HIS8 - ECOLI - GREMLIN Contacts

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HIS8 - Histidinol-phosphate aminotransferase

UniProt:	P06986	Sequences: MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPTLDNWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAIVVADEAYIEFCPQASLAGWLAEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVAQIIAEREYLIAALKEIPCVEQVFDSETNYILARFKASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQRVIDALRAEQV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10446
Length:	356 (324)
Sequences:	44009 (30796)
Seq/√Len:	1710.9

ECOLI - HIS8 ALAC YBDL MALY ALAA YJIR AVTA YDCR
BACSU - HIS8 YUGH MTNE AAT3 AAT1 PATA AAT2 YCXD YHDI CBL YISV YDFD YDEL YDEF GABR
HALSA - HIS8 Q9HQK2 Q9HRM6 Q9HQW2 Q9HRX4 Q9HPL0
SULSO - AAT HIS8 Q97YX5 Y104 Q97TY7 Q97ZX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
102_A	123_E	3.019	1.00
81_S	87_G	2.956	1.00
274_A	341_R	2.753	1.00
278_Y	345_Q	2.728	1.00
317_Q	353_A	2.712	1.00
66_N	258_S	2.711	1.00
96_C	122_V	2.639	1.00
273_I	277_E	2.570	1.00
165_P	169_R	2.484	1.00
101_D	148_K	2.411	1.00
228_A	233_I	2.320	1.00
346_R	350_A	2.250	1.00
141_S	177_G	2.241	1.00
290_E	303_R	2.192	1.00
102_A	125_R	2.191	1.00
89_E	93_R	2.137	1.00
340_T	343_E	2.104	1.00
278_Y	341_R	2.100	1.00
62_A	254_A	2.096	1.00
164_N	167_D	2.085	1.00
280_I	284_K	2.043	1.00
41_T	45_F	2.016	1.00
282_A	348_I	2.003	1.00
282_A	285_E	1.969	1.00
107_P	126_T	1.968	1.00
44_E	48_T	1.947	1.00
65_E	75_P	1.905	1.00
66_N	69_Q	1.896	1.00
223_C	253_A	1.867	1.00
306_A	309_A	1.832	1.00
282_A	352_R	1.779	1.00
139_G	143_K	1.777	1.00
134_Q	167_D	1.760	1.00
182_V	209_L	1.758	1.00
278_Y	282_A	1.751	1.00
169_R	173_E	1.740	1.00
280_I	293_F	1.716	1.00
61_K	65_E	1.713	1.00
114_S	118_E	1.690	1.00
346_R	349_D	1.667	1.00
317_Q	350_A	1.658	1.00
102_A	146_G	1.647	1.00
141_S	170_T	1.641	1.00
312_K	316_D	1.636	1.00
77_Q	230_E	1.632	1.00
136_D	139_G	1.624	1.00
175_T	181_V	1.622	1.00
246_S	249_V	1.614	1.00
65_E	69_Q	1.612	1.00
117_A	122_V	1.608	1.00
114_S	126_T	1.608	1.00
103_I	117_A	1.599	1.00
68_A	75_P	1.596	1.00
139_G	142_D	1.593	1.00
186_A	211_T	1.592	1.00
69_Q	258_S	1.585	1.00
45_F	49_Q	1.580	1.00
104_L	147_V	1.566	1.00
66_N	254_A	1.555	1.00
91_L	207_A	1.544	1.00
281_A	285_E	1.538	1.00
102_A	147_V	1.537	1.00
277_E	281_A	1.536	1.00
178_K	205_H	1.535	1.00
137_L	170_T	1.517	1.00
309_A	313_S	1.517	1.00
341_R	345_Q	1.510	1.00
67_Y	225_F	1.508	1.00
282_A	349_D	1.505	1.00
170_T	173_E	1.497	1.00
45_F	48_T	1.493	1.00
271_Q	341_R	1.480	1.00
