195_F224_R1.6171.00
124_V205_K1.6021.00
245_S273_P1.5801.00
70_A74_A1.5711.00
330_I342_I1.5661.00
312_D315_Q1.5551.00
52_R66_L1.5401.00
335_A350_L1.5331.00
159_L173_A1.5311.00
273_P310_T1.5231.00
85_K171_Y1.4991.00
254_S288_Q1.4921.00
215_T233_P1.4851.00
122_R390_M1.4821.00
48_D199_S1.4711.00
108_D116_R1.4511.00
84_L413_A1.4491.00
75_A79_R1.4391.00
182_F201_P1.4251.00
284_A288_Q1.4211.00
184_V200_V1.4141.00
87_A410_L1.4121.00
77_S171_Y1.4061.00
82_D86_Q1.4031.00
408_E412_A1.4001.00
161_S165_I1.3991.00
270_L281_V1.3971.00
128_G193_L1.3901.00
92_V143_L1.3801.00
245_S333_R1.3761.00
332_T338_L1.3721.00
143_L147_T1.3581.00
250_D287_R1.3511.00
363_S393_Q1.3501.00
104_L384_A1.3480.99
292_L298_A1.3330.99
127_V205_K1.3220.99
43_V191_A1.3150.99
87_A409_T1.3050.99
71_E75_A1.3020.99
384_A389_R1.2960.99
408_E420_K1.2950.99
142_V159_L1.2920.99
160_C189_A1.2910.99
76_A170_L1.2900.99
353_W397_K1.2890.99
88_M175_L1.2880.99
70_A174_Q1.2860.99
348_V390_M1.2840.99
158_V180_D1.2780.99
194_A221_V1.2750.99
280_R283_E1.2720.99
171_Y174_Q1.2710.99
331_Q352_D1.2640.99
344_S388_K1.2600.99
264_P300_Q1.2580.99
412_A420_K1.2530.99
286_E299_R1.2470.99
172_A176_C1.2400.99
300_Q303_N1.2390.99
240_L271_L1.2380.99
277_M281_V1.2380.99
92_V175_L1.2370.99
33_T37_N1.2300.99
158_V193_L1.2280.99
40_L224_R1.2160.99
33_T220_Q1.2150.99
212_A216_E1.2140.99
248_T251_F1.2090.99
141_T145_L1.2080.99
400_F423_V1.2010.99
157_V179_Q1.2000.99
195_F221_V1.2000.99
68_V170_L1.1890.99
80_L85_K1.1870.99
246_G352_D1.1870.99
84_L168_E1.1770.99
104_L387_Q1.1690.99
135_S294_R1.1670.99
242_I271_L1.1660.99
70_A179_Q1.1640.99
49_E198_E1.1600.98
420_K424_T1.1580.98
290_A295_A1.1550.98
320_S325_P1.1520.98
348_V392_V1.1370.98
205_K385_D1.1280.98
51_L184_V1.1150.98
288_Q421_N1.1130.98
37_N41_D1.1130.98
40_L221_V1.1120.98
242_I330_I1.1060.98
300_Q304_A1.1030.98
160_C184_V1.0940.98
271_L310_T1.0940.98
122_R388_K1.0930.98
39_I187_A1.0850.98
250_D425_L1.0840.98
362_A407_I1.0840.98
32_I216_E1.0830.98
221_V228_A1.0820.98
271_L319_I1.0750.97
252_V281_V1.0740.97
145_L368_V1.0680.97
324_G375_T1.0620.97
68_V183_N1.0560.97
332_T335_A1.0560.97
249_P280_R1.0550.97
116_R394_E1.0550.97
88_M410_L1.0550.97
247_A252_V1.0500.97
257_L298_A1.0430.97
150_S176_C1.0410.97
362_A406_T1.0400.97
34_R38_D1.0370.97
124_V127_V1.0370.97
129_L157_V1.0350.97
54_Y58_F1.0250.97
243_A277_M1.0210.97
272_T309_V1.0210.97
241_V256_L1.0180.97
104_L121_T1.0140.96
55_S188_Q1.0130.96
382_G389_R1.0080.96
242_I317_V1.0030.96
275_A309_V1.0010.96
330_I350_L0.9950.96
77_S85_K0.9930.96
100_T151_I0.9920.96
272_T307_L0.9890.96
283_E287_R0.9880.96
310_T319_I0.9750.96
271_L320_S0.9750.96
39_I43_V0.9710.95
374_Y377_T0.9690.95
257_L418_A0.9620.95
355_P422_A0.9620.95
239_V329_I0.9610.95
248_T352_D0.9560.95
55_S63_V0.9530.95
