GREMLIN Database
GSHR - Glutathione reductase
UniProt: P06715 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10412
Length: 450 (439)
Sequences: 13607 (8972)
Seq/√Len: 428.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_A254_V4.1531.00
35_A114_F3.9391.00
288_D292_N3.7951.00
405_I419_F2.9331.00
169_R192_K2.9251.00
278_K286_V2.8651.00
192_K224_Q2.6891.00
194_H226_H2.6471.00
5_Y109_D2.6131.00
119_D122_T2.6051.00
4_H133_D2.6051.00
367_Q398_S2.5951.00
142_R268_D2.5861.00
122_T129_T2.5811.00
271_N274_A2.4951.00
5_Y31_A2.4921.00
215_V219_N2.4731.00
4_H131_T2.4301.00
166_L191_A2.4111.00
418_G437_A2.3761.00
118_V124_E2.3681.00
208_P357_P2.3561.00
396_V399_E2.3531.00
19_S136_L2.3201.00
116_R124_E2.3161.00
132_A135_I2.3051.00
367_Q397_G2.3031.00
142_R266_A2.2741.00
144_S264_E2.2671.00
354_L362_Q2.1751.00
171_A196_F2.1651.00
31_A111_I2.1611.00
169_R255_D2.1581.00
8_I130_I2.1191.00
369_K397_G2.1151.00
400_E430_K2.1091.00
124_E129_T2.0831.00
233_A245_E2.0691.00
7_Y23_A2.0691.00
354_L359_A2.0651.00
280_N284_Y2.0301.00
401_K426_G2.0201.00
243_T251_S2.0201.00
407_G412_M2.0011.00
235_V245_E1.9951.00
321_L325_L1.9931.00
118_V129_T1.9791.00
200_H228_N1.9541.00
156_D159_G1.9271.00
8_I33_I1.9051.00
113_G125_V1.9041.00
122_T131_T1.8901.00
232_K247_E1.8861.00
8_I123_L1.8851.00
180_V195_L1.8831.00
149_P233_A1.8721.00
356_E360_R1.8351.00
243_T253_T1.8291.00
422_A427_A1.8281.00
15_G301_V1.8211.00
73_D80_N1.8211.00
368_V394_V1.7991.00
142_R264_E1.7941.00
73_D78_K1.7701.00
230_I247_E1.7541.00
8_I132_A1.7201.00
117_F135_I1.7181.00
121_K297_G1.7081.00
134_H297_G1.7071.00
357_P361_E1.6941.00
226_H250_R1.6931.00
235_V243_T1.6871.00
187_N192_K1.6621.00
8_I31_A1.6541.00
356_E392_K1.6541.00
289_K333_H1.6531.00
180_V345_S1.6531.00
6_D133_D1.6451.00
137_I304_N1.6441.00
170_V191_A1.6441.00
201_A211_S1.6331.00
292_N296_E1.6311.00
170_V186_I1.6291.00
348_P413_D1.6281.00
245_E251_S1.6181.00
80_N83_T1.6141.00
393_L405_I1.6081.00
10_I115_A1.5601.00
155_I163_L1.5431.00
209_M372_K1.5261.00
198_R230_I1.5171.00
111_I130_I1.5171.00
364_G403_V1.5091.00
136_L325_L1.5021.00
241_S253_T1.5001.00
237_N243_T1.4931.00
226_H229_A1.4891.00
428_T431_D1.4811.00
83_T86_A1.4791.00
155_I159_G1.4711.00
213_T408_I1.4641.00
168_E255_D1.4551.00
358_Q361_E1.4491.00
100_E112_K1.4461.00
59_I62_A1.4411.00
187_N223_P1.4401.00
171_A244_L1.4321.00
299_Y324_R1.4321.00
168_E192_K1.4301.00
134_H325_L1.4201.00
232_K245_E1.4191.00
290_Y324_R1.4171.00
7_Y28_Q1.4071.00
38_L110_V1.3971.00
359_A394_V1.3871.00
207_D392_K1.3871.00
359_A368_V1.3871.00
139_T304_N1.3671.00
6_D29_K1.3631.00
159_G162_A1.3621.00
194_H224_Q1.3611.00
155_I256_C1.3521.00
160_F186_I1.3461.00
22_R323_E1.3451.00
280_N286_V1.3281.00
188_G221_E1.3271.00
33_I130_I1.3251.00
