GREMLIN Database
METC - Cystathionine beta-lyase MetC
UniProt: P06721 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10583
Length: 395 (375)
Sequences: 10539 (5844)
Seq/√Len: 301.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_K198_D3.4441.00
103_H130_S3.1981.00
141_V175_S3.0661.00
77_G224_V3.0651.00
278_A293_G2.9521.00
7_D379_D2.8741.00
388_D392_A2.8521.00
76_G198_D2.8331.00
271_L275_E2.7091.00
284_A316_K2.6411.00
103_H145_Q2.6221.00
334_F345_S2.5051.00
71_M222_T2.4501.00
5_K379_D2.4351.00
167_P302_R2.3781.00
285_R314_V2.3491.00
150_I183_M2.3121.00
167_P171_A2.3111.00
9_Q73_E2.2091.00
276_W384_I2.2061.00
193_L267_H2.1381.00
297_H301_K2.1361.00
264_R268_E2.1261.00
276_W388_D2.0781.00
170_V182_I2.0011.00
164_H169_I1.9811.00
136_I139_D1.9441.00
314_V369_T1.9271.00
245_D248_T1.9141.00
128_T145_Q1.9071.00
208_A220_I1.8861.00
7_D260_G1.8721.00
67_L252_T1.8701.00
137_G168_A1.8681.00
211_Y309_G1.8661.00
349_A352_P1.8631.00
102_D149_K1.8511.00
273_V384_I1.8501.00
174_R202_D1.8451.00
65_F69_Q1.8411.00
184_I201_I1.8211.00
99_E124_K1.8061.00
320_N323_E1.7801.00
171_A175_S1.7711.00
130_S145_Q1.7621.00
265_Q268_E1.7611.00
174_R182_I1.7371.00
80_C224_V1.7071.00
6_L192_V1.7031.00
266_H309_G1.6861.00
380_V384_I1.6701.00
138_A141_V1.6591.00
269_S380_V1.6491.00
317_K320_N1.6491.00
151_V169_I1.6221.00
361_Q368_G1.6211.00
64_H249_A1.6181.00
272_K380_V1.6061.00
275_E292_P1.6051.00
75_E206_Q1.6021.00
106_M118_C1.5971.00
272_K384_I1.5921.00
182_I201_I1.5811.00
137_G172_A1.5781.00
103_H128_T1.5741.00
314_V367_S1.5691.00
195_K305_T1.5641.00
37_D41_A1.5591.00
272_K275_E1.5571.00
132_F143_H1.5511.00
326_N330_N1.5341.00
151_V173_V1.5311.00
54_L60_G1.5251.00
77_G197_L1.5231.00
331_F347_I1.5151.00
103_H148_T1.4931.00
315_L327_Y1.4801.00
188_W340_W1.4771.00
220_I244_V1.4551.00
141_V178_P1.4441.00
276_W280_H1.4421.00
273_V375_I1.4401.00
284_A369_T1.4381.00
103_H147_N1.4211.00
272_K381_D1.4161.00
321_N325_A1.4161.00
332_S389_A1.4161.00
13_A73_E1.4141.00
208_A252_T1.4141.00
72_C80_C1.4031.00
5_K381_D1.4001.00
284_A314_V1.3921.00
80_C222_T1.3891.00
168_A171_A1.3821.00
334_F387_L1.3811.00
67_L82_L1.3791.00
30_R247_D1.3751.00
321_N368_G1.3741.00
144_L180_A1.3681.00
167_P303_D1.3671.00
90_V152_F1.3561.00
208_A222_T1.3471.00
54_L65_F1.3391.00
5_K385_A1.3381.00
292_P297_H1.3351.00
170_V174_R1.3341.00
244_V249_A1.3311.00
263_L266_H1.3291.00