339_V350_L0.9530.95
258_S357_S0.9450.95
88_M172_A0.9430.95
395_L403_L0.9420.95
66_L184_V0.9400.95
358_A395_L0.9390.95
68_V76_A0.9370.94
36_V216_E0.9350.94
313_L338_L0.9320.94
252_V277_M0.9320.94
110_E113_P0.9320.94
145_L207_F0.9310.94
243_A247_A0.9310.94
33_T216_E0.9290.94
368_V381_L0.9260.94
124_V229_A0.9230.94
44_K224_R0.9230.94
103_K387_Q0.9210.94
287_R291_E0.9180.94
282_A286_E0.9180.94
42_N57_K0.9130.94
141_T368_V0.9120.94
74_A77_S0.9110.94
421_N425_L0.9090.94
256_L270_L0.9080.93
339_V392_V0.9080.93
93_K96_E0.9060.93
40_L195_F0.9040.93
407_I423_V0.9030.93
86_Q89_A0.9000.93
242_I313_L0.9000.93
290_A293_P0.9000.93
273_P316_C0.9000.93
40_L44_K0.8980.93
35_T38_D0.8960.93
46_R57_K0.8940.93
111_T115_V0.8940.93
73_I77_S0.8900.93
290_A299_R0.8900.93
101_A109_V0.8870.93
131_I159_L0.8840.93
84_L409_T0.8830.93
43_V187_A0.8830.93
44_K195_F0.8820.92
49_E53_E0.8810.92
254_S425_L0.8810.92
146_A176_C0.8810.92
400_F404_A0.8800.92
73_I174_Q0.8780.92
81_S84_L0.8750.92
89_A171_Y0.8730.92
296_E299_R0.8700.92
272_T277_M0.8580.91
192_A200_V0.8570.91
358_A403_L0.8560.91
286_E290_A0.8560.91
125_A204_D0.8530.91
313_L316_C0.8520.91
347_S391_T0.8510.91
83_E409_T0.8450.91
51_L187_A0.8430.91
273_P313_L0.8410.91
97_T101_A0.8370.90
347_S393_Q0.8370.90
30_E34_R0.8360.90
96_E147_T0.8350.90
93_K97_T0.8310.90
107_V119_Q0.8310.90
249_P281_V0.8300.90
251_F352_D0.8280.90
87_A406_T0.8250.90
97_T100_T0.8240.90
288_Q425_L0.8220.90
216_E219_R0.8220.90
342_I348_V0.8200.89
142_V172_A0.8190.89
204_D344_S0.8180.89
279_R282_A0.8160.89
99_H102_Q0.8140.89
256_L285_V0.8130.89
39_I54_Y0.8110.89
30_E37_N0.8100.89
51_L192_A0.8100.89
315_Q318_E0.8090.89
384_A387_Q0.8060.89
113_P402_A0.8060.89
241_V252_V0.8050.89
250_D428_N0.8050.89
61_T163_P0.8040.89
339_V348_V0.8020.88
318_E321_N0.8010.88
98_F365_T0.7990.88
103_K151_I0.7980.88
380_S391_T0.7970.88
158_V201_P0.7910.88
180_D201_P0.7900.88
107_V118_Q0.7870.87
398_E401_S0.7860.87
102_Q366_N0.7850.87
91_A95_I0.7840.87
347_S392_V0.7840.87
156_K182_F0.7830.87
139_F410_L0.7820.87
321_N341_S0.7810.87
46_R50_A0.7800.87
51_L197_T0.7790.87
129_L145_L0.7780.87
401_S427_V0.7760.87
100_T103_K0.7750.87
69_S183_N0.7740.87
202_K373_G0.7730.87
171_Y175_L0.7710.86
250_D288_Q0.7690.86
417_T421_N0.7690.86
56_A61_T0.7690.86
32_I212_A0.7680.86
158_V182_F0.7680.86
258_S422_A0.7670.86
52_R56_A0.7660.86
77_S175_L0.7640.86
94_N362_A0.7640.86
192_A197_T0.7630.86
137_P415_R0.7620.86
182_F200_V0.7620.86
381_L385_D0.7620.86
411_A420_K0.7610.86
271_L316_C0.7600.86
27_S30_E0.7600.86
409_T413_A0.7580.85
347_S363_S0.7580.85
247_A277_M0.7560.85
317_V341_S0.7550.85
150_S178_V0.7500.85
206_I221_V0.7490.85
355_P400_F0.7480.85
91_A362_A0.7470.85
38_D41_D0.7450.84
239_V268_V0.7420.84
145_L381_L0.7410.84
294_R297_T0.7410.84
382_G387_Q0.7400.84
