GREMLIN Database
DICA - HTH-type transcriptional regulator DicA
UniProt: P06966 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10226
Length: 135 (111)
Sequences: 1561 (1394)
Seq/√Len: 132.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_R28_K3.3341.00
26_L37_V3.0191.00
16_R41_E2.9941.00
21_H58_V2.9441.00
24_R34_H2.9191.00
8_I12_I2.6541.00
57_K69_G2.5161.00
39_Q44_D2.3541.00
63_P67_L2.1301.00
7_T43_G2.1001.00
9_G43_G1.9461.00
18_N73_K1.9131.00
32_I37_V1.8571.00
33_S36_S1.8161.00
15_R59_L1.8031.00
26_L59_L1.7901.00
26_L55_L1.7461.00
11_R65_W1.7441.00
29_A58_V1.7331.00
35_V39_Q1.6751.00
100_P103_E1.6431.00
64_T69_G1.6201.00
35_V38_S1.6161.00
39_Q45_S1.6121.00
46_E49_G1.5711.00
106_T113_A1.5101.00
40_W51_N1.4781.00
36_S39_Q1.4761.00
30_L58_V1.4731.00
23_Q34_H1.4181.00
110_E114_R1.3971.00
21_H29_A1.3931.00
49_G52_L1.3921.00
11_R14_Y1.3411.00
23_Q27_A1.3411.00
110_E118_F1.3311.00
25_S28_K1.3301.00
34_H38_S1.3261.00
10_E43_G1.3131.00
38_S42_R1.3041.00
56_S69_G1.2441.00
40_W47_P1.1670.99
11_R69_G1.1510.99
26_L58_V1.1430.99
37_V40_W1.0920.99
70_D73_K1.0890.99
33_S39_Q1.0600.99
39_Q42_R1.0480.99
25_S29_A1.0420.99
52_L63_P1.0400.99
32_I36_S1.0310.98
15_R61_C1.0210.98
110_E113_A1.0160.98
61_C65_W1.0090.98
11_R71_E0.9980.98
14_Y18_N0.9890.98
8_I49_G0.9770.98
48_T51_N0.9730.98
33_S38_S0.9670.98
12_I37_V0.9660.98
12_I26_L0.9640.98
40_W45_S0.9610.98
99_L104_Q0.9530.97
103_E106_T0.9490.97
107_Q114_R0.9480.97
30_L55_L0.9470.97
114_R117_N0.9380.97
8_I66_I0.9210.97
113_A117_N0.9150.97
103_E118_F0.9090.97
8_I59_L0.9070.96
85_L89_E0.9040.96
31_K54_A0.8820.96
11_R68_F0.8770.96
40_W48_T0.8760.96
23_Q37_V0.8720.96
22_T25_S0.8590.95
89_E96_F0.8450.95
106_T110_E0.8440.95
13_R17_K0.8430.95
106_T114_R0.8330.94
21_H25_S0.7990.93
34_H37_V0.7990.93
8_I47_P0.7910.93
32_I40_W0.7890.93
89_E97_N0.7840.92
86_S89_E0.7760.92
34_H39_Q0.7610.91
89_E92_L0.7580.91
96_F108_L0.7460.90
49_G53_F0.7430.90
19_L60_Q0.7420.90
107_Q111_M0.7410.90
34_H42_R0.7340.90
111_M115_V0.7330.90
51_N54_A0.7290.89
46_E51_N0.7290.89
24_R38_S0.7110.88
110_E117_N0.7090.88
72_D75_P0.7060.88
7_T10_E0.6960.87
100_P118_F0.6940.87
52_L64_T0.6860.86
45_S48_T0.6750.85
103_E114_R0.6690.85
99_L111_M0.6660.85
9_G12_I0.6540.84
16_R23_Q0.6380.82
87_P91_E0.6370.82
34_H44_D0.6370.82
12_I59_L0.6280.81
15_R65_W0.6260.81
53_F69_G0.6200.80
89_E93_L0.6180.80
52_L67_L0.6170.80
26_L30_L0.6170.80
110_E116_K0.6160.80
89_E104_Q0.6160.80
114_R118_F0.6130.79
32_I55_L0.6130.79
27_A37_V0.6030.78
8_I52_L0.6020.78
109_A113_A0.5980.78
53_F57_K0.5920.77
46_E50_K0.5910.77
82_P86_S0.5880.77
63_P68_F0.5880.77
21_H26_L0.5760.75
53_F63_P0.5740.75
115_V118_F0.5680.74
27_A34_H0.5670.74
31_K35_V0.5630.74
99_L116_K0.5600.73
27_A35_V0.5590.73
35_V42_R0.5570.73
10_E14_Y0.5530.72
116_K119_N0.5520.72
15_R58_V0.5510.72
102_S105_D0.5510.72
12_I17_K0.5510.72
38_S45_S0.5510.72
90_L98_A0.5510.72
47_P64_T0.5490.72
65_W68_F0.5470.71
106_T109_A0.5460.71
108_L114_R0.5450.71
62_S73_K0.5430.71
96_F104_Q0.5310.69
38_S47_P0.5270.69
96_F103_E0.5250.68
33_S51_N0.5250.68
73_K76_T0.5230.68
54_A57_K0.5220.68
100_P106_T0.5210.68
91_E95_L0.5190.67
111_M114_R0.5170.67
42_R46_E0.5130.67
13_R24_R0.5120.66
19_L58_V0.5100.66
70_D75_P0.5070.66
47_P51_N0.5060.66
23_Q42_R0.5050.65
90_L94_E0.5040.65
56_S68_F0.5040.65
108_L115_V0.5020.65
72_D76_T0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ndwA 2 0.8593 99.8 0.405 Contact Map
3ivpA 2 0.8296 99.8 0.423 Contact Map
3op9A 4 0.7926 99.7 0.426 Contact Map
3r1fA 2 0.8593 99.7 0.434 Contact Map
4o8bA 2 0.7185 99.7 0.44 Contact Map
1b0nA 2 0.7407 99.7 0.443 Contact Map
3qwgA 2 0.5926 99.7 0.446 Contact Map
4jcyA 2 0.6519 99.7 0.448 Contact Map
2ebyA 2 0.7481 99.6 0.479 Contact Map
1adrA 1 0.563 99.6 0.481 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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