364_G368_V1.3191.00
291_Q305_T1.3151.00
73_D83_T1.3081.00
89_T93_D1.2971.00
7_Y136_L1.2811.00
278_K294_N1.2731.00
367_Q396_V1.2591.00
396_V401_K1.2581.00
31_A130_I1.2551.00
5_Y111_I1.2471.00
209_M392_K1.2471.00
153_Y236_K1.2331.00
116_R271_N1.2291.00
292_N297_G1.2261.00
208_P212_E1.2251.00
217_V220_A1.2221.00
210_I390_R1.2191.00
136_L301_V1.2181.00
275_A295_I1.2171.00
201_A208_P1.2061.00
155_I160_F1.2041.00
196_F252_E1.1991.00
210_I408_I1.1921.00
216_E219_N1.1861.00
425_M431_D1.1791.00
32_L103_L1.1781.00
117_F137_I1.1761.00
45_V158_D1.1741.00
85_I89_T1.1691.00
86_A90_A1.1671.00
206_F351_T1.1661.00
117_F123_L1.1621.00
393_L419_F1.1621.00
229_A248_D1.1601.00
214_L408_I1.1501.00
358_Q362_Q1.1461.00
295_I298_I1.1391.00
349_I408_I1.1331.00
391_M445_E1.1311.00
246_L252_E1.1311.00
124_E127_G1.1301.00
375_F409_G1.1271.00
419_F446_F1.1251.00
201_A215_V1.1231.00
175_A202_P1.1221.00
370_V394_V1.1181.00
173_V257_L1.1151.00
145_H156_D1.1151.00
206_F341_T1.1131.00
33_I115_A1.1121.00
114_F269_N1.1111.00
341_T351_T1.1101.00
36_K45_V1.1061.00
65_M69_D1.1051.00
215_V227_T1.1041.00
100_E104_G1.1031.00
318_G322_S1.1021.00
118_V122_T1.1011.00
197_V227_T1.0921.00
237_N253_T1.0911.00
21_N106_N1.0891.00
215_V225_L1.0871.00
350_G416_L1.0861.00
338_N423_L1.0851.00
148_I151_V1.0781.00
417_Q438_I1.0751.00
411_G414_E1.0741.00
342_V438_I1.0731.00
29_K109_D1.0711.00
60_R64_H1.0641.00
234_V257_L1.0621.00
170_V256_C1.0591.00
125_V130_I1.0591.00
195_L225_L1.0541.00
169_R241_S1.0491.00
285_I304_N1.0481.00
272_L277_V1.0451.00
301_V321_L1.0441.00
267_N279_T1.0441.00
169_R194_H1.0411.00
359_A364_G1.0361.00
356_E370_V1.0281.00
116_R274_A1.0261.00
216_E220_A1.0241.00
364_G367_Q1.0221.00
82_E164_P1.0201.00
63_I67_G1.0201.00
235_V251_S1.0191.00
109_D128_E1.0191.00
427_A431_D1.0181.00
196_F246_L1.0181.00
90_A94_R1.0161.00
417_Q443_A1.0151.00
360_R368_V1.0141.00
202_P227_T1.0111.00
218_M223_P1.0081.00
111_I128_E1.0071.00
10_I137_I1.0071.00
12_G38_L1.0061.00
147_D151_V1.0041.00
81_W85_I1.0031.00
342_V413_D1.0011.00
355_T358_Q1.0001.00
15_G314_A0.9991.00
369_K400_E0.9981.00
12_G32_L0.9981.00
400_E429_K0.9981.00
372_K390_R0.9961.00
320_R334_L0.9951.00
169_R191_A0.9921.00
220_A388_P0.9871.00
28_Q134_H0.9801.00
61_E64_H0.9791.00
291_Q321_L0.9751.00
117_F132_A0.9741.00
165_A256_C0.9721.00
364_G396_V0.9701.00
85_I88_R0.9701.00
28_Q326_F0.9671.00
214_L349_I0.9661.00
169_R253_T0.9661.00
213_T216_E0.9661.00
350_G412_M0.9611.00
74_T77_N0.9591.00
28_Q133_D0.9591.00
93_D97_T0.9571.00
210_I406_H0.9571.00
229_A246_L0.9551.00
33_I125_V0.9541.00
55_H59_I0.9521.00
26_Y326_F0.9451.00
277_V285_I0.9451.00
286_V294_N0.9431.00
275_A298_I0.9431.00
279_T286_V0.9411.00
352_V423_L0.9361.00
237_N241_S0.9331.00
22_R26_Y0.9291.00
154_G234_V0.9271.00
