GREMLIN Database
MUTH - DNA mismatch repair protein MutH
UniProt: P06722 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10624
Length: 229 (208)
Sequences: 652 (476)
Seq/√Len: 33.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_E155_R4.9441.00
155_R159_E4.4061.00
169_Q172_R4.3591.00
108_W158_W2.7931.00
164_M177_H2.7701.00
189_N193_L2.7511.00
21_A141_P2.6631.00
92_T215_K2.6261.00
14_E76_V2.6191.00
17_L74_L2.5101.00
55_L80_T2.4891.00
94_F184_R2.4541.00
97_V208_P2.4340.99
163_D167_L2.3920.99
28_T137_R2.3400.99
36_V58_W2.3370.99
14_E119_R2.1650.99
114_R151_D2.1400.99
132_P135_Q2.1210.99
103_N106_V2.1040.98
190_A207_L2.0730.98
150_E217_F2.0620.98
89_P219_S1.9080.97
108_W144_W1.8800.97
147_N150_E1.8380.96
103_N165_I1.8010.96
126_E137_R1.7850.96
150_E224_R1.7770.96
83_V144_W1.7410.95
189_N192_A1.7070.94
32_L36_V1.6850.94
30_G134_A1.6700.94
170_V209_R1.6500.93
49_G121_L1.6490.93
98_A183_I1.6150.93
162_M166_V1.6050.92
151_D155_R1.5910.92
117_L213_L1.5760.92
52_G56_E1.5490.91
30_G135_Q1.4910.89
103_N161_L1.4820.89
192_A208_P1.4760.89
106_V158_W1.4750.89
56_E70_D1.4730.89
159_E163_D1.4590.88
107_T158_W1.4470.88
92_T214_K1.4390.87
186_K210_G1.4360.87
153_Q180_Y1.4340.87
160_E163_D1.4170.87
201_G206_T1.4110.86
123_I141_P1.4000.86
36_V138_V1.3960.86
182_Q212_Y1.3900.86
95_V117_L1.3790.85
14_E18_L1.3730.85
13_T16_Q1.3260.83
58_W138_V1.2960.81
142_L221_L1.2900.81
82_P136_R1.2860.81
164_M180_Y1.2680.80
56_E77_E1.2650.80
85_S128_E1.2610.79
28_T31_E1.2410.78
77_E116_K1.2370.78
157_D161_L1.2180.77
147_N224_R1.2090.76
24_L58_W1.2070.76
93_T218_T1.2040.76
205_L209_R1.1930.75
199_A202_E1.1910.75
122_W154_L1.1890.75
122_W144_W1.1790.75
119_R145_S1.1740.74
112_H115_H1.1740.74
76_V143_L1.1710.74
26_G139_G1.1690.74
84_D90_L1.1630.74
196_A207_L1.1580.73
108_W113_V1.1500.73
33_A54_L1.1450.72
21_A24_L1.1420.72
107_T110_T1.1420.72
68_E72_A1.1410.72
187_A208_P1.1320.72
221_L224_R1.1310.71
195_E205_L1.1280.71
55_L58_W1.1100.70
201_G204_I1.1010.69
34_A220_A1.0580.66
122_W143_L1.0560.66
79_K116_K1.0490.66
187_A192_A1.0490.66
147_N217_F1.0400.65
25_S141_P1.0390.65
219_S223_A1.0390.65
21_A123_I1.0280.64
34_A149_E1.0230.64
24_L72_A1.0220.64
52_G77_E1.0170.63
204_I207_L1.0010.62
96_C186_K0.9980.62
34_A223_A0.9970.62
94_F210_G0.9870.61
164_M169_Q0.9860.61
12_E17_L0.9830.60
194_T208_P0.9810.60
83_V222_L0.9810.60
49_G52_G0.9740.60
95_V120_V0.9730.60
199_A203_R0.9720.60
196_A204_I0.9700.59
52_G70_D0.9680.59
60_G75_G0.9650.59
56_E157_D0.9600.59
52_G157_D0.9540.58
190_A193_L0.9510.58
44_L133_L0.9450.57
52_G78_L0.9390.57
220_A223_A0.9380.57
66_K69_Q0.9380.57
100_L209_R0.9350.57
79_K94_F0.9220.56
69_Q215_K0.9210.55
97_V187_A0.9120.55
171_E200_R0.9110.55
96_C211_F0.9100.55
83_V139_G0.9060.54
63_A213_L0.8950.53
56_E61_A0.8940.53
67_P102_G0.8940.53
206_T209_R0.8920.53
199_A205_L0.8900.53
34_A163_D0.8850.52
182_Q185_P0.8800.52
102_G203_R0.8710.51
125_V138_V0.8660.51
56_E78_L0.8650.51
115_H156_E0.8590.50
92_T175_A0.8590.50
113_V166_V0.8580.50
164_M209_R0.8550.50
29_L51_I0.8550.50
17_L49_G0.8540.50
16_Q20_Q0.8530.50
109_E114_R0.8470.49
13_T205_L0.8450.49
78_L157_D0.8350.48
88_R216_N0.8280.48
70_D82_P0.8260.48
146_P213_L0.8210.47
24_L36_V0.8170.47
184_R212_Y0.8160.47
157_D186_K0.8140.47
96_C112_H0.8090.46
15_E128_E0.8070.46
144_W221_L0.8060.46
38_L76_V0.8010.45
14_E145_S0.7960.45
61_A64_G0.7950.45
168_G209_R0.7860.44