261_V377_L1.3251.00
144_L151_V1.3151.00
197_L226_N1.3101.00
99_E102_D1.3101.00
67_L222_T1.3031.00
94_I150_I1.3011.00
26_S66_S1.3011.00
334_F383_L1.2921.00
280_H388_D1.2881.00
273_V387_L1.2871.00
225_C230_W1.2811.00
38_S41_A1.2801.00
83_F223_A1.2731.00
181_I229_C1.2711.00
269_S377_L1.2671.00
144_L172_A1.2661.00
138_A142_K1.2651.00
153_L182_I1.2651.00
165_D168_A1.2571.00
106_M110_A1.2561.00
153_L166_V1.2541.00
175_S178_P1.2461.00
301_K307_S1.2461.00
98_I104_V1.2421.00
194_F199_F1.2351.00
183_M205_I1.2331.00
128_T147_N1.2321.00
347_I371_I1.2291.00
170_V201_I1.2271.00
297_H307_S1.2191.00
373_L387_L1.2191.00
273_V383_L1.2091.00
223_A233_L1.1921.00
38_S329_D1.1871.00
88_A242_Q1.1851.00
290_A307_S1.1831.00
218_A252_T1.1831.00
333_L383_L1.1831.00
278_A291_L1.1821.00
161_M289_P1.1751.00
119_S131_W1.1751.00
35_V335_S1.1721.00
167_P199_F1.1711.00
312_S370_L1.1661.00
270_S274_A1.1541.00
93_S183_M1.1541.00
274_A291_L1.1531.00
213_V218_A1.1511.00
108_N162_E1.1501.00
208_A212_L1.1481.00
71_M224_V1.1471.00
40_E329_D1.1401.00
265_Q269_S1.1381.00
173_V182_I1.1311.00
343_Y377_L1.1271.00
267_H306_G1.1211.00
212_L256_L1.1131.00
296_G299_F1.1111.00
298_E301_K1.1111.00
10_L260_G1.1101.00
171_A174_R1.1101.00
81_V234_R1.1031.00
140_I169_I1.0991.00
260_G264_R1.0931.00
118_C129_T1.0891.00
71_M212_L1.0881.00
81_V233_L1.0881.00
105_L143_H1.0871.00
268_E272_K1.0841.00
217_D254_R1.0791.00
275_E278_A1.0751.00
6_L195_K1.0701.00
78_A227_A1.0691.00
151_V180_A1.0661.00
65_F68_Q1.0651.00
189_A304_F1.0621.00
83_F92_N1.0611.00
24_V335_S1.0591.00
205_I223_A1.0551.00
161_M311_F1.0521.00
218_A248_T1.0501.00
300_W307_S1.0461.00
119_S123_S1.0451.00
273_V380_V1.0381.00
220_I252_T1.0321.00
79_G234_R1.0301.00
384_I388_D1.0271.00
141_V172_A1.0231.00
40_E325_A1.0211.00
70_A253_S1.0181.00
94_I98_I1.0171.00
91_A95_L1.0171.00
92_N242_Q1.0161.00
274_A286_V1.0161.00
139_D142_K1.0161.00
298_E302_R1.0141.00
70_A256_L1.0141.00
261_V265_Q0.9991.00
59_R238_Y0.9941.00
135_L296_G0.9931.00
327_Y371_I0.9921.00
83_F237_A0.9921.00
216_S342_G0.9901.00
166_V201_I0.9891.00
91_A117_F0.9891.00
153_L184_I0.9801.00
191_G206_Q0.9791.00
39_V329_D0.9791.00
98_I102_D0.9741.00
327_Y387_L0.9721.00
317_K323_E0.9721.00
144_L178_P0.9701.00
297_H300_W0.9671.00
85_C219_M0.9661.00
287_N314_V0.9591.00
247_D251_I0.9561.00
313_F373_L0.9541.00
97_F229_C0.9541.00
385_A388_D0.9521.00
193_L306_G0.9501.00
