GREMLIN Database
FLIM - Flagellar motor switch protein FliM
UniProt: P06974 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10323
Length: 334 (309)
Sequences: 1883 (1277)
Seq/√Len: 72.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_D135_G5.9361.00
263_A292_I5.7141.00
294_A304_S5.6031.00
264_N267_D5.0091.00
303_T319_H4.8941.00
147_T150_E4.0951.00
65_F161_A4.0541.00
294_A315_L3.9021.00
8_Q12_D3.8531.00
270_L275_I3.5781.00
293_I303_T3.3301.00
123_V154_I3.1661.00
291_R318_E3.1611.00
75_R209_G3.1251.00
131_F153_V3.0681.00
304_S315_L3.0611.00
68_G164_G2.9401.00
293_I300_P2.8861.00
166_S176_E2.7581.00
263_A294_A2.6811.00
270_L278_L2.5721.00
278_L282_D2.5251.00
266_A286_I2.4041.00
12_D18_D2.3451.00
21_V25_P2.2471.00
250_L253_Q2.2231.00
264_N293_I2.1611.00
48_R51_L2.0791.00
272_L275_I1.9951.00
264_N295_H1.9431.00
155_N159_K1.9121.00
221_F225_E1.8811.00
126_A157_M1.8351.00
91_E94_R1.8101.00
273_S277_K1.7941.00
128_D133_G1.7931.00
305_Q318_E1.7611.00
21_V24_E1.7451.00
300_P321_I1.7451.00
96_L100_T1.7441.00
23_D27_A1.7321.00
288_K293_I1.7181.00
203_P214_E1.7111.00
91_E95_N1.6941.00
88_P91_E1.6851.00
23_D26_T1.6431.00
131_F149_T1.6381.00
291_R305_Q1.6371.00
260_E297_D1.6270.99
22_K27_A1.6040.99
262_V298_G1.5980.99
199_V218_C1.5870.99
39_D43_Q1.5860.99
166_S177_V1.5790.99
108_K178_E1.5670.99
7_S15_L1.5630.99
103_N179_Y1.5350.99
46_V51_L1.5130.99
262_V295_H1.5010.99
53_A231_L1.4810.99
183_E188_F1.4740.99
205_H212_T1.4630.99
17_G21_V1.4580.99
19_S22_K1.4470.99
8_Q11_I1.4320.99
95_N201_N1.4290.99
81_V204_F1.4290.99
271_R274_Q1.4270.99
134_D137_F1.4110.99
292_I315_L1.4010.98
243_D246_W1.3970.98
63_R74_R1.3550.98
172_I231_L1.3460.98
90_H94_R1.3440.98
309_L314_A1.3390.98
20_E25_P1.3350.98
18_D21_V1.3280.98
89_Y199_V1.3260.98
307_G314_A1.3210.98
276_L286_I1.3200.98
308_T311_G1.3180.98
116_V217_I1.3010.97
261_L302_L1.2890.97
20_E23_D1.2640.97
105_I162_L1.2550.97
304_S308_T1.2500.97
272_L284_L1.2440.97
5_I18_D1.2250.96
8_Q15_L1.2190.96
92_F218_C1.2140.96
9_A21_V1.2140.96
38_Y43_Q1.1880.96
268_I286_I1.1850.96
114_G219_L1.1800.95
168_A231_L1.1770.95
6_L10_E1.1740.95
4_S17_G1.1740.95
21_V27_A1.1720.95
261_L296_V1.1670.95
12_D97_P1.1650.95
16_N19_S1.1640.95
254_V299_V1.1630.95
109_P176_E1.1560.95
122_L206_V1.1520.95
20_E27_A1.1490.95
10_E14_L1.1490.95
147_T162_L1.1380.94
21_V40_P1.1320.94
263_A279_N1.1240.94
291_R303_T1.1220.94
124_F150_E1.1200.94
70_F301_V1.1160.94
266_A308_T1.1060.94
