GREMLIN Database
EBGR - HTH-type transcriptional regulator EbgR
UniProt: P06846 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10254
Length: 327 (313)
Sequences: 33565 (24723)
Seq/√Len: 1397.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_A198_E3.2821.00
174_V236_K3.1401.00
10_E44_K3.0711.00
259_N262_Q3.0571.00
165_I267_I2.6771.00
174_V265_S2.5571.00
193_E197_A2.5361.00
117_G300_V2.4501.00
271_D286_R2.4261.00
163_K202_L2.3141.00
152_D303_K2.2671.00
32_E36_H2.2551.00
40_E44_K2.1891.00
222_Y255_E2.1651.00
36_H40_E2.1311.00
226_K256_R2.1231.00
92_Q298_N2.0801.00
170_I203_K2.0721.00
92_Q95_K2.0611.00
167_D199_Y2.0321.00
160_R164_E2.0071.00
295_Q298_N1.9881.00
226_K252_A1.9841.00
163_K198_E1.9741.00
21_V38_I1.9631.00
163_K199_Y1.9421.00
93_C297_V1.9311.00
25_D29_N1.9271.00
22_L42_A1.9161.00
35_K39_L1.8991.00
5_K15_L1.8751.00
159_A194_V1.8731.00
162_S166_I1.8581.00
161_I269_V1.8431.00
167_D171_N1.8311.00
166_I196_F1.8111.00
162_S239_F1.8061.00
286_R319_K1.8061.00
253_I264_I1.8011.00
88_G293_G1.8001.00
169_Y237_A1.7981.00
92_Q294_S1.7751.00
221_G248_G1.7641.00
10_E41_I1.7641.00
167_D203_K1.7501.00
230_A256_R1.7471.00
281_P324_G1.7431.00
11_A41_I1.7391.00
295_Q314_V1.7251.00
302_E307_G1.7041.00
179_F241_A1.6861.00
91_T290_E1.6741.00
163_K167_D1.6621.00
222_Y252_A1.6581.00
240_V249_V1.6291.00
67_A115_V1.6261.00
164_E318_S1.6231.00
88_G290_E1.6171.00
288_H291_M1.6161.00
254_H279_F1.6111.00
258_L263_D1.6071.00
259_N263_D1.6001.00
225_A249_V1.5951.00
178_G235_P1.5921.00
252_A256_R1.5871.00
168_F172_Q1.5651.00
142_I296_G1.5641.00
92_Q96_L1.5391.00
39_L43_E1.5161.00
291_M295_Q1.5011.00
212_W227_Q1.4881.00
176_R207_R1.4811.00
252_A255_E1.4781.00
157_D160_R1.4711.00
168_F322_L1.4681.00
96_L301_Y1.4631.00
39_L42_A1.4581.00
21_V42_A1.4481.00
160_R163_K1.4461.00
176_R234_Y1.4461.00
170_I199_Y1.4421.00
271_D323_R1.4391.00
7_I41_I1.4371.00
194_V198_E1.4361.00
267_I283_S1.4241.00
64_H116_T1.4011.00
291_M294_S1.3881.00
191_I194_V1.3861.00
168_F171_N1.3751.00
161_I318_S1.3601.00
92_Q297_V1.3441.00
26_P29_N1.3441.00
207_R210_D1.3411.00
253_I258_L1.3311.00
197_A201_R1.3241.00
10_E45_L1.3231.00
199_Y202_L1.3171.00
166_I199_Y1.3101.00
215_G220_S1.3101.00
5_K9_I1.2921.00
32_E35_K1.2901.00
166_I195_A1.2811.00
66_L93_C1.2811.00
37_R41_I1.2711.00
6_D9_I1.2701.00
41_I44_K1.2641.00
226_K230_A1.2621.00
178_G228_M1.2571.00
222_Y226_K1.2521.00
20_R25_D1.2481.00
176_R236_K1.2441.00
64_H98_I1.2421.00
225_A253_I1.2401.00
174_V237_A1.2381.00