294_S297_H0.9501.00
203_V225_C0.9491.00
322_E326_N0.9471.00
323_E369_T0.9461.00
152_F183_M0.9441.00
134_P140_I0.9431.00
11_V377_L0.9401.00
213_V252_T0.9401.00
267_H271_L0.9391.00
90_V205_I0.9381.00
386_D389_A0.9381.00
197_L204_S0.9361.00
115_Q119_S0.9341.00
327_Y347_I0.9301.00
192_V264_R0.9291.00
87_A90_V0.9291.00
94_I118_C0.9231.00
106_M131_W0.9181.00
166_V170_V0.9161.00
78_A225_C0.9141.00
188_W310_L0.9131.00
79_G230_W0.9131.00
81_V230_W0.9111.00
64_H244_V0.9111.00
351_Q361_Q0.9111.00
130_S143_H0.9101.00
257_R344_E0.9091.00
260_G265_Q0.9091.00
133_D139_D0.9061.00
76_G195_K0.9061.00
276_W391_F0.9041.00
106_M129_T0.9021.00
320_N369_T0.9011.00
282_Q391_F0.8981.00
109_T162_E0.8971.00
209_T219_M0.8961.00
28_I247_D0.8921.00
153_L164_H0.8921.00
328_L347_I0.8901.00
273_V373_L0.8881.00
277_L313_F0.8871.00
270_S288_H0.8841.00
169_I182_I0.8771.00
173_V180_A0.8761.00
16_S69_Q0.8751.00
334_F373_L0.8751.00
156_P194_F0.8741.00
82_L222_T0.8731.00
282_Q316_K0.8721.00
22_G37_D0.8691.00
381_D385_A0.8681.00
124_K232_Q0.8651.00
57_G64_H0.8651.00
93_S203_V0.8571.00
152_F205_I0.8561.00
203_V229_C0.8551.00
123_S128_T0.8541.00
325_A329_D0.8531.00
280_H391_F0.8511.00
275_E291_L0.8501.00
64_H82_L0.8471.00
7_D265_Q0.8461.00
153_L169_I0.8441.00
163_V296_G0.8431.00
285_R369_T0.8391.00
208_A244_V0.8351.00
166_V194_F0.8341.00
105_L132_F0.8191.00
28_I250_Y0.8191.00
150_I181_I0.8161.00
330_N390_G0.8151.00
137_G141_V0.8141.00
192_V263_L0.8121.00
98_I150_I0.8121.00
311_F373_L0.8111.00
93_S223_A0.8111.00
18_K21_L0.8091.00
203_V223_A0.8091.00
96_A233_L0.8091.00
98_I127_V0.8081.00
194_F303_D0.8071.00
91_A240_M0.8051.00
166_V199_F0.8051.00
212_L252_T0.8041.00
334_F347_I0.7971.00
26_S253_S0.7961.00
83_F88_A0.7951.00
78_A226_N0.7921.00
271_L288_H0.7921.00
156_P303_D0.7900.99
104_V150_I0.7890.99
260_G379_D0.7840.99
280_H392_A0.7830.99
68_Q234_R0.7830.99
163_V299_F0.7800.99
9_Q13_A0.7790.99
360_P363_E0.7750.99
79_G225_C0.7750.99
322_E325_A0.7750.99
276_W387_L0.7740.99
269_S273_V0.7650.99
269_S375_I0.7640.99
271_L278_A0.7620.99
271_L306_G0.7620.99
79_G227_A0.7540.99
275_E279_E0.7530.99
99_E149_K0.7530.99
206_Q224_V0.7520.99
194_F304_F0.7520.99
67_L212_L0.7510.99
232_Q236_N0.7500.99
300_W304_F0.7470.99
174_R180_A0.7460.99
327_Y331_F0.7450.99
272_K276_W0.7440.99
23_A29_Q0.7430.99
104_V118_C0.7410.99
102_D147_N0.7390.99
381_D384_I0.7360.99
228_R231_E0.7350.99
