GREMLIN Database
HIS8 - Histidinol-phosphate aminotransferase
UniProt: P06986 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10446
Length: 356 (324)
Sequences: 44009 (30796)
Seq/√Len: 1710.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_A123_E3.0191.00
81_S87_G2.9561.00
274_A341_R2.7531.00
278_Y345_Q2.7281.00
317_Q353_A2.7121.00
66_N258_S2.7111.00
96_C122_V2.6391.00
273_I277_E2.5701.00
165_P169_R2.4841.00
101_D148_K2.4111.00
228_A233_I2.3201.00
346_R350_A2.2501.00
141_S177_G2.2411.00
290_E303_R2.1921.00
102_A125_R2.1911.00
89_E93_R2.1371.00
340_T343_E2.1041.00
278_Y341_R2.1001.00
62_A254_A2.0961.00
164_N167_D2.0851.00
280_I284_K2.0431.00
41_T45_F2.0161.00
282_A348_I2.0031.00
282_A285_E1.9691.00
107_P126_T1.9681.00
44_E48_T1.9471.00
65_E75_P1.9051.00
66_N69_Q1.8961.00
223_C253_A1.8671.00
306_A309_A1.8321.00
282_A352_R1.7791.00
139_G143_K1.7771.00
134_Q167_D1.7601.00
182_V209_L1.7581.00
278_Y282_A1.7511.00
169_R173_E1.7401.00
280_I293_F1.7161.00
61_K65_E1.7131.00
114_S118_E1.6901.00
346_R349_D1.6671.00
317_Q350_A1.6581.00
102_A146_G1.6471.00
141_S170_T1.6411.00
312_K316_D1.6361.00
77_Q230_E1.6321.00
136_D139_G1.6241.00
175_T181_V1.6221.00
246_S249_V1.6141.00
65_E69_Q1.6121.00
117_A122_V1.6081.00
114_S126_T1.6081.00
103_I117_A1.5991.00
68_A75_P1.5961.00
139_G142_D1.5931.00
186_A211_T1.5921.00
69_Q258_S1.5851.00
45_F49_Q1.5801.00
104_L147_V1.5661.00
66_N254_A1.5551.00
91_L207_A1.5441.00
281_A285_E1.5381.00
102_A147_V1.5371.00
277_E281_A1.5361.00
178_K205_H1.5351.00
137_L170_T1.5171.00
309_A313_S1.5171.00
341_R345_Q1.5101.00
67_Y225_F1.5081.00
282_A349_D1.5051.00
170_T173_E1.4971.00
45_F48_T1.4931.00
271_Q341_R1.4801.00
107_P128_P1.4631.00
275_E341_R1.4501.00
226_T236_L1.4431.00
92_I117_A1.4391.00
34_L347_V1.4371.00
167_D170_T1.4281.00
282_A345_Q1.4261.00
73_V227_L1.4251.00
91_L182_V1.4221.00
138_Q170_T1.4161.00
84_A209_L1.4081.00
282_A286_I1.4001.00
286_I352_R1.3991.00
279_L300_I1.3821.00
309_A312_K1.3671.00
105_Y124_C1.3671.00
271_Q274_A1.3631.00
280_I300_I1.3601.00
149_V182_V1.3551.00
254_A258_S1.3551.00
212_L253_A1.3541.00
321_L334_L1.3541.00
41_T44_E1.3521.00
307_S325_N1.3481.00
285_E352_R1.3471.00
59_Q237_M1.3351.00
308_S325_N1.3351.00
98_P121_G1.3301.00
301_L324_Q1.3261.00
144_L174_L1.3231.00
266_R270_A1.3151.00
175_T179_A1.3111.00
280_I291_Q1.3111.00
76_E230_E1.3071.00
279_L348_I1.2941.00
303_R333_C1.2931.00
284_K291_Q1.2901.00
235_L238_K1.2901.00
303_R332_G1.2861.00
196_L200_L1.2821.00
210_R225_F1.2821.00
271_Q275_E1.2731.00
141_S174_L1.2611.00
93_R120_I1.2561.00
29_N318_G1.2541.00
97_E101_D1.2461.00