162_S195_A1.2351.00
166_I170_I1.2321.00
31_K34_T1.2301.00
226_K255_E1.2271.00
222_Y251_R1.2241.00
167_D202_L1.2231.00
225_A238_L1.2201.00
298_N302_E1.2121.00
250_L266_L1.2121.00
41_I45_L1.2111.00
301_Y305_R1.2091.00
195_A199_Y1.2071.00
89_I297_V1.1971.00
200_G205_V1.1851.00
34_T37_R1.1831.00
175_N236_K1.1811.00
164_E167_D1.1781.00
7_I11_A1.1771.00
4_L15_L1.1771.00
227_Q231_R1.1771.00
159_A191_I1.1761.00
7_I45_L1.1621.00
130_A134_A1.1611.00
93_C100_L1.1611.00
89_I119_L1.1561.00
119_L296_G1.1521.00
68_I89_I1.1481.00
159_A163_K1.1451.00
21_V30_V1.1201.00
50_S55_L1.1181.00
36_H39_L1.1171.00
232_E235_P1.1171.00
196_F200_G1.1151.00
177_I200_G1.1141.00
295_Q299_L1.1121.00
172_Q322_L1.0951.00
180_I249_V1.0951.00
290_E294_S1.0921.00
199_Y203_K1.0891.00
219_S223_E1.0861.00
40_E43_E1.0791.00
238_L249_V1.0731.00
96_L298_N1.0691.00
198_E202_L1.0661.00
179_F193_E1.0631.00
293_G297_V1.0621.00
224_L227_Q1.0621.00
68_I100_L1.0611.00
24_D35_K1.0581.00
299_L314_V1.0571.00
165_I239_F1.0561.00
248_G252_A1.0541.00
243_D284_T1.0541.00
159_A195_A1.0501.00
171_N203_K1.0361.00
176_R233_D1.0341.00
243_D268_S1.0261.00
160_R317_P1.0251.00
65_I101_T1.0241.00
59_A64_H1.0151.00
96_L305_R1.0131.00
4_L18_V1.0081.00
42_A45_L1.0081.00
294_S298_N1.0051.00
295_Q316_V1.0031.00
194_V197_A1.0031.00
170_I205_V1.0011.00
240_V246_A0.9891.00
221_G225_A0.9831.00
300_V304_A0.9801.00
90_E94_E0.9791.00
250_L260_I0.9791.00
65_I99_E0.9771.00
217_S220_S0.9761.00
98_I301_Y0.9711.00
175_N205_V0.9621.00
172_Q265_S0.9571.00
11_A18_V0.9541.00
184_D213_R0.9531.00
286_R321_K0.9531.00
223_E227_Q0.9471.00
240_V245_I0.9381.00
177_I237_A0.9331.00
165_I285_V0.9321.00
250_L278_T0.9311.00
168_F283_S0.9301.00
220_S223_E0.9291.00
153_A313_L0.9241.00
212_W224_L0.9231.00
94_E111_D0.9221.00
166_I200_G0.9221.00
170_I175_N0.9201.00
190_D194_V0.9191.00
24_D39_L0.9161.00
319_K322_L0.9151.00
299_L302_E0.9101.00
225_A229_L0.9021.00
238_L264_I0.8941.00
95_K294_S0.8931.00
176_R210_D0.8911.00
91_T294_S0.8781.00
288_H316_V0.8771.00
288_H319_K0.8771.00
187_G191_I0.8761.00
152_D299_L0.8741.00
156_I288_H0.8671.00
206_V209_E0.8671.00
196_F239_F0.8641.00
154_V299_L0.8641.00
218_S251_R0.8621.00
89_I293_G0.8621.00
21_V39_L0.8611.00
160_R318_S0.8591.00
119_L300_V0.8571.00
155_D313_L0.8531.00
66_L119_L0.8531.00
157_D315_F0.8521.00
68_I86_R0.8491.00
156_I318_S0.8461.00
155_D315_F0.8451.00
152_D312_L0.8431.00
258_L264_I0.8421.00
271_D321_K0.8411.00
85_I142_I0.8411.00
87_H91_T0.8361.00
157_D317_P0.8361.00
229_L252_A0.8351.00