202_P215_V0.9261.00
63_I74_T0.9251.00
26_Y323_E0.9211.00
356_E394_V0.9181.00
175_A197_V0.9181.00
58_Q62_A0.9181.00
170_V258_I0.9171.00
217_V221_E0.9171.00
354_L358_Q0.9141.00
75_T78_K0.9141.00
117_F274_A0.9121.00
226_H252_E0.9121.00
277_V294_N0.9071.00
173_V259_W0.9071.00
56_A84_L0.9071.00
265_P284_Y0.9071.00
61_E221_E0.9071.00
391_M407_G0.9051.00
68_P83_T0.9051.00
173_V261_I0.9041.00
269_N272_L0.9021.00
219_N224_Q0.9011.00
335_D424_K0.8991.00
321_L324_R0.8991.00
117_F275_A0.8971.00
180_V218_M0.8961.00
10_I123_L0.8951.00
202_P225_L0.8951.00
5_Y29_K0.8911.00
287_V305_T0.8911.00
135_I298_I0.8891.00
151_V154_G0.8861.00
356_E368_V0.8831.00
300_A304_N0.8831.00
277_V295_I0.8811.00
171_A252_E0.8781.00
213_T217_V0.8771.00
292_N299_Y0.8771.00
116_R269_N0.8731.00
348_P411_G0.8731.00
33_I113_G0.8711.00
287_V300_A0.8691.00
422_A432_F0.8621.00
320_R324_R0.8611.00
117_F271_N0.8611.00
94_R382_V0.8601.00
57_A188_G0.8601.00
402_I419_F0.8581.00
212_E215_V0.8561.00
308_V339_I0.8531.00
352_V420_A0.8521.00
217_V388_P0.8501.00
42_C47_C0.8491.00
6_D28_Q0.8471.00
210_I349_I0.8471.00
134_H299_Y0.8461.00
169_R254_V0.8461.00
322_S326_F0.8461.00
364_G394_V0.8441.00
99_Y103_L0.8421.00
292_N324_R0.8401.00
103_L110_V0.8401.00
396_V403_V0.8391.00
144_S261_I0.8361.00
53_M85_I0.8351.00
18_A315_V0.8341.00
61_E65_M0.8311.00
56_A87_S0.8271.00
196_F226_H0.8271.00
120_A297_G0.8261.00
101_N105_K0.8251.00
229_A250_R0.8231.00
177_Y343_V0.8221.00
217_V408_I0.8221.00
201_A212_E0.8221.00
236_K242_L0.8211.00
22_R322_S0.8211.00
172_V258_I0.8191.00
212_E216_E0.8171.00
121_K131_T0.8171.00
103_L108_V0.8111.00
179_A197_V0.8111.00
10_I270_I0.8041.00
28_Q325_L0.7991.00
201_A357_P0.7991.00
97_T100_E0.7971.00
194_H254_V0.7931.00
54_W185_V0.7921.00
424_K434_N0.7891.00
276_G295_I0.7891.00
86_A164_P0.7891.00
136_L321_L0.7881.00
284_Y309_E0.7881.00
22_R25_M0.7881.00
418_G421_V0.7831.00
44_N96_H0.7821.00
243_T246_L0.7821.00
113_G126_N0.7811.00
427_A432_F0.7801.00
271_N275_A0.7791.00
187_N221_E0.7781.00
92_I95_I0.7761.00
19_S318_G0.7751.00
355_T406_H0.7751.00
144_S147_D0.7741.00
8_I135_I0.7721.00
323_E332_E0.7701.00
7_Y322_S0.7701.00
291_Q324_R0.7691.00
234_V242_L0.7691.00
172_V179_A0.7681.00
67_G74_T0.7661.00
61_E188_G0.7651.00
82_E86_A0.7651.00
275_A294_N0.7641.00
372_K392_K0.7631.00
68_P73_D0.7631.00
173_V231_P0.7631.00
395_C429_K0.7611.00
23_A322_S0.7611.00
23_A28_Q0.7591.00
359_A403_V0.7591.00
196_F229_A0.7561.00
150_G156_D0.7541.00
313_V339_I0.7541.00
290_Y333_H0.7531.00
139_T270_I0.7521.00
224_Q250_R0.7521.00
50_K54_W0.7501.00
188_G346_H0.7461.00
9_A16_G0.7431.00
121_K295_I0.7401.00
153_Y256_C0.7391.00
203_L214_L0.7391.00
293_T300_A0.7391.00
88_R92_I0.7341.00
19_S322_S0.7321.00
34_E37_E0.7291.00
374_S377_A0.7271.00
394_V397_G0.7251.00
