GREMLIN Database
OTC2 - Ornithine carbamoyltransferase chain F
UniProt: P06960 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10067
Length: 334 (297)
Sequences: 7174 (3677)
Seq/√Len: 213.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_A304_E4.1381.00
158_T183_D3.8741.00
158_T185_R3.3351.00
41_Q44_T3.2961.00
271_F301_V3.1601.00
160_V226_A3.1011.00
220_A263_L3.0631.00
31_K147_E2.8271.00
145_M228_F2.7951.00
26_L329_M2.7661.00
98_G122_G2.7211.00
99_R315_D2.6531.00
227_D266_N2.6421.00
218_D221_A2.5961.00
148_H312_I2.5811.00
270_K312_I2.5631.00
28_A146_Q2.4731.00
91_K116_T2.3211.00
11_K133_F2.3191.00
49_A101_Y2.3151.00
25_T146_Q2.2861.00
67_A72_A2.1921.00
272_L312_I2.1881.00
28_A143_M2.1531.00
48_I67_A2.1161.00
21_T146_Q2.1081.00
103_G328_M2.0911.00
196_E200_A2.0371.00
138_L176_A2.0321.00
190_K217_E2.0061.00
149_L268_N1.9541.00
187_L222_G1.9511.00
193_W217_E1.9341.00
142_L176_A1.9101.00
223_V229_I1.8961.00
278_F299_M1.8731.00
69_D325_K1.8531.00
261_M269_V1.8501.00
148_H315_D1.8431.00
177_A184_L1.8281.00
99_R318_E1.8051.00
17_P21_T1.7951.00
258_A262_A1.7671.00
68_F73_R1.7601.00
183_D214_T1.7591.00
105_Q128_G1.7471.00
16_T19_Q1.6821.00
216_T221_A1.6811.00
22_S330_A1.6771.00
61_C97_L1.6591.00
110_G113_V1.6401.00
185_R216_T1.6231.00
30_L329_M1.5781.00
136_T327_V1.5771.00
259_Q262_A1.5691.00
48_I103_G1.5681.00
23_L330_A1.5641.00
149_L157_M1.5531.00
264_T269_V1.5451.00
192_C250_L1.4971.00
269_V310_A1.4901.00
26_L330_A1.4901.00
183_D212_K1.4841.00
190_K193_W1.4801.00
173_M230_Y1.4791.00
78_G81_G1.4781.00
53_E113_V1.4751.00
160_V187_L1.4681.00
7_K19_Q1.4661.00
17_P179_L1.4641.00
9_F139_L1.4461.00
133_F175_E1.4391.00
42_K329_M1.4271.00
17_P155_N1.4261.00
228_F270_K1.4121.00
246_E250_L1.4121.00
220_A260_M1.3821.00
27_A143_M1.3781.00
136_T324_I1.3671.00
230_Y316_Q1.3601.00
95_R307_E1.3551.00
229_I256_V1.3521.00
225_G266_N1.3491.00
162_A223_V1.3411.00
219_V260_M1.3291.00
24_L146_Q1.3211.00
188_A193_W1.3201.00
160_V185_R1.3171.00
115_E119_Q1.3061.00
257_N302_T1.2861.00
94_A117_L1.2821.00
24_L143_M1.2751.00
103_G332_L1.2691.00
26_L29_Q1.2631.00
29_Q33_D1.2521.00
60_R64_E1.2501.00
57_T93_T1.2481.00
224_K263_L1.2421.00
95_R314_F1.2371.00
261_M271_F1.2351.00
9_F327_V1.2341.00
12_L176_A1.2321.00
13_L175_E1.2231.00
298_G303_D1.2221.00
322_H325_K1.2191.00
231_T256_V1.2161.00
255_Q302_T1.2161.00
277_A306_F1.2161.00
