GREMLIN Database
BGA2 - Evolved beta-galactosidase subunit alpha
UniProt: P06864 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10252
Length: 1030 (976)
Sequences: 2038 (1578)
Seq/√Len: 50.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_S200_D5.3371.00
287_S290_S4.5671.00
148_V165_M4.2801.00
354_M382_R4.1091.00
116_I170_D4.0201.00
730_G733_F4.0041.00
569_D572_N3.6121.00
746_S753_S3.5891.00
443_I485_I3.5631.00
78_A83_E3.5631.00
49_N73_H3.5521.00
371_S541_Y3.5421.00
604_I677_V3.4621.00
314_R389_I3.3411.00
871_R911_H3.2721.00
881_Q911_H3.2461.00
632_A644_Q3.2171.00
433_H466_L3.1901.00
97_F184_T3.1791.00
126_K205_G3.1411.00
432_I463_A3.1241.00
322_V471_L3.1141.00
682_R687_E2.9781.00
284_Q292_Y2.9561.00
130_I141_V2.9481.00
68_M114_Q2.9131.00
676_T691_P2.8681.00
433_H436_K2.8681.00
944_N957_S2.8631.00
118_T170_D2.8101.00
670_E913_R2.8021.00
248_E301_K2.7811.00
916_A926_L2.7781.00
721_D739_K2.7751.00
347_R551_Q2.7731.00
896_M909_R2.7641.00
367_H592_L2.7251.00
72_G85_H2.6851.00
372_V392_L2.6581.00
464_K472_V2.6281.00
532_Y619_K2.6241.00
47_Q73_H2.6111.00
462_A466_L2.5681.00
867_A890_R2.5571.00
428_I463_A2.5521.00
218_T227_A2.5441.00
135_V139_F2.5431.00
525_T529_N2.5311.00
575_N769_D2.5131.00
874_G883_A2.4981.00
127_Q161_D2.4871.00
859_I962_L2.4791.00
613_E658_P2.4761.00
75_T83_E2.4721.00
358_E389_I2.4711.00
74_I83_E2.4681.00
302_D306_N2.4431.00
254_G292_Y2.4331.00
12_E147_Y2.4281.00
138_Y181_A2.4151.00
544_E548_H2.3791.00
132_F175_V2.3621.00
143_V173_L2.3371.00
602_V625_L2.3191.00
679_K686_S2.3191.00
345_D356_R2.3031.00
361_L390_Y2.2961.00
143_V162_I2.2881.00
554_D558_N2.2831.00
219_D319_D2.2741.00
836_V995_F2.2671.00
358_E362_Q2.2621.00
497_N501_E2.2601.00
372_V383_F2.2491.00
460_Y464_K2.2421.00
516_A521_P2.2271.00
779_W783_H2.2231.00
544_E579_D2.2221.00
631_H678_T2.2081.00
630_L677_V2.2011.00
614_L675_I2.1911.00
605_H615_K2.1911.00
288_A393_F2.1701.00
867_A916_A2.1671.00
130_I162_I2.1551.00
229_L317_F2.1551.00
361_L392_L2.1521.00
227_A283_P2.1471.00
114_Q172_L2.1311.00
839_S992_S2.1281.00
491_T510_I2.1241.00
323_R328_W2.1241.00
367_H593_K2.1231.00
151_S158_A2.1161.00
864_D939_H2.1131.00
615_K656_E2.1071.00
866_V896_M2.1011.00
329_I334_V2.0851.00
26_S29_Q2.0671.00
738_S745_T2.0501.00
415_T424_Y2.0241.00
542_V595_Y2.0211.00
617_E656_E2.0121.00
280_V283_P2.0091.00
252_F297_V2.0071.00
396_A431_H2.0071.00
421_E458_A2.0051.00
220_F224_Y1.9871.00
120_S123_W1.9701.00
221_D226_D1.9650.99
336_L442_I1.9600.99
973_S981_L1.9540.99
857_M962_L1.9520.99
624_T650_D1.9480.99
348_K351_A1.9440.99
388_D438_H1.9380.99
251_L315_V1.9330.99
497_N533_K1.9280.99
226_D281_E1.9280.99
867_A888_I1.9270.99
635_R887_D1.9200.99
856_T943_E1.9130.99
211_I233_V1.9100.99
636_A669_R1.9030.99
214_F298_M1.8830.99
551_Q559_V1.8800.99
396_A435_Q1.8780.99
526_E984_W1.8740.99
927_V962_L1.8710.99
578_L901_P1.8670.99
112_A174_C1.8660.99
621_W654_N1.8620.99
337_H601_P1.8510.99