69_Q115_H0.7810.44
27_Y206_T0.7800.44
28_T35_L0.7770.43
195_E203_R0.7770.43
163_D171_E0.7750.43
140_S170_V0.7710.43
70_D77_E0.7700.43
137_R155_R0.7660.43
102_G106_V0.7600.42
177_H180_Y0.7570.42
81_I125_V0.7530.42
16_Q24_L0.7510.41
15_E19_A0.7500.41
88_R219_S0.7450.41
144_W147_N0.7430.41
114_R118_K0.7420.41
84_D215_K0.7300.40
98_A186_K0.7250.39
104_S163_D0.7230.39
148_E152_R0.7220.39
66_K74_L0.7220.39
129_R136_R0.7210.39
52_G116_K0.7200.39
53_V57_I0.7190.39
201_G207_L0.7190.39
18_L76_V0.7190.39
116_K157_D0.7160.39
93_T117_L0.7130.38
84_D88_R0.7120.38
90_L129_R0.7060.38
23_Q27_Y0.7040.38
173_I178_G0.7040.38
92_T184_R0.7000.37
32_L57_I0.6980.37
96_C146_P0.6980.37
117_L120_V0.6980.37
126_E222_L0.6980.37
164_M173_I0.6970.37
70_D116_K0.6950.37
72_A112_H0.6940.37
36_V102_G0.6940.37
96_C117_L0.6930.37
69_Q118_K0.6910.37
12_E15_E0.6870.36
19_A62_S0.6830.36
92_T182_Q0.6760.35
132_P155_R0.6720.35
62_S72_A0.6690.35
77_E121_L0.6630.34
92_T185_P0.6620.34
149_E187_A0.6600.34
14_E74_L0.6590.34
83_V89_P0.6560.34
146_P182_Q0.6530.34
176_R207_L0.6520.34
70_D121_L0.6520.34
73_A138_V0.6510.34
14_E108_W0.6510.34
174_T177_H0.6490.33
50_W218_T0.6470.33
27_Y31_E0.6450.33
32_L44_L0.6450.33
38_L223_A0.6430.33
71_F79_K0.6400.33
94_F218_T0.6400.33
117_L146_P0.6370.33
100_L165_I0.6370.33
72_A102_G0.6300.32
170_V206_T0.6300.32
176_R182_Q0.6300.32
27_Y35_L0.6290.32
149_E221_L0.6200.31
92_T216_N0.6180.31
157_D181_L0.6130.31
20_Q58_W0.6130.31
31_E37_G0.6120.31
28_T172_R0.6100.31
171_E174_T0.6100.31
103_N215_K0.6030.30
58_W209_R0.6010.30
15_E37_G0.5950.30
56_E116_K0.5910.29
127_G212_Y0.5900.29
49_G116_K0.5900.29
93_T184_R0.5900.29
17_L189_N0.5880.29
46_R66_K0.5880.29
36_V57_I0.5870.29
83_V145_S0.5870.29
55_L123_I0.5830.29
170_V174_T0.5810.29
124_P211_F0.5800.29
74_L121_L0.5790.28
40_T45_K0.5750.28
55_L130_S0.5750.28
76_V121_L0.5730.28
20_Q59_L0.5720.28
22_Q62_S0.5690.28
135_Q200_R0.5680.28
72_A105_G0.5680.28
159_E162_M0.5650.28
96_C113_V0.5640.27
157_D180_Y0.5610.27
110_T118_K0.5590.27
70_D74_L0.5520.27
196_A206_T0.5510.27
19_A66_K0.5500.27
145_S148_E0.5460.26
152_R155_R0.5460.26
31_E112_H0.5440.26
186_K211_F0.5440.26
123_I138_V0.5440.26
77_E157_D0.5430.26
192_A195_E0.5420.26
187_A209_R0.5410.26
182_Q186_K0.5390.26
97_V158_W0.5380.26
110_T224_R0.5350.26
90_L127_G0.5340.26
93_T217_F0.5330.25
123_I216_N0.5300.25
102_G107_T0.5300.25
185_P207_L0.5270.25
104_S166_V0.5260.25
100_L208_P0.5250.25
173_I179_E0.5240.25
81_I184_R0.5220.25
82_P209_R0.5220.25
98_A176_R0.5210.25
66_K152_R0.5200.25
73_A110_T0.5200.25
175_A215_K0.5180.25
117_L184_R0.5170.24
75_G130_S0.5140.24
74_L126_E0.5140.24
82_P116_K0.5140.24
21_A58_W0.5140.24
134_A156_E0.5120.24
100_L120_V0.5120.24
85_S130_S0.5110.24
32_L220_A0.5090.24
15_E23_Q0.5080.24
108_W114_R0.5070.24
81_I219_S0.5060.24
72_A76_V0.5050.24
127_G184_R0.5050.24
73_A113_V0.5040.24
164_M206_T0.5040.24
19_A27_Y0.5040.24
34_A107_T0.5020.24
209_R214_K0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1azoA 1 0.9345 100 0.153 Contact Map
2aorA 1 0.9607 100 0.157 Contact Map
4pxgA 1 0.9432 100 0.176 Contact Map
2reuA 1 0.8428 100 0.195 Contact Map
2odiA 1 0.8384 38 0.945 Contact Map
2oa9A 1 0.7249 32.6 0.947 Contact Map
3ulqB 1 0.2533 12.7 0.956 Contact Map
2jpcA 1 0.2664 7.4 0.961 Contact Map
1je8A 2 0.2926 6.6 0.962 Contact Map
3kfuF 2 0.1179 6.3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.