69_L224_I1.1050.94
90_H185_Q1.1040.94
21_V321_I1.0920.93
17_G298_G1.0850.93
207_E212_T1.0820.93
243_D247_R1.0790.93
24_E27_A1.0770.93
97_P196_N1.0670.92
56_I181_R1.0620.92
266_A296_V1.0600.92
295_H304_S1.0490.92
64_H315_L1.0480.92
102_L259_L1.0460.92
174_P290_D1.0450.92
58_N202_T1.0420.91
92_F216_N1.0390.91
272_L276_L1.0380.91
22_K25_P1.0360.91
78_D207_E1.0350.91
24_E284_L1.0310.91
125_I129_N1.0260.91
82_G205_H1.0250.91
263_A302_L1.0250.91
104_L113_T1.0220.91
83_A214_E1.0190.90
122_L213_G1.0170.90
16_N20_E1.0070.90
54_L200_V1.0050.90
49_E113_T0.9960.89
242_E247_R0.9960.89
305_Q316_R0.9920.89
9_A17_G0.9890.89
67_M188_F0.9850.89
251_V254_V0.9840.89
114_G217_I0.9820.89
167_D170_K0.9820.89
119_S213_G0.9790.89
173_N290_D0.9670.88
61_F165_Y0.9570.88
46_V88_P0.9510.87
59_E63_R0.9460.87
266_A288_K0.9350.86
130_L304_S0.9320.86
69_L157_M0.9320.86
150_E319_H0.9290.86
58_N169_W0.9260.86
110_L226_P0.9200.85
223_M227_L0.9190.85
7_S10_E0.9150.85
289_P292_I0.9070.85
183_E186_V0.9060.84
36_R81_V0.9020.84
168_A298_G0.8990.84
16_N23_D0.8930.84
254_V257_S0.8880.83
204_F259_L0.8790.83
176_E259_L0.8740.82
172_I189_T0.8730.82
150_E223_M0.8700.82
89_Y194_S0.8680.82
11_I18_D0.8590.81
19_S23_D0.8550.81
267_D295_H0.8540.81
309_L316_R0.8540.81
93_A186_V0.8530.81
292_I304_S0.8530.81
40_P43_Q0.8510.81
198_I221_F0.8510.81
16_N24_E0.8500.80
4_S7_S0.8490.80
155_N258_Q0.8480.80
95_N274_Q0.8460.80
256_H299_V0.8460.80
114_G162_L0.8420.80
72_L160_L0.8420.80
40_P45_R0.8420.80
101_N151_Q0.8400.80
18_D23_D0.8390.80
107_L175_L0.8370.79
122_L158_L0.8340.79
264_N315_L0.8330.79
151_Q155_N0.8310.79
46_V49_E0.8310.79
50_R225_E0.8300.79
170_K303_T0.8280.79
50_R55_E0.8250.78
262_V318_E0.8240.78
114_G158_L0.8190.78
112_G126_A0.8120.77
229_E236_L0.8070.77
89_Y93_A0.8040.77
147_T199_V0.8010.76
52_Q55_E0.7980.76
118_F215_F0.7970.76
84_I200_V0.7970.76
215_F265_F0.7950.76
84_I179_Y0.7940.76
49_E88_P0.7930.76
5_I9_A0.7920.76
238_N241_N0.7910.76
107_L114_G0.7860.75
92_F102_L0.7830.75
272_L280_P0.7810.75
292_I306_Y0.7780.74
124_F144_R0.7760.74
169_W197_D0.7720.74
39_D42_T0.7690.73
194_S197_D0.7670.73
183_E191_I0.7670.73
101_N146_F0.7660.73
62_A298_G0.7660.73
157_M290_D0.7640.73
36_R39_D0.7620.73
91_E187_K0.7620.73
20_E24_E0.7620.73
77_P202_T0.7580.72
163_E167_D0.7530.72
214_E254_V0.7520.72
144_R189_T0.7510.72
19_S26_T0.7470.71
9_A13_A0.7470.71
68_G160_L0.7400.71
4_S22_K0.7350.70
79_I206_V0.7320.70
101_N130_L0.7230.69
128_D317_I0.7230.69
