GREMLIN Database
HEM3 - Porphobilinogen deaminase
UniProt: P06983 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10429
Length: 313 (299)
Sequences: 3548 (2334)
Seq/√Len: 135.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_N225_A4.3191.00
157_S161_N4.2991.00
9_A75_A3.3101.00
7_R39_V3.2251.00
100_E221_H2.9671.00
102_E175_K2.9031.00
24_K28_M2.8751.00
171_V186_A2.6891.00
12_Q40_P2.6841.00
200_A228_V2.5841.00
237_R292_E2.5721.00
265_A269_S2.4631.00
124_I146_R2.4001.00
274_G290_L2.3981.00
206_R209_D2.3451.00
160_D182_R2.3451.00
12_Q42_V2.2871.00
256_E277_R2.2641.00
26_K29_A2.2481.00
276_R293_E2.2461.00
94_G207_L2.0891.00
92_G207_L2.0761.00
133_Q137_A2.0641.00
115_S118_A2.0271.00
274_G293_E2.0261.00
146_R164_Y2.0131.00
152_V177_L1.9981.00
48_I51_T1.9931.00
124_I144_I1.9571.00
260_R275_E1.9531.00
258_W277_R1.9511.00
14_P153_G1.9231.00
5_V35_V1.9101.00
221_H224_T1.9011.00
263_V299_A1.8871.00
96_V205_C1.8741.00
94_G213_R1.8731.00
148_L167_I1.8721.00
234_M261_A1.8711.00
8_I24_K1.8531.00
5_V37_E1.8511.00
68_V72_E1.8061.00
278_G286_M1.8021.00
276_R290_L1.7981.00
99_C201_V1.7771.00
225_A229_T1.7691.00
258_W275_E1.7671.00
21_H25_D1.7581.00
67_E204_E1.7451.00
22_Y26_K1.7341.00
82_M197_G1.7281.00
237_R288_I1.7101.00
20_A38_L1.6741.00
97_T220_N1.6261.00
274_G297_N1.6131.00
71_L93_L1.5831.00
292_E296_N1.5811.00
105_R186_A1.5771.00
75_A78_A1.5681.00
210_S214_E1.5571.00
4_N211_R1.5541.00
114_D118_A1.5411.00
188_P191_I1.5361.00
17_L40_P1.5301.00
153_G179_L1.5151.00
42_V47_V1.5091.00
270_Q301_E1.4871.00
196_V248_S1.4771.00
227_R252_L1.4761.00
21_H24_K1.4581.00
139_R191_I1.4521.00
10_T38_L1.4381.00
247_G262_L1.4351.00
98_I200_A1.4331.00
209_D212_T1.4321.00
31_H218_A1.4291.00
205_C213_R1.4211.00
28_M35_V1.4041.00
69_A74_R1.4001.00
229_T284_E1.3961.00
7_R37_E1.3951.00
105_R171_V1.3941.00
117_D191_I1.3901.00
137_A145_I1.3811.00
282_D285_Q1.3751.00
276_R289_S1.3511.00
125_V166_A1.3501.00
175_K180_E1.3401.00
96_V213_R1.3391.00
222_H226_L1.3321.00
24_K36_V1.3211.00
293_E297_N1.3141.00
234_M290_L1.3111.00
288_I292_E1.2941.00
103_D171_V1.2931.00
82_M202_G1.2821.00
251_E258_W1.2791.00
230_A259_L1.2571.00
18_W22_Y1.2531.00
289_S293_E1.2521.00
8_I77_I1.2441.00
146_R163_E1.2401.00
107_A171_V1.2351.00
41_M66_L1.2341.00
251_E260_R1.2341.00
133_Q147_S1.2291.00
6_L212_T1.2291.00
25_D29_A1.2281.00
185_A191_I1.2271.00