341_R379_N1.8510.99
128_T166_V1.8420.99
783_H786_I1.8360.99
428_I459_M1.8310.99
892_T895_A1.8300.99
82_M550_I1.8230.99
248_E299_T1.8190.99
40_L126_K1.8110.99
837_A992_S1.8050.99
888_I914_W1.8020.99
583_Y587_T1.7950.99
514_A521_P1.7920.99
86_G179_Q1.7910.99
583_Y898_E1.7900.99
327_F442_I1.7800.99
221_D285_Q1.7800.99
296_L315_V1.7800.99
526_E983_S1.7800.99
615_K658_P1.7800.99
348_K353_G1.7720.99
27_V250_T1.7710.99
908_N934_N1.7700.99
548_H579_D1.7670.99
226_D285_Q1.7550.99
629_T645_Q1.7490.99
600_A693_A1.7410.99
912_V935_F1.7320.99
62_A65_S1.7250.99
694_T885_I1.7210.99
562_K567_Y1.7200.99
249_Y298_M1.7140.99
732_N750_N1.7140.99
345_D353_G1.7050.99
359_K362_Q1.7020.99
299_T307_V1.6930.98
620_L627_D1.6910.98
425_V462_A1.6900.98
597_Q695_Y1.6890.98
15_L129_L1.6860.98
915_T935_F1.6830.98
59_V176_R1.6710.98
489_M511_C1.6680.98
295_H314_R1.6670.98
11_H14_R1.6650.98
144_N171_N1.6640.98
250_T299_T1.6630.98
249_Y296_L1.6560.98
139_F151_S1.6560.98
672_F886_I1.6540.98
301_K307_V1.6530.98
66_E167_K1.6500.98
886_I932_P1.6370.98
837_A994_G1.6360.98
762_N963_N1.6300.98
15_L161_D1.6290.98
601_P620_L1.6250.98
329_I442_I1.6230.98
674_N696_Q1.6210.98
509_I538_Q1.6140.98
152_K182_D1.6110.98
215_T436_K1.6110.98
735_I744_P1.6100.98
561_Y584_S1.6060.98
891_S896_M1.6060.98
546_C586_Q1.6030.98
521_P524_L1.5930.98
927_V997_L1.5910.98
473_H487_S1.5910.98
133_D202_Y1.5840.98
100_D103_F1.5820.98
871_R881_Q1.5760.98
141_V173_L1.5750.98
635_R674_N1.5730.98
215_T466_L1.5650.97
566_D950_H1.5590.97
584_S901_P1.5440.97
636_A671_A1.5420.97
327_F336_L1.5420.97
549_G584_S1.5380.97
353_G356_R1.5340.97
363_L545_W1.5300.97
596_K691_P1.5270.97
841_E990_D1.5220.97
941_T961_T1.5130.97
127_Q208_L1.5130.97
375_A379_N1.5100.97
59_V112_A1.5090.97
791_L794_F1.5070.97
595_Y599_I1.5040.97
382_R385_E1.5010.97
452_Y482_V1.5010.97
75_T78_A1.5000.97
626_D650_D1.4980.97
652_A655_S1.4980.97
651_V657_A1.4920.97
497_N530_V1.4910.97
284_Q290_S1.4900.97
634_V699_L1.4900.97
728_V828_I1.4810.96
394_V440_S1.4710.96
361_L383_F1.4700.96
881_Q910_Q1.4690.96
383_F394_V1.4680.96
436_K466_L1.4640.96
602_V677_V1.4630.96
918_T924_G1.4610.96
894_D939_H1.4600.96
842_R990_D1.4560.96
81_Q195_A1.4510.96
553_Q559_V1.4500.96
835_N996_T1.4500.96
253_D257_V1.4480.96
211_I311_V1.4450.96
510_I531_F1.4450.96
633_E640_T1.4430.96
214_F313_Q1.4410.96
79_M351_A1.4310.96
216_V296_L1.4260.96
339_V581_L1.4120.95
597_Q600_A1.4120.95
473_H511_C1.4100.95
912_V933_I1.4020.95
726_C796_V1.4000.95
369_I595_Y1.3910.95
132_F135_V1.3890.95
937_A962_L1.3820.95
726_C794_F1.3790.95
115_R173_L1.3760.95
218_T469_T1.3740.95
554_D952_N1.3710.94
354_M358_E1.3660.94
880_S971_L1.3610.94
429_V462_A1.3540.94
327_F471_L1.3520.94
135_V197_I1.3510.94
47_Q75_T1.3490.94
218_T283_P1.3390.94
514_A524_L1.3350.94
213_D436_K1.3350.94
866_V909_R1.3350.94
14_R17_P1.3340.94
186_V423_V1.3340.94
366_Q690_H1.3290.93
828_I834_V1.3270.93
891_S895_A1.3260.93
894_D956_R1.3250.93