82_R86_E1.2451.00
74_K77_Q1.2451.00
128_P139_G1.2431.00
130_L167_D1.2301.00
62_A258_S1.2271.00
137_L174_L1.2261.00
260_Q263_V1.2251.00
174_L179_A1.2241.00
62_A251_D1.2041.00
173_E177_G1.2031.00
61_K75_P1.2021.00
92_I151_Y1.1871.00
234_N238_K1.1851.00
166_Q169_R1.1831.00
104_L127_V1.1741.00
64_I68_A1.1721.00
196_L199_W1.1681.00
204_P229_N1.1661.00
173_E176_R1.1631.00
302_A336_I1.1621.00
166_Q170_T1.1601.00
255_Q258_S1.1601.00
87_G226_T1.1491.00
345_Q349_D1.1461.00
313_S316_D1.1391.00
79_L233_I1.1381.00
180_I207_A1.1361.00
71_A227_L1.1351.00
251_D254_A1.1331.00
276_R280_I1.1321.00
92_I96_C1.1271.00
349_D353_A1.1211.00
276_R338_V1.1211.00
270_A273_I1.1161.00
255_Q259_P1.1101.00
343_E346_R1.1091.00
275_E278_Y1.1081.00
176_R203_Y1.1081.00
284_K293_F1.1051.00
314_L321_L1.0981.00
66_N70_Y1.0911.00
267_E271_Q1.0901.00
144_L179_A1.0851.00
207_A228_A1.0841.00
86_E240_I1.0821.00
313_S317_Q1.0801.00
59_Q64_I1.0791.00
193_Q295_S1.0771.00
197_A200_L1.0751.00
278_Y281_A1.0671.00
142_D145_D1.0651.00
94_A239_V1.0551.00
266_R269_V1.0521.00
308_S312_K1.0491.00
46_Q255_Q1.0471.00
150_V179_A1.0461.00
270_A274_A1.0461.00
176_R202_E1.0411.00
311_F321_L1.0351.00
42_A45_F1.0301.00
96_C103_I1.0281.00
103_I149_V1.0251.00
46_Q49_Q1.0171.00
30_G346_R1.0161.00
192_P273_I1.0111.00
281_A284_K1.0111.00
207_A226_T1.0051.00
165_P198_G0.9971.00
67_Y80_V0.9961.00
63_V80_V0.9951.00
62_A65_E0.9931.00
30_G318_G0.9831.00
264_A267_E0.9821.00
117_A124_C0.9811.00
67_Y78_V0.9771.00
176_R204_P0.9761.00
172_L206_L0.9691.00
307_S332_G0.9691.00
109_T153_C0.9651.00
77_Q233_I0.9581.00
107_P330_L0.9581.00
180_I205_H0.9551.00
306_A331_S0.9541.00
137_L141_S0.9521.00
74_K230_E0.9511.00
176_R205_H0.9491.00
169_R202_E0.9481.00
127_V143_K0.9441.00
180_I232_V0.9431.00
308_S323_D0.9421.00
96_C149_V0.9421.00
95_F149_V0.9411.00
264_A268_R0.9361.00
78_V227_L0.9311.00
314_L351_L0.9291.00
118_E124_C0.9241.00
350_A353_A0.9221.00
138_Q142_D0.9191.00
230_E234_N0.9191.00
191_C194_A0.9111.00
233_I237_M0.9081.00
68_A78_V0.9061.00
144_L147_V0.8991.00
336_I347_V0.8891.00
137_L171_L0.8861.00
307_S323_D0.8851.00
113_Y151_Y0.8851.00
71_A225_F0.8841.00
147_V179_A0.8841.00
87_G209_L0.8811.00
95_F180_I0.8801.00
207_A232_V0.8771.00
84_A211_T0.8741.00
195_S198_G0.8741.00
49_Q255_Q0.8721.00
82_R246_S0.8721.00
138_Q141_S0.8701.00
90_L240_I0.8691.00
70_Y189_E0.8691.00
106_C135_L0.8671.00
104_L143_K0.8641.00
286_I349_D0.8611.00
274_A278_Y0.8601.00
223_C245_L0.8601.00
106_C127_V0.8571.00
115_V118_E0.8561.00
61_K64_I0.8531.00
79_L236_L0.8521.00
209_L226_T0.8491.00
304_F334_L0.8441.00
125_R143_K0.8441.00