187_L192_S1.2261.00
285_Q289_S1.2221.00
212_T216_L1.2191.00
20_A24_K1.2171.00
117_D185_A1.2161.00
158_K163_E1.2111.00
264_G271_I1.2031.00
260_R273_R1.1850.99
82_M228_V1.1840.99
110_S184_R1.1840.99
109_V156_L1.1730.99
39_V74_R1.1720.99
164_Y167_I1.1670.99
125_V136_L1.1650.99
171_V175_K1.1640.99
134_C264_G1.1640.99
294_L299_A1.1570.99
133_Q145_I1.1520.99
95_L202_G1.1500.99
226_L280_P1.1330.99
287_G291_A1.1170.99
234_M294_L1.1160.99
109_V174_L1.1150.99
253_I258_W1.1120.99
115_S185_A1.1090.99
234_M259_L1.1060.99
179_L182_R1.1020.99
41_M69_A1.1020.99
295_L300_R1.1020.99
138_E271_I1.1010.99
214_E217_A1.0910.99
237_R295_L1.0800.99
284_E288_I1.0760.99
28_M36_V1.0740.99
236_T284_E1.0740.99
278_G283_A1.0700.99
17_L21_H1.0610.99
159_L167_I1.0610.99
253_I277_R1.0580.99
205_C216_L1.0540.99
223_E280_P1.0420.99
25_D28_M1.0380.99
23_V99_C1.0320.99
89_F204_E1.0240.98
33_G36_V0.9910.98
12_Q41_M0.9870.98
8_I20_A0.9860.98
98_I228_V0.9820.98
230_A257_I0.9800.98
7_R73_N0.9790.98
49_L153_G0.9730.98
183_I186_A0.9730.98
233_A237_R0.9690.98
259_L290_L0.9630.98
52_P147_S0.9630.98
279_A282_D0.9590.98
103_D186_A0.9530.98
85_V202_G0.9510.98
180_E183_I0.9490.97
69_A75_A0.9480.97
119_L123_S0.9480.97
125_V143_L0.9400.97
285_Q288_I0.9400.97
136_L143_L0.9370.97
21_H38_L0.9340.97
110_S113_Y0.9340.97
8_I36_V0.9330.97
171_V183_I0.9300.97
67_E93_L0.9300.97
283_A287_G0.9240.97
122_G143_L0.9220.97
152_V169_L0.9220.97
193_L247_G0.9210.97
124_I164_Y0.9170.97
223_E227_R0.9080.97
153_G157_S0.9070.97
152_V179_L0.9000.97
248_S259_L0.8990.97
44_R48_I0.8970.96
93_L204_E0.8940.96
272_I302_I0.8930.96
261_A290_L0.8880.96
103_D175_K0.8880.96
240_G246_I0.8830.96
104_P249_Y0.8810.96
262_L273_R0.8720.96
213_R217_A0.8660.96
123_S140_R0.8630.96
117_D139_R0.8590.96
253_I256_E0.8500.95
134_C268_G0.8480.95
120_P123_S0.8440.95
53_L58_G0.8430.95
59_K65_E0.8400.95
94_G205_C0.8380.95
175_K186_A0.8340.95
193_L260_R0.8340.95
210_S213_R0.8270.94
169_L173_G0.8260.94
138_E273_R0.8250.94
140_R143_L0.8210.94
56_V61_L0.8200.94
114_D184_R0.8170.94
39_V75_A0.8160.94
51_T55_K0.8150.94
44_R56_V0.8100.94
90_P93_L0.8050.94
82_M95_L0.8030.94
123_S143_L0.8030.94
76_D206_R0.8010.93
121_A144_I0.8010.93
200_A224_T0.7990.93
10_T16_A0.7930.93
262_L271_I0.7930.93
6_L36_V0.7930.93
121_A142_D0.7920.93
136_L145_I0.7920.93
12_Q17_L0.7890.93
91_Q207_L0.7880.93
252_L280_P0.7790.93