107_P	128_P	1.463	1.00
275_E	341_R	1.450	1.00
226_T	236_L	1.443	1.00
92_I	117_A	1.439	1.00
34_L	347_V	1.437	1.00
167_D	170_T	1.428	1.00
282_A	345_Q	1.426	1.00
73_V	227_L	1.425	1.00
91_L	182_V	1.422	1.00
138_Q	170_T	1.416	1.00
84_A	209_L	1.408	1.00
282_A	286_I	1.400	1.00
286_I	352_R	1.399	1.00
279_L	300_I	1.382	1.00
309_A	312_K	1.367	1.00
105_Y	124_C	1.367	1.00
271_Q	274_A	1.363	1.00
280_I	300_I	1.360	1.00
149_V	182_V	1.355	1.00
254_A	258_S	1.355	1.00
212_L	253_A	1.354	1.00
321_L	334_L	1.354	1.00
41_T	44_E	1.352	1.00
307_S	325_N	1.348	1.00
285_E	352_R	1.347	1.00
59_Q	237_M	1.335	1.00
308_S	325_N	1.335	1.00
98_P	121_G	1.330	1.00
301_L	324_Q	1.326	1.00
144_L	174_L	1.323	1.00
266_R	270_A	1.315	1.00
175_T	179_A	1.311	1.00
280_I	291_Q	1.311	1.00
76_E	230_E	1.307	1.00
279_L	348_I	1.294	1.00
303_R	333_C	1.293	1.00
284_K	291_Q	1.290	1.00
235_L	238_K	1.290	1.00
303_R	332_G	1.286	1.00
196_L	200_L	1.282	1.00
210_R	225_F	1.282	1.00
271_Q	275_E	1.273	1.00
141_S	174_L	1.261	1.00
93_R	120_I	1.256	1.00
29_N	318_G	1.254	1.00
97_E	101_D	1.246	1.00
82_R	86_E	1.245	1.00
74_K	77_Q	1.245	1.00
128_P	139_G	1.243	1.00
130_L	167_D	1.230	1.00
62_A	258_S	1.227	1.00
137_L	174_L	1.226	1.00
260_Q	263_V	1.225	1.00
174_L	179_A	1.224	1.00
62_A	251_D	1.204	1.00
173_E	177_G	1.203	1.00
61_K	75_P	1.202	1.00
92_I	151_Y	1.187	1.00
234_N	238_K	1.185	1.00
166_Q	169_R	1.183	1.00
104_L	127_V	1.174	1.00
64_I	68_A	1.172	1.00
196_L	199_W	1.168	1.00
204_P	229_N	1.166	1.00
173_E	176_R	1.163	1.00
302_A	336_I	1.162	1.00
166_Q	170_T	1.160	1.00
255_Q	258_S	1.160	1.00
87_G	226_T	1.149	1.00
345_Q	349_D	1.146	1.00
313_S	316_D	1.139	1.00
79_L	233_I	1.138	1.00
180_I	207_A	1.136	1.00
71_A	227_L	1.135	1.00
251_D	254_A	1.133	1.00
276_R	280_I	1.132	1.00
92_I	96_C	1.127	1.00
349_D	353_A	1.121	1.00
276_R	338_V	1.121	1.00
270_A	273_I	1.116	1.00
255_Q	259_P	1.110	1.00
343_E	346_R	1.109	1.00
275_E	278_Y	1.108	1.00
176_R	203_Y	1.108	1.00
284_K	293_F	1.105	1.00
314_L	321_L	1.098	1.00
66_N	70_Y	1.091	1.00
267_E	271_Q	1.090	1.00
144_L	179_A	1.085	1.00
207_A	228_A	1.084	1.00
86_E	240_I	1.082	1.00
313_S	317_Q	1.080	1.00
59_Q	64_I	1.079	1.00
193_Q	295_S	1.077	1.00
197_A	200_L	1.075	1.00
278_Y	281_A	1.067	1.00
142_D	145_D	1.065	1.00
94_A	239_V	1.055	1.00
266_R	269_V	1.052	1.00
308_S	312_K	1.049	1.00
46_Q	255_Q	1.047	1.00
150_V	179_A	1.046	1.00
270_A	274_A	1.046	1.00
176_R	202_E	1.041	1.00
311_F	321_L	1.035	1.00
42_A	45_F	1.030	1.00
96_C	103_I	1.028	1.00
103_I	149_V	1.025	1.00
46_Q	49_Q	1.017	1.00