223_C249_V0.8441.00
68_A74_K0.8431.00
301_L333_C0.8401.00
279_L344_S0.8401.00
310_V334_L0.8351.00
42_A255_Q0.8351.00
286_I348_I0.8341.00
267_E270_A0.8341.00
325_N331_S0.8321.00
277_E293_F0.8301.00
84_A186_A0.8271.00
277_E280_I0.8271.00
311_F323_D0.8241.00
276_R294_D0.8241.00
137_L167_D0.8221.00
310_V314_L0.8201.00
52_L251_D0.8201.00
93_R239_V0.8201.00
279_L282_A0.8181.00
274_A277_E0.8131.00
130_L136_D0.8051.00
77_Q203_Y0.8031.00
189_E215_A0.8011.00
129_T156_N0.8001.00
86_E242_P0.7981.00
321_L336_I0.7971.00
28_G318_G0.7971.00
62_A66_N0.7941.00
228_A236_L0.7941.00
85_D112_M0.7941.00
63_V67_Y0.7921.00
342_E345_Q0.7901.00
275_E344_S0.7861.00
104_L140_I0.7731.00
215_A265_M0.7701.00
305_K332_G0.7691.00
79_L226_T0.7691.00
42_A259_P0.7671.00
86_E90_L0.7641.00
30_G343_E0.7641.00
102_A148_K0.7631.00
94_A236_L0.7591.00
43_V47_L0.7591.00
60_P250_A0.7581.00
273_I276_R0.7581.00
319_I350_A0.7571.00
237_M240_I0.7551.00
70_Y216_F0.7511.00
247_T251_D0.7501.00
96_C101_D0.7481.00
349_D352_R0.7471.00
172_L181_V0.7461.00
130_L134_Q0.7461.00
315_W320_I0.7441.00
156_N159_T0.7441.00
185_E208_I0.7421.00
68_A73_V0.7411.00
127_V139_G0.7381.00
39_Y272_I0.7361.00
279_L338_V0.7361.00
265_M269_V0.7351.00
89_E120_I0.7331.00
44_E47_L0.7331.00
281_A345_Q0.7291.00
283_L302_A0.7251.00
135_L167_D0.7241.00
134_Q164_N0.7181.00
228_A232_V0.7161.00
251_D255_Q0.7161.00
90_L236_L0.7151.00
252_I255_Q0.7141.00
263_V266_R0.7131.00
125_R147_V0.7101.00
268_R272_I0.7091.00
169_R199_W0.7061.00
104_L150_V0.7051.00
307_S331_S0.7021.00
81_S226_T0.6981.00
69_Q72_G0.6981.00
64_I75_P0.6981.00
113_Y117_A0.6941.00
302_A333_C0.6941.00
105_Y117_A0.6931.00
188_I210_R0.6911.00
192_P296_E0.6891.00
278_Y348_I0.6881.00
91_L236_L0.6881.00
231_E234_N0.6871.00
263_V267_E0.6861.00
291_Q303_R0.6851.00
140_I174_L0.6851.00
57_E61_K0.6801.00
70_Y188_I0.6791.00
152_V168_F0.6791.00
66_N257_L0.6771.00
290_E305_K0.6771.00
106_C156_N0.6761.00
162_L296_E0.6761.00
311_F315_W0.6701.00
73_V77_Q0.6681.00
319_I347_V0.6671.00
212_L225_F0.6651.00
103_I122_V0.6641.00
163_I167_D0.6641.00
234_N237_M0.6601.00
154_S185_E0.6601.00
193_Q273_I0.6591.00
195_S200_L0.6591.00
85_D110_Y0.6561.00
42_A46_Q0.6521.00
163_I168_F0.6521.00
105_Y126_T0.6491.00
201_A204_P0.6491.00
165_P199_W0.6471.00
89_E116_S0.6461.00
319_I351_L0.6451.00
64_I237_M0.6441.00
83_G222_R0.6431.00
140_I150_V0.6421.00
170_T174_L0.6391.00
229_N232_V0.6391.00
250_A254_A0.6381.00
307_S311_F0.6381.00
312_K315_W0.6371.00
34_L344_S0.6371.00
269_V273_I0.6361.00
128_P143_K0.6361.00
134_Q161_Q0.6301.00
192_P276_R0.6301.00
107_P328_P0.6281.00
190_F272_I0.6241.00