153_G399_D1.3210.93
227_A285_Q1.3210.93
534_H537_I1.3140.93
799_S802_E1.3130.93
42_L120_S1.3130.93
525_T882_Q1.3110.93
856_T963_N1.3040.93
876_N884_N1.3040.93
910_Q934_N1.3040.93
217_R469_T1.3040.93
112_A176_R1.3000.93
227_A317_F1.2990.93
874_G884_N1.2980.93
128_T205_G1.2960.93
521_P591_G1.2930.93
129_L161_D1.2890.92
581_L592_L1.2860.92
358_E361_L1.2860.92
613_E660_Q1.2790.92
672_F698_P1.2790.92
717_L728_V1.2780.92
488_T495_L1.2730.92
857_M964_L1.2730.92
762_N942_Q1.2720.92
691_P885_I1.2690.92
379_N384_Y1.2670.92
92_D573_N1.2660.92
364_M369_I1.2600.92
290_S623_T1.2590.91
357_V372_V1.2590.91
606_A609_L1.2580.91
416_D454_C1.2560.91
74_I78_A1.2560.91
926_L998_L1.2550.91
733_F828_I1.2460.91
138_Y150_F1.2420.91
282_Q285_Q1.2420.91
364_M392_L1.2410.91
357_V383_F1.2410.91
332_R654_N1.2390.91
460_Y472_V1.2360.91
633_E676_T1.2360.91
29_Q39_S1.2350.91
383_F387_C1.2320.91
802_E827_R1.2320.91
221_D224_Y1.2300.91
545_W592_L1.2290.90
509_I541_Y1.2180.90
260_S278_F1.2180.90
552_A562_K1.2150.90
915_T927_V1.2150.90
161_D166_V1.2130.90
630_L646_I1.2110.90
251_L296_L1.2100.90
360_D586_Q1.2090.90
620_L628_Y1.2070.90
50_F111_G1.2070.90
861_G958_D1.2050.90
875_E900_Y1.2050.90
864_D894_D1.2000.89
396_A434_A1.1940.89
25_D29_Q1.1940.89
366_Q686_S1.1930.89
458_A461_H1.1930.89
55_H58_Q1.1930.89
10_T426_E1.1890.89
215_T469_T1.1890.89
827_R837_A1.1880.89
230_S277_A1.1820.89
738_S741_S1.1820.89
15_L212_N1.1790.89
603_K619_K1.1790.89
488_T491_T1.1780.88
232_E275_S1.1760.88
765_K771_H1.1750.88
126_K207_H1.1730.88
911_H932_P1.1700.88
651_V655_S1.1650.88
227_A319_D1.1640.88
497_N534_H1.1620.88
848_H985_R1.1600.88
583_Y899_N1.1590.88
59_V110_T1.1580.88
466_L469_T1.1570.88
329_I393_F1.1530.87
372_V387_C1.1530.87
297_V312_P1.1530.87
220_F285_Q1.1500.87
432_I462_A1.1480.87
335_M538_Q1.1480.87
835_N994_G1.1480.87
327_F443_I1.1480.87
31_R297_V1.1460.87
95_F404_G1.1450.87
335_M532_Y1.1430.87
395_M443_I1.1410.87
597_Q694_T1.1400.87
252_F258_V1.1400.87
81_Q86_G1.1380.87
779_W782_N1.1360.87
218_T319_D1.1330.86
153_G430_R1.1280.86
25_D39_S1.1270.86
116_I172_L1.1250.86
791_L807_S1.1220.86
906_N938_W1.1220.86
973_S976_W1.1220.86
624_T652_A1.1210.86
143_V148_V1.1190.86
206_K309_E1.1190.86
387_C394_V1.1180.86
135_V177_V1.1180.86
633_E674_N1.1170.86
68_M172_L1.1170.86
974_N977_G1.1150.86
766_P945_I1.1140.86
20_Y381_P1.1120.85
461_H465_A1.1100.85
6_N9_L1.1080.85
728_V803_V1.1050.85
866_V935_F1.1000.85
514_A542_V1.1000.85
670_E869_Y1.0960.85
91_T96_P1.0950.85
717_L830_A1.0930.84
467_D470_R1.0930.84
164_A168_T1.0930.84
393_F622_F1.0930.84
609_L612_G1.0920.84
63_F174_C1.0920.84
431_H441_I1.0910.84
620_L623_T1.0900.84
17_P430_R1.0890.84
552_A560_W1.0860.84
526_E981_L1.0850.84
763_F976_W1.0840.84
7_I419_Q1.0840.84
748_Q753_S1.0810.84
156_L431_H1.0810.84
734_A748_Q1.0790.84
215_T232_E1.0770.84
358_E382_R1.0770.84
729_R734_A1.0770.84
81_Q136_E1.0770.84
982_D987_W1.0760.83
224_Y331_N1.0710.83
629_T680_D1.0700.83
