GREMLIN Database
CCA - Multifunctional CCA protein
UniProt: P06961 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10136
Length: 412 (385)
Sequences: 4051 (2867)
Seq/√Len: 146.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_G118_N4.2411.00
191_Q237_S4.0251.00
13_A100_Q3.9281.00
209_E287_R3.5881.00
93_L138_V3.3051.00
115_D122_R3.2581.00
291_P294_I3.1991.00
135_V202_A3.1631.00
15_L116_L2.9551.00
101_D105_E2.8571.00
235_T252_T2.8541.00
111_N114_G2.7851.00
88_L99_A2.6931.00
157_L200_C2.5991.00
98_L113_L2.5881.00
384_K387_E2.5651.00
95_I121_L2.5031.00
95_I116_L2.4941.00
157_L199_D2.4671.00
48_V61_A2.2901.00
153_A156_T2.2761.00
83_T86_D2.2731.00
113_L117_Q2.2631.00
33_E36_D2.2541.00
143_A187_T2.2331.00
3_I24_W2.1751.00
285_C295_R2.1151.00
135_V169_L2.1001.00
38_G51_H2.0881.00
245_Q337_Q2.0651.00
149_G192_V2.0351.00
186_T246_V2.0221.00
184_A193_F1.9701.00
204_R211_D1.9551.00
42_V50_L1.9371.00
70_G75_T1.9311.00
98_L106_I1.9261.00
182_E246_V1.8981.00
70_G74_F1.8931.00
152_I156_T1.8701.00
195_Q230_I1.8661.00
142_A152_I1.8611.00
282_E299_R1.8451.00
215_G227_D1.8381.00
182_E290_V1.8181.00
297_L337_Q1.8141.00
98_L109_P1.7931.00
399_A402_S1.7861.00
14_L116_L1.7571.00
179_K183_S1.7561.00
30_T33_E1.7271.00
114_G117_Q1.7191.00
121_L150_F1.7141.00
250_F254_C1.7121.00
195_Q199_D1.7091.00
5_L22_R1.7091.00
250_F285_C1.7081.00
378_V381_A1.6981.00
315_N318_T1.6851.00
89_K110_Y1.6381.00
365_E368_E1.6351.00
138_V160_M1.6251.00
29_S33_E1.6141.00
198_R211_D1.6071.00
388_I400_V1.5921.00
295_R299_R1.5841.00
343_E364_R1.5811.00
98_L116_L1.5791.00
139_A197_L1.5731.00
2_K101_D1.5651.00
170_E205_V1.5581.00
169_L205_V1.5541.00
178_W290_V1.5491.00
198_R214_F1.5391.00
376_K380_E1.5361.00
285_C298_A1.5341.00
59_A64_E1.5341.00
281_V302_A1.5231.00
32_Q36_D1.5181.00
398_A402_S1.5141.00
72_T76_C1.5081.00
24_W58_Y1.5051.00
34_M38_G1.5001.00
84_L99_A1.4921.00
256_D259_K1.4881.00
135_V160_M1.4871.00
181_T193_F1.4841.00
100_Q104_G1.4831.00
343_E361_R1.4761.00
35_L41_Q1.4711.00
121_L138_V1.4661.00
374_P377_A1.4621.00
318_T321_K1.4571.00
85_E109_P1.4551.00
67_S75_T1.4501.00
133_L173_T1.4491.00
128_F156_T1.4491.00
389_R400_V1.4471.00
122_R153_A1.4411.00
307_L325_S1.4391.00
263_P268_P1.4271.00
246_V294_I1.4221.00
158_A162_E1.4221.00
142_A196_V1.4211.00
320_V324_D1.4191.00
301_V341_T1.4141.00
375_T378_V1.4101.00
230_I234_M1.3931.00
152_I196_V1.3901.00
67_S76_C1.3881.00
320_V400_V1.3881.00