30_G	346_R	1.016	1.00
192_P	273_I	1.011	1.00
281_A	284_K	1.011	1.00
207_A	226_T	1.005	1.00
165_P	198_G	0.997	1.00
67_Y	80_V	0.996	1.00
63_V	80_V	0.995	1.00
62_A	65_E	0.993	1.00
30_G	318_G	0.983	1.00
264_A	267_E	0.982	1.00
117_A	124_C	0.981	1.00
67_Y	78_V	0.977	1.00
176_R	204_P	0.976	1.00
172_L	206_L	0.969	1.00
307_S	332_G	0.969	1.00
109_T	153_C	0.965	1.00
77_Q	233_I	0.958	1.00
107_P	330_L	0.958	1.00
180_I	205_H	0.955	1.00
306_A	331_S	0.954	1.00
137_L	141_S	0.952	1.00
74_K	230_E	0.951	1.00
176_R	205_H	0.949	1.00
169_R	202_E	0.948	1.00
127_V	143_K	0.944	1.00
180_I	232_V	0.943	1.00
308_S	323_D	0.942	1.00
96_C	149_V	0.942	1.00
95_F	149_V	0.941	1.00
264_A	268_R	0.936	1.00
78_V	227_L	0.931	1.00
314_L	351_L	0.929	1.00
118_E	124_C	0.924	1.00
350_A	353_A	0.922	1.00
138_Q	142_D	0.919	1.00
230_E	234_N	0.919	1.00
191_C	194_A	0.911	1.00
233_I	237_M	0.908	1.00
68_A	78_V	0.906	1.00
144_L	147_V	0.899	1.00
336_I	347_V	0.889	1.00
137_L	171_L	0.886	1.00
307_S	323_D	0.885	1.00
113_Y	151_Y	0.885	1.00
71_A	225_F	0.884	1.00
147_V	179_A	0.884	1.00
87_G	209_L	0.881	1.00
95_F	180_I	0.880	1.00
207_A	232_V	0.877	1.00
84_A	211_T	0.874	1.00
195_S	198_G	0.874	1.00
49_Q	255_Q	0.872	1.00
82_R	246_S	0.872	1.00
138_Q	141_S	0.870	1.00
90_L	240_I	0.869	1.00
70_Y	189_E	0.869	1.00
106_C	135_L	0.867	1.00
104_L	143_K	0.864	1.00
286_I	349_D	0.861	1.00
274_A	278_Y	0.860	1.00
223_C	245_L	0.860	1.00
106_C	127_V	0.857	1.00
115_V	118_E	0.856	1.00
61_K	64_I	0.853	1.00
79_L	236_L	0.852	1.00
209_L	226_T	0.849	1.00
304_F	334_L	0.844	1.00
125_R	143_K	0.844	1.00
223_C	249_V	0.844	1.00
68_A	74_K	0.843	1.00
301_L	333_C	0.840	1.00
279_L	344_S	0.840	1.00
310_V	334_L	0.835	1.00
42_A	255_Q	0.835	1.00
286_I	348_I	0.834	1.00
267_E	270_A	0.834	1.00
325_N	331_S	0.832	1.00
277_E	293_F	0.830	1.00
84_A	186_A	0.827	1.00
277_E	280_I	0.827	1.00
311_F	323_D	0.824	1.00
276_R	294_D	0.824	1.00
137_L	167_D	0.822	1.00
310_V	314_L	0.820	1.00
52_L	251_D	0.820	1.00
93_R	239_V	0.820	1.00
279_L	282_A	0.818	1.00
274_A	277_E	0.813	1.00
130_L	136_D	0.805	1.00
77_Q	203_Y	0.803	1.00
189_E	215_A	0.801	1.00
129_T	156_N	0.800	1.00
86_E	242_P	0.798	1.00
321_L	336_I	0.797	1.00
28_G	318_G	0.797	1.00
62_A	66_N	0.794	1.00
228_A	236_L	0.794	1.00
85_D	112_M	0.794	1.00
63_V	67_Y	0.792	1.00
342_E	345_Q	0.790	1.00
275_E	344_S	0.786	1.00
104_L	140_I	0.773	1.00
215_A	265_M	0.770	1.00
305_K	332_G	0.769	1.00
79_L	226_T	0.769	1.00
42_A	259_P	0.767	1.00
86_E	90_L	0.764	1.00
30_G	343_E	0.764	1.00
102_A	148_K	0.763	1.00