49_T53_R0.8331.00
297_V301_Y0.8261.00
234_Y258_L0.8251.00
210_D231_R0.8231.00
197_A206_V0.8171.00
223_E226_K0.8101.00
181_G193_E0.8101.00
81_Y289_S0.8061.00
182_G216_F0.8031.00
178_G238_L0.8021.00
243_D271_D0.8021.00
13_V38_I0.8011.00
214_G245_I0.7931.00
158_L192_R0.7901.00
169_Y267_I0.7871.00
198_E201_R0.7871.00
33_E36_H0.7861.00
126_P130_A0.7831.00
180_I240_V0.7821.00
88_G92_Q0.7811.00
117_G304_A0.7791.00
253_I266_L0.7771.00
16_A20_R0.7701.00
271_D275_A0.7701.00
84_A290_E0.7681.00
145_H313_L0.7681.00
65_I113_K0.7671.00
225_A252_A0.7671.00
33_E37_R0.7661.00
156_I287_I0.7631.00
191_I195_A0.7571.00
3_T6_D0.7561.00
17_T20_R0.7521.00
229_L256_R0.7511.00
268_S284_T0.7511.00
88_G294_S0.7491.00
164_E285_V0.7471.00
239_F267_I0.7461.00
212_W231_R0.7461.00
90_E104_Y0.7441.00
254_H281_P0.7431.00
20_R26_P0.7421.00
220_S224_L0.7421.00
206_V211_I0.7411.00
168_F320_L0.7401.00
275_A278_T0.7361.00
193_E211_I0.7351.00
20_R29_N0.7311.00
236_K265_S0.7281.00
253_I260_I0.7281.00
243_D246_A0.7281.00
86_R102_N0.7261.00
133_S150_G0.7251.00
179_F239_F0.7241.00
251_R254_H0.7241.00
89_I100_L0.7231.00
67_A118_I0.7221.00
251_R281_P0.7181.00
185_E190_D0.7181.00
274_T278_T0.7171.00
131_A134_A0.7101.00
247_I278_T0.7091.00
66_L297_V0.7071.00
52_A55_L0.7041.00
90_E100_L0.6951.00
101_T115_V0.6951.00
225_A228_M0.6941.00
170_I200_G0.6921.00
86_R90_E0.6911.00
60_V116_T0.6911.00
139_I151_Y0.6901.00
270_N287_I0.6891.00
21_V35_K0.6871.00
91_T95_K0.6871.00
36_H43_E0.6841.00
141_F151_Y0.6841.00
133_S139_I0.6811.00
108_G111_D0.6801.00
177_I236_K0.6791.00
302_E306_D0.6761.00
13_V34_T0.6741.00
164_E168_F0.6731.00
141_F146_E0.6721.00
130_A133_S0.6711.00
251_R255_E0.6711.00
87_H90_E0.6701.00
227_Q230_A0.6701.00
117_G140_C0.6691.00
212_W228_M0.6681.00
59_A305_R0.6681.00
281_P323_R0.6671.00
214_G220_S0.6641.00
75_L82_Y0.6601.00
251_R279_F0.6571.00
231_R234_Y0.6571.00
59_A116_T0.6551.00
221_G224_L0.6551.00
283_S320_L0.6531.00
119_L142_I0.6471.00
163_K195_A0.6391.00
98_I304_A0.6361.00
84_A289_S0.6331.00
133_S151_Y0.6311.00
225_A248_G0.6311.00
87_H290_E0.6281.00
302_E312_L0.6281.00
179_F196_F0.6281.00
231_R235_P0.6231.00
246_A268_S0.6211.00
177_I196_F0.6211.00
20_R30_V0.6191.00
250_L254_H0.6181.00
189_A216_F0.6181.00
37_R40_E0.6171.00
303_K306_D0.6161.00
140_C300_V0.6151.00
79_D244_S0.6151.00
140_C303_K0.6141.00
85_I289_S0.6131.00
132_A139_I0.6101.00
43_E46_E0.6081.00
106_H111_D0.6071.00
5_K56_Q0.6061.00
7_I18_V0.6051.00
163_K166_I0.6051.00
216_F241_A0.6051.00