31_P34_M1.3671.00
163_M167_G1.3561.00
19_V22_R1.3461.00
213_L232_T1.3371.00
343_E347_R1.3371.00
388_I404_K1.3181.00
286_Q295_R1.3071.00
336_E364_R1.2921.00
214_F229_G1.2891.00
52_P57_E1.2871.00
119_R148_L1.2821.00
189_N237_S1.2781.00
139_A202_A1.2751.00
320_V323_F1.2671.00
394_R399_A1.2671.00
97_A124_V1.2661.00
29_S34_M1.2641.00
301_V338_L1.2621.00
5_L9_A1.2621.00
152_I157_L1.2581.00
383_F387_E1.2551.00
35_L44_R1.2481.00
304_F325_S1.2431.00
14_L113_L1.2421.00
276_A279_K1.2411.00
168_E171_H1.2361.00
139_A200_C1.2361.00
44_R49_F1.2251.00
292_N295_R1.2221.00
335_V339_A1.2221.00
31_P35_L1.2091.00
2_K28_G1.2061.00
181_T206_L1.2021.00
179_K182_E1.1881.00
182_E250_F1.1781.00
299_R303_E1.1781.00
84_L88_L1.1761.00
278_V299_R1.1761.00
304_F326_I1.1761.00
123_H128_F1.1741.00
157_L161_R1.1671.00
360_G364_R1.1541.00
322_L326_I1.1501.00
316_P320_V1.1471.00
161_R199_D1.1461.00
239_A248_V1.1451.00
363_L366_A1.1451.00
32_Q35_L1.1430.99
108_D112_G1.1390.99
375_T381_A1.1340.99
292_N296_D1.1340.99
316_P319_I1.1280.99
17_L147_H1.1250.99
387_E390_E1.1190.99
257_L284_L1.1130.99
255_H259_K1.1080.99
59_A62_R1.1060.99
234_M238_M1.1040.99
98_L110_Y1.1040.99
129_G163_M1.1030.99
247_D294_I1.0960.99
139_A196_V1.0940.99
365_E369_V1.0930.99
264_P269_R1.0910.99
197_L203_L1.0860.99
339_A342_S1.0860.99
282_E296_D1.0850.99
212_A260_G1.0850.99
181_T194_F1.0790.99
28_G31_P1.0710.99
376_K381_A1.0690.99
88_L110_Y1.0690.99
376_K379_V1.0660.99
30_T34_M1.0610.99
386_V390_E1.0560.99
68_G74_F1.0460.99
375_T379_V1.0330.99
319_I324_D1.0270.99
243_S340_L1.0240.99
68_G76_C1.0190.99
219_P268_P1.0150.99
258_G262_T1.0140.99
27_V31_P1.0130.99
181_T207_F1.0100.99
259_K273_H1.0100.99
65_R81_D1.0090.99
149_G189_N1.0070.99
395_R399_A1.0050.99
361_R365_E1.0040.99
194_F233_L1.0010.99
30_T82_V0.9840.98
119_R149_G0.9760.98
4_Y63_T0.9720.98
246_V250_F0.9690.98
234_M237_S0.9690.98
120_L151_R0.9690.98
235_T348_G0.9680.98
102_D105_E0.9650.98
256_D345_D0.9580.98
9_A19_V0.9560.98
374_P378_V0.9520.98
323_F327_D0.9510.98
310_T313_M0.9470.98
120_L153_A0.9450.98
308_I338_L0.9440.98
160_M202_A0.9420.98
191_Q195_Q0.9410.98
67_S74_F0.9410.98
201_G204_R0.9330.98
377_A380_E0.9270.98
215_G218_A0.9240.98
4_Y107_I0.9240.98
229_G233_L0.9230.98
393_T397_I0.9210.98
190_P249_R0.9190.98
221_K267_W0.9140.98
70_G76_C0.9120.98
42_V46_F0.9080.97
72_T75_T0.9050.97
304_F307_L0.9040.97
138_V152_I0.9010.97
264_P267_W0.8990.97
35_L39_Y0.8940.97