94_A	236_L	0.759	1.00
43_V	47_L	0.759	1.00
60_P	250_A	0.758	1.00
273_I	276_R	0.758	1.00
319_I	350_A	0.757	1.00
237_M	240_I	0.755	1.00
70_Y	216_F	0.751	1.00
247_T	251_D	0.750	1.00
96_C	101_D	0.748	1.00
349_D	352_R	0.747	1.00
172_L	181_V	0.746	1.00
130_L	134_Q	0.746	1.00
315_W	320_I	0.744	1.00
156_N	159_T	0.744	1.00
185_E	208_I	0.742	1.00
68_A	73_V	0.741	1.00
127_V	139_G	0.738	1.00
39_Y	272_I	0.736	1.00
279_L	338_V	0.736	1.00
265_M	269_V	0.735	1.00
89_E	120_I	0.733	1.00
44_E	47_L	0.733	1.00
281_A	345_Q	0.729	1.00
283_L	302_A	0.725	1.00
135_L	167_D	0.724	1.00
134_Q	164_N	0.718	1.00
228_A	232_V	0.716	1.00
251_D	255_Q	0.716	1.00
90_L	236_L	0.715	1.00
252_I	255_Q	0.714	1.00
263_V	266_R	0.713	1.00
125_R	147_V	0.710	1.00
268_R	272_I	0.709	1.00
169_R	199_W	0.706	1.00
104_L	150_V	0.705	1.00
307_S	331_S	0.702	1.00
81_S	226_T	0.698	1.00
69_Q	72_G	0.698	1.00
64_I	75_P	0.698	1.00
113_Y	117_A	0.694	1.00
302_A	333_C	0.694	1.00
105_Y	117_A	0.693	1.00
188_I	210_R	0.691	1.00
192_P	296_E	0.689	1.00
278_Y	348_I	0.688	1.00
91_L	236_L	0.688	1.00
231_E	234_N	0.687	1.00
263_V	267_E	0.686	1.00
291_Q	303_R	0.685	1.00
140_I	174_L	0.685	1.00
57_E	61_K	0.680	1.00
70_Y	188_I	0.679	1.00
152_V	168_F	0.679	1.00
66_N	257_L	0.677	1.00
290_E	305_K	0.677	1.00
106_C	156_N	0.676	1.00
162_L	296_E	0.676	1.00
311_F	315_W	0.670	1.00
73_V	77_Q	0.668	1.00
319_I	347_V	0.667	1.00
212_L	225_F	0.665	1.00
103_I	122_V	0.664	1.00
163_I	167_D	0.664	1.00
234_N	237_M	0.660	1.00
154_S	185_E	0.660	1.00
193_Q	273_I	0.659	1.00
195_S	200_L	0.659	1.00
85_D	110_Y	0.656	1.00
42_A	46_Q	0.652	1.00
163_I	168_F	0.652	1.00
105_Y	126_T	0.649	1.00
201_A	204_P	0.649	1.00
165_P	199_W	0.647	1.00
89_E	116_S	0.646	1.00
319_I	351_L	0.645	1.00
64_I	237_M	0.644	1.00
83_G	222_R	0.643	1.00
140_I	150_V	0.642	1.00
170_T	174_L	0.639	1.00
229_N	232_V	0.639	1.00
250_A	254_A	0.638	1.00
307_S	311_F	0.638	1.00
312_K	315_W	0.637	1.00
34_L	344_S	0.637	1.00
269_V	273_I	0.636	1.00
128_P	143_K	0.636	1.00
134_Q	161_Q	0.630	1.00
192_P	276_R	0.630	1.00
107_P	328_P	0.628	1.00
190_F	272_I	0.624	1.00
204_P	231_E	0.622	1.00
126_T	329_S	0.622	1.00
162_L	191_C	0.622	1.00
79_L	237_M	0.622	1.00
50_Q	53_N	0.622	1.00
60_P	64_I	0.619	1.00
196_L	206_L	0.619	1.00
63_V	66_N	0.619	1.00
276_R	293_F	0.615	1.00
132_N	167_D	0.613	1.00
187_Y	299_Y	0.608	1.00
135_L	140_I	0.607	1.00
88_I	116_S	0.602	1.00
65_E	68_A	0.602	1.00
79_L	228_A	0.598	1.00
172_L	202_E	0.597	1.00
41_T	48_T	0.596	1.00
33_W	38_E	0.596	1.00
82_R	245_L	0.595	1.00