143_M323_T1.2081.00
153_A157_M1.2061.00
13_L201_E1.2051.00
48_I105_Q1.2021.00
216_T222_G1.1931.00
57_T87_K1.1841.00
91_K120_Y1.1771.00
21_T180_T1.1671.00
297_G307_E1.1661.00
177_A182_L1.1521.00
8_H118_A1.1441.00
185_R214_T1.1381.00
68_F74_V1.1371.00
34_K69_D1.1351.00
57_T83_Q1.1351.00
157_M228_F1.1291.00
261_M310_A1.1281.00
245_A249_A1.1221.00
199_V215_L1.1191.00
104_I123_V1.1121.00
104_I117_L1.1111.00
149_L227_D1.1091.00
66_A328_M1.1051.00
223_V260_M1.0981.00
139_L327_V1.0931.00
256_V271_F1.0711.00
21_T25_T1.0671.00
67_A74_V1.0671.00
28_A147_E1.0661.00
11_K14_D1.0651.00
308_S311_S1.0601.00
149_L270_K1.0561.00
31_K319_N1.0521.00
9_F15_F1.0511.00
112_E116_T1.0381.00
159_L177_A1.0311.00
318_E322_H1.0291.00
174_L186_L1.0271.00
24_L28_A1.0211.00
96_V317_A1.0201.00
55_D85_G1.0191.00
187_L216_T1.0121.00
95_R120_Y0.9931.00
138_L173_M0.9881.00
138_L169_M0.9831.00
142_L180_T0.9791.00
20_F180_T0.9771.00
69_D321_M0.9641.00
306_F313_V0.9641.00
24_L323_T0.9641.00
64_E76_Y0.9571.00
126_W327_V0.9571.00
159_L173_M0.9451.00
103_G126_W0.9431.00
250_L253_G0.9380.99
98_G123_V0.9370.99
61_C77_L0.9340.99
31_K143_M0.9320.99
48_I72_A0.9310.99
217_E254_Y0.9300.99
221_A224_K0.9230.99
11_K175_E0.9210.99
83_Q93_T0.9200.99
32_A36_N0.9190.99
114_V130_T0.9180.99
20_F179_L0.9170.99
153_A156_E0.9160.99
194_P215_L0.9140.99
147_E319_N0.9140.99
165_A188_A0.9120.99
108_G130_T0.9080.99
171_N198_L0.9010.99
111_Q115_E0.8960.99
41_Q71_G0.8890.99
91_K307_E0.8880.99
64_E68_F0.8880.99
149_L312_I0.8880.99
145_M157_M0.8810.99
91_K95_R0.8800.99
47_N73_R0.8750.99
245_A248_I0.8730.99
214_T221_A0.8720.99
8_H98_G0.8710.99
187_L226_A0.8690.99
297_G306_F0.8690.99
246_E249_A0.8690.99
67_A328_M0.8670.99
83_Q86_H0.8670.99
64_E74_V0.8650.99
133_F172_S0.8630.99
154_F180_T0.8630.99
12_L138_L0.8620.99
143_M147_E0.8580.99
220_A224_K0.8560.99
185_R226_A0.8550.99
315_D318_E0.8540.99
106_Y117_L0.8530.99
258_A308_S0.8520.99
47_N69_D0.8480.99
8_H121_A0.8470.99
139_L323_T0.8440.99
25_T29_Q0.8440.99
259_Q263_L0.8360.99
33_D36_N0.8360.99
63_F136_T0.8310.99
132_E195_E0.8270.99
158_T225_G0.8210.99
162_A229_I0.8200.99
297_G303_D0.8190.99
165_A170_G0.8160.99
145_M154_F0.8150.99
83_Q87_K0.8140.99
91_K303_D0.8110.98
261_M305_V0.8100.98
303_D307_E0.8100.98
33_D40_V0.8100.98
6_K331_T0.8100.98
187_L219_V0.8070.98
174_L184_L0.8040.98
53_E84_I0.8020.98
29_Q32_A0.8010.98
261_M264_T0.7990.98