69_S76_C0.8820.97
181_T288_L0.8820.97
43_G46_F0.8820.97
163_M168_E0.8800.97
216_V263_P0.8800.97
252_T341_T0.8790.97
396_R400_V0.8780.97
254_C257_L0.8780.97
100_Q106_I0.8760.97
207_F288_L0.8750.97
394_R400_V0.8730.97
318_T325_S0.8710.97
377_A381_A0.8680.97
49_F61_A0.8680.97
157_L196_V0.8670.97
65_R86_D0.8650.97
101_D107_I0.8650.97
154_D158_A0.8640.97
123_H153_A0.8610.96
275_P303_E0.8610.96
135_V163_M0.8590.96
110_Y124_V0.8590.96
28_G33_E0.8580.96
231_H255_H0.8560.96
338_L342_S0.8550.96
127_A130_E0.8550.96
294_I298_A0.8530.96
167_G170_E0.8530.96
9_A24_W0.8530.96
45_D48_V0.8510.96
282_E295_R0.8490.96
231_H305_H0.8460.96
129_G168_E0.8460.96
212_A261_L0.8460.96
388_I393_T0.8440.96
367_W370_A0.8440.96
296_D299_R0.8440.96
71_Y74_F0.8420.96
231_H345_D0.8410.96
256_D273_H0.8380.96
267_W270_H0.8370.96
323_F326_I0.8360.96
375_T380_E0.8330.96
316_P321_K0.8320.96
160_M200_C0.8310.96
94_T122_R0.8270.96
163_M166_A0.8240.95
362_W365_E0.8240.95
259_K305_H0.8230.95
273_H277_G0.8190.95
147_H183_S0.8190.95
386_V389_R0.8160.95
158_A161_R0.8120.95
321_K324_D0.8110.95
284_L287_R0.8100.95
175_E289_R0.8080.95
152_I160_M0.8080.95
321_K325_S0.8000.95
263_P270_H0.8000.95
257_L277_G0.8000.95
254_C284_L0.7980.95
228_T260_G0.7980.95
232_T236_L0.7980.95
248_V340_L0.7960.95
2_K102_D0.7950.95
323_F367_W0.7940.94
267_W271_H0.7920.94
34_M37_A0.7920.94
73_G168_E0.7900.94
26_V61_A0.7880.94
218_A223_H0.7880.94
362_W366_A0.7860.94
254_C285_C0.7860.94
194_F236_L0.7850.94
326_I338_L0.7830.94
120_L126_P0.7780.94
366_A370_A0.7780.94
231_H235_T0.7770.94
259_K345_D0.7740.94
178_W182_E0.7710.94
85_E89_K0.7700.94
361_R364_R0.7690.93
154_D157_L0.7660.93
59_A63_T0.7650.93
319_I327_D0.7640.93
261_L276_A0.7640.93
9_A22_R0.7610.93
274_G277_G0.7600.93
182_E294_I0.7570.93
51_H60_L0.7560.93
196_V200_C0.7550.93
223_H259_K0.7540.93
69_S75_T0.7510.93
335_V338_L0.7460.92
46_F50_L0.7450.92
300_L334_R0.7450.92
87_D140_R0.7450.92
278_V281_V0.7440.92
279_K283_Q0.7440.92
143_A193_F0.7440.92
285_C290_V0.7400.92
88_L109_P0.7400.92
28_G38_G0.7360.92
139_A160_M0.7340.92
255_H258_G0.7330.92
27_V30_T0.7330.92
256_D260_G0.7320.92
46_F61_A0.7280.92
369_V373_V0.7270.91
254_C281_V0.7270.91
333_Q337_Q0.7230.91
333_Q340_L0.7220.91
280_L283_Q0.7210.91
219_P222_W0.7190.91
324_D393_T0.7190.91
257_L280_L0.7180.91
73_G132_P0.7150.91
161_R166_A0.7130.91
374_P380_E0.7110.91
289_R292_N0.7110.91
151_R154_D0.7090.90
99_A110_Y0.7080.90
122_R155_E0.7070.90