80_T227_L0.7220.69
238_N294_A0.7220.69
170_K208_I0.7210.69
81_V213_G0.7190.68
306_Y313_Y0.7170.68
254_V280_P0.7150.68
79_I204_F0.7150.68
70_F77_P0.7140.68
245_N269_S0.7140.68
273_S313_Y0.7140.68
125_I261_L0.7130.68
291_R319_H0.7110.67
271_R277_K0.7080.67
219_L264_N0.7070.67
51_L183_E0.7060.67
163_E304_S0.7040.67
66_R81_V0.7030.67
103_N183_E0.7030.67
19_S25_P0.6990.66
219_L233_N0.6970.66
262_V306_Y0.6950.66
247_R251_V0.6950.66
264_N270_L0.6940.66
45_R185_Q0.6910.65
110_L175_L0.6910.65
267_D293_I0.6860.65
109_P112_G0.6860.65
95_N119_S0.6850.65
144_R150_E0.6850.65
154_I254_V0.6840.64
105_I114_G0.6840.64
257_S302_L0.6840.64
301_V306_Y0.6830.64
231_L287_E0.6820.64
52_Q60_R0.6810.64
264_N319_H0.6790.64
149_T220_P0.6790.64
188_F226_P0.6790.64
27_A269_S0.6790.64
44_R88_P0.6760.64
187_K192_T0.6750.63
249_N253_Q0.6750.63
208_I236_L0.6720.63
259_L276_L0.6720.63
127_V154_I0.6710.63
18_D26_T0.6700.63
104_L231_L0.6700.63
258_Q267_D0.6690.63
46_V90_H0.6690.63
164_G168_A0.6680.63
155_N179_Y0.6680.63
225_E231_L0.6650.62
5_I21_V0.6650.62
77_P152_R0.6630.62
148_H246_W0.6630.62
282_D307_G0.6610.62
270_L274_Q0.6610.62
13_A54_L0.6580.61
129_N167_D0.6570.61
186_V189_T0.6550.61
228_R231_L0.6540.61
86_I196_N0.6540.61
308_T320_L0.6540.61
56_I263_A0.6540.61
159_K212_T0.6520.61
266_A287_E0.6520.61
263_A288_K0.6500.61
44_R86_I0.6490.60
158_L170_K0.6470.60
118_F198_I0.6460.60
143_G290_D0.6460.60
179_Y184_M0.6430.60
38_Y41_N0.6430.60
134_D175_L0.6420.60
309_L312_Q0.6410.59
76_S124_F0.6390.59
295_H308_T0.6360.59
110_L173_N0.6350.59
185_Q201_N0.6350.59
95_N190_N0.6340.59
116_V178_E0.6310.58
21_V184_M0.6300.58
251_V255_Q0.6300.58
264_N309_L0.6300.58
219_L226_P0.6290.58
185_Q226_P0.6290.58
264_N308_T0.6290.58
4_S21_V0.6270.58
99_P143_G0.6270.58
155_N302_L0.6260.58
54_L57_I0.6250.58
263_A315_L0.6250.58
285_P288_K0.6230.57
144_R191_I0.6220.57
133_G220_P0.6200.57
19_S27_A0.6190.57
302_L320_L0.6180.57
150_E183_E0.6170.57
256_H262_V0.6170.57
39_D186_V0.6130.56
80_T152_R0.6130.56
16_N26_T0.6120.56
39_D218_C0.6120.56
21_V26_T0.6110.56
130_L158_L0.6090.56
116_V248_D0.6060.55
95_N186_V0.6050.55
39_D45_R0.6040.55
86_I197_D0.6030.55
85_R153_V0.6000.55
82_G297_D0.5990.54
257_S296_V0.5970.54
181_R191_I0.5960.54
68_G153_V0.5940.54
269_S320_L0.5940.54
13_A257_S0.5930.54
162_L170_K0.5910.53
252_R303_T0.5900.53
12_D100_T0.5890.53
234_P317_I0.5880.53
120_P124_F0.5880.53
252_R284_L0.5880.53
206_V234_P0.5870.53
130_L251_V0.5860.53