305_V308_S0.7950.98
185_R225_G0.7930.98
28_A32_A0.7840.98
106_Y113_V0.7820.98
145_M149_L0.7810.98
144_T312_I0.7780.98
162_A260_M0.7750.98
46_K102_D0.7730.98
20_F176_A0.7720.98
22_S26_L0.7700.98
47_N65_V0.7700.98
116_T120_Y0.7670.98
10_L118_A0.7600.98
23_L323_T0.7570.98
158_T226_A0.7550.98
303_D306_F0.7520.98
12_L20_F0.7510.98
144_T319_N0.7510.98
49_A104_I0.7500.97
108_G113_V0.7470.97
115_E118_A0.7460.97
95_R98_G0.7450.97
62_S100_M0.7450.97
220_A259_Q0.7400.97
62_S324_I0.7370.97
43_L103_G0.7350.97
150_P156_E0.7310.97
15_F23_L0.7300.97
27_A326_A0.7290.97
326_A330_A0.7290.97
222_G226_A0.7280.97
94_A121_A0.7280.97
256_V301_V0.7260.97
248_I299_M0.7250.97
149_L228_F0.7240.97
174_L194_P0.7240.97
257_N260_M0.7190.97
101_Y123_V0.7170.97
87_K93_T0.7160.97
110_G131_N0.7150.97
170_G186_L0.7150.97
150_P154_F0.7100.97
312_I315_D0.7090.96
33_D39_E0.7090.96
27_A323_T0.7070.96
116_T119_Q0.7000.96
229_I269_V0.6980.96
145_M177_A0.6960.96
66_A324_I0.6930.96
23_L326_A0.6910.96
173_M177_A0.6890.96
223_V263_L0.6840.96
26_L30_L0.6830.96
17_P209_H0.6820.96
18_A21_T0.6820.96
145_M270_K0.6810.96
252_R255_Q0.6810.96
199_V213_I0.6810.96
7_K330_A0.6800.96
235_V243_K0.6800.96
57_T86_H0.6800.96
162_A219_V0.6800.96
261_M301_V0.6790.96
9_F331_T0.6790.96
82_S87_K0.6710.95
112_E115_E0.6710.95
193_W196_E0.6700.95
258_A302_T0.6680.95
6_K330_A0.6660.95
48_I328_M0.6650.95
50_L67_A0.6650.95
90_I113_V0.6640.95
43_L72_A0.6640.95
148_H270_K0.6640.95
298_G304_E0.6600.95
50_L76_Y0.6590.95
50_L74_V0.6590.95
249_A252_R0.6540.95
260_M263_L0.6530.94
193_W215_L0.6450.94
103_G331_T0.6440.94
262_A310_A0.6440.94
159_L230_Y0.6410.94
233_V237_M0.6390.94
138_L316_Q0.6380.94
308_S313_V0.6360.94
20_F139_L0.6360.94
277_A301_V0.6350.94
142_L146_Q0.6330.94
82_S86_H0.6320.93
271_F305_V0.6320.93
12_L15_F0.6310.93
63_F324_I0.6290.93
243_K248_I0.6290.93
160_V222_G0.6270.93
145_M159_L0.6270.93
230_Y233_V0.6270.93
98_G121_A0.6270.93
62_S136_T0.6260.93
229_I261_M0.6250.93
47_N68_F0.6230.93
219_V223_V0.6210.93
65_V75_T0.6210.93
55_D83_Q0.6200.93
230_Y272_L0.6140.92
93_T97_L0.6120.92
162_A231_T0.6120.92
241_K246_E0.6060.92
89_S307_E0.6060.92
175_E201_E0.6040.92
258_A310_A0.6020.92
178_A209_H0.6020.92
129_L168_N0.6000.92
30_L33_D0.6000.92
233_V278_F0.5980.91
126_W331_T0.5970.91
57_T82_S0.5960.91
12_L133_F0.5950.91
39_E44_T0.5930.91
54_K238_G0.5910.91
126_W328_M0.5900.91