216_V219_P0.7070.90
2_K63_T0.7040.90
14_L98_L0.7030.90
196_V199_D0.7000.90
246_V249_R0.7000.90
28_G34_M0.6970.90
319_I326_I0.6940.89
35_L38_G0.6930.89
239_A252_T0.6930.89
221_K269_R0.6880.89
157_L160_M0.6860.89
52_P55_H0.6850.89
76_C173_T0.6840.89
132_P168_E0.6840.89
366_A369_V0.6830.89
138_V156_T0.6820.89
320_V397_I0.6800.88
26_V63_T0.6800.88
41_Q50_L0.6790.88
178_W294_I0.6790.88
231_H273_H0.6790.88
271_H274_G0.6790.88
353_E356_D0.6770.88
232_T235_T0.6760.88
123_H159_L0.6760.88
231_H256_D0.6760.88
210_I214_F0.6710.88
394_R403_W0.6710.88
257_L260_G0.6710.88
4_Y84_L0.6700.88
255_H305_H0.6700.88
339_A360_G0.6680.88
373_V378_V0.6680.88
28_G35_L0.6680.88
135_V200_C0.6660.87
262_T273_H0.6620.87
166_A204_R0.6610.87
117_Q120_L0.6580.87
261_L280_L0.6570.87
360_G363_L0.6560.87
307_L310_T0.6550.87
101_D104_G0.6540.87
334_R339_A0.6540.87
252_T256_D0.6540.87
54_T58_Y0.6540.87
70_G73_G0.6540.87
336_E342_S0.6540.87
317_K320_V0.6520.86
258_G261_L0.6490.86
26_V34_M0.6490.86
116_L119_R0.6480.86
182_E186_T0.6480.86
8_G21_D0.6480.86
240_A249_R0.6470.86
226_I230_I0.6470.86
84_L109_P0.6460.86
68_G77_Y0.6460.86
192_V195_Q0.6430.86
337_Q342_S0.6420.85
73_G76_C0.6420.85
40_Q55_H0.6420.85
353_E357_Y0.6410.85
251_A341_T0.6380.85
389_R393_T0.6380.85
272_G276_A0.6370.85
314_L318_T0.6370.85
373_V377_A0.6370.85
8_G12_D0.6340.85
49_F62_R0.6340.85
100_Q105_E0.6320.85
8_G11_R0.6300.84
77_Y81_D0.6290.84
124_V127_A0.6280.84
81_D88_L0.6270.84
342_S345_D0.6250.84
281_V299_R0.6240.84
4_Y101_D0.6240.84
27_V34_M0.6230.84
210_I253_L0.6220.84
185_L236_L0.6210.84
251_A301_V0.6200.83
223_H256_D0.6200.83
227_D230_I0.6200.83
7_G11_R0.6200.83
169_L173_T0.6190.83
320_V325_S0.6190.83
381_A395_R0.6190.83
233_L237_S0.6170.83
151_R192_V0.6160.83
333_Q336_E0.6150.83
27_V38_G0.6150.83
250_F294_I0.6130.83
195_Q198_R0.6130.83
281_V298_A0.6120.83
189_N192_V0.6090.82
272_G275_P0.6080.82
341_T345_D0.6060.82
111_N118_N0.6060.82
293_E297_L0.6050.82
387_E404_K0.6050.82
233_L239_A0.6050.82
326_I335_V0.6050.82
124_V130_E0.6050.82
390_E393_T0.6040.82
271_H276_A0.6010.82
284_L288_L0.6010.82
394_R401_A0.6010.82
282_E286_Q0.5990.81
67_S72_T0.5950.81
61_A90_R0.5940.81
42_V49_F0.5910.80
378_V392_L0.5910.80
95_I98_L0.5890.80
380_E384_K0.5890.80
341_T346_V0.5890.80
255_H345_D0.5880.80
231_H259_K0.5840.80
389_R396_R0.5840.80
214_F233_L0.5830.80
34_M49_F0.5830.80
6_V99_A0.5820.79
381_A400_V0.5810.79
216_V260_G0.5800.79