152_D311_P0.6041.00
242_S270_N0.6001.00
169_Y239_F0.5971.00
279_F324_G0.5951.00
81_Y85_I0.5941.00
253_I256_R0.5941.00
285_V318_S0.5941.00
66_L117_G0.5941.00
117_G296_G0.5941.00
247_I272_I0.5911.00
269_V287_I0.5901.00
200_G206_V0.5901.00
158_L191_I0.5881.00
18_V42_A0.5881.00
239_F269_V0.5851.00
218_S248_G0.5841.00
98_I116_T0.5841.00
140_C154_V0.5841.00
18_V21_V0.5831.00
299_L303_K0.5821.00
29_N34_T0.5811.00
54_K57_T0.5791.00
168_F267_I0.5791.00
118_I137_D0.5781.00
143_D158_L0.5771.00
140_C296_G0.5751.00
254_H259_N0.5751.00
93_C301_Y0.5741.00
254_H280_P0.5711.00
140_C299_L0.5701.00
128_L131_A0.5681.00
181_G213_R0.5681.00
66_L304_A0.5651.00
178_G210_D0.5641.00
88_G289_S0.5641.00
197_A211_I0.5631.00
65_I116_T0.5621.00
242_S245_I0.5591.00
295_Q302_E0.5581.00
182_G189_A0.5581.00
143_D188_K0.5571.00
165_I237_A0.5571.00
25_D30_V0.5551.00
208_E211_I0.5551.00
255_E279_F0.5511.00
249_V253_I0.5511.00
145_H153_A0.5501.00
290_E293_G0.5501.00
189_A241_A0.5471.00
53_R57_T0.5461.00
101_T113_K0.5461.00
87_H106_H0.5431.00
11_A21_V0.5401.00
219_S222_Y0.5401.00
76_E87_H0.5401.00
276_R281_P0.5401.00
155_D158_L0.5391.00
220_S245_I0.5381.00
274_T277_F0.5381.00
260_I263_D0.5351.00
201_R204_Q0.5341.00
154_V295_Q0.5311.00
13_V18_V0.5311.00
6_D10_E0.5301.00
67_A103_C0.5301.00
229_L253_I0.5301.00
89_I93_C0.5291.00
258_L261_P0.5291.00
275_A282_L0.5281.00
193_E213_R0.5271.00
222_Y248_G0.5251.00
292_M316_V0.5241.00
240_V268_S0.5221.00
16_A25_D0.5211.00
30_V35_K0.5201.00
172_Q236_K0.5191.00
249_V266_L0.5181.00
176_R235_P0.5171.00
82_Y121_V0.5171.00
209_E231_R0.5171.00
127_A130_A0.5161.00
156_I269_V0.5151.00
84_A273_P0.5141.00
115_V118_I0.5141.00
18_V38_I0.5121.00
197_A208_E0.5121.00
78_N84_A0.5111.00
235_P238_L0.5111.00
79_D82_Y0.5101.00
243_D272_I0.5091.00
251_R276_R0.5081.00
92_Q301_Y0.5071.00
234_Y263_D0.5071.00
80_P244_S0.5051.00
237_A265_S0.5041.00
222_Y225_A0.5041.00
278_T281_P0.5041.00
24_D29_N0.5041.00
131_A135_L0.5031.00
38_I41_I0.5021.00
117_G138_N0.5021.00
200_G203_K0.5011.00
181_G211_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8012 100 0.094 Contact Map
2hsgA 1 0.9633 100 0.097 Contact Map
2o20A 2 0.8073 100 0.101 Contact Map
3bilA 2 0.7462 100 0.104 Contact Map
1qpzA 2 0.9694 100 0.106 Contact Map
4o5aA 2 0.7829 100 0.106 Contact Map
3ctpA 2 0.7798 100 0.111 Contact Map
3jvdA 2 0.7676 100 0.113 Contact Map
3e3mA 2 0.7798 100 0.114 Contact Map
3h5oA 2 0.789 100 0.115 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.011 seconds.