38_D57_K0.7400.84
333_R352_D0.7390.84
229_A377_T0.7370.84
362_A403_L0.7360.84
35_T57_K0.7360.84
317_V332_T0.7360.84
156_K201_P0.7350.84
395_L399_G0.7290.83
279_R283_E0.7270.83
119_Q382_G0.7270.83
54_Y188_Q0.7260.83
245_S276_D0.7260.83
40_L220_Q0.7260.83
49_E52_R0.7240.83
52_R63_V0.7230.83
365_T393_Q0.7220.83
67_K156_K0.7210.82
240_L323_Y0.7200.82
358_A400_F0.7190.82
51_L55_S0.7180.82
257_L289_L0.7180.82
212_A265_D0.7170.82
32_I36_V0.7130.82
379_S389_R0.7130.82
31_S34_R0.7110.82
92_V176_C0.7110.82
35_T54_Y0.7100.82
337_E340_D0.7090.81
52_R64_T0.7080.81
251_F331_Q0.7060.81
404_A408_E0.7050.81
292_L418_A0.7050.81
142_V178_V0.7040.81
83_E405_S0.7040.81
129_L207_F0.7020.81
145_L366_N0.7020.81
247_A352_D0.7020.81
89_A93_K0.7010.81
143_L172_A0.6990.81
46_R54_Y0.6980.80
191_A221_V0.6980.80
42_N45_A0.6970.80
48_D198_E0.6970.80
52_R65_A0.6970.80
121_T387_Q0.6940.80
197_T200_V0.6930.80
354_S395_L0.6930.80
296_E300_Q0.6910.80
285_V302_L0.6900.80
221_V224_R0.6880.79
97_T109_V0.6880.79
316_C320_S0.6880.79
174_Q181_V0.6880.79
412_A421_N0.6870.79
206_I228_A0.6860.79
56_A63_V0.6830.79
34_R37_N0.6810.79
90_V362_A0.6800.79
55_S60_K0.6780.78
77_S89_A0.6760.78
283_E286_E0.6750.78
313_L317_V0.6740.78
16_Q19_Q0.6720.78
128_G160_C0.6710.78
292_L421_N0.6710.78
122_R343_T0.6700.78
349_F359_G0.6690.78
400_F407_I0.6680.77
405_S409_T0.6660.77
136_A416_L0.6660.77
90_V93_K0.6660.77
93_K100_T0.6650.77
31_S35_T0.6650.77
229_A378_C0.6640.77
108_D336_R0.6630.77
67_K70_A0.6580.76
106_P121_T0.6580.76
249_P277_M0.6560.76
219_R223_Q0.6560.76
313_L320_S0.6540.76
277_M280_R0.6520.76
103_K106_P0.6500.76
321_N339_V0.6480.75
276_D279_R0.6480.75
75_A78_E0.6480.75
257_L292_L0.6470.75
137_P166_A0.6460.75
313_L332_T0.6450.75
77_S170_L0.6430.75
52_R62_T0.6400.74
126_S204_D0.6390.74
182_F199_S0.6390.74
50_A54_Y0.6360.74
320_S342_I0.6350.74
335_A339_V0.6350.74
258_S418_A0.6330.74
247_A331_Q0.6320.73
94_N407_I0.6320.73
268_V305_S0.6300.73
282_A285_V0.6290.73
203_V228_A0.6270.73
120_V340_D0.6250.73
184_V192_A0.6250.73
71_E74_A0.6240.73
325_P328_L0.6240.73
345_A348_V0.6220.72
20_L306_R0.6210.72
92_V95_I0.6210.72
68_V72_E0.6210.72
129_L178_V0.6210.72
234_A366_N0.6200.72
273_P312_D0.6190.72
142_V176_C0.6150.71
233_P378_C0.6150.71
242_I332_T0.6150.71
52_R199_S0.6130.71
168_E413_A0.6100.71
124_V154_C0.6090.71
321_N343_T0.6080.71
129_L159_L0.6080.71
202_K224_R0.6060.70
72_E75_A0.6060.70
287_R290_A0.6060.70
223_Q377_T0.6050.70
417_T424_T0.6040.70
86_Q90_V0.6030.70
51_L66_L0.6010.70
317_V348_V0.6010.70
354_S393_Q0.6010.70
51_L54_Y0.5990.69
88_M168_E0.5980.69
289_L299_R0.5980.69
292_L417_T0.5980.69
285_V290_A0.5980.69
108_D392_V0.5970.69
68_V181_V0.5970.69
314_A318_E0.5970.69
67_K158_V0.5970.69
80_L171_Y0.5950.69
335_A394_E0.5950.69
205_K229_A0.5940.69