42_V48_V0.5780.79
68_G75_T0.5770.79
46_F49_F0.5770.79
379_V384_K0.5770.79
57_E62_R0.5760.79
397_I401_A0.5760.79
305_H345_D0.5760.79
70_G172_L0.5750.79
389_R394_R0.5750.79
317_K321_K0.5730.78
247_D251_A0.5720.78
30_T35_L0.5710.78
321_K326_I0.5700.78
270_H273_H0.5690.78
197_L202_A0.5690.78
364_R368_E0.5690.78
65_R68_G0.5670.78
139_A193_F0.5660.78
266_L271_H0.5650.77
255_H273_H0.5640.77
259_K262_T0.5640.77
278_V303_E0.5620.77
34_M60_L0.5620.77
174_P178_W0.5610.77
95_I141_F0.5600.77
123_H156_T0.5600.77
166_A169_L0.5600.77
277_G280_L0.5590.77
33_E37_A0.5580.77
274_G306_D0.5580.77
142_A149_G0.5530.76
218_A345_D0.5530.76
395_R400_V0.5530.76
128_F159_L0.5510.76
228_T270_H0.5500.76
48_V52_P0.5500.76
342_S346_V0.5490.75
60_L64_E0.5460.75
278_V282_E0.5460.75
322_L363_L0.5460.75
260_G270_H0.5460.75
203_L207_F0.5450.75
384_K389_R0.5430.75
59_A127_A0.5420.75
233_L236_L0.5420.75
17_L20_K0.5410.74
128_F190_P0.5400.74
27_V33_E0.5370.74
174_P287_R0.5370.74
24_W56_E0.5360.74
359_Q362_W0.5360.74
258_G273_H0.5340.73
74_F124_V0.5340.73
382_G387_E0.5340.73
90_R130_E0.5330.73
56_E60_L0.5330.73
6_V84_L0.5320.73
340_L343_E0.5310.73
27_V60_L0.5300.73
239_A243_S0.5290.73
244_P249_R0.5290.73
20_K179_K0.5290.73
74_F77_Y0.5280.73
300_L303_E0.5270.72
193_F197_L0.5250.72
227_D231_H0.5250.72
76_C132_P0.5250.72
169_L202_A0.5240.72
45_D49_F0.5240.72
322_L327_D0.5230.72
116_L150_F0.5230.72
29_S35_L0.5220.72
275_P278_V0.5210.72
373_V381_A0.5200.71
336_E340_L0.5200.71
187_T190_P0.5190.71
155_E158_A0.5170.71
76_C172_L0.5170.71
290_V294_I0.5170.71
334_R337_Q0.5170.71
233_L240_A0.5140.71
258_G277_G0.5140.71
343_E346_V0.5140.71
181_T250_F0.5130.70
202_A206_L0.5130.70
5_L13_A0.5120.70
355_A358_P0.5100.70
251_A302_A0.5100.70
266_L269_R0.5090.70
160_M163_M0.5080.70
273_H345_D0.5070.70
277_G305_H0.5040.69
168_E173_T0.5030.69
290_V298_A0.5020.69
317_K323_F0.5020.69
41_Q44_R0.5010.69
60_L127_A0.5000.69
133_L175_E0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wfoA 1 0.835 100 0.232 Contact Map
3wfrE 1 0.8641 100 0.234 Contact Map
3wfpA 2 0.8592 100 0.263 Contact Map
1miwA 2 0.835 100 0.29 Contact Map
3h38A 1 0.8592 100 0.302 Contact Map
3wfsC 1 0.8519 100 0.308 Contact Map
4wbyA 1 0.8083 100 0.308 Contact Map
4x4wA 2 0.8058 100 0.313 Contact Map
3aqlA 2 0.8228 100 0.372 Contact Map
2qgsA 2 0.4296 98 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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