8_T333_L0.7340.99
328_L371_I0.7300.99
287_N294_S0.7290.99
244_V252_T0.7290.99
98_I149_K0.7270.99
75_E204_S0.7260.99
323_E326_N0.7260.99
334_F375_I0.7260.99
359_R362_G0.7250.99
268_E380_V0.7240.99
172_A178_P0.7230.99
345_S373_L0.7220.99
137_G140_I0.7220.99
320_N324_L0.7210.99
103_H146_P0.7210.99
288_H311_F0.7200.99
165_D302_R0.7180.99
202_D226_N0.7170.99
134_P164_H0.7160.99
157_G162_E0.7160.99
67_L208_A0.7140.99
105_L148_T0.7130.99
84_P242_Q0.7120.99
83_F242_Q0.7080.99
193_L263_L0.7080.99
114_S152_F0.7060.99
132_F139_D0.7000.99
25_N250_Y0.6990.99
162_E296_G0.6960.99
186_N206_Q0.6950.99
362_G368_G0.6950.99
6_L9_Q0.6940.99
267_H309_G0.6920.99
30_R218_A0.6920.99
283_V313_F0.6910.99
212_L259_L0.6890.99
282_Q323_E0.6890.99
247_D250_Y0.6890.99
71_M82_L0.6890.99
186_N196_A0.6880.99
157_G160_T0.6870.99
199_F303_D0.6870.99
317_K322_E0.6870.99
130_S147_N0.6850.99
30_R250_Y0.6820.99
251_I254_R0.6820.99
120_K235_E0.6810.99
163_V300_W0.6800.98
268_E306_G0.6800.98
82_L244_V0.6790.98
71_M208_A0.6790.98
156_P304_F0.6780.98
139_D143_H0.6770.98
282_Q392_A0.6700.98
273_V276_W0.6700.98
55_F59_R0.6690.98
85_C243_M0.6660.98
228_R232_Q0.6660.98
6_L10_L0.6630.98
313_F371_I0.6610.98
283_V391_F0.6590.98
173_V178_P0.6570.98
183_M203_V0.6560.98
282_Q315_L0.6510.98
81_V223_A0.6500.98
271_L290_A0.6480.98
118_C152_F0.6470.98
168_A172_A0.6440.98
385_A389_A0.6440.98
104_V129_T0.6440.98
387_L391_F0.6430.98
163_V294_S0.6410.98
33_S339_S0.6410.98
287_N312_S0.6400.98
225_C229_C0.6390.98
193_L305_T0.6390.98
141_V168_A0.6380.98
327_Y390_G0.6370.98
166_V182_I0.6370.98
151_V174_R0.6360.98
97_F183_M0.6340.98
135_L162_E0.6340.98
60_G65_F0.6310.98
136_I142_K0.6290.98
21_L29_Q0.6260.97
267_H307_S0.6260.97
144_L148_T0.6250.97
211_Y310_L0.6250.97
132_F140_I0.6250.97
191_G212_L0.6250.97
326_N329_D0.6250.97
93_S97_F0.6210.97
327_Y391_F0.6200.97
202_D228_R0.6190.97
362_G367_S0.6180.97
351_Q368_G0.6180.97
78_A230_W0.6180.97
90_V114_S0.6170.97
155_S186_N0.6170.97
244_V248_T0.6160.97
347_I373_L0.6150.97
95_L125_L0.6150.97
186_N189_A0.6150.97
142_K146_P0.6120.97
65_F79_G0.6110.97
84_P243_M0.6110.97
140_I151_V0.6110.97
274_A311_F0.6100.97
330_N389_A0.6100.97
218_A255_G0.6090.97
257_R343_Y0.6080.97
151_V172_A0.6070.97
219_M243_M0.6070.97
100_Q126_G0.6060.97
266_H269_S0.6060.97
109_T157_G0.6060.97
107_T134_P0.6050.97
68_Q82_L0.6040.97
345_S387_L0.6030.97