272_L275_A0.7231.00
120_A276_G0.7231.00
363_Y367_Q0.7221.00
375_F445_E0.7211.00
135_I297_G0.7201.00
5_Y8_I0.7191.00
50_K182_L0.7191.00
218_M225_L0.7191.00
213_T390_R0.7171.00
405_I423_L0.7171.00
183_A195_L0.7161.00
214_L345_S0.7161.00
323_E328_N0.7151.00
421_V427_A0.7151.00
88_R162_A0.7141.00
421_V432_F0.7131.00
199_K204_R0.7121.00
268_D273_E0.7101.00
290_Y329_K0.7091.00
275_A279_T0.7091.00
163_L256_C0.7081.00
200_H208_P0.7061.00
337_S362_Q0.7061.00
267_N304_N0.7041.00
206_F349_I0.7031.00
79_F84_L0.7031.00
371_Y395_C0.6991.00
285_I300_A0.6991.00
90_A93_D0.6981.00
401_K428_T0.6961.00
63_I77_N0.6961.00
185_V189_L0.6961.00
37_E45_V0.6911.00
419_F423_L0.6911.00
97_T101_N0.6901.00
145_H259_W0.6891.00
149_P152_E0.6891.00
402_I423_L0.6881.00
421_V435_T0.6851.00
414_E443_A0.6851.00
291_Q320_R0.6841.00
369_K395_C0.6841.00
407_G415_M0.6821.00
56_A70_Y0.6821.00
226_H246_L0.6801.00
206_F343_V0.6751.00
55_H58_Q0.6741.00
73_D77_N0.6731.00
141_G263_R0.6701.00
163_L186_I0.6661.00
207_D406_H0.6651.00
421_V425_M0.6641.00
101_N104_G0.6621.00
19_S321_L0.6621.00
316_A319_R0.6621.00
371_Y393_L0.6590.99
85_I164_P0.6580.99
73_D76_I0.6580.99
395_C400_E0.6540.99
64_H76_I0.6540.99
431_D434_N0.6520.99
429_K433_D0.6500.99
277_V298_I0.6500.99
236_K241_S0.6490.99
184_G188_G0.6480.99
150_G154_G0.6480.99
180_V202_P0.6480.99
67_G70_Y0.6470.99
151_V234_V0.6460.99
89_T162_A0.6430.99
87_S91_Y0.6430.99
120_A275_A0.6430.99
98_S102_V0.6420.99
23_A30_C0.6410.99
399_E426_G0.6400.99
279_T285_I0.6400.99
287_V291_Q0.6360.99
323_E327_N0.6350.99
60_R63_I0.6350.99
183_A223_P0.6330.99
284_Y306_G0.6320.99
198_R204_R0.6310.99
363_Y368_V0.6300.99
24_A108_V0.6300.99
299_Y325_L0.6290.99
354_L404_G0.6250.99
143_P146_P0.6220.99
386_R410_F0.6220.99
317_A336_Y0.6220.99
351_T406_H0.6220.99
179_A198_R0.6210.99
148_I234_V0.6200.99
158_D161_F0.6180.99
292_N295_I0.6160.99
151_V259_W0.6150.99
154_G259_W0.6150.99
122_T125_V0.6140.99
338_N424_K0.6120.99
439_H444_E0.6120.99
63_I72_F0.6100.99
82_E85_I0.6100.99
107_N110_V0.6090.99
160_F163_L0.6070.99
177_Y341_T0.6070.99
368_V403_V0.6060.99
409_G412_M0.6060.99
148_I231_P0.6050.99
83_T87_S0.6030.99
56_A59_I0.6030.99
242_L257_L0.6030.99
242_L245_E0.6020.99
26_Y328_N0.6000.99
184_G221_E0.6000.99
55_H62_A0.5980.99
169_R187_N0.5970.99
405_I446_F0.5970.99
186_I191_A0.5970.99
95_I382_V0.5970.99
155_I158_D0.5970.99
184_G218_M0.5940.99
86_A89_T0.5940.99
197_V204_R0.5930.99
146_P259_W0.5920.99
145_H151_V0.5910.99
237_N240_G0.5910.99
100_E110_V0.5910.99
272_L279_T0.5900.99
253_T256_C0.5900.99
65_M385_H0.5890.99
6_D31_A0.5880.99
84_L189_L0.5880.99
381_A442_A0.5870.99
241_S255_D0.5860.99
35_A266_A0.5860.99
281_E286_V0.5850.99
62_A65_M0.5840.99
424_K435_T0.5830.99
99_Y102_V0.5830.99
196_F254_V0.5820.99