204_P231_E0.6221.00
126_T329_S0.6221.00
162_L191_C0.6221.00
79_L237_M0.6221.00
50_Q53_N0.6221.00
60_P64_I0.6191.00
196_L206_L0.6191.00
63_V66_N0.6191.00
276_R293_F0.6151.00
132_N167_D0.6131.00
187_Y299_Y0.6081.00
135_L140_I0.6071.00
88_I116_S0.6021.00
65_E68_A0.6021.00
79_L228_A0.5981.00
172_L202_E0.5971.00
41_T48_T0.5961.00
33_W38_E0.5961.00
82_R245_L0.5951.00
155_P296_E0.5951.00
185_E188_I0.5941.00
80_V223_C0.5941.00
344_S347_V0.5941.00
203_Y206_L0.5931.00
212_L257_L0.5931.00
141_S144_L0.5911.00
151_Y182_V0.5911.00
132_N164_N0.5881.00
195_S199_W0.5881.00
70_Y260_Q0.5851.00
56_P247_T0.5851.00
268_R271_Q0.5821.00
172_L175_T0.5811.00
131_D139_G0.5801.00
161_Q295_S0.5791.00
31_D320_I0.5761.00
198_G201_A0.5751.00
92_I149_V0.5751.00
41_T46_Q0.5721.00
63_V253_A0.5711.00
147_V150_V0.5701.00
154_S162_L0.5691.00
46_Q252_I0.5681.00
278_Y344_S0.5681.00
92_I122_V0.5641.00
98_P101_D0.5641.00
346_R353_A0.5631.00
32_V346_R0.5621.00
285_E345_Q0.5621.00
87_G224_G0.5621.00
101_D146_G0.5611.00
91_L95_F0.5601.00
193_Q276_R0.5591.00
33_W36_A0.5591.00
190_F269_V0.5591.00
94_A235_L0.5561.00
99_G123_E0.5561.00
183_A208_I0.5511.00
342_E346_R0.5501.00
90_L239_V0.5501.00
311_F334_L0.5491.00
43_V46_Q0.5471.00
73_V78_V0.5461.00
175_T178_K0.5451.00
97_E148_K0.5451.00
92_I120_I0.5441.00
92_I116_S0.5431.00
306_A325_N0.5411.00
174_L177_G0.5411.00
128_P136_D0.5401.00
105_Y114_S0.5391.00
175_T205_H0.5381.00
65_E258_S0.5361.00
240_I245_L0.5361.00
249_V252_I0.5351.00
292_V303_R0.5351.00
102_A145_D0.5351.00
171_L181_V0.5341.00
150_V175_T0.5341.00
245_L250_A0.5341.00
176_R201_A0.5341.00
279_L336_I0.5331.00
279_L347_V0.5331.00
37_N187_Y0.5321.00
39_Y268_R0.5311.00
149_V180_I0.5271.00
324_Q333_C0.5261.00
111_G326_K0.5261.00
168_F183_A0.5241.00
28_G31_D0.5221.00
245_L249_V0.5211.00
307_S334_L0.5201.00
103_I151_Y0.5201.00
71_A208_I0.5191.00
172_L176_R0.5181.00
107_P114_S0.5161.00
68_A77_Q0.5151.00
192_P338_V0.5141.00
38_E54_R0.5111.00
91_L149_V0.5081.00
213_S222_R0.5081.00
282_A344_S0.5061.00
341_R344_S0.5051.00
131_D134_Q0.5041.00
279_L283_L0.5021.00
85_D243_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fg7A 2 0.9944 100 0.26 Contact Map
3piuA 2 0.9635 100 0.313 Contact Map
1iayA 2 0.9888 100 0.342 Contact Map
3dydA 2 0.9494 100 0.344 Contact Map
3getA 2 0.9747 100 0.344 Contact Map
3h14A 2 0.9551 100 0.349 Contact Map
2x5dA 3 0.9579 100 0.35 Contact Map
3pplA 2 0.9888 100 0.35 Contact Map
3ez1A 2 0.9719 100 0.353 Contact Map
3ly1A 2 0.9213 100 0.354 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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