139_T144_R0.5860.53
262_V292_I0.5850.53
92_F115_L0.5840.53
78_D195_P0.5810.52
295_H300_P0.5790.52
116_V163_E0.5780.52
61_F74_R0.5780.52
260_E298_G0.5760.52
17_G25_P0.5750.51
220_P278_L0.5730.51
87_Q92_F0.5720.51
208_I211_L0.5700.51
256_H293_I0.5700.51
262_V283_V0.5690.51
125_I213_G0.5690.51
64_H107_L0.5690.51
178_E206_V0.5680.51
120_P182_S0.5650.50
44_R221_F0.5610.50
52_Q228_R0.5610.50
257_S309_L0.5610.50
302_L307_G0.5600.50
266_A291_R0.5600.50
46_V50_R0.5590.49
114_G159_K0.5590.49
99_P126_A0.5590.49
268_I308_T0.5570.49
17_G23_D0.5560.49
64_H164_G0.5550.49
206_V214_E0.5540.49
37_P240_R0.5540.49
184_M188_F0.5530.49
39_D190_N0.5520.49
274_Q311_G0.5510.48
183_E226_P0.5500.48
131_F291_R0.5500.48
267_D292_I0.5500.48
177_V294_A0.5490.48
250_L259_L0.5480.48
156_R316_R0.5480.48
206_V215_F0.5480.48
302_L309_L0.5470.48
43_Q99_P0.5460.48
285_P289_P0.5450.48
9_A22_K0.5440.48
302_L317_I0.5440.48
170_K287_E0.5440.48
109_P124_F0.5430.47
256_H309_L0.5430.47
203_P235_P0.5410.47
257_S310_N0.5410.47
183_E190_N0.5400.47
93_A209_G0.5390.47
44_R198_I0.5390.47
106_H180_V0.5370.47
115_L280_P0.5360.47
261_L277_K0.5340.46
209_G276_L0.5340.46
22_K241_N0.5320.46
39_D89_Y0.5320.46
73_L208_I0.5320.46
161_A175_L0.5300.46
276_L295_H0.5300.46
117_V301_V0.5250.45
134_D312_Q0.5240.45
184_M187_K0.5230.45
95_N218_C0.5230.45
39_D48_R0.5230.45
206_V312_Q0.5220.45
262_V290_D0.5220.45
78_D181_R0.5220.45
265_F274_Q0.5220.45
115_L185_Q0.5200.45
159_K170_K0.5190.45
97_P231_L0.5180.44
23_D238_N0.5150.44
18_D90_H0.5140.44
54_L136_R0.5130.44
153_V160_L0.5130.44
9_A290_D0.5130.44
149_T231_L0.5120.44
293_I318_E0.5120.44
116_V277_K0.5110.44
64_H171_A0.5110.44
112_G225_E0.5110.44
290_D308_T0.5100.43
82_G106_H0.5080.43
86_I187_K0.5080.43
9_A270_L0.5060.43
182_S197_D0.5060.43
53_A72_L0.5050.43
155_N214_E0.5050.43
108_K119_S0.5050.43
263_A304_S0.5050.43
254_V277_K0.5030.43
41_N192_T0.5030.43
104_L123_V0.5010.42
203_P216_N0.5010.42
90_H186_V0.5010.42
262_V268_I0.5000.42
40_P48_R0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gc8A 1 0.5509 100 0.524 Contact Map
4fhrA 1 0.5449 100 0.608 Contact Map
4hynA 1 0.5749 100 0.657 Contact Map
1xkrA 1 0.5569 100 0.659 Contact Map
4yxcB 1 0.4701 99.9 0.697 Contact Map
3qtaA 2 0.5778 99.8 0.733 Contact Map
1o6aA 2 0.2545 99.8 0.743 Contact Map
4yxbD 2 0.2335 99.8 0.755 Contact Map
3uepA 2 0.2485 99.8 0.756 Contact Map
4tt9A 2 0.2126 99.7 0.766 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.