115_Q131_W0.6030.97
299_F302_R0.6020.97
31_A34_L0.6000.97
338_Y348_L0.5990.97
314_V370_L0.5990.97
121_I239_L0.5990.97
156_P189_A0.5980.97
310_L340_W0.5960.97
189_A300_W0.5930.96
9_Q76_G0.5920.96
105_L134_P0.5920.96
206_Q222_T0.5880.96
290_A297_H0.5870.96
278_A294_S0.5840.96
69_Q73_E0.5830.96
6_L260_G0.5830.96
92_N223_A0.5810.96
108_N133_D0.5800.96
93_S205_I0.5800.96
174_R179_D0.5800.96
66_S253_S0.5790.96
33_S337_A0.5780.96
274_A290_A0.5770.96
166_V184_I0.5770.96
72_C79_G0.5740.96
67_L253_S0.5730.96
122_L127_V0.5720.96
279_E388_D0.5720.96
299_F303_D0.5700.96
12_N335_S0.5700.96
347_I387_L0.5690.96
30_R245_D0.5680.95
331_F334_F0.5670.95
227_A231_E0.5630.95
315_L391_F0.5610.95
348_L353_E0.5600.95
237_A243_M0.5590.95
21_L54_L0.5560.95
68_Q80_C0.5550.95
345_S383_L0.5550.95
215_H254_R0.5530.95
167_P198_D0.5530.95
130_S148_T0.5530.95
24_V35_V0.5520.95
324_L369_T0.5520.95
324_L349_A0.5510.95
5_K9_Q0.5480.95
271_L291_L0.5480.95
359_R363_E0.5460.94
291_L297_H0.5460.94
337_A346_L0.5460.94
116_D120_K0.5440.94
63_T253_S0.5440.94
37_D52_G0.5430.94
93_S236_N0.5420.94
39_V325_A0.5420.94
264_R267_H0.5390.94
121_I236_N0.5390.94
133_D136_I0.5360.94
61_T64_H0.5350.94
288_H307_S0.5330.94
327_Y330_N0.5320.94
269_S272_K0.5300.94
278_A292_P0.5270.93
211_Y266_H0.5270.93
276_W279_E0.5260.93
155_S194_F0.5250.93
69_Q72_C0.5250.93
111_Y339_S0.5240.93
267_H270_S0.5230.93
161_M312_S0.5230.93
105_L130_S0.5190.93
145_Q148_T0.5180.93
284_A315_L0.5180.93
271_L274_A0.5180.93
358_I364_I0.5160.93
97_F232_Q0.5160.93
90_V117_F0.5120.92
164_H299_F0.5120.92
192_V260_G0.5110.92
124_K236_N0.5110.92
172_A175_S0.5110.92
81_V237_A0.5110.92
20_T29_Q0.5100.92
112_E355_I0.5090.92
316_K323_E0.5080.92
105_L151_V0.5060.92
230_W234_R0.5060.92
33_S338_Y0.5040.92
121_I240_M0.5040.92
263_L309_G0.5040.92
17_K35_V0.5010.92
189_A194_F0.5010.92
32_S219_M0.5000.91
102_D127_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ibjA 4 0.9519 100 0.397 Contact Map
1qgnA 4 0.9823 100 0.404 Contact Map
3ri6A 4 0.838 100 0.427 Contact Map
3cogA 4 0.9646 100 0.436 Contact Map
4itxA 4 0.9924 100 0.437 Contact Map
4kamA 4 0.8937 100 0.446 Contact Map
4iy7A 4 0.9544 100 0.447 Contact Map
1e5eA 4 0.9823 100 0.461 Contact Map
3ndnA 4 0.9823 100 0.478 Contact Map
4oc9A 5 0.9722 100 0.489 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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