226_L283_A0.7790.93
116_L185_A0.7750.92
24_K38_L0.7740.92
108_F111_N0.7730.92
22_Y201_V0.7670.92
238_L261_A0.7630.92
27_L34_L0.7620.92
111_N160_D0.7600.92
105_R188_P0.7580.91
293_E296_N0.7570.91
233_A284_E0.7570.91
15_L152_V0.7560.91
63_V93_L0.7500.91
14_P18_W0.7490.91
63_V87_V0.7490.91
6_L77_I0.7480.91
265_A270_Q0.7470.91
289_S292_E0.7450.91
187_L191_I0.7410.91
57_G61_L0.7410.91
53_L61_L0.7400.90
238_L246_I0.7380.90
276_R286_M0.7370.90
137_A144_I0.7370.90
107_A174_L0.7330.90
53_L57_G0.7320.90
189_P249_Y0.7320.90
82_M98_I0.7280.90
227_R250_A0.7270.90
234_M291_A0.7270.90
44_R65_E0.7270.90
215_L218_A0.7250.90
135_Q193_L0.7250.90
123_S142_D0.7220.89
108_F166_A0.7210.89
224_T228_V0.7210.89
217_A220_N0.7190.89
126_G164_Y0.7160.89
148_L164_Y0.7150.89
98_I225_A0.7040.88
9_A39_V0.6960.88
44_R47_V0.6960.88
193_L249_Y0.6940.87
87_V134_C0.6930.87
234_M248_S0.6920.87
17_L38_L0.6910.87
105_R189_P0.6880.87
264_G273_R0.6840.87
194_P249_Y0.6830.87
67_E89_F0.6800.86
26_K100_E0.6800.86
208_D213_R0.6800.86
227_R251_E0.6790.86
97_T216_L0.6790.86
274_G294_L0.6790.86
22_Y99_C0.6770.86
18_W21_H0.6750.86
223_E252_L0.6750.86
270_Q297_N0.6750.86
265_A268_G0.6740.86
233_A288_I0.6740.86
67_E85_V0.6730.86
233_A287_G0.6700.86
157_S160_D0.6680.85
190_E260_R0.6680.85
257_I286_M0.6680.85
7_R76_D0.6670.85
70_L73_N0.6670.85
101_R227_R0.6650.85
23_V219_L0.6630.85
64_K67_E0.6630.85
21_H40_P0.6630.85
196_V235_N0.6610.85
255_G281_Q0.6600.85
87_V235_N0.6570.84
27_L215_L0.6550.84
135_Q192_S0.6520.84
87_V241_G0.6500.84
67_E70_L0.6500.84
77_I216_L0.6500.84
15_L102_E0.6500.84
31_H215_L0.6500.84
18_W201_V0.6490.84
172_A201_V0.6490.84
112_N165_D0.6480.84
226_L252_L0.6470.84
108_F116_L0.6470.84
159_L164_Y0.6450.83
27_L36_V0.6440.83
73_N208_D0.6430.83
108_F184_R0.6400.83
97_T205_C0.6390.83
23_V203_I0.6380.83
139_R187_L0.6340.82
20_A77_I0.6330.82
116_L119_L0.6330.82
120_P140_R0.6310.82
71_L92_G0.6290.82
156_L160_D0.6280.82
272_I294_L0.6270.82
139_R142_D0.6260.82
77_I205_C0.6260.82
108_F113_Y0.6250.81
10_T40_P0.6250.81
34_L215_L0.6190.81
230_A283_A0.6150.80
93_L206_R0.6130.80
255_G280_P0.6110.80
159_L166_A0.6100.80
51_T54_A0.6060.79
41_M153_G0.6060.79
23_V97_T0.6050.79
197_G200_A0.6040.79
107_A183_I0.6020.79
22_Y25_D0.6010.79
241_G244_V0.6010.79
66_L99_C0.6010.79
20_A36_V0.6000.79
211_R214_E0.5990.79
283_A286_M0.5980.79
52_P55_K0.5970.78
