GREMLIN Database
DUT - Deoxyuridine 5'-triphosphate nucleotidohydrolase
UniProt: P06968 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10251
Length: 151 (139)
Sequences: 3854 (2317)
Seq/√Len: 196.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_T27_S2.6671.00
57_H136_D2.6421.00
111_Q114_E2.4541.00
30_L129_F2.4151.00
43_A107_S2.4031.00
39_A111_Q2.3561.00
65_A119_M2.3021.00
43_A46_D2.0811.00
27_S91_D2.0451.00
24_T91_D2.0151.00
41_E109_T2.0131.00
77_H108_F1.9731.00
75_H99_S1.9241.00
29_G120_I1.8961.00
26_G90_S1.8611.00
51_P97_M1.8241.00
22_Y126_Q1.7381.00
47_T78_G1.7301.00
79_I108_F1.7281.00
16_E112_P1.7191.00
68_L87_L1.7011.00
58_I121_F1.6791.00
46_D105_Q1.6541.00
56_I65_A1.6471.00
39_A112_P1.6441.00
114_E150_R1.6301.00
34_A110_I1.6181.00
41_E107_S1.6121.00
44_P107_S1.6081.00
18_P33_R1.6061.00
58_I65_A1.6001.00
49_L75_H1.6001.00
22_Y30_L1.6001.00
57_H93_Q1.4981.00
66_M122_V1.4551.00
32_L65_A1.4271.00
65_A121_F1.4221.00
22_Y127_A1.3981.00
66_M87_L1.3911.00
17_F112_P1.3821.00
64_A87_L1.3761.00
12_R131_L1.3731.00
68_L122_V1.3701.00
49_L97_M1.3661.00
51_P95_Q1.3641.00
21_T33_R1.3461.00
98_I117_A1.3301.00
69_P84_L1.3271.00
80_V103_R1.2731.00
42_L48_T1.2511.00
63_L125_V1.1981.00
80_V101_W1.1931.00
53_G95_Q1.1831.00
39_A109_T1.1761.00
99_S145_F1.1751.00
121_F127_A1.1721.00
10_D19_L1.1511.00
63_L121_F1.1421.00
23_A33_R1.1331.00
64_A68_L1.1321.00
32_L119_M1.1121.00
68_L85_V1.1111.00
67_M117_A1.1011.00
9_L57_H1.0981.00
35_C112_P1.0971.00
52_T98_I1.0871.00
67_M119_M1.0841.00
58_I63_L1.0781.00
70_R115_R1.0651.00
98_I116_I1.0621.00
13_V55_A1.0591.00
14_G35_C1.0551.00
69_P80_V1.0521.00
26_G60_D1.0491.00
17_F35_C1.0271.00
82_G101_W1.0081.00
14_G17_F1.0071.00
64_A122_V1.0031.00
34_A38_D0.9901.00
45_G105_Q0.9800.99
115_R149_G0.9620.99
56_I96_L0.9580.99
93_Q135_F0.9450.99
40_V50_V0.9420.99
32_L67_M0.9350.99
28_A90_S0.9350.99
44_P102_N0.9270.99
77_H114_E0.9240.99
47_T101_W0.9100.99
45_G103_R0.9100.99
30_L119_M0.9070.99
14_G53_G0.9050.99
23_A147_H0.9030.99
28_A64_A0.8940.99
56_I119_M0.8920.99
50_V100_V0.8870.99
40_V110_I0.8860.99
55_A135_F0.8780.99
81_L100_V0.8720.99
14_G18_P0.8650.99
82_G99_S0.8580.99
143_G148_S0.8570.99
38_D51_P0.8310.98
40_V48_T0.8280.98
80_V84_L0.8220.98
25_S139_D0.8190.98
66_M120_I0.8180.98
35_C51_P0.8140.98
54_L96_L0.8110.98
69_P81_L0.8050.98
69_P85_V0.8040.98
68_L120_I0.8030.98
12_R19_L0.7980.98
75_H97_M0.7970.98
77_H150_R0.7950.98
67_M98_I0.7940.98
10_D13_V0.7860.98
42_L102_N0.7780.97
11_P14_G0.7780.97
82_G85_V0.7730.97
81_L85_V0.7660.97
23_A148_S0.7630.97
34_A50_V0.7600.97
66_M85_V0.7600.97
30_L127_A0.7490.97
49_L99_S0.7440.97
45_G104_G0.7410.97
57_H135_F0.7400.96
28_A58_I0.7360.96
78_G104_G0.7320.96
90_S124_V0.7300.96
11_P55_A0.7210.96
100_V116_I0.7110.96
85_V99_S0.7090.96
74_G99_S0.7080.95
110_I116_I0.7040.95
32_L54_L0.7030.95
12_R17_F0.7000.95
9_L12_R0.6970.95
58_I90_S0.6950.95
88_I99_S0.6940.95
33_R54_L0.6900.95
143_G147_H0.6830.95
67_M81_L0.6800.94
77_H106_D0.6780.94
69_P83_N0.6750.94
38_D48_T0.6720.94
16_E35_C0.6600.93
24_T148_S0.6580.93
32_L117_A0.6560.93
47_T103_R0.6560.93
32_L98_I0.6520.93
79_I100_V0.6500.93
64_A120_I0.6490.93
11_P134_D0.6430.93
88_I96_L0.6420.93
87_L120_I0.6300.92
10_D131_L0.6300.92
75_H82_G0.6220.91
38_D112_P0.6140.91
93_Q138_T0.6070.90
19_L131_L0.6070.90
10_D14_G0.6060.90
60_D90_S0.6020.90
74_G85_V0.6000.90
12_R15_K0.5940.89
55_A142_E0.5930.89
22_Y129_F0.5930.89
11_P15_K0.5910.89
28_A124_V0.5910.89
71_S144_G0.5890.89
34_A39_A0.5880.89
13_V17_F0.5880.89
134_D137_A0.5850.89
55_A95_Q0.5850.89
62_S123_P0.5850.89
14_G112_P0.5840.89
59_A62_S0.5810.88
42_L101_W0.5730.88
78_G103_R0.5720.88
28_A121_F0.5710.87
137_A141_G0.5670.87
74_G82_G0.5670.87
65_A88_I0.5670.87
73_L77_H0.5670.87
69_P73_L0.5570.86
25_S60_D0.5530.86
57_H138_T0.5530.86
53_G97_M0.5520.86
9_L132_V0.5490.85
17_F33_R0.5450.85
132_V135_F0.5400.84
81_L84_L0.5380.84
87_L122_V0.5310.83
47_T99_S0.5280.83
44_P105_Q0.5280.83
127_A131_L0.5260.83
9_L130_N0.5250.83
18_P112_P0.5240.83
58_I62_S0.5210.82
124_V129_F0.5210.82
15_K112_P0.5140.81
64_A85_V0.5110.81
82_G103_R0.5070.81
96_L119_M0.5030.80
23_A26_G0.5030.80
86_G89_D0.5010.80
17_F113_G0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hzaA 3 0.9801 100 0.126 Contact Map
3mdxA 3 0.894 100 0.135 Contact Map
4gv8A 3 0.8411 100 0.142 Contact Map
3zf6A 3 0.9338 100 0.143 Contact Map
3tqzA 3 0.8808 100 0.146 Contact Map
3ecyA 2 0.7881 100 0.151 Contact Map
3f4fA 3 0.9073 100 0.152 Contact Map
1euwA 3 0.8609 100 0.153 Contact Map
3ca9A 3 0.8477 100 0.155 Contact Map
3t64A 3 0.9205 100 0.157 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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