127_Q164_A1.0690.83
139_F175_V1.0690.83
986_V991_F1.0680.83
885_I889_W1.0640.83
808_R823_T1.0600.83
216_V315_V1.0600.83
424_Y450_S1.0600.83
927_V964_L1.0600.83
367_H588_P1.0590.82
588_P592_L1.0580.82
388_D440_S1.0580.82
496_M537_I1.0550.82
80_W111_G1.0550.82
231_C249_Y1.0530.82
679_K689_G1.0490.82
254_G284_Q1.0490.82
53_F112_A1.0440.82
233_V247_L1.0430.82
136_E350_R1.0430.82
804_L825_I1.0410.81
131_K204_V1.0400.81
357_V361_L1.0390.81
554_D557_G1.0390.81
369_I599_I1.0390.81
220_F227_A1.0380.81
114_Q174_C1.0360.81
804_L827_R1.0350.81
326_L538_Q1.0350.81
325_G536_C1.0330.81
450_S474_Y1.0330.81
886_I913_R1.0320.81
937_A960_I1.0300.81
759_P857_M1.0300.81
428_I431_H1.0270.80
253_D292_Y1.0270.80
915_T962_L1.0220.80
797_E804_L1.0210.80
773_Q975_S1.0200.80
737_F744_P1.0200.80
933_I993_Y1.0200.80
364_M545_W1.0160.80
735_I747_W1.0140.80
486_I506_K1.0110.79
18_R159_E1.0110.79
560_W952_N1.0080.79
829_A833_Q1.0080.79
628_Y692_I1.0080.79
132_F139_F1.0070.79
320_I327_F1.0070.79
339_V369_I1.0070.79
400_V459_M1.0070.79
865_Q892_T1.0060.79
636_A641_L1.0040.79
565_G568_G1.0020.79
343_D383_F1.0020.79
398_T431_H0.9990.79
385_E438_H0.9980.79
224_Y285_Q0.9970.78
852_C965_D0.9940.78
982_D985_R0.9940.78
549_G578_L0.9920.78
222_E226_D0.9910.78
137_T181_A0.9900.78
361_L382_R0.9900.78
640_T643_T0.9900.78
222_E319_D0.9890.78
228_T277_A0.9890.78
432_I466_L0.9880.78
602_V628_Y0.9880.78
457_R461_H0.9880.78
891_S909_R0.9870.78
633_E643_T0.9870.78
216_V231_C0.9870.78
974_N979_E0.9870.78
217_R232_E0.9840.78
156_L430_R0.9840.78
224_Y319_D0.9820.77
362_Q366_Q0.9820.77
806_I823_T0.9810.77
322_V336_L0.9810.77
110_T178_M0.9730.77
735_I834_V0.9730.77
334_V442_I0.9730.77
623_T627_D0.9720.77
590_P898_E0.9710.77
356_R546_C0.9710.77
878_A968_L0.9700.77
414_I424_Y0.9690.76
247_L298_M0.9680.76
192_W344_N0.9670.76
762_N856_T0.9650.76
500_G536_C0.9650.76
498_E502_Y0.9630.76
629_T678_T0.9620.76
869_Y886_I0.9610.76
856_T942_Q0.9610.76
839_S990_D0.9610.76
605_H617_E0.9600.76
49_N68_M0.9590.76
918_T922_G0.9590.76
673_L699_L0.9580.76
192_W549_G0.9580.76
942_Q963_N0.9560.75
676_T885_I0.9540.75
735_I828_I0.9530.75
670_E886_I0.9520.75
426_E430_R0.9500.75
598_V882_Q0.9490.75
974_N978_S0.9480.75
192_W567_Y0.9470.75
834_V997_L0.9470.75
868_Y891_S0.9460.75
361_L386_L0.9460.75
63_F112_A0.9460.75
246_T301_K0.9450.75
374_T435_Q0.9450.75
500_G534_H0.9430.74
563_F950_H0.9400.74
462_A465_A0.9400.74
258_V261_S0.9390.74
137_T183_S0.9370.74
10_T422_K0.9350.74
583_Y589_G0.9350.74
597_Q882_Q0.9330.74
41_F202_Y0.9310.74
335_M619_K0.9310.74
488_T508_R0.9290.73
429_V433_H0.9280.73
496_M510_I0.9280.73
578_L584_S0.9280.73
290_S627_D0.9280.73
939_H960_I0.9260.73
314_R388_D0.9250.73
86_G109_P0.9220.73
211_I300_L0.9210.73
457_R481_E0.9210.73
495_L498_E0.9200.73
865_Q890_R0.9200.73
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86_G153_G0.5300.35
558_N953_E0.5300.35
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463_A472_V0.5290.35