43_T65_E0.5960.78
207_L213_R0.5950.78
61_L240_G0.5930.78
251_E254_D0.5920.78
193_L262_L0.5910.78
32_P36_V0.5910.78
102_E170_A0.5900.78
64_K71_L0.5890.77
59_K67_E0.5850.77
156_L159_L0.5820.77
256_E279_A0.5800.76
230_A287_G0.5790.76
11_R15_L0.5790.76
278_G282_D0.5790.76
50_D56_V0.5770.76
102_E172_A0.5770.76
229_T283_A0.5760.76
152_V173_G0.5750.76
55_K243_Q0.5740.76
156_L174_L0.5730.76
12_Q43_T0.5720.75
162_G166_A0.5720.75
153_G177_L0.5710.75
122_G140_R0.5710.75
272_I298_G0.5710.75
56_V63_V0.5700.75
78_A194_P0.5700.75
41_M75_A0.5680.75
48_I56_V0.5680.75
64_K69_A0.5680.75
238_L263_V0.5670.75
14_P177_L0.5620.74
119_L125_V0.5620.74
136_L168_I0.5620.74
126_G162_G0.5600.74
298_G302_I0.5600.74
239_E246_I0.5600.74
239_E300_R0.5550.73
54_A243_Q0.5550.73
51_T56_V0.5540.73
59_K244_V0.5530.73
18_W174_L0.5500.73
9_A41_M0.5500.73
121_A140_R0.5500.73
272_I290_L0.5490.72
11_R16_A0.5490.72
89_F93_L0.5470.72
194_P250_A0.5460.72
58_G63_V0.5460.72
278_G290_L0.5450.72
48_I61_L0.5440.72
244_V298_G0.5430.72
64_K68_V0.5420.71
239_E261_A0.5420.71
168_I192_S0.5400.71
47_V51_T0.5400.71
223_E226_L0.5390.71
49_L52_P0.5390.71
49_L130_L0.5380.71
119_L166_A0.5380.71
226_L257_I0.5380.71
249_Y260_R0.5370.71
107_A186_A0.5360.71
284_E287_G0.5360.71
81_S202_G0.5340.70
88_E236_T0.5340.70
295_L299_A0.5340.70
32_P215_L0.5330.70
128_S147_S0.5330.70
290_L293_E0.5330.70
261_A291_A0.5330.70
127_T133_Q0.5330.70
248_S287_G0.5320.70
49_L60_G0.5320.70
36_V77_I0.5300.70
64_K90_P0.5290.70
243_Q246_I0.5270.69
28_M32_P0.5250.69
135_Q262_L0.5230.69
57_G60_G0.5220.69
290_L297_N0.5210.69
214_E218_A0.5200.68
226_L278_G0.5170.68
77_I212_T0.5160.68
14_P21_H0.5160.68
18_W152_V0.5150.68
63_V197_G0.5130.67
261_A287_G0.5110.67
111_N184_R0.5100.67
23_V26_K0.5070.66
4_N212_T0.5060.66
128_S172_A0.5050.66
51_T243_Q0.5050.66
63_V66_L0.5050.66
81_S170_A0.5040.66
70_L204_E0.5030.66
10_T20_A0.5000.65
110_S166_A0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gtkA 1 0.9393 100 0.012 Contact Map
4mlvA 1 0.9137 100 0.034 Contact Map
3ecrA 1 0.9297 100 0.036 Contact Map
4htgA 2 0.9393 100 0.042 Contact Map
4gotA 1 0.6805 97.5 0.928 Contact Map
3un6A 1 0.8339 97.3 0.93 Contact Map
4qhqA 1 0.6486 97.2 0.932 Contact Map
1xs5A 1 0.6677 97.1 0.933 Contact Map
4ef1A 1 0.6741 97 0.934 Contact Map
4ntlA 1 0.6645 97 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.