145_L159_L0.5930.69
51_L200_V0.5910.68
21_L24_P0.5910.68
70_A73_I0.5910.68
43_V61_T0.5860.68
96_E151_I0.5850.68
91_A410_L0.5850.68
102_Q119_Q0.5830.67
88_M171_Y0.5830.67
207_F368_V0.5830.67
98_F391_T0.5830.67
116_R396_S0.5820.67
291_E421_N0.5800.67
294_R415_R0.5800.67
68_V163_P0.5790.67
108_D118_Q0.5780.67
288_Q292_L0.5740.66
251_F353_W0.5740.66
322_Q376_A0.5730.66
159_L178_V0.5720.66
360_D367_H0.5700.66
278_A282_A0.5700.66
301_A305_S0.5680.65
252_V331_Q0.5670.65
126_S203_V0.5660.65
136_A294_R0.5650.65
400_F427_V0.5640.65
161_S164_P0.5630.65
53_E56_A0.5600.64
298_A302_L0.5570.64
260_A268_V0.5560.64
349_F356_E0.5540.63
259_Q360_D0.5540.63
163_P184_V0.5530.63
293_P298_A0.5510.63
120_V392_V0.5510.63
399_G403_L0.5510.63
347_S365_T0.5500.63
39_I58_F0.5500.63
318_E322_Q0.5490.63
160_C163_P0.5470.63
284_A423_V0.5460.62
73_I171_Y0.5450.62
251_F425_L0.5440.62
126_S158_V0.5410.62
138_L416_L0.5410.62
83_E87_A0.5390.61
172_A410_L0.5390.61
48_D192_A0.5370.61
240_L319_I0.5370.61
21_L319_I0.5360.61
121_T389_R0.5360.61
135_S232_M0.5360.61
170_L181_V0.5350.61
107_V120_V0.5350.61
408_E427_V0.5340.61
80_L175_L0.5330.61
40_L194_A0.5320.60
257_L302_L0.5320.60
122_R392_V0.5320.60
236_P265_D0.5320.60
85_K175_L0.5300.60
120_V390_M0.5280.60
62_T65_A0.5280.60
101_A107_V0.5270.60
94_N111_T0.5260.60
396_S399_G0.5260.60
256_L268_V0.5260.60
403_L406_T0.5250.59
272_T281_V0.5250.59
329_I366_N0.5240.59
357_S423_V0.5240.59
36_V220_Q0.5230.59
308_I319_I0.5230.59
125_A321_N0.5230.59
170_L386_F0.5220.59
342_I390_M0.5220.59
35_T43_V0.5220.59
355_P404_A0.5200.59
156_K179_Q0.5190.59
40_L51_L0.5190.59
273_P277_M0.5190.59
219_R222_S0.5180.58
245_S280_R0.5180.58
219_R377_T0.5180.58
207_F381_L0.5180.58
86_Q406_T0.5180.58
30_E41_D0.5180.58
400_F425_L0.5180.58
119_Q389_R0.5170.58
76_A171_Y0.5170.58
366_N381_L0.5160.58
85_K174_Q0.5150.58
143_L176_C0.5140.58
246_G252_V0.5130.58
118_Q336_R0.5110.57
70_A75_A0.5110.57
244_D247_A0.5110.57
267_Q323_Y0.5100.57
138_L215_T0.5100.57
133_G136_A0.5100.57
99_H151_I0.5090.57
73_I85_K0.5090.57
322_Q373_G0.5090.57
94_N112_Q0.5080.57
115_V399_G0.5070.57
124_V385_D0.5070.57
127_V207_F0.5060.57
117_C347_S0.5040.56
43_V160_C0.5030.56
257_L288_Q0.5020.56
293_P412_A0.5020.56
84_L410_L0.5010.56
222_S378_C0.5010.56
355_P423_V0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kaeA 2 1 100 0.017 Contact Map
4g09A 2 0.9724 100 0.032 Contact Map
4gicA 2 0.8594 100 0.061 Contact Map
3k9dA 2 0.8341 98 0.947 Contact Map
3my7A 2 0.7558 97.7 0.951 Contact Map
4itaA 2 0.7949 97.6 0.952 Contact Map
1euhA 4 0.818 97.6 0.952 Contact Map
4jbeA 2 0.7811 97.5 0.953 Contact Map
2w8nA 4 0.7995 97.5 0.953 Contact Map
3v4cA 2 0.8502 97.5 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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