163_S803_V0.5290.35
480_A506_K0.5290.35
547_D584_S0.5280.35
833_Q998_L0.5280.35
761_I822_C0.5280.35
863_Y924_G0.5280.35
179_Q546_C0.5280.35
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362_Q390_Y0.5270.34
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807_S834_V0.5260.34
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335_M621_W0.5200.34
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969_L974_N0.5190.34
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763_F820_M0.5190.34
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358_E386_L0.5180.34
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350_R589_G0.5180.34
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100_D104_V0.5170.34
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528_Q599_I0.5170.34
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132_F177_V0.5160.33
392_L545_W0.5160.33
564_G576_F0.5160.33
87_K193_W0.5150.33
225_C285_Q0.5150.33
343_D386_L0.5150.33
906_N954_L0.5140.33
89_Q451_G0.5140.33
31_R295_H0.5140.33
110_T193_W0.5140.33
476_E489_M0.5130.33
52_F109_P0.5130.33
416_D653_P0.5130.33
24_Y744_P0.5130.33
493_V981_L0.5130.33
301_K675_I0.5130.33
679_K690_H0.5120.33
97_F598_V0.5120.33
499_F502_Y0.5120.33
462_A477_D0.5120.33
534_H769_D0.5110.33
923_N927_V0.5110.33
134_G350_R0.5110.33
546_C582_I0.5110.33
121_D124_Q0.5110.33
27_V299_T0.5100.33
324_D535_D0.5100.33
68_M71_W0.5100.33
410_D413_R0.5100.33
488_T538_Q0.5100.33
35_R41_F0.5100.33
119_L936_S0.5100.33
193_W477_D0.5090.33
117_F144_N0.5090.33
375_A959_D0.5090.33
192_W562_K0.5090.33
231_C280_V0.5080.33
91_T94_G0.5080.33
399_D579_D0.5080.33
414_I430_R0.5080.33
431_H463_A0.5080.33
575_N589_G0.5080.33
930_Q994_G0.5080.33
322_V485_I0.5080.33
90_Y579_D0.5070.33
262_A278_F0.5070.33
326_L333_Y0.5070.33
155_R415_T0.5060.33
148_V302_D0.5060.33
292_Y889_W0.5060.33
43_P202_Y0.5050.32
409_G412_S0.5050.32
469_T742_G0.5050.32
496_M530_V0.5050.32
173_L835_N0.5050.32
966_H991_F0.5050.32
104_V107_D0.5040.32
117_F167_K0.5040.32
647_K652_A0.5040.32
779_W785_Q0.5040.32
255_E728_V0.5040.32
16_A234_V0.5040.32
29_Q38_S0.5040.32
90_Y563_F0.5030.32
616_V709_F0.5030.32
550_I909_R0.5030.32
480_A483_V0.5030.32
973_S978_S0.5030.32
224_Y323_R0.5020.32
728_V834_V0.5010.32
912_V934_N0.5010.32
230_S825_I0.5010.32
477_D483_V0.5010.32
675_I800_D0.5010.32
424_Y476_E0.5000.32
255_E292_Y0.5000.32
406_A450_S0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jz7A 4 0.9485 100 0.26 Contact Map
3bgaA 2 0.9505 100 0.27 Contact Map
3obaA 4 0.9262 100 0.293 Contact Map
1yq2A 4 0.9165 100 0.311 Contact Map
4ypjA 1 0.6602 100 0.68 Contact Map
3cmgA 3 0.5825 100 0.688 Contact Map
3gm8A 1 0.6291 100 0.689 Contact Map
3fn9A 4 0.5874 100 0.69 Contact Map
4cu7A 1 0.6612 100 0.707 Contact Map
3hn3A 4 0.5087 100 0.711 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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