194_P199_V0.5900.91
176_A180_T0.5890.91
30_L39_E0.5890.91
142_L154_F0.5880.91
30_L42_K0.5880.91
69_D102_D0.5870.91
10_L115_E0.5860.91
23_L327_V0.5860.91
251_L302_T0.5860.91
112_E130_T0.5840.90
188_A194_P0.5820.90
39_E42_K0.5810.90
138_L142_L0.5800.90
55_D87_K0.5790.90
175_E198_L0.5760.90
178_A184_L0.5760.90
150_P270_K0.5740.90
160_V229_I0.5730.90
239_E242_E0.5720.90
146_Q153_A0.5670.89
306_F311_S0.5670.89
55_D81_G0.5670.89
18_A22_S0.5660.89
242_E247_R0.5640.89
112_E132_E0.5640.89
228_F272_L0.5630.89
147_E315_D0.5610.89
197_S200_A0.5610.89
65_V321_M0.5600.89
8_H122_G0.5580.88
160_V216_T0.5570.88
24_L27_A0.5550.88
328_M332_L0.5540.88
169_M230_Y0.5530.88
63_F105_Q0.5530.88
55_D82_S0.5510.88
104_I121_A0.5500.88
94_A104_I0.5480.88
62_S96_V0.5470.87
63_F128_G0.5460.87
54_K237_M0.5450.87
306_F314_F0.5440.87
41_Q45_G0.5440.87
179_L209_H0.5410.87
133_F198_L0.5410.87
308_S312_I0.5410.87
9_F20_F0.5410.87
217_E221_A0.5390.87
129_L237_M0.5370.86
65_V69_D0.5360.86
188_A217_E0.5350.86
14_D179_L0.5340.86
157_M227_D0.5330.86
191_A250_L0.5320.86
94_A125_V0.5310.86
96_V99_R0.5310.86
25_T28_A0.5310.86
34_K39_E0.5300.86
243_K278_F0.5300.86
31_K322_H0.5300.86
169_M173_M0.5290.86
105_Q126_W0.5280.86
149_L153_A0.5270.85
88_E92_D0.5270.85
13_L133_F0.5260.85
271_F311_S0.5260.85
22_S25_T0.5250.85
154_F182_L0.5220.85
186_L213_I0.5210.85
247_R251_L0.5210.85
166_R192_C0.5200.85
256_V261_M0.5180.84
96_V314_F0.5170.84
60_R76_Y0.5160.84
53_E108_G0.5140.84
109_H113_V0.5130.84
223_V264_T0.5130.84
90_I106_Y0.5120.84
19_Q330_A0.5120.84
146_Q149_L0.5120.84
19_Q22_S0.5100.84
258_A261_M0.5090.83
77_L82_S0.5090.83
214_T225_G0.5090.83
178_A213_I0.5080.83
178_A211_G0.5080.83
169_M316_Q0.5070.83
43_L328_M0.5050.83
191_A249_A0.5050.83
275_L314_F0.5040.83
81_G84_I0.5030.83
195_E200_A0.5020.83
20_F142_L0.5020.83
36_N40_V0.5010.82
187_L217_E0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h31A 3 0.991 100 0.049 Contact Map
1duvG 3 0.994 100 0.053 Contact Map
2w37A 5 0.985 100 0.054 Contact Map
1dxhA 6 0.988 100 0.058 Contact Map
1pvvA 6 0.9311 100 0.06 Contact Map
4nf2A 3 0.9162 100 0.063 Contact Map
3gd5A 4 0.8533 100 0.066 Contact Map
4amuA 6 0.988 100 0.067 Contact Map
2i6uA 3 0.9162 100 0.069 Contact Map
1vlvA 6 0.9012 100 0.075 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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