155_P	296_E	0.595	1.00
185_E	188_I	0.594	1.00
80_V	223_C	0.594	1.00
344_S	347_V	0.594	1.00
203_Y	206_L	0.593	1.00
212_L	257_L	0.593	1.00
141_S	144_L	0.591	1.00
151_Y	182_V	0.591	1.00
132_N	164_N	0.588	1.00
195_S	199_W	0.588	1.00
70_Y	260_Q	0.585	1.00
56_P	247_T	0.585	1.00
268_R	271_Q	0.582	1.00
172_L	175_T	0.581	1.00
131_D	139_G	0.580	1.00
161_Q	295_S	0.579	1.00
31_D	320_I	0.576	1.00
198_G	201_A	0.575	1.00
92_I	149_V	0.575	1.00
41_T	46_Q	0.572	1.00
63_V	253_A	0.571	1.00
147_V	150_V	0.570	1.00
154_S	162_L	0.569	1.00
46_Q	252_I	0.568	1.00
278_Y	344_S	0.568	1.00
92_I	122_V	0.564	1.00
98_P	101_D	0.564	1.00
346_R	353_A	0.563	1.00
32_V	346_R	0.562	1.00
285_E	345_Q	0.562	1.00
87_G	224_G	0.562	1.00
101_D	146_G	0.561	1.00
91_L	95_F	0.560	1.00
193_Q	276_R	0.559	1.00
33_W	36_A	0.559	1.00
190_F	269_V	0.559	1.00
94_A	235_L	0.556	1.00
99_G	123_E	0.556	1.00
183_A	208_I	0.551	1.00
342_E	346_R	0.550	1.00
90_L	239_V	0.550	1.00
311_F	334_L	0.549	1.00
43_V	46_Q	0.547	1.00
73_V	78_V	0.546	1.00
175_T	178_K	0.545	1.00
97_E	148_K	0.545	1.00
92_I	120_I	0.544	1.00
92_I	116_S	0.543	1.00
306_A	325_N	0.541	1.00
174_L	177_G	0.541	1.00
128_P	136_D	0.540	1.00
105_Y	114_S	0.539	1.00
175_T	205_H	0.538	1.00
65_E	258_S	0.536	1.00
240_I	245_L	0.536	1.00
249_V	252_I	0.535	1.00
292_V	303_R	0.535	1.00
102_A	145_D	0.535	1.00
171_L	181_V	0.534	1.00
150_V	175_T	0.534	1.00
245_L	250_A	0.534	1.00
176_R	201_A	0.534	1.00
279_L	336_I	0.533	1.00
279_L	347_V	0.533	1.00
37_N	187_Y	0.532	1.00
39_Y	268_R	0.531	1.00
149_V	180_I	0.527	1.00
324_Q	333_C	0.526	1.00
111_G	326_K	0.526	1.00
168_F	183_A	0.524	1.00
28_G	31_D	0.522	1.00
245_L	249_V	0.521	1.00
307_S	334_L	0.520	1.00
103_I	151_Y	0.520	1.00
71_A	208_I	0.519	1.00
172_L	176_R	0.518	1.00
107_P	114_S	0.516	1.00
68_A	77_Q	0.515	1.00
192_P	338_V	0.514	1.00
38_E	54_R	0.511	1.00
91_L	149_V	0.508	1.00
213_S	222_R	0.508	1.00
282_A	344_S	0.506	1.00
341_R	344_S	0.505	1.00
131_D	134_Q	0.504	1.00
279_L	283_L	0.502	1.00
85_D	243_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1fg7A	2	0.9944	100	0.26	Contact Map
3piuA	2	0.9635	100	0.313	Contact Map
1iayA	2	0.9888	100	0.342	Contact Map
3dydA	2	0.9494	100	0.344	Contact Map
3getA	2	0.9747	100	0.344	Contact Map
3h14A	2	0.9551	100	0.349	Contact Map
2x5dA	3	0.9579	100	0.35	Contact Map
3pplA	2	0.9888	100	0.35	Contact Map
3ez1A	2	0.9719	100	0.353	Contact Map
3ly1A	2	0.9213	100	0.354	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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