34_E110_V0.5820.99
301_V318_G0.5800.99
210_I213_T0.5780.99
146_P151_V0.5780.99
37_E96_H0.5750.99
380_T383_T0.5710.99
167_P191_A0.5710.99
21_N25_M0.5690.99
420_A424_K0.5690.99
179_A260_A0.5690.99
221_E346_H0.5690.99
323_E329_K0.5680.98
280_N306_G0.5670.98
98_S101_N0.5650.98
118_V274_A0.5650.98
87_S385_H0.5630.98
48_V379_Y0.5630.98
236_K239_D0.5630.98
111_I125_V0.5630.98
246_L250_R0.5620.98
234_V259_W0.5610.98
87_S90_A0.5610.98
313_V317_A0.5600.98
57_A60_R0.5590.98
418_G443_A0.5580.98
430_K434_N0.5560.98
155_I162_A0.5560.98
354_L364_G0.5540.98
241_S246_L0.5540.98
157_S263_R0.5530.98
415_M442_A0.5530.98
69_D385_H0.5520.98
194_H252_E0.5510.98
421_V437_A0.5500.98
4_H29_K0.5500.98
182_L185_V0.5490.98
319_R323_E0.5480.98
9_A20_I0.5470.98
423_L427_A0.5450.98
191_A255_D0.5440.98
387_Q410_F0.5430.98
378_M381_A0.5430.98
150_G153_Y0.5430.98
393_L402_I0.5430.98
313_V336_Y0.5420.98
136_L322_S0.5420.98
213_T374_S0.5400.98
121_K135_I0.5400.98
198_R261_I0.5390.98
229_A247_E0.5390.98
335_D338_N0.5380.98
209_M390_R0.5380.98
285_I293_T0.5370.98
406_H419_F0.5370.98
157_S178_I0.5370.98
70_Y87_S0.5360.98
405_I416_L0.5360.98
9_A30_C0.5360.98
58_Q346_H0.5350.98
37_E44_N0.5350.98
171_A257_L0.5350.98
59_I63_I0.5350.98
323_E330_P0.5340.98
51_K54_W0.5330.98
420_A435_T0.5320.98
316_A320_R0.5310.98
117_F297_G0.5310.98
36_K112_K0.5290.98
242_L246_L0.5270.98
176_G262_G0.5270.98
338_N420_A0.5270.98
24_A29_K0.5270.98
25_M106_N0.5260.98
100_E103_L0.5260.98
57_A189_L0.5250.97
32_L108_V0.5250.97
379_Y382_V0.5250.97
55_H384_T0.5240.97
354_L363_Y0.5240.97
375_F442_A0.5240.97
82_E165_A0.5220.97
158_D263_R0.5220.97
153_Y242_L0.5220.97
67_G72_F0.5210.97
7_Y19_S0.5210.97
184_G346_H0.5190.97
143_P157_S0.5180.97
346_H410_F0.5170.97
182_L258_I0.5160.97
180_V225_L0.5160.97
416_L438_I0.5160.97
246_L249_G0.5160.97
152_E236_K0.5140.97
373_S377_A0.5120.97
417_Q420_A0.5120.97
38_L100_E0.5120.97
351_T358_Q0.5120.97
141_G309_E0.5120.97
375_F391_M0.5110.97
346_H386_R0.5100.97
59_I67_G0.5080.97
197_V231_P0.5080.97
137_I285_I0.5080.97
382_V387_Q0.5080.97
357_P360_R0.5070.97
132_A297_G0.5050.97
338_N352_V0.5050.97
407_G416_L0.5040.97
363_Y403_V0.5030.97
138_A301_V0.5030.97
170_V193_T0.5020.97
89_T92_I0.5010.97
38_L103_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r9zA 2 0.9867 100 0.171 Contact Map
1gesA 2 0.9978 100 0.176 Contact Map
3o0hA 2 0.9822 100 0.178 Contact Map
3dk9A 2 0.9956 100 0.178 Contact Map
2wpfA 2 0.9911 100 0.179 Contact Map
1ojtA 2 0.9867 100 0.186 Contact Map
3ic9A 2 0.9889 100 0.186 Contact Map
4dnaA 2 0.9844 100 0.187 Contact Map
2hqmA 2 0.9889 100 0.188 Contact Map
1lvlA 2 0.9778 100 0.19 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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